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微液滴制备技术在功能化纳米载体构建中的应用
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作者 沈小钟 葛铭晨 +1 位作者 付泯宇 王亚晶 《中国医药工业杂志》 CAS CSCD 北大核心 2019年第2期148-157,共10页
以微流控芯片为基础的微液滴技术在制备结构和粒径均一的功能纳米载体方面具有独特优势。本文总结了目前利用微液滴技术和不同制备材料构建的具有不同结构和功能的纳米载体在药物递送方面的研究进展。纳米载体主要包括纳米脂质体、聚合... 以微流控芯片为基础的微液滴技术在制备结构和粒径均一的功能纳米载体方面具有独特优势。本文总结了目前利用微液滴技术和不同制备材料构建的具有不同结构和功能的纳米载体在药物递送方面的研究进展。纳米载体主要包括纳米脂质体、聚合物纳米粒、固体脂质纳米粒、杂化纳米复合物、Janus纳米粒等。 展开更多
关键词 微流控 微液滴 脂质体 纳米粒 Janus纳米粒
A tri-layer approach to controlling nanopore formation in oxide supports
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作者 Abha A.Gosavi James L.Hedrick +2 位作者 Peng-Cheng Chen Justin M.Notestein Chad A.Mirkin 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第6期1223-1228,共6页
A novel tri-layer approach for immobilizing metal nanoparticles in SiO2 supports is presented.In this work,we show that under rapid heating to temperatures of approximately 1,000 ℃,metal nanoparticles less than 15 nm... A novel tri-layer approach for immobilizing metal nanoparticles in SiO2 supports is presented.In this work,we show that under rapid heating to temperatures of approximately 1,000 ℃,metal nanoparticles less than 15 nm in size will entrench in the SiO2 layer on a silicon wafer to create pores as deep as 250 nm.We studied and characterized this entrenching behavior and subsequent nanopore formation for a wide variety of metal nanoparticles,including Au,Ag,Pt,Pd,and Cu.We also demonstrate that an Al2O3 layer acts as a barrier to such pore formation.Thus,by creating a tri-layer architecture consisting of SiO2 on Al2O3 on silicon wafers,we can control the depth to which nanoparticles entrench between 3-5 nm.This small range allows one to entrench particles for the purpose of immobilization but still present them above the surface.The two advances of moving into the sub-15 nm size regime and of controlled particle immobilization through entrenchment have important implications in studying site-isolated and stabilized metal nanoparticles for applications in sensing,separations,and catalysis. 展开更多
关键词 NANOPORE formation NANOPARTICLE ENTRENCHMENT NANOPARTICLE stabilization ATOMIC force MICROSCOPY Au nanoparticles
Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle
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作者 Dongyoon Kim Quoc-Viet Le +1 位作者 Young Bong Kim Yu-Kyoung Oh 《药学学报:英文版》 CSCD 2019年第3期565-574,共10页
The safety of nanomaterials, a crucial consideration for clinical translation, is enhanced by using building blocks that are biologically nontoxic. Here, we used poly(γ-glutamic acid)(γ-PGA) and dopamine as building... The safety of nanomaterials, a crucial consideration for clinical translation, is enhanced by using building blocks that are biologically nontoxic. Here, we used poly(γ-glutamic acid)(γ-PGA) and dopamine as building blocks of polymeric nanomaterials for carrying hydrophobic anticancer drugs. The introduction of phenylalanine onto γ-PGA enabled the resulting amphiphilic derivative of γ-PGA acid to self-assemble in the presence of the anticancer drug paclitaxel(PTX) to form PTX-encapsulated micelles.The surfaces of PTX-loaded micelles were then coated with polymerized dopamine(PDA). The PDAcoated, amphiphilic γ-PGA-based micelles(AM) carrying PTX(PDA/AM/P) exerted near-infraredresponsive photothermal effects. Near-infrared irradiation of cancer cells treated with PDA/AM/P nanoparticles produced a greater anticancer effect than that observed in other treatment groups, indicating a synergistic effect. Intravenous administration of PDA/AM/P completely ablated tumors and prevented their recurrence. Notably, the in vivo safety profile of PDA/AM/P nanoparticles allowed PTX to be delivered at a 3.6-fold higher dose than was possible with PTX solubilized in surfactant, and circumvented the side effects of the surfactant. These results support the multifunctional potential of PDA/AM for the delivery of various hydrophobic drugs and imaging dyes for safe translation of nanomaterials into the clinic. 展开更多
关键词 SAFETY PHOTOCHEMOTHERAPY Biopolymeric nanoparticle Poly(γ-glutamic acid) Polymerized DOPAMINE PACLITAXEL
Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
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作者 Xi Cao Ying Hu +5 位作者 Shi Luo Yuejing Wang Tao Gong Xun Sun Yao Fun Zhirong Zhang 《药学学报:英文版》 CSCD 2019年第3期575-589,共15页
Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of cela... Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via na?ve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid)(PEG-PLGA) nanoparticles. Neutrophil membranecoated nanoparticles(NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models,celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma. 展开更多
关键词 Na■ve NEUTROPHILS membrane CELASTROL PEG-PLGA nanoparticle Pancreatic carcinoma Inflammation
玉米醇溶蛋白-多酚纳米颗粒对Pickering乳液稳定性的调控 预览
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作者 唐瑜婉 王启明 +3 位作者 杨雅轩 李富华 赵吉春 明建 《食品与发酵工业》 CAS CSCD 北大核心 2019年第11期280-285,共6页
pickering乳液由于具有良好的稳定性备受食品行业青睐。玉米醇溶蛋白纳米颗粒(Zein Nanoparticles,ZNPs)作为Pickering乳液的一种新型乳化剂,具有公认安全、生物可降解、来源广泛等优势。多酚具有良好的抗氧化活性,它能与玉米醇溶蛋白(z... pickering乳液由于具有良好的稳定性备受食品行业青睐。玉米醇溶蛋白纳米颗粒(Zein Nanoparticles,ZNPs)作为Pickering乳液的一种新型乳化剂,具有公认安全、生物可降解、来源广泛等优势。多酚具有良好的抗氧化活性,它能与玉米醇溶蛋白(zein)相互作用形成玉米醇溶蛋白-多酚纳米颗粒(Zein-Polyphenol Nanoparticles,ZPNPs),调控其自组装行为。文中主要对ZPNPs的制备方法和机理进行了综述,并分析了这种纳米颗粒对乳液稳定性的影响,结果发现ZPNPs能提高pickering乳液的抗氧化能力,增加乳液体系的稳定性,这为乳液食品的发展提供了新思路。 展开更多
关键词 玉米醇溶蛋白 纳米颗粒 多酚 pickering乳液
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纳米颗粒物毒性效应研究进展 预览
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作者 曾繁华 王易 +3 位作者 何俊燃 赵小双 李梦兰 曾静 《广东化工》 CAS 2019年第13期79-80,84共3页
随着纳米颗粒物的广泛应用,职业暴露于纳米颗粒物引起的健康问题也越来越受到人们的关注。本文从纳米颗粒物类型、粒径的影响等方面综述了目前关于纳米颗粒毒性效应的研究进展。总结了当前针对纳米颗粒物的职业卫生监管技术,为进一步开... 随着纳米颗粒物的广泛应用,职业暴露于纳米颗粒物引起的健康问题也越来越受到人们的关注。本文从纳米颗粒物类型、粒径的影响等方面综述了目前关于纳米颗粒毒性效应的研究进展。总结了当前针对纳米颗粒物的职业卫生监管技术,为进一步开展人造纳米颗粒物职业卫生管控提供了参考。 展开更多
关键词 纳米颗粒物 毒性效应 职业卫生监管
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Preparation and characterization of atrazine-loaded biodegradable PLGA nanospheres 预览
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作者 CHEN Xiao-ting Tongxin Wang 《农业科学学报:英文版》 SCIE CAS CSCD 2019年第5期1035-1041,共7页
Atrazine is the second mostly used herbicide in USA,but low utilization ratio causes severe environmental problem,so controlled release system is highly needed in order to minimize the negative impact on environment.I... Atrazine is the second mostly used herbicide in USA,but low utilization ratio causes severe environmental problem,so controlled release system is highly needed in order to minimize the negative impact on environment.In this paper,a herbicide delivery system,atrazine-loaded poly(lactic-co-glycolic acid)(PLGA)nanoparticles(NPs)were prepared by forming an oilin-water emulsion using the emulsion-solvent evaporation method.By varying the preparation conditions of PLGA-NPs,such as sonication time,surfactant content,solvent fraction,and polymer content,the particle sizes of the PLGA-NPs were well controlled from 204 to 520 nm.The morphology and size distribution of PLGA-NPs were evaluated using dynamic light scattering(DLS)and scanning electron microscopy(SEM).Both the encapsulation efficiency and release profile of the herbicide from the PLGA-NPs were typically evaluated by using 2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine(atrazine,ATZ)as the model.ATZ encapsulation efficiency within the PLGA-NPs was ranged from 31.6 to 50.5%.The release profiles of ATZ-loaded PLGA-NPs exhibited a much slower release rate in comparison with that of pure herbicide.The results demonstrated that the prepared PLGA-NPs had a high encapsulation efficiency and slow release rate,which could be used as a promising herbicide release system in agriculture to diminish the impact on the environment and minimize the potential harm to the farmers. 展开更多
关键词 ATRAZINE PLGA NANOPARTICLE controlled release DRUG delivery
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Peanut-Like Hematite Prepared by a New Facile Hydrothermal Process for Removal of As(V) 预览
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作者 Chengjin Zhang Shaoyi Jia +1 位作者 Songhai Wu Yong Liu 《天津大学学报:英文版》 EI CAS 2019年第1期23-30,共8页
Peanut-like hematite has been prepared by a new facile hydrothermal method and applied in the adsorption removal of As(V). The structural features of the as-prepared hematite were characterized systematically by X-ray... Peanut-like hematite has been prepared by a new facile hydrothermal method and applied in the adsorption removal of As(V). The structural features of the as-prepared hematite were characterized systematically by X-ray diff raction, X-ray photoelectron spectroscopy, Brunauer-Emmett-Teller, scanning electron microscopy, energy-dispersive X-ray spectroscopy mapping, Fourier transform infrared spectroscopy, and transmission electron microscopy. Results showed that the morphologies of hematite could be tuned to spindle-like, oval-like, and cantaloupe-like shapes by adjusting the hydrothermal conditions. The peanut-like hematite formation followed a fi ve-step route. At pH = 3, the adsorption amount of As(V) over peanut-like hematite reached 13.84 mg/g, and the adsorption kinetic process corresponded to the pseudo-second-order kinetic model. The peanut-like hematite also showed partial selectivity over As(V) in the hydrosphere. This method can be a reference for the preparation of other architectural metal oxide materials. 展开更多
关键词 Peanut-like HEMATITE ARSENIC ADSORBENT Nanoparticle
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乳腺癌微环境响应的透明质酸纳米粒的构建及其体外功能评价
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作者 龙凯花 王春柳 +4 位作者 李晔 张红 刘洋 孙婷婷 宗时宇 《中国药学杂志》 CAS CSCD 北大核心 2019年第16期1311-1316,共6页
目的探讨透明质酸修饰的乳腺癌微环境响应纳米粒的制备方法,并对其理化性质,体外功能进行评价。方法首先通过腙键将透明质酸(HA)与聚天冬氨酸(PASP)连接,制备聚合物HA-PASP,并且采用聚乙二醇(PEG)制备对照聚合物PEGPASP。以多柔比星(DOX... 目的探讨透明质酸修饰的乳腺癌微环境响应纳米粒的制备方法,并对其理化性质,体外功能进行评价。方法首先通过腙键将透明质酸(HA)与聚天冬氨酸(PASP)连接,制备聚合物HA-PASP,并且采用聚乙二醇(PEG)制备对照聚合物PEGPASP。以多柔比星(DOX)为模型药物,采用透析法制备纳米粒HA-PASP-NPs@DOX和PEG-PASP-NPs@DOX。采用粒度测定仪和透射电镜(TEM)观察纳米粒粒径、形态及Zeta电位;纳米粒的理化性质从包封率、载药量、稳定性、释药能力等方面进行评价;体外功能从乳腺癌细胞靶向性、肿瘤微环境响应性进行评价。结果HA-PASP-NPs@DOX呈球形大小均一,平均粒径为(143±21)nm,平均Zeta电位(-27.8±3.8)mV,包封率和载药量为58.3%和5.2%;在pH7.4条件下纳米粒结构稳定超过30d,在pH6.5条件下药物释放高达96%;HA-PASP-NPs@DOX对MDA-MB-231细胞具有靶向性,提高肿瘤细胞对DOX的摄取。结论透析法制备的HA-PASP-NPs@DOX粒径均一,能有效包裹DOX,实现对乳腺癌细胞的靶向以及在肿瘤酸性的环境中高效释放药物,从而提高抗肿瘤活性。 展开更多
关键词 乳腺癌 抗肿瘤活性 CD44 酸敏 纳米粒
Preparation of pyramid-SiNWs binary structure with Ag nanoparticles-assisted chemical etching
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作者 Zi-Long Zhang Bo Wang +4 位作者 Yu Chen Yun-Hui Tang Xue-Mei Song Qing-Liu Li Hui Yan 《稀有金属:英文版》 SCIE EI CAS CSCD 2019年第4期312-315,共4页
It is an important way to improve the efficiency of solar cells by using the special microstructures of surface.In this work,a pyramid-silicon nanowires (pyramidSiNWs) binary structure was prepared on the silicon surf... It is an important way to improve the efficiency of solar cells by using the special microstructures of surface.In this work,a pyramid-silicon nanowires (pyramidSiNWs) binary structure was prepared on the silicon surfaces with the metal-assisted chemical etching (MACE) method.Scanning electron microscope (SEM) was used to observe the micromorphology of the pyramid-SiNWs binary structure.The formation mechanism of the binary structure was discussed.The role of Ag nanoparticles in MACE is considered to be the template and the catalyzer.The optical reflectivity of the silicon surfaces was studied with ultraviolet-visible (UV-Vis) spectrophotometer.Compared with the fiat silicon surface and the simple pyramidal structure,the silicon surfaces with the pyramid-SiNWs binary structure achieve a much lower reflectance in a wide range of wavelength.The effect of etching time as a parameter on the reflectivity was also discussed. 展开更多
关键词 Ag NANOPARTICLE PYRAMID STRUCTURE Silicon NANOWIRES BINARY STRUCTURE Reflectance
细菌小细胞在癌症治疗中的应用
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作者 杨玉莹 刘青 +3 位作者 李沛 罗洪艳 王豪举 孔庆科 《生物工程学报》 CAS CSCD 北大核心 2019年第6期998-1008,共11页
癌症一直是危害人类健康的主要疾病之一。传统的癌症治疗方法包括放疗、化疗和手术,均具有明显的毒副作用或局限性。脂质体和纳米颗粒作为被广泛研究的药物递送载体,在人体临床试验中也出现了药物渗漏和装载功能不全等问题。目前而言,... 癌症一直是危害人类健康的主要疾病之一。传统的癌症治疗方法包括放疗、化疗和手术,均具有明显的毒副作用或局限性。脂质体和纳米颗粒作为被广泛研究的药物递送载体,在人体临床试验中也出现了药物渗漏和装载功能不全等问题。目前而言,应用具有肿瘤靶向性的载体递送抗肿瘤药物或小分子,是有希望介导安全、有效的肿瘤治疗的策略之一。近年来,细菌来源的非复制型小细胞已受到越来越多的关注。小细胞是细菌异常分裂时期产生的纳米级无核细胞,其直径为200–400 nm,因而具有较大的药物装载能力。对小细胞的表面进行修饰,例如,装配能与肿瘤细胞表面特异性抗原或受体结合的抗体/配体,可显著提高小细胞的肿瘤靶向性。这种具有靶向性的纳米材料能将抗肿瘤的化疗药物、功能性核酸或编码功能性小分子的质粒靶向递送至肿瘤,而减少药物在正常组织器官的集聚。因此,使用小细胞作为靶向递送载体有助于降低药物对机体的毒性,从而最大限度地发挥药物分子在体内的抗肿瘤活性。文中将对小细胞的产生与纯化、药物装载、肿瘤细胞靶向性、内化过程以及其用于递送抗肿瘤药物的研究进展等方面进行综述,为开发基于小细胞的癌症治疗策略提供一定的参考。 展开更多
关键词 小细胞 癌症治疗 纳米颗粒
Solvent-free microwave-assisted synthesis of tenorite nanoparticle-decorated multi-walled carbon nanotubes
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作者 Jennifer A. Rudd Cathren E. Gowenlock +4 位作者 Virginia Gomez Ewa Kazimierska Abdullah M. Al-Enizi Enrico Andreoli Andrew R. Barron 《材料科学技术学报:英文版》 SCIE EI CAS CSCD 2019年第6期1121-1127,共7页
Copper-decorated carbon nanotubes(CNTs) have important applications as precursors for ultraconductive copper wires. Tenorite-decorated CNTs(CuO-CNTs) are ideal candidates and are currently developed using laborious pr... Copper-decorated carbon nanotubes(CNTs) have important applications as precursors for ultraconductive copper wires. Tenorite-decorated CNTs(CuO-CNTs) are ideal candidates and are currently developed using laborious processes. For this reason, we have developed a facile and scalable method for the synthesis of CuO-CNTs from copper acetate. It was found that the optimal loading of copper acetate onto the CNTs was 23.1 wt% and that three 1-minute microwave treatments were sufficient for the decomposition of copper acetate to copper oxide. The loading of copper oxide onto the nanotubes was confirmed using X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy and thermogravimetric analysis. The materials were characterised using X-ray diffraction and scanning electron microscopy. 展开更多
关键词 MICROWAVE-ASSISTED synthesis Multi-walled CARBON NANOTUBES Tenorite NANOPARTICLE
Preparation of Non-spherical Colloidal Silica Nanoparticle and Its Application on Chemical Mechanical Polishing of Sapphire
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作者 孔慧 WANG Dan +1 位作者 刘卫丽 SONG Zhitang 《武汉理工大学学报:材料科学英文版》 SCIE EI CAS 2019年第1期86-90,共5页
Non-spherical colloidal silica nanoparticle was prepared by a simple new method, and its particle size distribution and shape morphology were characterized by dynamic light scattering(DLS) and the Focus Ion Beam(FIB) ... Non-spherical colloidal silica nanoparticle was prepared by a simple new method, and its particle size distribution and shape morphology were characterized by dynamic light scattering(DLS) and the Focus Ion Beam(FIB) system. This kind of novel colloidal silica particles can be well used in chemical mechanical polishing(CMP) of sapphire wafer surface. And the polishing test proves that non-spherical colloidal silica slurry shows much higher material removal rate(MRR) with higher coefficient of friction(COF) when compared to traditional large spherical colloidal silica slurry with particle size 80 nm by DLS. Besides, sapphire wafer polished by non-spherical abrasive also has a good surface roughness of 0.460 6 nm. Therefore, non-spherical colloidal silica has shown great potential in the CMP field because of its higher MRR and better surface roughness. 展开更多
关键词 COLLOIDAL silica NANOPARTICLE NON-SPHERICAL chemical mechanical POLISHING SAPPHIRE WAFER
电泳沉积纳米粒子增强树脂基碳纤维复合材料界面性能的研究进展
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作者 杨玉 徐海兵 +4 位作者 颜春 刘东 陈明达 祝颖丹 王冬梅 《塑料科技》 CAS 北大核心 2019年第8期112-117,共6页
介绍了电泳沉积的基本原理,纳米粒子悬浮液的分散机制,并详细讨论了电泳沉积碳纳米管、氧化石墨烯、二氧化硅、纳米纤维等纳米粒子在碳纤维增强树脂基复合材料界面改性方面的研究进展。
关键词 电泳沉积 碳纤维 纳米粒子 复合材料 界面性能
高纯纳米氢氧化铟粉末的制备 预览
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作者 黄娟 钟小华 +1 位作者 谭继军 朱刘 《广东化工》 CAS 2019年第4期57-58,共2页
本文通过以4N金属铟和高纯氨气为主要原料,采用化学沉淀法制备了高纯纳米氢氧化铟粉末。利用Marlven激光粒度分析仪,SEM和XRD对粉体的粒径分布、形貌和晶体结构进行表征,用ICP进行杂质元素分析。分析结果表明:制备的氢氧化铟粉末为立方... 本文通过以4N金属铟和高纯氨气为主要原料,采用化学沉淀法制备了高纯纳米氢氧化铟粉末。利用Marlven激光粒度分析仪,SEM和XRD对粉体的粒径分布、形貌和晶体结构进行表征,用ICP进行杂质元素分析。分析结果表明:制备的氢氧化铟粉末为立方结构的纳米棒状颗粒,其纯度高达99.995%;粉体粒度分布范围窄,粒径均匀。 展开更多
关键词 高纯氢氧化铟 纳米级 金属铟
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中空玉米醇溶蛋白-芍药苷纳米粒的制备及其体外释药研究
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作者 钱佳佳 王蓓蕾 +3 位作者 查丽琼 张彩云 张伟 洪璐峰 《中国药学杂志》 CAS CSCD 北大核心 2019年第4期297-302,共6页
目的为提高芍药苷的稳定性和口服生物利用度,制备了实心和中空玉米醇溶蛋白-芍药苷纳米粒,并比较其性质和体外释药特性。方法采用相分离法制备了实心和中空玉米醇溶蛋白-芍药苷纳米粒,以包封率为指标,采用正交设计优化处方并进行表征,... 目的为提高芍药苷的稳定性和口服生物利用度,制备了实心和中空玉米醇溶蛋白-芍药苷纳米粒,并比较其性质和体外释药特性。方法采用相分离法制备了实心和中空玉米醇溶蛋白-芍药苷纳米粒,以包封率为指标,采用正交设计优化处方并进行表征,考察体外释放度。结果实心玉米醇溶蛋白-芍药苷纳米粒的最优处方为:芍药苷质量为10 mg,玉米醇溶蛋白质量浓度为10 mg·mL-1,搅拌时间为2 h;包封率为53. 87%,载药量为26. 94%,平均粒径110 nm左右。中空玉米醇溶蛋白-芍药苷纳米粒的最优处方为:芍药苷质量为20 mg,玉米醇溶蛋白质量浓度为5 mg·mL-1,搅拌时间为1 h;包封率为55. 65%,载药量为44. 52%,平均粒径50 nm左右。体外释放表明,2种制剂均具有缓释作用。结论采用相分离法成功制备了实心和中空玉米醇溶蛋白-芍药苷纳米粒,方法简单可靠。和实心纳米粒相比较,中空纳米粒载药量和体外缓释效果均有明显提高。 展开更多
关键词 芍药苷 中空玉米醇溶蛋白 实心 纳米粒 载药量 体外释放
Trimetallic Au@PdPt core-shell nanoparticles with ultrathin PdPt skin as highly stable electrocatalysts for the oxygen reduction reaction in acid solution
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作者 Xiaokun Li Chunmei Zhang +5 位作者 Cheng Du Zhihua Zhuang Fuqin Zheng Ping Li Ziwei Zhang Wei Chen 《中国科学:化学英文版》 SCIE EI CAS CSCD 2019年第3期378-384,共7页
To design efficient and low-cost core-shell electrocatalysts with an ultrathin platinum shell, the balance between platinum dosage and durability in acid solution is of great importance. In the present work, trimetall... To design efficient and low-cost core-shell electrocatalysts with an ultrathin platinum shell, the balance between platinum dosage and durability in acid solution is of great importance. In the present work, trimetallic Au@PdPt core-shell nanoparticles(NPs)with Pd/Pt molar ratios ranging from 0.31:1 to 4.20:1 were synthesized based on the Au catalytic reduction strategy and the subsequent metallic replacement reaction. When the Pd/Pt molar ratio is 1.19:1(designated as Au@Pd1.19 Pt1 NPs), the superior electrochemical activity and stability were achieved for oxygen reduction reaction(ORR) in acid solution. Especially, the specific and mass activities of Au@Pd1.19 Pt1 NPs are 1.31 and 6.09 times higher than those of commercial Pt/C catalyst. In addition, the Au@Pd1.19 Pt1 NPs presented a good durability in acid solution. After 3000 potential cycles between 0.1 and 0.7 V(vs. Ag/AgCl), the oxygen reduction activity is almost unchanged. This study provides a simple strategy to synthesize highperformance trimetallic ORR electrocatalyst for fuel cells. 展开更多
关键词 ELECTROCATALYST CORE-SHELL PLATINUM oxygen reduction reaction NANOPARTICLE fuel cell
Nanosecond Pulse Generation with Silver Nanoparticle Saturable Absorber
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作者 R.Z.R.R.Rosdin M.T.Ahmad +3 位作者 A.R.Muhammad Z.Jusoh H.Arof S.W.Harun 《中国物理快报:英文版》 SCIE CAS CSCD 2019年第5期31-34,共4页
Nanosecond pulse generation in an erbium-doped fiber laser (EDFL) passively mode-locked by a silver nanoparticle(SNP)-based saturable absorber(SA) is experimentally demonstrated. The SA is fabricated by depositing a n... Nanosecond pulse generation in an erbium-doped fiber laser (EDFL) passively mode-locked by a silver nanoparticle(SNP)-based saturable absorber(SA) is experimentally demonstrated. The SA is fabricated by depositing a nanosized SNP layer onto the surface of polyvinyl alcohol film through the thermal evaporation process. By inserting the SA into an EDFL cavity, stable mode-locked operation is achieved at 1561.5 nm with the maximum pulse energy up to 52.3 nJ. The laser operates at a pulse repetition frequency of 1.0 MHz with a pulse width of 202 ns. These results suggest that SNPs could be developed as an effective SA for mode-locking pulse generation. 展开更多
关键词 SA Nanosecond PULSE Generation with SILVER NANOPARTICLE Saturable ABSORBER
Structural and Electronic Properties of Cyclic Peptide-gold Nanoparticle as a Drug Delivery System 预览
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作者 KHOSHBAYAN Bahareh MORSALI Ali BOZORGMEHR Mohammad Reza 《结构化学》 SCIE CAS CSCD 2019年第4期566-580,共15页
Using Au6 cluster and cyclooctaglycine model for gold nanoparticle(AuNP) and cyclic peptide(CP), twelve configurations for the functionalization of cyclic peptide-gold nanoparticle(CPAuNP) with gemcitabine(GEM) antica... Using Au6 cluster and cyclooctaglycine model for gold nanoparticle(AuNP) and cyclic peptide(CP), twelve configurations for the functionalization of cyclic peptide-gold nanoparticle(CPAuNP) with gemcitabine(GEM) anticancer drug were investigated(CPAuNP/GEM1-12). Structural and electronic properties have been studied in gas phase and aqueous solution at M06-2 X/6-31 g(d,p). The energetic stability of CPAuNP/GEM1-12 was confirmed by the calculation of binding energies. Since the solubility of drug, CP and AuNP increases in CPAuNP/GEM1-12, cyclic peptide-gold nanoparticle could be used as an appropriate drug delivery system. Quantum molecular descriptors such as electrophilicity power and global hardness demonstrated that the reactivity of CP and GEM drug increases in CPAuNP/GEM1-12 configurations. The AIM analysis for CPAuNP/GEM1-12 indicated that the Au-L(L = H, O, F, C, N) interactions and intermolecular hydrogen bonds play important roles in this drug delivery system. All Au-Au and some of Au-L interactions are related to medium interactions. The most stable configurations are those in which GEM drug is parallel to the CPAuNP and interacts simultaneously with AuNP and CP. 展开更多
关键词 gold NANOPARTICLE GEMCITABINE CYCLIC PEPTIDE AIM analysis NANOCARRIER
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Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by a-cyclodextrin
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作者 Lei Huang Jiaojiao Chen +4 位作者 Muye He Xinyu Hou Yiben Lu Kaiyan Lou Feng Gao 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第1期163-166,共4页
This paper presented an interesting nanoparticle-based drug delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface, which is adjustable by addition of... This paper presented an interesting nanoparticle-based drug delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface, which is adjustable by addition of different amount of cyclodextrin(a-CD). The effect of a-CD inclusion to the self-assembly behavior of methoxy polyethylene glycol(mPEG) grafted chitosan(CS) was studied. The results showed that the mPEG grafted chitosan(mPEG-[9_TD$IF]g-CS) forms self-assembled nanoparticles with either micelle or hollow sphere morphology depending on the ratio of a-CD to mPEG, as characterized by atomic force microscopy(AFM), transmission electron microscopy(TEM), and X-ray diffraction(XRD). Their sizes and zeta potential increased from 257.6 nmto 768.2 nm and from +4.5 mV to +11.6 mV, respectively, with the increasing amount of a-CD. The correlation between zeta potential and particle size of a-CD/mPEG-[9_TD$IF]g-CS nanoparticles indicated varied PEG density on surface of nanoparticles. Based on the above experimental observations, a likely mechanism for the morphological transition of the rod-coil graft copolymer mPEG-[9_TD$IF]g-CS was proposed. 展开更多
关键词 Α-CYCLODEXTRIN MPEG Grafted CHITOSAN Self-assembly NANOPARTICLE Drug delivery
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