期刊文献+
共找到88,546篇文章
< 1 2 250 >
每页显示 20 50 100
Soluble Nogo receptor 1 fusion protein protects neural progenitor cells in rats with ischemic stroke 预览
1
作者 Hai-Wei He Yue-Lin Zhang +4 位作者 Bao-Qi Yu Gen Ye Wei You Kwok-fai So Xin Li 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1755-1764,共10页
Soluble Nogo66 receptor-Fc protein(sNgR-Fc)enhances axonal regeneration following central nervous system injury.However,the underlying mechanisms remain unclear.In this study,we investigated the effects of sNgR-Fc on ... Soluble Nogo66 receptor-Fc protein(sNgR-Fc)enhances axonal regeneration following central nervous system injury.However,the underlying mechanisms remain unclear.In this study,we investigated the effects of sNgR-Fc on the proliferation and differentiation of neural progenitor cells.The photothrombotic cortical injury model of ischemic stroke was produced in the parietal cortex of Sprague-Dawley rats.The rats with photothrombotic cortical injury were randomized to receive infusion of 400μg/kg sNgR-Fc(sNgR-Fc group)or an equal volume of phosphate-buffered saline(photothrombotic cortical injury group)into the lateral ventricle for 3 days.The effects of sNgR-Fc on the proliferation and differentiation of endogenous neural progenitor cells were examined using BrdU staining.Neurological function was evaluated with the Morris water maze test.To further examine the effects of sNgR-Fc treatment on neural progenitor cells,photothrombotic cortical injury was produced in another group of rats that received transplantation of neural progenitor cells from the hippocampus of embryonic Sprague-Dawley rats.The animals were then given an infusion of phosphate-buffered saline(neural progenitor cells group)or sNgR-Fc(sNgR-Fc+neural progenitor cells group)into the lateral ventricle for 3 days.sNgR-Fc enhanced the proliferation of cultured neural progenitor cells in vitro as well as that of endogenous neural progenitor cells in vivo,compared with phosphate-buffered saline,and it also induced the differentiation of neural progenitor cells into neurons.Compared with the photothrombotic cortical injury group,escape latency in the Morris water maze and neurological severity score were greatly reduced,and distance traveled in the target quadrant was considerably increased in the sNgR-Fc group,indicating a substantial improvement in neurological function.Furthermore,compared with phosphate-buffered saline infusion,sNgR-Fc infusion strikingly improved the survival and differentiation of grafted neural progenitor cells.Our findings show that 展开更多
关键词 NEURAL REGENERATION Nogo-66 RECEPTOR Nogo66 receptor-Fc protein NEURAL PROGENITOR cells proliferation differentiation stroke photothrombotic cortical injury transplantation NEUROLOGICAL function nerve REGENERATION
在线阅读 下载PDF
Mapping theme trends and knowledge structures for human neural stem cells:a quantitative and co-word biclustering analysis for the 2013-2018 period 预览
2
作者 Wen-Juan Wei Bei Shi +3 位作者 Xin Guan Jing-Yun Ma Ya-Chen Wang Jing Liu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1823-1832,共10页
Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends a... Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells. 展开更多
关键词 nerve REGENERATION human NEURAL stem cells PubMed bibliometric ANALYSIS biclustering ANALYSIS co-word ANALYSIS strategic diagram ANALYSIS social network ANALYSIS hot research topics MAPPING THEME TRENDS knowledge structures NEURAL REGENERATION
在线阅读 下载PDF
MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acidinduced spina bifida aperta 预览
3
作者 He-Nan Zhang Yi Guo +3 位作者 Wei Ma Jia Xue Wei-Lin Wang Zheng-Wei Yuan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第2期361-368,共8页
O6-methylguanine DNA methyltransferase (MGMT), a DNA repair enzyme, has been reported in some congenital malformations, but it is less frequently reported in neural tube defects. This study investigated MGMT mRNA expr... O6-methylguanine DNA methyltransferase (MGMT), a DNA repair enzyme, has been reported in some congenital malformations, but it is less frequently reported in neural tube defects. This study investigated MGMT mRNA expression and methylation levels in the early embryo and in different embryonic stages, as well as the relationship between MGMT and neural tube defects. Spina bifida aperta was induced in rats by a single intragastric administration of all-trans retinoic acid on embryonic day (E) 10, whereas normal control rats received the same amount of olive oil on the same embryonic day. DNA damage was assessed by detecting γ-H2A.X in spina bifida aperta rats. Real time-polymerase chain reaction was used to examine mRNA expression of MGMT in normal control and spina bifida aperta rats. In normal controls, the MGMT mRNA expression decreased with increasing embryonic days, and was remarkably reduced from E11 to E14, reaching a minimum at E18. In the spina bifida aperta model, γ-H2A.X protein expression was increased, and mRNA expression of MGMT was markedly decreased on E14, E16, and E18. Bisulfite sequencing polymerase chain reaction for MGMT promoter methylation demonstrated that almost all CpG sites in the MGMT promoter remained unmethylated in both spina bifida aperta rats and normal controls, and there was no significant difference in methylation level between the two groups on either E14 or E18. Our results show that DNA damage occurs in spina bifida aperta rats. The mRNA expression of MGMT is downregulated, and this downregulation is independent of promoter DNA methylation. 展开更多
关键词 nerve REGENERATION NEURAL tube defects spina bifida aperta spinal cord ALL-TRANS retinoic acid O6-methylguanine DNA methyltransferase gene expression DNA methylation PROMOTER BISULFITE sequencing polymerase chain reaction NEURAL REGENERATION
在线阅读 下载PDF
P2X7 receptor signaling during adult hippocampal neurogenesis 预览
4
作者 Hannah C. Leeson Tailoi Chan-Ling +3 位作者 Michael D. Lovelace Jeremy C. Brownlie Ben J. Gu Michael W. Weible II 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1684-1694,共11页
Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus.Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation ... Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus.Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories.Regulation of hippocampal neurogenesis is complex and multifaceted,and numerous signaling pathways converge to modulate cell proliferation,apoptosis,and clearance of cellular debris,as well as synaptic integration of newborn immature neurons.The expression of functional P2X7 receptors in the central nervous system has attracted much interest and the regulatory role of this purinergic receptor during adult neurogenesis has only recently begun to be explored.P2X7 receptors are exceptionally versatile:in their canonical role they act as adenosine triphosphate-gated calcium channels and facilitate calcium-signaling cascades exerting control over the cell via calcium-encoded sensory proteins and transcription factor activation.P2X7 also mediates transmembrane pore formation to regulate cytokine release and facilitate extracellular communication,and when persistently stimulated by high extracellular adenosine triphosphate levels large P2X7 pores form,which induce apoptotic cell death through cytosolic ion dysregulation.Lastly,as a scavenger receptor P2X7 directly facilitates phagocytosis of the cellular debris that arises during neurogenesis,as well as during some disease states.Understanding how P2X7 receptors regulate the physiology of stem and progenitor cells in the adult hippocampus is an important step towards developing useful therapeutic models for regenerative medicine.This review considers the relevant aspects of adult hippocampal neurogenesis and explores how P2X7 receptor activity may influence the molecular physiology of the hippocampus,and neural stem and progenitor cells. 展开更多
关键词 P2X7 P2X7R adult neurogenesis NEURAL stem CELLS NEURAL PROGENITOR CELLS hippocampus SGZ calcium SIGNALING PURINERGIC SIGNALING
在线阅读 下载PDF
Neural-like cells from adipose-derived stem cells for cavernous nerve injury in rats 预览
5
作者 Cheng-Cheng Ying1 Mei Yang +3 位作者 Yong Wang Yong-Lian Guo Wan-Li Hu Xin-Min Zheng 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第6期1085-1090,共6页
Although the remaining nerve tissue can regenerate and partly restore erectile function when the cavernous nerve is compressed/severed and function lost,the limited regenerative ability of these nerve tissues often fa... Although the remaining nerve tissue can regenerate and partly restore erectile function when the cavernous nerve is compressed/severed and function lost,the limited regenerative ability of these nerve tissues often fails to meet clinical needs.Adipose-derived stem cells are easy to obtain and culture,and can differentiate into neural cells.Their proliferation rate is easy to control and they may be used to help restore injured cavernous nerve function.Sprague-Dawley male rats(n=45)were equally randomized into three groups:fifteen rats as a sham-operated group,fifteen rats as a bilateral nerve crush(BINC)group(with no further intervention),fifteen rats as a BINC with intracavernous injection of one million neural-like cells from adipose-derived stem cells(NAS)(BINC+NAS)group.After 4 weeks,erectile function was assessed by stimulating the cavernous body.The number of myelinated axons in the dorsal cavernous nerve was determined by toluidine blue staining.The area of neuronal nitric oxide synthase-positive fibers in the dorsal penile nerve was measured by immunohistochemical staining.Masson staining was used to analyze the ratio of smooth muscle to collagen in penile tissue.The results demonstrate that maximal intracavernous pressure,the ratio of maximal intracavernous pressure to mean arterial pressure,the numbers of myelinated axons and neuronal nitric oxide synthase-positive fibers in the dorsal penile nerve,and the ratio of smooth muscle to collagen could be increased after cell transplantation.These findings indicate that neural-like cells from adipose-derived stem cells can effectively alleviate cavernous nerve injury and improve erectile function.All animal experiments were approved by the Animal Ethics Committee of Huazhong University of Science and Technology,China(approval No.2017-1925)on September 15,2017. 展开更多
关键词 NERVE REGENERATION adipose-derived NEURAL stem CELLS corpus cavernosum CAVERNOUS NERVE erectile dysfunction radical prostatectomy neurons cell differentiation NEURAL REGENERATION
在线阅读 下载PDF
Unsupervised Electric Motor Fault Detection by Using Deep Autoencoders 预览
6
作者 Emanuele Principi Damiano Rossetti +1 位作者 Stefano Squartini Francesco Piazza 《自动化学报:英文版》 CSCD 2019年第2期441-451,共11页
Fault diagnosis of electric motors is a fundamental task for production line testing, and it is usually performed by experienced human operators. In the recent years, several methods have been proposed in the literatu... Fault diagnosis of electric motors is a fundamental task for production line testing, and it is usually performed by experienced human operators. In the recent years, several methods have been proposed in the literature for detecting faults automatically. Deep neural networks have been successfully employed for this task, but, up to the authors’ knowledge, they have never been used in an unsupervised scenario. This paper proposes an unsupervised method for diagnosing faults of electric motors by using a novelty detection approach based on deep autoencoders. In the proposed method, vibration signals are acquired by using accelerometers and processed to extract LogMel coefficients as features. Autoencoders are trained by using normal data only, i.e., data that do not contain faults. Three different autoencoders architectures have been evaluated: the multilayer perceptron(MLP) autoencoder, the convolutional neural network autoencoder, and the recurrent autoencoder composed of long short-term memory(LSTM) units. The experiments have been conducted by using a dataset created by the authors, and the proposed approaches have been compared to the one-class support vector machine(OC-SVM) algorithm. The performance has been evaluated in terms area under curve(AUC) of the receiver operating characteristic curve, and the results showed that all the autoencoder-based approaches outperform the OCSVM algorithm. Moreover, the MLP autoencoder is the most performing architecture, achieving an AUC equal to 99.11 %. 展开更多
关键词 Autoencoder convolutional NEURAL NETWORKS electric motor fault DETECTION long short-term memory NEURAL NETWORKS NOVELTY DETECTION
在线阅读 下载PDF
Exogenous neural stem cell transplantation for cerebral ischemia 预览
7
作者 Ling-Yi Liao Benson Wui-Man Lau +1 位作者 Dalinda Isabel Sánchez-Vida?a Qiang Gao 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第7期1129-1137,共9页
Cerebral ischemic injury is the main manifestation of stroke,and its incidence in stroke patients is 70–80%.Although ischemic stroke can be treated with tissue-type plasminogen activator,its time window of effectiven... Cerebral ischemic injury is the main manifestation of stroke,and its incidence in stroke patients is 70–80%.Although ischemic stroke can be treated with tissue-type plasminogen activator,its time window of effectiveness is narrow.Therefore,the incidence of paralysis,hypoesthesia,aphasia,dysphagia,and cognitive impairment caused by cerebral ischemia is high.Nerve tissue regeneration can promote the recovery of the aforementioned dysfunction.Neural stem cells can participate in the reconstruction of the damaged nervous system and promote the recovery of nervous function during self-repair of damaged brain tissue.Neural stem cell transplantation for ischemic stroke has been a hot topic for more than 10 years.This review discusses the treatment of ischemic stroke with neural stem cells,as well as the mechanisms of their involvement in stroke treatment. 展开更多
关键词 nerve REGENERATION STEM CELL therapy NEURAL STEM cells CELL transplantation ischemic stroke cerebral ischemia NEUROPLASTICITY functional recovery NEURAL REGENERATION
在线阅读 下载PDF
Physiological and pathological effects of amyloid-β species in neural stem cell biology 预览
8
作者 Adela Bernabeu-Zornoza Raquel Coronel +3 位作者 Charlotte Palmer María Monteagudo Alberto Zambrano Isabel Liste 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第12期2035-2042,共8页
Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been extens... Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been extensively studied due to its implication in Alzheimer’s disease, but its physiological function remains poorly understood. Amyloid-β peptide can be detected in non-aggregated (monomeric) and aggregated (oligomeric and fibrillary) forms. Each form has different cytotoxic and/or physiological properties, so amyloid-β peptide and its role in Alzheimer’s disease need to be studied further. Neural stem cells and neural precursor cells are good tools for the study on neurodegenerative diseases and can provide future therapeutic applications in diseases such as Alzheimer’s disease. In this review, we provide an outline of the effects of amyloid-β peptide, in monomeric and aggregated forms, on the biology of neural stem cells/neural precursor cells, and discuss the controversies. We also describe the possible molecular targets that could be implicated in these effects, especially GSK3β. A better understanding of amyloid-β peptide (both physiological and pathological), and the signaling pathways involved are essential to advance the field of Alzheimer’s disease. 展开更多
关键词 amyloid-β peptide NEURAL stem CELLS NEURAL PROGENITOR CELLS Alzheimer's disease AMYLOID precursor protein toxicity neurogenesis GLIOGENESIS GSK3β
在线阅读 下载PDF
Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury 预览
9
作者 Elisa García Roxana Rodríguez-Barrera +10 位作者 Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla Marco Guerrero-Godinez Estefanía De la Cruz-Castillo Laura Castillo-Carvajal Monserrat Rivas-Gonzalez Paola Santiago-Tovar Ivis Morales Cesar Borlongan Antonio Ibarra 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第6期1060-1068,共9页
Spinal cord injury is a very common pathological event that has devastating functional consequences in patients.In recent years,several research groups are trying to find an effective therapy that could be applied in ... Spinal cord injury is a very common pathological event that has devastating functional consequences in patients.In recent years,several research groups are trying to find an effective therapy that could be applied in clinical practice.In this study,we analyzed the combination of different strategies as a potential therapy for spinal cord injury.Immunization with neural derived peptides(INDP),inhibition of glial scar formation(dipyridyl:DPY),as well as the use of biocompatible matrix(fibrin glue:FG)impregnated with bone marrow mesenchymal stem cells(MSCs)were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI.Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups:1)phosphate buffered saline;2)DPY;3)INDP+DPY;4)DPY+FG;5)INDP+DPY+FG+MSCs.In all rats,intervention was performed 72 hours after spinal cord injury.Locomotor and sensibility recovery was assessed in all rats.At 60 days after treatment,histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining)were performed.Our results showed that the combination therapy(DPY+INDP+FG+MSCs)was the best strategy to promote motor and sensibility recovery.In addition,significant increases in tissue preservation and axonal density were observed in the combination therapy group.Findings from this study suggest that the combination theapy(DPY+INDP+FG+MSCs)exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury.All procedures were approved by the Animal Bioethics and Welfare Committee(approval No.178544;CSNBTBIBAJ 090812960)on August 15,2016. 展开更多
关键词 FIBRIN GLUE mesenchymal stem cells GLIAL scar protective AUTOIMMUNITY NEURAL derived peptides NEURAL regeneration
在线阅读 下载PDF
SRNET:A Shallow Skip Connection Based Convolutional Neural Network Design for Resolving Singularities
10
作者 Robail Yasrab 《计算机科学技术学报:英文版》 SCIE EI CSCD 2019年第4期924-938,共15页
Convolutional neural networks(CNNs)have shown tremendous progress and performance in recent years.Since emergence,CNNs have exhibited excellent performance in most of classification and segmentation tasks.Currently,th... Convolutional neural networks(CNNs)have shown tremendous progress and performance in recent years.Since emergence,CNNs have exhibited excellent performance in most of classification and segmentation tasks.Currently,the CNN family includes various architectures that dominate major vision-based recognition tasks.However,building a neural network(NN)by simply stacking convolution blocks inevitably limits its optimization ability and introduces overfitting and vanishing gradient problems.One of the key reasons for the aforementioned issues is network singularities,which have lately caused degenerating manifolds in the loss landscape.This situation leads to a slow learning process and lower performance.In this scenario,the skip connections turned out to be an essential unit of the CNN design to mitigate network singularities.The proposed idea of this research is to introduce skip connections in NN architecture to augment the information flow,mitigate singularities and improve performance.This research experimented with different levels of skip connections and proposed the placement strategy of these links for any CNN.To prove the proposed hypothesis,we designed an experimental CNN architecture,named as Shallow Wide ResNet or SRNet,as it uses wide residual network as a base network design.We have performed numerous experiments to assess the validity of the proposed idea.CIFAR-10 and CIFAR-100,two well-known datasets are used for training and testing CNNs.The final empirical results have shown a great many of promising outcomes in terms of performance,efficiency and reduction in network singularities issues. 展开更多
关键词 convolutional NEURAL network(CNN) wide residual network(WRN) DROPOUT SKIP CONNECTION deep NEURAL network(DNN)
Learning Hand Latent Features for Unsupervised 3D Hand Pose Estimation 预览
11
作者 Jamal Banzi Isack Bulugu Zhongfu Ye 《自主智能(英文)》 2019年第1期1-10,共10页
Recent hand pose estimation methods require large numbers of annotated training data to extract the dynamic information from a hand representation.Nevertheless,precise and dense annotation on the real data is difficul... Recent hand pose estimation methods require large numbers of annotated training data to extract the dynamic information from a hand representation.Nevertheless,precise and dense annotation on the real data is difficult to come by and the amount of information passed to the training algorithm is significantly higher.This paper presents an approach to developing a hand pose estimation system which can accurately regress a 3D pose in an unsupervised manner.The whole process is performed in three stages.Firstly,the hand is modelled by a novel latent tree dependency model (LTDM) which transforms internal joints location to an explicit representation.Secondly,we perform predictive coding of image sequences of hand poses in order to capture latent features underlying a given image without supervision.A mapping is then performed between an image depth and a generated representation.Thirdly,the hand joints are regressed using convolutional neural networks to finally estimate the latent pose given some depth map.Finally,an unsupervised error term which is a part of the recurrent architecture ensures smooth estimation of the final pose.To demonstrate the performance of the proposed system,a complete experiment was conducted on three challenging public datasets,ICVL,MSRA,and NYU.The empirical results show the significant performance of our method which is comparable or better than the state-of-the-art approaches. 展开更多
关键词 HAND Pose Estimation Convolutional NEURAL NETWORKS Recurrent NEURAL NETWORKS HUMAN-MACHINE Interaction Predictive Coding UNSUPERVISED LEARNING
在线阅读 免费下载
Video Description with Integrated Visual and Textual Information 预览
12
作者 Yue Wang Jinlai Liu Xiaojie Wang 《中国通信:英文版》 SCIE CSCD 2019年第1期119-128,共10页
Video Description aims to automatically generate descriptive natural language for videos.Due to the large volume of multi-modal data and successful implementations of Deep Neural Networks(DNNs),a wide range of models ... Video Description aims to automatically generate descriptive natural language for videos.Due to the large volume of multi-modal data and successful implementations of Deep Neural Networks(DNNs),a wide range of models have been proposed.However,previous models learn insufficient linguistic information or correlation between visual and textual modalities.In order to address those problems,this paper proposes an integrated model using Long Short-Term Memory(LSTM).This proposed model consists of triple channels in parallel:a primary video description channel,a sentence-to-sentence channel for language learning,and a channel to integrate visual and textual information.Additionally,the parallel three channels are connected by LSTM weight matrices during training.The VD-ivt model is evaluated on two publicly available datasets,i.e.Youtube2Text and LSMDC.Experimental results demonstrate that the performance of the proposed model outperforms those benchmarks. 展开更多
关键词 VIDEO description(VD) deep NEURAL network(DNN) convolutional NEURAL network(CNN) long short-term memory(LSTM)
在线阅读 下载PDF
Effect of sevoflurane preconditioning on astrocytic dynamics and neural network formation after cerebral ischemia and reperfusion in rats 预览
13
作者 Qiong Yu Li Li Wei-Min Liang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第2期265-271,共7页
Astrocytes, the major component of blood-brain barriers, have presented paradoxical profiles after cerebral ischemia and reperfusion in vivo and in vitro. Our previous study showed that sevoflurane preconditioning imp... Astrocytes, the major component of blood-brain barriers, have presented paradoxical profiles after cerebral ischemia and reperfusion in vivo and in vitro. Our previous study showed that sevoflurane preconditioning improved the integrity of blood-brain barriers after ischemia and reperfusion injury in rats. This led us to investigate the effects of sevoflurane preconditioning on the astrocytic dynamics in ischemia and reperfusion rats, in order to explore astrocytic cell-based mechanisms of sevoflurane preconditioning. In the present study, 2,3,5-triphenyltetrazolium chloride staining and Garcia behavioral scores were utilized to evaluate cerebral infarction and neurological outcome from day 1 to day 3 after transient middle cerebral artery occlusion surgery. Using immunofluorescent staining, we found that sevoflurane preconditioning substantially promoted the astrocytic activation and migration from the penumbra to the infarct with microglial activation from day 3 after middle cerebral artery occlusion. The formation of astrocytic scaffolds facilitated neuroblasts migrating from the subventricular zone to the lesion sites on day 14 after injury. Neural networks increased in the infarct of sevoflurane preconditioned rats, consistent with decreased infarct volume and improved neurological scores after ischemia and reperfusion injury. These findings demonstrate that sevoflurane preconditioning confers neuroprotection, not only by accelerating astrocytic spatial and temporal dynamics, but also providing astrocytic scaffolds for neuroblasts migration to ischemic regions, which facilitates neural reconstruction after brain ischemia. 展开更多
关键词 nerve REGENERATION sevoflurane ischemia and reperfusion neuroprotection astrocytes DYNAMICS NEUROBLAST glial scar NEURAL network stroke INHALATIONAL ANESTHETICS NEURAL REGENERATION
在线阅读 下载PDF
Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus 预览
14
作者 Peng Wu Yue Hu +2 位作者 Xiu-Juan Li Min Cheng Li Jiang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第3期480-484,共5页
Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dent... Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dentate gyrus and the subventricular zone. Simultaneously, proliferating stem cells tend to migrate to areas with obvious damage. Our previous studies have clearly confirmed the effect of sodium valproate on cognitive function in rats with convulsive status epilepticus. However, whether neurogenesis can play a role in the antiepileptic effect of sodium valproate remains unknown. A model of convulsive status epilepticus was established in Wistar rats by intraperitoneal injection of 3 mEq/kg lithium chloride, and intraperitoneal injection of pilocarpine 40 mg/kg after 18–20 hours. Sodium valproate(100, 200, 300, 400, 500, or 600 mg/kg) was intragastrically administered six times every day(4-hour intervals) for 5 days. To determine the best dosage, sodium valproate concentration was measured from the plasma. The effective concentration of sodium valproate in the plasma of the rats that received the 300-mg/kg intervention was 82.26 ± 11.23 μg/mL. Thus, 300 mg/kg was subsequently used as the intervention concentration of sodium valproate. The following changes were seen: Recording excitatory postsynaptic potentials in the CA1 region revealed high-frequency stimulation-induced long-term potentiation. Immunohistochemical staining for BrdU-positive cells in the brain revealed that sodium valproate intervention markedly increased the success rate and the duration of induced long-term potentiation in rats with convulsive status epilepticus. The intervention also reduced the number of newborn neurons in the subgranular area of the hippocampus and subventricular zone and inhibited the migration of newborn neurons to the dentate gyrus. These results indicate that sodium valproate can effectively inhibit the abnormal proliferation and migration of neural stem cells and newborn neurons after convulsive status epile 展开更多
关键词 NERVE REGENERATION status epilepticus sodium valproate long-term POTENTIATION NEURAL stem cells NEUROGENESIS migration subgranular ZONE subventricular ZONE NEURAL REGENERATION
在线阅读 下载PDF
Robust Neural Control of Discrete Time Uncertain Nonlinear Systems Using Sliding Mode Backpropagation Training Algorithm
15
作者 Imen Zaidi Mohamed Chtourou Mohamed Djemel 《国际自动化与计算杂志:英文版》 EI CSCD 2019年第2期213-225,共13页
This work deals with robust inverse neural control strategy for a class of single-input single-output (SISO) discrete-time nonlinear system affected by parametric uncertainties. According to the control scheme, in the... This work deals with robust inverse neural control strategy for a class of single-input single-output (SISO) discrete-time nonlinear system affected by parametric uncertainties. According to the control scheme, in the first step, a direct neural model (DNM) is used to learn the behavior of the system, then, an inverse neural model (INM) is synthesized using a specialized learning technique and cascaded to the uncertain system as a controller. In previous works, the neural models are trained classically by backpropagation (BP) algorithm. In this work, the sliding mode-backpropagation (SM-BP) algorithm, presenting some important properties such as robustness and speedy learning, is investigated. Moreover, four combinations using classical BP and SM-BP are tested to determine the best configuration for the robust control of uncertain nonlinear systems. Two simulation examples are treated to illustrate the effectiveness of the proposed control strategy. 展开更多
关键词 Discrete time UNCERTAIN nonlinear systems NEURAL modelling SLIDING mode backpropagation (BP) algorithm ROBUST NEURAL control
Fresh human amniotic membrane effectively promotes the repair of injured common peroneal nerve 预览
16
作者 Zhong-Yuan Zhang Jin Yang +5 位作者 Zhen-Hai Fan Da-Li Wang Yu-Ying Wang Tao Zhang Li-Mei Yu Chang-Yin Yu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第12期2199-2208,共10页
Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of... Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of nerve regeneration and repair. Previous studies have shown that human amniotic membrane can promote the healing of a variety of tissues. In this study, the right common peroneal nerve underwent a 5-mm transection in rats. Epineural nerve repair was performed using 10/0 non-absorbable surgical suture. The repair site was wrapped with a two-layer amniotic membrane with α-cyanoacrylate rapid medical adhesive after suture. Hindlimb motor function was assessed using footprint analysis. Conduction velocity of the common peroneal nerve was calculated by neural electrical stimulation. The retrograde axoplasmic transport of the common peroneal nerve was observed using fast blue BB salt retrograde fluorescent staining. Hematoxylin- eosin staining was used to detect the pathological changes of the common peroneal nerve sputum. The mRNA expression of axon regeneration-related neurotrophic factors and inhibitors was measured using real-time polymerase chain reaction. The results showed that the amniotic membrane significantly improved the function of the injured nerve;the toe spread function rapidly recovered, the nerve conduction velocity was restored, and the number of fast blue BB salt particles were increased in the spinal cord. The amniotic membrane also increased the recovery rate of the tibialis anterior muscle and improved the tissue structure of the muscle. Meanwhile, mRNA expression of nerve growth factor, growth associated protein-43, collapsin response mediator protein-2, and brain-derived neurotrophic factor recovered to near-normal levels, while Lingo-1 mRNA expression decreased significantly in spinal cord tissues. mRNA expression of glial-derived neurotrophic factor did not change significantly. Changes in mRNA levels were more significant in amniotic-membrane-wrapping-treated rats compared with 展开更多
关键词 NERVE REGENERATION human amniotic membrane AXONAL Schwann cells α-cyanoacrylate rapid medical adhesive NEURAL suture TIBIAL anterior muscle neuronal growth factor common PERONEAL NERVE injury NEURAL REGENERATION
在线阅读 下载PDF
Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved 预览
17
作者 Raquel Coronel Charlotte Palmer +4 位作者 Adela Bernabeu-Zornoza María Monteagudo Andreea Rosca Alberto Zambrano Isabel Liste 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1661-1671,共11页
The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of AP... The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of APP are still poorly understood.APP is considered a multimodal protein due to its role in a wide variety of processes,both in the embryo and in the adult brain.Specifically,APP seems to play a key role in the proliferation,differentiation and maturation of neural stem cells.In addition,APP can be processed through two canonical processing pathways,generating different functionally active fragments:soluble APP-α,soluble APP-β,amyloid-β peptide and the APP intracellular C-terminal domain.These fragments also appear to modulate various functions in neural stem cells,including the processes of proliferation,neurogenesis,gliogenesis or cell death.However,the molecular mechanisms involved in these effects are still unclear.In this review,we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells,as well as the possible signaling pathways that could be implicated in these effects.The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease,and in the search for potential therapeutic targets. 展开更多
关键词 AMYLOID precursor protein APP SOLUBLE APP alpha SOLUBLE APP BETA AMYLOID BETA peptide APP intracellular domain NEURAL stem CELLS NEURAL progenitor CELLS neurogenesis signaling pathways
在线阅读 下载PDF
Effects of Sofren injection combined with oxygen free radical scavenger on neural function and apoptosis in patients with acute cerebral infarction
18
作者 Jian-Ping Feng 《海南医科大学学报(英文版)》 2019年第1期71-74,共4页
Objective:To investigate the effects of Sofren injection combined with oxygen free radical scavenger on neural function and apoptosis in patients with acute cerebral infarction.Methods:The patients with acute cerebral... Objective:To investigate the effects of Sofren injection combined with oxygen free radical scavenger on neural function and apoptosis in patients with acute cerebral infarction.Methods:The patients with acute cerebral infarction who received treatment in Xi'an Union Hospital between September 2016and February 2018 were selected as the study subjects and divided into the control group and Sofren injection group by random number table method. Control group received both conventional treatment and oxygen free radical scavenger treatment, and Sofren injection group received both conventional treatment and Sofren injection combined with oxygen free radical scavenger treatment. The differences in serum levels of neurotrophy indexes, nerve injury indexes and neural apoptosis indexes were compared between the two groups before treatment (T0), after 1 week of treatment (T1), and after 2 weeks treatment (T2).Results: At T0, serum levels of neurotrophy indexes, nerve injury indexes and neural apoptosis indexes were not significantly different between the two groups. At T1 and T2, serum neurotrophy indexes IGF-1, bFGF, BDNF and GDNF levels of Sofren injection group were higher than those of control group;serum nerve injury indexes RBP4, H-FABP, SAA and NPY levels were lower than those of control group;serum neural apoptosis index Bcl-2 level was higher than that of control group whereas Bax and caspase-3 levels were lower than those of control group.Conclusion: Sofren injection combined with oxygen free radical scavenger therapy can effectively optimize the neural function and inhibit the neural apoptosis in patients with acute cerebral infarction. 展开更多
关键词 Acute CEREBRAL INFARCTION Sofren INJECTION NEURAL FUNCTION NEURAL APOPTOSIS
Voice Recognition by Neuro-Heuristic Method
19
作者 Dawid Pofap Marcin Wozniak 《清华大学学报自然科学版(英文版)》 EI CAS CSCD 2019年第1期9-17,共9页
The amount of digital data is increasing every day.At every step of our daily lives,we deal with technologies in which our data are stored (e.g.,mobile phones and laptops),and this is one of the main reasons for the d... The amount of digital data is increasing every day.At every step of our daily lives,we deal with technologies in which our data are stored (e.g.,mobile phones and laptops),and this is one of the main reasons for the design of various types of encryption and user identity verification algorithms.These algorithms are meant not only to fulfill the desire of protecting data but also to address the possibility of granting access of specific digital data to selected individuals.This process brings with it the problem of identity verification.This paper discusses the problem of voice verification and presents a voice verification method based on artificial intelligence methods. Numerous tests are performed herein to demonstrate the effectiveness of the presented solution.The research results are shown and discussed in terms of the advantages and disadvantages of the solution. 展开更多
关键词 NEURAL network HEURISTIC ALGORITHMS Discrete FOURIER TRANSFORM (DFT) image processin
Online scheduling of image satellites based on neural networks and deep reinforcement learning
20
作者 Haijiao WANG Zhen YANG +1 位作者 Wugen ZHOU Dalin LI 《中国航空学报:英文版》 SCIE EI CAS CSCD 2019年第4期1011-1019,共9页
In the ‘‘Internet Plus' era, space-based information services require effective and fast image satellite scheduling. Most existing studies consider image satellite scheduling to be an optimization problem to sol... In the ‘‘Internet Plus' era, space-based information services require effective and fast image satellite scheduling. Most existing studies consider image satellite scheduling to be an optimization problem to solve with searching algorithms in a batch-wise manner. No real-time speed method for satellite scheduling exists. In this paper, with the idea of building a real-time speed method, satellite scheduling is remodeled based on a Dynamic and Stochastic Knapsack Problem(DSKP), and the objective is to maximize the total expected profit. No existing algorithm could be able to solve this novel scheduling problem properly. With inspiration from the recent achievements in Deep Reinforcement Learning(DRL) in video games, AlphaGo and dynamic controlling,a novel DRL-based method is applied to training a neural network to schedule tasks. The numerical results show that the method proposed in this paper can achieve relatively good performance with real-time speed and immediate respond style. 展开更多
关键词 DEEP REINFORCEMENT learning Dynamic SCHEDULING IMAGE SATELLITES Neural network Online SCHEDULING
上一页 1 2 250 下一页 到第
使用帮助 返回顶部 意见反馈