目的:探讨腹膜透析(PD)和血液透析(HD)对尿毒症患者肾功能及并发症的影响。方法:采用数表法,将96例接受透析治疗的尿毒症患者随机分为PD组和HD组,每组各48例。分别于治疗前、透析3个月后检测血清肌酐(SCr)、尿素氮(BUN)、超敏C-反应蛋白...目的:探讨腹膜透析(PD)和血液透析(HD)对尿毒症患者肾功能及并发症的影响。方法:采用数表法,将96例接受透析治疗的尿毒症患者随机分为PD组和HD组,每组各48例。分别于治疗前、透析3个月后检测血清肌酐(SCr)、尿素氮(BUN)、超敏C-反应蛋白((hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和降钙素原(PCT)等指标,统计两组并发症发生情况。结果:透析3个月后,两组患者的血清SCr、BUN、hs-CRP、IL-6、TNF-α和PCT水平均较透析前明显下降( P <0.05);两组患者SCr、BUN、IL-6、TNF-α和PCT水平与透析前比较,差异无统计学意义( P >0.05)。透析后,PD组患者的hs-CRP水平低于HD组,差异有统计学意义( P <0.05);PD组的感染发生率(16.67%)、低蛋白血症发生率(20.83%)分别高于HD组的4.17%、4.17%;PD组的高血压发生率(10.42%)、心律失常发生率(6.25%)和充血性心衰发生率(12.50%)明显低于HD组的29.17%、22.92%、35.42%,差异均有统计学意义( P <0.05)。结论: PD和HD均是保护尿毒症患者残余肾功能的有效透析模式,并发症方面也各有优势和不足,但PD对降低hs-CRP水平效果更为显著,可考虑作为尿毒症患者主要透析方式。展开更多
红细胞分布宽度(red bloodeel distribution width,RDW)是反映循环系统中红细胞体积异质性的参数,是血常规检测的指标之一。RDW既往主要与MCV一起使用以鉴别各种不同类型的贫血。近年来,RDW提示疾病预后及死亡的作用越来越受到关注。许...红细胞分布宽度(red bloodeel distribution width,RDW)是反映循环系统中红细胞体积异质性的参数,是血常规检测的指标之一。RDW既往主要与MCV一起使用以鉴别各种不同类型的贫血。近年来,RDW提示疾病预后及死亡的作用越来越受到关注。许多研究发现,RDW可作为各种急慢性临床疾病,尤其是心血管疾病预后及死亡风险的重要预测因子。据报道,高RDW水平可预测急性冠状动脉综合征、缺血性脑血管病、外周动脉疾病、心房颤动和心力衰竭患者的不良结局。此外,RDW被报道与肾脏替代治疗的死亡风险显著相关,可作为独立预测肾脏病患者死亡率及预后的又一新指标。本文旨在探讨RDW对慢性透析患者预后的临床意义做一综述。展开更多
The population of patients with end stage renal disease(ESRD)is increasing,lengthening waiting lists for kidney transplantation.Majority of the patients are not able to receive a kidney transplant in timely manner eve...The population of patients with end stage renal disease(ESRD)is increasing,lengthening waiting lists for kidney transplantation.Majority of the patients are not able to receive a kidney transplant in timely manner even though it is well established that patient survival and quality of life after kidney transplantation is far better when compared to being on dialysis.A large number of patients who desire a kidney transplant ultimately end up needing some form of dialysis therapy.Most of incident ESRD patients choose hemodialysis(HD)over peritoneal dialysis(PD)as the modality of choice in the United States,even though studies have favored PD as a better choice of pre-transplant dialysis modality than HD.PD is largely underutilized in the United States due to variety of reasons.As a part of the decision making process,patients are often educated how the choice regarding modality of dialysis would fit into their life but it is not clear and not usually discussed,how it can affect eventual kidney transplantation in the future.In this article we would like to discuss ESRD demographics and outcomes,modality of dialysis and kidney transplant related events.We have summarized the data comparing PD and HD as the modality of dialysis and its impact on allograft and recipient outcomes after kidney transplantation.展开更多
文摘目的:探讨腹膜透析(PD)和血液透析(HD)对尿毒症患者肾功能及并发症的影响。方法:采用数表法,将96例接受透析治疗的尿毒症患者随机分为PD组和HD组,每组各48例。分别于治疗前、透析3个月后检测血清肌酐(SCr)、尿素氮(BUN)、超敏C-反应蛋白((hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和降钙素原(PCT)等指标,统计两组并发症发生情况。结果:透析3个月后,两组患者的血清SCr、BUN、hs-CRP、IL-6、TNF-α和PCT水平均较透析前明显下降( P <0.05);两组患者SCr、BUN、IL-6、TNF-α和PCT水平与透析前比较,差异无统计学意义( P >0.05)。透析后,PD组患者的hs-CRP水平低于HD组,差异有统计学意义( P <0.05);PD组的感染发生率(16.67%)、低蛋白血症发生率(20.83%)分别高于HD组的4.17%、4.17%;PD组的高血压发生率(10.42%)、心律失常发生率(6.25%)和充血性心衰发生率(12.50%)明显低于HD组的29.17%、22.92%、35.42%,差异均有统计学意义( P <0.05)。结论: PD和HD均是保护尿毒症患者残余肾功能的有效透析模式,并发症方面也各有优势和不足,但PD对降低hs-CRP水平效果更为显著,可考虑作为尿毒症患者主要透析方式。
文摘红细胞分布宽度(red bloodeel distribution width,RDW)是反映循环系统中红细胞体积异质性的参数,是血常规检测的指标之一。RDW既往主要与MCV一起使用以鉴别各种不同类型的贫血。近年来,RDW提示疾病预后及死亡的作用越来越受到关注。许多研究发现,RDW可作为各种急慢性临床疾病,尤其是心血管疾病预后及死亡风险的重要预测因子。据报道,高RDW水平可预测急性冠状动脉综合征、缺血性脑血管病、外周动脉疾病、心房颤动和心力衰竭患者的不良结局。此外,RDW被报道与肾脏替代治疗的死亡风险显著相关,可作为独立预测肾脏病患者死亡率及预后的又一新指标。本文旨在探讨RDW对慢性透析患者预后的临床意义做一综述。
文摘The population of patients with end stage renal disease(ESRD)is increasing,lengthening waiting lists for kidney transplantation.Majority of the patients are not able to receive a kidney transplant in timely manner even though it is well established that patient survival and quality of life after kidney transplantation is far better when compared to being on dialysis.A large number of patients who desire a kidney transplant ultimately end up needing some form of dialysis therapy.Most of incident ESRD patients choose hemodialysis(HD)over peritoneal dialysis(PD)as the modality of choice in the United States,even though studies have favored PD as a better choice of pre-transplant dialysis modality than HD.PD is largely underutilized in the United States due to variety of reasons.As a part of the decision making process,patients are often educated how the choice regarding modality of dialysis would fit into their life but it is not clear and not usually discussed,how it can affect eventual kidney transplantation in the future.In this article we would like to discuss ESRD demographics and outcomes,modality of dialysis and kidney transplant related events.We have summarized the data comparing PD and HD as the modality of dialysis and its impact on allograft and recipient outcomes after kidney transplantation.