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The efficacy and safety of besifloxacin for acute bacterial conjunctivitis: a Meta-analysis
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作者 Jun-Jie Wang Xin-Yi Gao +1 位作者 Hong-Zhuo Li Shan-Shuang Du 《国际眼科杂志:英文版》 SCIE CAS 2019年第6期1027-1036,共10页
AIM: To evaluate the relative efficacy and safety of besifloxacin for treatment of acute bacterial conjunctivitis.METHODS: A comprehensive search in PubMed, EMBASE Web of Science, Cochrane Central Database and CNKI wa... AIM: To evaluate the relative efficacy and safety of besifloxacin for treatment of acute bacterial conjunctivitis.METHODS: A comprehensive search in PubMed, EMBASE Web of Science, Cochrane Central Database and CNKI was undertaken for randomized controlled trials(RCTs) comparing besifloxacin with other treatments or placebo. The primary outcome measures were clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, and bacterial eradication rates of different kinds of pathogens. Safety outcomes were the number of adverse effects(AEs). The final search was performed on August 2018.RESULTS: Eight RCTs were included. Five studies compared the efficacy and safety of besifloxacin with placebo, 2 studies compared besifloxacin with moxifloxacin, and 1 study compared besifloxacin with gatifloxacin. A total of 3105 patients met the inclusion criteria. Besifloxacin presented higher efficacy and safety than did placebo in clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, bacterial eradication rates of different kinds of pathogens and the number of AEs. There was no significant difference between besifloxacin and moxifloxacin or gatifloxacin in the comparison items mentioned above.CONCLUSION: Besifloxacin is highly effective and safe for treatment of acute bacterial conjunctivitis. Further comparative trials regarding the effect of besifloxacin for treatment of acute bacterial conjunctivitis will aid in treatment decisions. 展开更多
关键词 besifloxacin ACUTE BACTERIAL CONJUNCTIVITIS META-ANALYSIS RANDOMIZED CONTROLLED trials
Jiawei Xiaoyao capsule treatment for mild to moderate major depression with anxiety symptoms: a randomized, double-blind, double-dummy, controlled, multicenter, parallel-treatment trial
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作者 Su Rui Fan Jiping +4 位作者 Li Tao Cao Xindong Zhou Jie Han Zhenyun Ma Yan 《中医杂志:英文版》 SCIE CAS CSCD 2019年第3期410-417,共8页
OBJECTIVE:To assess the efficacy and safety of Jiawei Xiaoyao (JWXY) capsules on mild to moderate depression with anxiety symptoms,a randomized,double-blind,double-dummy controlled,multicenter,parallel-treatment trial... OBJECTIVE:To assess the efficacy and safety of Jiawei Xiaoyao (JWXY) capsules on mild to moderate depression with anxiety symptoms,a randomized,double-blind,double-dummy controlled,multicenter,parallel-treatment trial was carried out among 210 outpatients with mild to moderate depression and anxiety symptoms from three hospitals in Beijing China.METHODS:Participants were randomized into the JWXY group or the sertraline group.Each group received JWXY treatment and sertraline placebo,or sertraline and JWXY placebo for 8 weeks.Main outcomes were measured using the Hamilton Depression Rating Scale (HAMD),Hamilton Anxiety Rating Scale (HAMA) and the Clinical Global Impression Scale.RESULTS:JWXY and sertraline had the equivalent effect on HAMD at every interview point.JWXY was more effective at reducing the HAMA scores at the 2nd and 12th week,HAMD sleep disturbance subscale scores at the 8th and 12th week,and HAMA somatic anxiety subscale scores at the 12th week.The rate of adverse events in the two groups was the same.CONCLUSION:For mild to moderate depression with anxiety symptoms,JWXY could be as effective as sertraline in alleviating depressive symptoms.For anxiety symptoms,JWXY may be effective more quickly and with longer lasting effects than sertraline.In particular,it may also improve quality of sleep and somatic anxiety symptoms.JWXY is safe and cheaper than conventional antidepressants,and may be the first alternative choice for depression with anxiety symptoms. 展开更多
关键词 Depression Anxiety Safety RANDOMIZED CONTROLLED TRIAL Jiawei Xiaoyao
Effect of electrically stimulating acupoint, Zusanli (ST 36), on patient's recovery after laparoscopic colorectal cancer resection: a randomized controlled trial
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作者 Huang Wei Yu Tingyu +2 位作者 Long Wenfei Xiao Jianbin Zhao Gaofeng 《中医杂志:英文版》 SCIE CAS CSCD 2019年第3期433-439,共7页
OBJECTIVE:To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on enhanced recovery after surgery (ERAS) in laparoscopic colorectal cancer resection and its clinical significance.METHODS:... OBJECTIVE:To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on enhanced recovery after surgery (ERAS) in laparoscopic colorectal cancer resection and its clinical significance.METHODS:Sixty-four patients undergoing laparoscopic colorectal resection were randomly divided into two groups,the control group (group A) and the TEAS group (group B).Patients in the TEAS group received electroacupuncture stimulation of bilateral Zusanli (ST 36) at 30 min before anesthesia to the end of surgery.The patients in the control group were not given the stimulation.Perioperative anesthesia management of the two groups were performed according to the ERAS guidelines,and postoperative patient-controlled intravenous analgesia (PCIA) was used.The amount of remifentanil used in the two groups was observed and recorded,and the visual analogue scale (VAS) of the 4,12,24 and 48 h after surgery in the two groups was recorded.Moreover,postoperative anal exhaust time,postoperative feeding time,postoperative first ambulation time and postoperative hospital stay length were compared between the two groups.RESULTS:Compared with group A,the VAS score of group B decreased significantly at 48 h after operation (P < 0.05).The postoperative anal exhaust time in group B was significantly shorter than that of group A (P < 0.05).There was no significant difference between the two groups with regards to remifentanil consumption,postoperative feeding time,postoperative first ambulation time and postoperative hospital stay (all P > 0.05).CONCLUSION:TEAS can promote the recovery of postoperative gastrointestinal function and reduce the pain intensity 48 h after surgery,thus satisfying the need of early postoperative analgesia. 展开更多
关键词 Colorectal neoplasms Laparoscopes TRANSCUTANEOUS electric NERVE stimulation RECOVERY of function RANDOMIZED controlled trial
Evaluation on Effectiveness and Safety of Chinese Herbs inTreatment of Sub-health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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作者 ZHAO Jun LIAO Xing +3 位作者 ZHAO Hui LI Zhi-geng WANG Nan-yue WANG Li-min 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第6期471-480,共10页
Objective: To evaluate the effectiveness and safety of Chinese herbs in the treatment of sub-health systematical y. Methods: Nine databases were systematicaly and extensively searched to col ect randomized control ed ... Objective: To evaluate the effectiveness and safety of Chinese herbs in the treatment of sub-health systematical y. Methods: Nine databases were systematicaly and extensively searched to col ect randomized control ed trials(RCTs) about Chinese herbs in the treatment of sub-health. The outcomes included overal effective rate, main symptoms, quality of life, etc. Literature screening, data extraction and quality assessment were conducted according to Cochrane Handbook 5.1. Meta-analysis was conducted to the included literature with Review Manager Software.Results: Seventy-two studies involving 9,296 patients with sub-health were included with 4,908 patients in experimental groups and 4,387 patients in control groups. The overal quality of included clinical research was not high. In the aspect of improving overall effective rate, relieving main symptoms, Pittsburgh sleep quality index(PSQI) score, Athens Insomnia Scale(AIS) score, Fatigue Scale-14(FS-14), Cornel Medical Index(CMI) score and discontinuation rate, the effects of experimental groups were better than that of control groups. According to available research reports, adverse reactions in Chinese herb groups were mainly mild gastrointestinal symptoms, which did not affect the treatment.Conclusion: Chinese herbs have a curative effect in the treatment of sub-health. However, there are no clear criteria for diagnosis and curative effectiveness judgment global y, which would affect the accuracy of curative effect evaluation. 展开更多
关键词 SUB-HEALTH RANDOMIZED controlled trials Chinese MEDICINE systematic review
Blood-Letting Therapy for Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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作者 XIONG Xing-jiang WANG Peng-qian LI Sheng-jie 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第2期139-146,共8页
Objective:To evaluate the efficacy and safety of blood-letting therapy(BLT)in treatment of hypertension.Methods:A comprehensive electronic and manual bibliographic searches were performed in Cochrane Central Register ... Objective:To evaluate the efficacy and safety of blood-letting therapy(BLT)in treatment of hypertension.Methods:A comprehensive electronic and manual bibliographic searches were performed in Cochrane Central Register of Controlled Trials,Excerpt Medica Database(EMBASE),PubMed,China National Knowledge Infrastructure,Chinese Scientific Journal Database,Chinese Biomedical Literature Database,and Wanfang Database to identify randomized controlled trials(RCTs)in which hypertensive patients were treated with BLT or BLT plus antihypertensive drugs(BPAD)against placebo,no treatment or antihypertensive drugs.The Cochrane Risk Assessment Tool was used to assess the methodological quality of trials.The Review Manager 5.3 software was used for meta-analysis.Results:A total of 7 RCTs with 637 hypertensive patients from 1989 to 2017 were identified.Compared with antihypertensive drugs,blood pressure was significantly reduced by BLT(RR=1.21,95%CI:1.01 to 1.44,P=0.03;heterogeneity:P=0.06,I^2=60%)and BPAD(RR=1.25,95%CI,1.02 to 1.53,P=0.03;heterogeneity:P=0.01,I^2=71%).Moreover,a significant improvement in Chinese medicine syndrome by BLT(RR=1.32;95%CI:1.14 to 1.53,P=0.0002;heterogeneity:P=0.53,I^2=0%)and BPAD(RR=1.47;95%CI:1.06 to 2.04,P=0.02;heterogeneity:P=0.13,I^2=56%)was identified.The reported adverse effects were well tolerated.Conclusions:Although some positive findings were identified,no definite conclusions regarding the efficacy and safety of BLT as complementary and alternative approach for treatment of hypertension could be drew due to the generally poor methodological design,significant heterogeneity,and insufficient clinical data.Further rigorously designed trials are warranted to confirm the results. 展开更多
关键词 blood-letting THERAPY PHLEBOTOMY BLOOD pressure Chinese MEDICINE COMPLEMENTARY and alternative MEDICINE systematic review META-ANALYSIS randomized controlled trials
Triple Puncture for Primary Trigeminal Neuralgia:A Randomized Clinical Trial 预览
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作者 Yang-pu ZHANG Yan WANG +1 位作者 Wen-guang XIA Ai-qun SONG 《当代医学科学(英文)》 SCIE CAS 2019年第4期638-644,共7页
To evaluate the effect of triple puncture on primary trigeminal neuralgia (pTN),64 patients with pTN were randomly assigned to two groups:treatment group and control group.The participants in the treatment group recei... To evaluate the effect of triple puncture on primary trigeminal neuralgia (pTN),64 patients with pTN were randomly assigned to two groups:treatment group and control group.The participants in the treatment group received triple puncture treatment of 6 times per week for 4 weeks,and those in control group were given carbamazepine (300-600 mg per day) for at least 1 month.Before and after treatment,the primary outcomes including the total efficiency rate and the VAS pain scores,and the secondary outcomes including the frequency of pain attack and adverse events were observed.Sixty-two participants finished the study (33 in treatment group and 29 in control group individually).After treatment,the symptoms (mainly pain) of the two groups were alleviated.The total efficiency rate in the treatment group and control group was 90.9% and 75.9% respectively.The VAS pain scores and frequency of pain attack were significantly reduced in the treatment group as compared with the control group (P<0.05).The incidence of adverse events in the treatment group and control group was 9.1% and 24.1% respectively.It can be inferred that triple puncture can effectively improve the quality of life of patients with pTN and has less side effects. 展开更多
关键词 TRIPLE PUNCTURE primary TRIGEMINAL NEURALGIA RANDOMIZED clinical TRIAL
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Efficacy and safety of acupuncture on the treatment of functional constipation: Study protocol for a randomized controlled trial
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作者 尹平 高宁阳 +6 位作者 董波 郑慧敏 陈泽钦 殷萱 吴君怡 曹燕 徐世芬 《世界针灸杂志:英文版》 CSCD 2019年第2期145-152,共8页
Objective:This trial is aimed at evaluating the efficacy and safety of acupuncture on treating FC.Methods:We describe the protocol for a randomized,patient-assessor-blinded,sham controlled trial.Seventy-two eligible p... Objective:This trial is aimed at evaluating the efficacy and safety of acupuncture on treating FC.Methods:We describe the protocol for a randomized,patient-assessor-blinded,sham controlled trial.Seventy-two eligible patients will be randomly assigned to the intervention group(acupuncture)or the control group(sham acupuncture).All treatment will be given 26 sessions of acupuncture or sham acupuncture over 8 weeks(5 times per week in the first 2 weeks,3 times per week during weeks 3-6,and 2 times per week during weeks 7 and 8).Each treatment will last for 20 min.The primary outcome is the change in mean complete spontaneous bowel movements(CSBMs)per week.The secondary out?comes are patient assessment of constipation quality of life questionnaire(PAC-QOL),self-rating anxiety scale(SAS),and the dosage of the medication.All adverse events will be recorded in detail and managed by corresponding researchers as quickly as possible.Outcomes will be evaluated at baseline(1 week before treatment),2 weeks after intervention begins,6 weeks after intervention begins,8 weeks after intervention begins,4 weeks follow-up,and 12 weeks follow-up.Discussion:The results of this study will provide the evidence of the efficacy and safety of acupuncture as a traditional treatment methods for functional constipation.Trial registration:Chinese Clinical Trial Registry,ChiCTR-INR-17011472.Registered on 23 May 2017. 展开更多
关键词 ACUPUNCTURE Functional CONSTIPATION RANDOMIZED CONTROLLED TRIAL (RCT) Protocol
Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial
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作者 LIU Shi-wei GUO Jie +2 位作者 WU Wei-kang CHEN Ze-liang ZHANG Ning 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第1期16-22,共7页
Objective:To evaluate Chinese medicine (CM)formula Bazheng Powder (八正散)as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI).Methods:A randomized double-blinded tria... Objective:To evaluate Chinese medicine (CM)formula Bazheng Powder (八正散)as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI).Methods:A randomized double-blinded trial was performed.Eligible female patients with RUTI were recruited from one hospital and two community health centers.By using a blocked randomization scheme,participants were randomized to receive a CM formula (10 herbs)and antibiotics placebo for 4 weeks,or antibiotics for 1 week followed by 3 weeks of placebo and CM formula placebo.Clinical cure rate and microbiological cure and recurrence after treatment were evaluated.Results:A total 122 eligible patients were enrolled,with 61 cases in each group.The clinical cure rate by the intent-to-treatment approach was 90.2% or the CM group and 82.0% for the antibiotics group (P>0.05).Bacteria were cleared from 88.5%(54/61)of patients in the CM group and 82.0%(50/61)in the antibiotics group.The recurrence rate in recovered patients at the 6-month follow-up was 9.1%(5/61)and 14.0(7/61)in the CM and antibiotics groups,respectively (P>0.05).Conclusion:CM formula Bazheng Powder is a good alternative option for RUTI treatment.(Registration No.NCT01745328) 展开更多
关键词 Chinese medicine RECURRENT URINARY TRACT infection RANDOMIZED control TRIAL
Effect and Safety of Huannao Yicong Formula (还脑益聪方) in Patients with Mild-to-Moderate Alzheimer's Disease: A Randomized, Double-Blinded, Donepezil-Controlled Trial
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作者 YANG Yang LIU Jian-ping +6 位作者 FANG Jun-yan WANG Hui-chan WEI Yun CAO Yu LIU Jian-gang LIU Long-tao LI Hao 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第8期574-581,共8页
Objective: To assess the effect and safety of Huannao Yicong Formula (还脑益聪方, HYF) in the treatment of patients with mild-to-moderate Alzheimer's disease (AD). Methods: Sixty patients with mild-to moderate AD ... Objective: To assess the effect and safety of Huannao Yicong Formula (还脑益聪方, HYF) in the treatment of patients with mild-to-moderate Alzheimer's disease (AD). Methods: Sixty patients with mild-to moderate AD were evenly randomized into HYF group and donepezil group with the random number method. Patients in the HYF group took 5 g of HYF granules twice daily and 5 mg placebo of donepezil once daily. Patients in the donepezil group took 5 mg donepezil once daily and 5 g placebo of HYF granules twice daily. The intervention lasted for 6 months. Clinical researchers, participants and statisticians were blinded to the treatment assignment throughout the study. The primary outcomes were scores of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) and Chinese Medicine Symptom Scale (CM-SS). The secondary outcomes were scores of Montreal Cognitive Assessment (MoCA) test and Mini-Mental State Exam (MMSE). The serum levels of acetylcholinesterase (AchE) and amyloid-β protein 42 (Aβ 42) were detected with enzyme linked immunosorbent assay kits. The scale assessments were conducted at baseline, the 3rd and 6th months of treatment, respectively. Biochemistry tests were conducted at baseline and the 6th month of treatment. Results: A total of 52 patients completed the trial, 28 in HYF group and 24 in donepezil group. Compared with the baseline, HYF and donepezil significantly decreased the total scores of ADAS-Cog and CM-SS, and significantly increased the scores of MoCA and MMSE after 6-month treatment (all P<0.01). Both treatments remarkably reduced the serum levels of AchE and Aβ 42 (both P<0.05). The CM-SS total effective rate of HYF was significantly higher than donepezil [75.00%(21/28) vs. 54.17%(13/24), P<0.05]. No severe adverse events were observed in both groups. Conclusion: HYF is effective and safe for improving the cognitive function in mild to-moderate AD patients.[Trial registration: Chinese Clinical Trial Registry (Reg No. ChiCTR-IOR-17011746)]. 展开更多
关键词 Alzheimer's disease Huannao Yicong FORMULA RANDOMIZED controlled double-blinded trial Chinese medicine
Effect of Tai Chi on Cardiac and Static Pulmonary Function in Older Community-Dwelling Adults at Risk of Ischemic Stroke: A Randomized Controlled Trial
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作者 ZHENG Guo-hua ZHENG Xin +3 位作者 LI Jun-zhe DUAN Ting-jin TAO Jing CHEN Li-dian 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第8期582-589,共8页
Objective: To evaluate the effect of tai chi exercise on cardiac and static lung function for older community-dwelling adults at risk of ischemic stroke. Methods: A total of 170 older community-dwelling adults (aged 5... Objective: To evaluate the effect of tai chi exercise on cardiac and static lung function for older community-dwelling adults at risk of ischemic stroke. Methods: A total of 170 older community-dwelling adults (aged 55–75 years old) at risk of ischemic stroke were allocated to either tai chi training group (85 cases, five 60-min sessions of tai chi training per week for 12 weeks) or control group (85 cases, usual pbysical activity for 12 weeks) using a computer-generated randomization. The echocardiographic parameters of cardiac structure, cardiac function and static lung function were measured at baseline, after 12 weeks of intervention and additional 12-week follow-up period by a blinded professional staff member using a color Doppler ultrasound imaging device or a cardiopulmonary function instrument. The t test and linear mixed model based on the intention-to-treat analysis principle was used to calculate the effect. The adverse effect was observed. Results: Most of echocardiographic parameters on the cardiac structure, cardiac function and static lung function between the tai chi group and control group did not have a significant difference either post 12-week intervention or additional 12-week follow-up period. Only three parameters involving in right ventricular diameter (P=0.024), main pulmonary artery diameter (P=0.002) and vital capacity maximum (P=0.036) were beneficial to be improved in the tai chi group compared to the control group by the analysis of mixed linear model. No adverse effects were found during the intervention period. Conclusions: The 12-week tai chi exercise did not have an obvious beneficial effect on cardiac structure, cardiac function and static lung function in older community-dwelling adults at risk of ischemic stroke.(Trial registration No. ChiCTR-TRC-13003601) 展开更多
关键词 tai chi CARDIAC structure and FUNCTION STATIC lung FUNCTION ischemic stroke randomized controlled trial
Effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊) on Treatment of Functional Dyspepsia: A Meta-Analysis of Randomized Controlled Trials
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作者 WEN Ming-yi ZHANG Fu-cheng WANG Yao-jun 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第8期625-630,共6页
Objective: To evaluate the effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊, ZKC) for functional dyspepsia (FD) through meta-analysis. Methods: Online databases, including PubMed, EM base, China National Knowledge In... Objective: To evaluate the effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊, ZKC) for functional dyspepsia (FD) through meta-analysis. Methods: Online databases, including PubMed, EM base, China National Knowledge Infrastructure, Wanfang Data, VIP database and Cochrane Library, were searched for randomized controlled trials (RCTs) of ZKC for FD from the inception to April, 2016. Trials were selected according to inclusion criteria and were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions and Jadad scale. RevMan 5.3 and GRADEprofiler 3.6 were used for statistical analysis and evidence quality assessment. Results: Twenty-three trials with 2,496 patients were included and most of them were of poor methodological quality. ZKC alone or ZKC combined with routine Western medicine (WM) showed a better clinical effect rate compared with the control group of WM [odds ratio (OR)=3.32, 95% confidence interval (2.66, 4.15), P<0.00001]. No serious adverse reactions were reported. Conclusions: ZKC alone or ZKC combined with routine WM could significantly improve the clinical effective rate in the treatment of FD. The quality of the evidence is low, so it is necessary to design multicenter, strictly randomized and double-blind controlled trials with large samples to validate the conclusions. 展开更多
关键词 Zhizhu Kuanzhong CAPSULES functional DYSPEPSIA RANDOMIZED controlled TRIAL META-ANALYSIS Chinese MEDICINE
Compound Kushen injection combined with chemotherapy in the treatment of gastric cancer: a meta-analysis of randomized controlled trials 预览
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作者 Su-Tong Liu Kai-Qi Su Wen-Xia Zhao 《TMR肿瘤》 2019年第1期118-126,共9页
Objective: This study aims to systematically evaluate the efficacy and safety of compound kushen injection (CKI) in combination with chemotherapy in patients with gastric cancer (GC). Methods: A comprehensive electron... Objective: This study aims to systematically evaluate the efficacy and safety of compound kushen injection (CKI) in combination with chemotherapy in patients with gastric cancer (GC). Methods: A comprehensive electronic search was conducted by searching PubMed, EMBASE, Cochrane Library, Chinese Biological Medical disc, China National Knowledge Infrastructure and Wanfang databases (the last update January 20, 2018). All randomized controlled trials (RCTs) of CKI plus chemotherapy versus chemotherapy alone in GC patients were identified. The quality of each study was evaluated using the Jadad’s scale, and the meta-analysis was performed using Review Manager 5.3 and STATA 14 software. Results: A total of nine studies on 688 cases were included in this study. The results showed that CKI combined with chemotherapy had a better effect on improving patients’ overall response rate (ORR) and life quality. The consequences of Egger’s and Begg’s tests showed there was no significant publication bias. Conclusion: The current evidence showed that CKI may enhance the clinical efficacy of chemotherapy, improve the quality of life and increase the safety in patients with gastric cancer. 展开更多
关键词 Compound kushen INJECTION CHEMOTHERAPY GASTRIC cancer RANDOMIZED controlled trials
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Burnout in the emergency department:Randomized controlled trial of an attention-based training program
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作者 Pádraic J. Dunne Julie Lynch +10 位作者 Lucia Prihodova Caoimhe Oleary Atiyeh Ghoreyshi Sharee A. Basdeo Donal J. Cox Rachel Breen Ali Sheikhi Aine Carroll Cathal Walsh Geraldine McMahon Barry White 《结合医学学报:英文版》 CAS CSCD 2019年第3期173-180,共8页
Background:Burnout(encompassing emotional exhaustion,depersonalization and personal accomplishment)in healthcare professionals is a major issue worldwide.Emergency medicine physicians are particularly affected,potenti... Background:Burnout(encompassing emotional exhaustion,depersonalization and personal accomplishment)in healthcare professionals is a major issue worldwide.Emergency medicine physicians are particularly affected,potentially impacting on quality of care and attrition from the specialty.Objective:The aim of this study was to apply an attention-based training(ABT)program to reduce burnout among emergency multidisciplinary team(MDT)members from a large urban hospital.Design,setting,participants and interventions:Emergency MDT members were randomized to either a notreatment control or an in terve ntion group.In tervention group participa nts engaged in a four sessi on(4 h/sessi on)ABT program over 7 weeks with a practice target of 20 min twice-daily.Practice adhere nee was measured using a smart phone application together with a wearable Charge 2 device.Main outcome measures:The primary outcome was a change in burnout,comprising emotional exhaustion,depersonalization and personal achieveme nt.The sec on dary outcomes were cha nges in other psychological and biometric parameters.Results:The ABT program resulted in a significant reduction(P<0.05;T1|one week before intervention]vs T3[follow-up at two mon ths after intervention])in burnout,specifically,emotional exhaustion,with an effect size(probability of superiority)of 59%.Similar reductions were observed for stress(P<0.05)and anxiety(P<0.05).Furthermore,ABT group participants demonstrated significant improvements in heart rate variability,resting heart rate,sleep as well as an in crease in pro-inflammatory cytokine expression.Conclusion:This study describes a positive impact of ABT on emergency department staff bumout compared to a no-treatment control group.Trial registration:ClinicalTrials.gov identifier NCT02887300. 展开更多
关键词 BURNOUT EMOTIONAL EXHAUSTION MEDITATION Healthcare professional Sleep Stress Cytokines CORTISOL Randomized controlled trial
Effectiveness of Acupuncture on Pain, Physical Function and Health-Related Quality of Life in Patients with Rheumatoid Arthritis: A Systematic Review of Quantitative Evidence
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作者 Susana Seca Diana Miranda +4 位作者 Daniela Cardoso Bernice Nogueira Henry J.Greten Antonio Cabrita Manuel Alves Rodrigues 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第9期704-709,共6页
Objective: To identify and synthesize the most recent available evidence of effectiveness of acupuncture on pain, physical function and health-related quality of life(HRQoL) in patients with rheumatoid arthritis(RA). ... Objective: To identify and synthesize the most recent available evidence of effectiveness of acupuncture on pain, physical function and health-related quality of life(HRQoL) in patients with rheumatoid arthritis(RA). Methods: A comprehensive search of 12 Western and Chinese databases was undertaken from their inception up to end of 2016. Randomized controlled trials(RCTs), concerning patients with RA treated with needle acupuncture, written in English, Portuguese, German or Chinese were included. Primary outcomes included pain, physical function and HRQoL. Secondary outcomes included morning stiffness, functional impairment, number of tender and swollen joints and serum concentrations of inflamatory markers. Methodological quality was assessed by three independent reviewers using the standardized critical appraisal instrument from the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument. Results: Twenty-two studies met the inclusion criteria. Of those, 9 studies were excluded after assessment of their methodological quality. The remaining 13 original RCTs included 974 patients. Ten of these studies published in China, showed favorable statistical significant effects of acupuncture in relieving symptoms of RA compared with controls. Conclusions: Evidence suggests that acupuncture interventions may have a positive effect in pain relief, physical function and HRQo L in RA patients. However, due to the heterogeneity and methodologic limitations of the studies included in this systematic review, evidence is not strong enough to produce a best practice guideline. 展开更多
关键词 ACUPUNCTURE RHEUMATOID ARTHRITIS quality of life PAIN physical function RANDOMIZED clinical TRIAL
Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy? 预览
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作者 Anthony Davies Guido Wassink +2 位作者 Laura Bennet Alistair J. Gunn Joanne O. Davidson 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1678-1683,共6页
Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability.Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;ho... Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability.Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;however,many infants still experience lifelong disabilities to movement,sensation and cognition.Clinical guidelines,based on strong clinical and preclinical evidence,recommend therapeutic hypothermia should be started within 6 hours of birth and continued for a period of 72 hours,with a target brain temperature of 33.5 ±0.5℃ for infants with moderate to severe hypoxic-ischemic encephalopathy.The clinical guidelines also recommend that infants be re warmed at a rate of 0.5℃ per hour,but this is not based on strong evidence.There are no randomized controlled trials investigating the optimal rate of rewarming after therapeutic hypothermia for infants with hypoxic-ischemic encephalopathy.Preclinical studies of rewarming are conflicting and results were confounded by treatment with sub-optimal durations of hypothermia.In this review,we evaluate the evidence for the optimal start time,duration and depth of hypothermia,and whether the rate of rewarming after treatment affects brain injury and neurological outcomes. 展开更多
关键词 HYPOXIA-ISCHEMIA hypoxic-ischemic ENCEPHALOPATHY THERAPEUTIC HYPOTHERMIA neuroprotection THERAPEUTIC strategies randomized controlled trials animal models fetal sheep PIGLETS
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Effect of cream, prepared with Tripterygium wilfordii Hook F and other four medicinals, on joint pain and swelling in patients with rheumatoid arthritis: a double-blinded, randomized, placebo controlled clinical trial
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作者 Jiao Juan Wei Chengchung +3 位作者 Tang Xiaopo Gong Xun Yin Haibo Jiang Quan 《中医杂志:英文版》 SCIE CAS CSCD 2019年第1期89-96,共8页
OBJECTIVE: To investigate the effectiveness a cream onjoint pain and swelling in patients with rheumatoid arthritis(RA). The cream, topically used, in was prepared with Tripterygium wilfordii Hook F(TwHF), Mangxiao(Na... OBJECTIVE: To investigate the effectiveness a cream onjoint pain and swelling in patients with rheumatoid arthritis(RA). The cream, topically used, in was prepared with Tripterygium wilfordii Hook F(TwHF), Mangxiao(Nalrii Sulfas), Chuanxiong(Rhizoma Chuanxiong), stir-frying with liquid adjuvant Ruxiang(Olibanum), and stir-frying with liquid adjuvant Moyao(Myrrh).METHODS: Patients were 1∶1 randomized to addon TwHF cream twice a day or placebo for 4 weeks.The primary endpoint was achievement rate of20% improvement in American College of Rheuma-tology criteria(ACR20) at week 4. Secondary endpoints were ACR50, 28-joint count Disease Activity Score(DAS28) improvement and safety profiles.Statistical analyses were performed using intention to treat analysis(ITT) set.RESULTS: A total of 70 active RA patients were enrolled. At week 4, the ACR20 was 34.3%(12/35) in TwHF cream group and 11.4%(4/35) in placebo group(P = 0.015). Similarly, a higher ACR50 responder proportion was seen in TwHF cream group with 17.1%(6/35) comparing to it in placebo group with 2.9%(1/35)(P = 0.046). The TwHF cream group also had more improvement than the placebo group on DAS28-ESR(1.1 vs 0.5, P = 0.001), DAS28-CRP(1.4 vs 0.7, P = 0.001), tender joint count(5.5 vs2.6, P = 0.018), swollen joint count(3.5 vs 1.6, P =0.003) and Physician’s global assessment(25.8 vs13.0, P = 0.002), as well as C-reactive protein(11.2 vs 2.7, P = 0.048). Except 2 skin allergy events in TwHF cream group, no other substantive adverse events were observed.CONCLUSION: On the short term, TwHF cream is likely to be an effective and safety complimentary treatment in patients with active RA. 展开更多
关键词 TRIPTERYGIUM wilfordii Arthritis rheumatoid External therapy RANDOMIZED controlled trial
Acupoint Catgut Embedding Alleviates Insomnia in Different Chinese Medicine Syndrome Types: A Randomized Controlled Trial
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作者 XU Fu XUAN Li-hua +4 位作者 ZHOU Hai-jiang CHEN Fei-yu ZHENG Zhao-jian BI Ying WU Xiang 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第7期543-549,共7页
Objective: To investigate the effects and safety of catgut embedding on alleviating insomnia. Methods: Totally 510 patients with insomnia were divided into 5 Chinese medicine(CM) syndrome types: Xin(Heart) and Pi(Sple... Objective: To investigate the effects and safety of catgut embedding on alleviating insomnia. Methods: Totally 510 patients with insomnia were divided into 5 Chinese medicine(CM) syndrome types: Xin(Heart) and Pi(Spleen) deficiency, yin deficiency with excess fire, Xin and gut qi deficiency, Wei(Stomach) disorder, and qi and blood deficiency, respectively. These 5 types of patients were randomly assigned to a catgut embedding group, an acupuncture group or a medication group(30 cases in Xin and Pi deficiency type, Wei disorder type, Xin and gut qi deficiency type, respectively;40 cases in yin deficiency with excess fire type and qi and blood deficiency type, respectively). In the catgut embedding group, patients were treated by implanting catgut into acupoints once every 10 days for a total of 30 days. In the acupuncture group, patients were treated with acupuncture once per day over 30 days(excluding weekends);and patients in the medication group took 1 mg Eurodin Tablet orally every night for 30 days. Pittsburgh Sleep Quality Index(PSQI) was evaluated before treatment, on 30 and 60 days after the first treatment, respectively. The International Unified Sleep Efficiency Value(IUSEV) was measured at 30 and 60 days. The safety was evaluated after treatment and adverse events were analyzed. Results: The objective PSQI scores including subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, daytime dysfunction, and total scores at 30 days were significantly improved compared with pre-treatment in the catgut embedding and acupuncture groups(P<0.01 or P<0.05). At 30 days, the PSQI scores in catgut embedding group were superior to the medication group in the patients with each type of insomnia, with the exception of sleep duration(P<0.01 or P<0.05). At 60 days, significant differences were found between the catgut embedding group and the medication group(P<0.01 for all indices). The IUSEV scores in the catgut embedding group were significantly higher than the acupuncture g 展开更多
关键词 INSOMNIA ACUPOINT CATGUT EMBEDDING acupuncture therapy MEDICATION randomized controlled trial
Efficacy and safety of standard and anti-reflux self-expanding metal stent: A systematic review and meta-analysis of randomized controlled trials 预览
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作者 Sudha Pandit Hrishikesh Samant +1 位作者 James Morris Steven J Alexander 《世界胃肠内镜杂志:英文版(电子版)》 2019年第4期271-280,共10页
BACKGROUND Self-expanding metal stents are the main palliative treatment modality for unresectable esophageal cancer. Gastroesophageal reflux is a common adverse outcome after placement of esophageal stent for cancer ... BACKGROUND Self-expanding metal stents are the main palliative treatment modality for unresectable esophageal cancer. Gastroesophageal reflux is a common adverse outcome after placement of esophageal stent for cancer involving the gastroesophageal junction and the gastric cardia. Anti-reflux stents with valve have been designed to prevent the acid reflux. The superiority of anti-reflux stent over standard stent in preventing gastroesophageal reflux has not been established well. This study compares the anti-reflux stent and the standard stent in terms of their efficacy to prevent acid reflux. AIM To compare the standard and the anti-reflux stents in terms of their efficacy, safety, and complications. METHODS The meta-analysis included 8 randomized clinical trials (RCTs) to compare pooled outcomes of total 395 patients. Primary outcomes include improvement in reflux symptoms and dysphagia score. Secondary outcomes include complications of stent migration, occlusion, and bleeding. RESULTS A total of eight RCTs were included in the meta-analysis. Compared to the standard stent, the anti-reflux stent showed a trend towards reduction in the dysphagia score without reaching a statistical significance [Standardized mean difference (SMD):-0.33 (-0.71, 0.05);P = 0.09, I2: 37%]. There was no statistical difference in the gastrointestinal reflux (GER) scores between the two types of stents [SMD:-0.17 (-0.78, 0.45);P = 0.008, I2: 74%]. Compared to standard stent, anti-reflux stent showed no difference in the risk of stent migration [OR: 1.37 (0.66, 2.83);P = 0.40, I2: 0 %], bleeding [OR: 1.43 (0.40, 5.13);P = 0.59, I2: 0 %], and obstruction [OR: 1.66 (0.60, 4.60);P = 0.33, I2: 0 %]. CONCLUSION Traditional self-expanding standard esophageal stent and anti-reflux stent with valve are similar in terms of outcomes and complications. 展开更多
关键词 Self EXPANDING metal STENT Anti-reflux STENT RANDOMIZED controlled TRIAL Esophageal STENT META-ANALYSIS
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Efficacy and safety of tranexamic acid in elderly patients with intertrochanteric fracture: An updated meta-analysis 预览
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作者 Xin-Die Zhou Jin Li +2 位作者 Guo-Ming Fan Yong Huang Nan-Wei Xu 《世界临床病例杂志》 2019年第11期1302-1314,共13页
BACKGROUND Intertrochanteric fracture (ITF) is a common type of injury, and nearly 30% of ITF patients die in the first 12 mo, especially the elderly with limited activity. Tranexamic acid (TXA) has been widely used i... BACKGROUND Intertrochanteric fracture (ITF) is a common type of injury, and nearly 30% of ITF patients die in the first 12 mo, especially the elderly with limited activity. Tranexamic acid (TXA) has been widely used in reducing traumatic and surgical bleeding, however, the paucity of studies regarding its use in orthopedic trauma surgery has limited its integration into this field, which may benefit most from TXA. The safety of TXA in this group has not achieved a consensus. AIM This meta-analysis was designed to investigate the efficacy and safety of TXA in elderly ITF patients undergoing surgery. METHODS Databases, including Medline and PubMed, were searched for randomized controlled trials (RCTs) that were published before October 2018 and that addressed the efficacy and safety of TXA in patients who underwent ITF surgery. The Consolidated Standards of Reporting Trials 2010 Statement Checklist was used to assess the methodological quality of each study. Trials without and with heterogeneity were compared by fixed-effects analysis and random-effects analysis, respectively. For each study, odds ratio (OR) and 95%CI and mean differences and 95%CI were calculated for dichotomous and continuous outcomes, respectively. The Power and Sample Size Program software was used to calculate power and sample size. Stability of the results was assessed via sensitivity analysis. RESULTS A total of 836 patients from eight RCTs were subjected to meta-analysis. TXA treatment compared with the control group significantly reduced postoperative blood loss (95%CI,-20.83 to -7.93 mL, P < 0.0001), hidden blood loss (95%CI,- 213.67 to -64.43 mL, P = 0.0003), and total blood loss (95%CI,-332.49 to -23.18 mL, P = 0.02) by weighted mean differences of -14.38,-139.05, and -177.83 mL, respectively. However, no significant difference was observed between groups for analysis of intraoperative blood loss. The meta-analysis also proved that the usage of TXA in ITFs may not significantly increase the incidence of deep venous thrombosis. Allogenei 展开更多
关键词 Tranexamic acid INTERTROCHANTERIC FRACTURE Blood LOSS RANDOMIZED controlled TRIAL META-ANALYSIS
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中药外用治疗甲状腺肿临床疗效Meta分析
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作者 刘雨薇 赖倚文 +1 位作者 陈雪莹 高天舒 《中医药导报》 2019年第9期77-80,共4页
目的:评价中药外用治疗甲状腺肿的疗效及安全性。方法:计算机检索中国知网、维普期刊资源整合服务平台、万方数据库,查找中药外用治疗甲状腺肿的随机对照试验。2名研究者独立对纳入研究进行资料提取和方法学质量评价,采用Rev Man5.3软... 目的:评价中药外用治疗甲状腺肿的疗效及安全性。方法:计算机检索中国知网、维普期刊资源整合服务平台、万方数据库,查找中药外用治疗甲状腺肿的随机对照试验。2名研究者独立对纳入研究进行资料提取和方法学质量评价,采用Rev Man5.3软件进行Meta分析。结果:共纳入12项研究,共781例患者。Meta分析结果显示:中药外用疗效优于西药治疗[OR=7.99,95%CI(2.65,24.06),P=0.000,1];中药外用加中药内服疗效优于西药治疗[OR=5.94,95%CI(2.93,12.03),P<0.000,01];中药外用加西药疗效优于单纯西药治疗[OR=8.31,95%CI(3.49,19.75),P<0.000,01]。结论:中药外用是治疗甲状腺肿的有效方法,仍需设计合理、执行严格、多中心、大样本的随机对照试验进一步验证。 展开更多
关键词 中药外用 甲状腺肿 内外合治 随机对照 META分析
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