目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对降低酒依赖患者渴求的影响。方法选取2017年10月至2018年12月在济宁市精神病防治院住院的酒依赖患者100例为研究对象,随机分为观察组和对照组,每组50例,进...目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对降低酒依赖患者渴求的影响。方法选取2017年10月至2018年12月在济宁市精神病防治院住院的酒依赖患者100例为研究对象,随机分为观察组和对照组,每组50例,进行2周的酒精戒断治疗后分别给予4周的rTMS和伪刺激治疗。应用宾夕法尼亚酒精渴求量表(PACS)、密西根酒精依赖调查问卷(MAST)评估两组患者入组时、治疗后1个月、6个月、12个月对酒精的渴求及酒依赖的严重程度,同时应用症状自评量表(SCL-90)和社会功能缺陷筛选量表(SDSS)评估其精神状况及社会功能。患者在12月内复饮标记为复饮病例不再评估。结果两组患者的年龄、教育年限、婚姻、职业、家族史、初次饮酒年龄、饮酒时间、嗜酒时间、每日酒精摄入量均无显著性差异(P>0.05)。治疗后1个月,观察组复饮率4%,对照组复饮率18%,差异具有统计学意义(P<0.05);两组间PACS、MAST、SCL-90得分有显著性差异(P<0.05),SDSS无显著性差异(P>0.05)。6个月后观察组复饮率34%,对照组复饮率44%,差异具有统计学意义(P<0.05);两组间未复饮患者的PACS、MAST得分有显著性差异(P<0.05),但SCL-90及SDSS得分无显著性差异(P>0.05)。12个月后观察组复饮率64%,对照组复饮率72%,差异具有统计学意义(P<0.05);两组未复饮患者的PACS、MAST、SCL-90、SDSS均无显著性差异(P>0.05)。结论rTMS能够有效帮助酒依赖患者降低对酒精的渴求,同时改善其精神症状和社会功能;rTMS的效果治疗早期明显,随着时间的延长治疗效果逐渐减弱。展开更多
Herein,the relationship between the structure and base properties of Mg–Al hydrotalcite catalysts was comprehensively investigated in relation to heat treatment and rehydration processes,which are well known as memor...Herein,the relationship between the structure and base properties of Mg–Al hydrotalcite catalysts was comprehensively investigated in relation to heat treatment and rehydration processes,which are well known as memory effects of hydrotalcite.The structure of Mg–Al hydrotalcites changed from layered double hydroxide(LDH)to mixed metal oxide and subsequently to a spinel structure during heat treatment,and it was returned from mixed metal oxide to a LDH structure by rehydration.Based on various characterizations,we successfully proposed a detailed mechanism of memory effect.We also confirmed that the Mg–Al hydrotalcites had weak or strong base sites and that their base properties could be systematically tuned by heat treatment and rehydration.The prepared Mg–Al hydrotalcites were applied to a model reaction,isomerization of glucose to fructose,as base catalysts.Among the catalysts tested,the rehydrated Mg–Al hydrotalcite efficiently produced fructose due to its appropriate base and structure properties.We finally concluded that the base sites of Mg–Al hydrotalcites can be designed as desired by heat treatment and rehydration.Moreover,through systematic design of the base sites of Mg–Al hydrotalcites,these can be promising catalysts for various heterogeneous reactions over base catalysts,giving excellent catalytic performances.展开更多
It is universally recognized that excessive depletion of fluid from the circulation after severe burn injury result in burn shock.This initial hypovolemic phase is a potentially fatal condition coincides with early de...It is universally recognized that excessive depletion of fluid from the circulation after severe burn injury result in burn shock.This initial hypovolemic phase is a potentially fatal condition coincides with early death and serves as a predisposing cause of many life-threatening complications such as tissue edema and multiple organ dysfunctions(MODS).Prompt and sufficient fluid resuscitation as early as possible is widely used to restore effective intravascular volume and improve organ perfusion as the standard treatment regime for this hypovolemic phase post severe burn injury.Unfortunately,conventional fluid resuscitation is inevitable delayed and even impossible when mass victims occur in austere environments such as battlefield,earthquake,or accidents.In such circumstance,severe burn injury is associated with high mortality for the lack of sufficient medical support.At present,oral fluid resuscitation and HDACI in early period of burn shock are important measures in the treatment of casualties in the battlefield as well as in mass casualties in lieu of the means of establishing a venous line.展开更多
文摘目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对降低酒依赖患者渴求的影响。方法选取2017年10月至2018年12月在济宁市精神病防治院住院的酒依赖患者100例为研究对象,随机分为观察组和对照组,每组50例,进行2周的酒精戒断治疗后分别给予4周的rTMS和伪刺激治疗。应用宾夕法尼亚酒精渴求量表(PACS)、密西根酒精依赖调查问卷(MAST)评估两组患者入组时、治疗后1个月、6个月、12个月对酒精的渴求及酒依赖的严重程度,同时应用症状自评量表(SCL-90)和社会功能缺陷筛选量表(SDSS)评估其精神状况及社会功能。患者在12月内复饮标记为复饮病例不再评估。结果两组患者的年龄、教育年限、婚姻、职业、家族史、初次饮酒年龄、饮酒时间、嗜酒时间、每日酒精摄入量均无显著性差异(P>0.05)。治疗后1个月,观察组复饮率4%,对照组复饮率18%,差异具有统计学意义(P<0.05);两组间PACS、MAST、SCL-90得分有显著性差异(P<0.05),SDSS无显著性差异(P>0.05)。6个月后观察组复饮率34%,对照组复饮率44%,差异具有统计学意义(P<0.05);两组间未复饮患者的PACS、MAST得分有显著性差异(P<0.05),但SCL-90及SDSS得分无显著性差异(P>0.05)。12个月后观察组复饮率64%,对照组复饮率72%,差异具有统计学意义(P<0.05);两组未复饮患者的PACS、MAST、SCL-90、SDSS均无显著性差异(P>0.05)。结论rTMS能够有效帮助酒依赖患者降低对酒精的渴求,同时改善其精神症状和社会功能;rTMS的效果治疗早期明显,随着时间的延长治疗效果逐渐减弱。
基金supported by C1 Gas Refinery Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT&Future Planning(2015M3D3A1A01064908)supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2015R1D1A1A01059724)。
文摘Herein,the relationship between the structure and base properties of Mg–Al hydrotalcite catalysts was comprehensively investigated in relation to heat treatment and rehydration processes,which are well known as memory effects of hydrotalcite.The structure of Mg–Al hydrotalcites changed from layered double hydroxide(LDH)to mixed metal oxide and subsequently to a spinel structure during heat treatment,and it was returned from mixed metal oxide to a LDH structure by rehydration.Based on various characterizations,we successfully proposed a detailed mechanism of memory effect.We also confirmed that the Mg–Al hydrotalcites had weak or strong base sites and that their base properties could be systematically tuned by heat treatment and rehydration.The prepared Mg–Al hydrotalcites were applied to a model reaction,isomerization of glucose to fructose,as base catalysts.Among the catalysts tested,the rehydrated Mg–Al hydrotalcite efficiently produced fructose due to its appropriate base and structure properties.We finally concluded that the base sites of Mg–Al hydrotalcites can be designed as desired by heat treatment and rehydration.Moreover,through systematic design of the base sites of Mg–Al hydrotalcites,these can be promising catalysts for various heterogeneous reactions over base catalysts,giving excellent catalytic performances.
基金National Natural Science Foundation of China(No.81774422)The Key Project of Scientific Research in Universities of Hebei Province Education Department(No.1810655)Key scientific research projects of Chinese People's Police University(No.2019zdgg017)。
文摘It is universally recognized that excessive depletion of fluid from the circulation after severe burn injury result in burn shock.This initial hypovolemic phase is a potentially fatal condition coincides with early death and serves as a predisposing cause of many life-threatening complications such as tissue edema and multiple organ dysfunctions(MODS).Prompt and sufficient fluid resuscitation as early as possible is widely used to restore effective intravascular volume and improve organ perfusion as the standard treatment regime for this hypovolemic phase post severe burn injury.Unfortunately,conventional fluid resuscitation is inevitable delayed and even impossible when mass victims occur in austere environments such as battlefield,earthquake,or accidents.In such circumstance,severe burn injury is associated with high mortality for the lack of sufficient medical support.At present,oral fluid resuscitation and HDACI in early period of burn shock are important measures in the treatment of casualties in the battlefield as well as in mass casualties in lieu of the means of establishing a venous line.