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Automatic test report augmentation to assist crowdsourced testing
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作者 Xin CHEN He JIANG +2 位作者 Zhenyu CHEN Tieke HE Liming NIE 《中国计算机科学前沿:英文版》 SCIE EI CSCD 2019年第5期943-959,共17页
In crowdsourced mobile application testing, workers are often inexperienced in and unfamiliar with software testing. Meanwhile, workers edit test reports in descriptive natural language on mobile devices. Thus, these ... In crowdsourced mobile application testing, workers are often inexperienced in and unfamiliar with software testing. Meanwhile, workers edit test reports in descriptive natural language on mobile devices. Thus, these test reports generally lack important details and challenge developers in understanding the bugs. To improve the quality of inspected test reports, we issue a new problem of test report augmentation by leveraging the additional useful information contained in duplicate test reports. In this paper, we propose a new framework named test report augmentation framework (TRAF) towards resolving the problem. First, natural language processing (NLP) techniques are adopted to preprocess the crowdsourced test reports. Then, three strategies are proposed to augment the environments, inputs, and descriptions of the inspected test reports, respectively. Finally, we visualize the augmented test reports to help developers distinguish the added information. To evaluate TRAF, we conduct experiments over five industrial datasets with 757 crowdsourced test reports. Experimental results show that TRAF can recommend relevant inputs to augment the inspected test reports with 98.49% in terms of NDCG and 88.65% in terms of precision on average, and identify valuable sentences from the descriptions of duplicates to augment the inspected test reports with 83.58% in terms of precision, 77.76% in terms of recall, and 78.72% in terms of F-measure on average. Meanwhile, empirical evaluation also demonstrates that augmented test reports can help developers understand and fix bugs better. 展开更多
关键词 crowdsourced TESTING TEST REPORT TF-IDF natural language processing TEST REPORT augmentation
Follicular dendritic cell sarcoma detected in hepatogastric ligament: A case report and review of the literature 预览
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作者 Wen-Xin Yan You-Xi Yu +2 位作者 Ping Zhang Xing-Kai Liu Yan Li 《世界临床病例杂志》 2019年第1期116-121,共6页
The most common organ where follicular dendritic cell sarcoma (FDCS) occurs is in cervical lymph nodes, while few cases are found in extranodal organs such as liver, spleen, and soft tissue. This is a case report that... The most common organ where follicular dendritic cell sarcoma (FDCS) occurs is in cervical lymph nodes, while few cases are found in extranodal organs such as liver, spleen, and soft tissue. This is a case report that FDCS occurs in the hepatogastric ligament. To our knowledge, there is no such case that has been reported previously. A 47-year-old male patient was found to have an intraabdominal mass during an annual physical examination. Computed tomography showed a 4.2 cm × 4.1 cm mass located at the lesser curvature of the stomach, above the pancreas. During operation, a tumor mass was found in the hepatogastric ligament and a radical resection was performed. The tumor was diagnosed as FDCS by pathology and immunohistochemical testing. The patient had a favorable recovery, and no obvious abnormality was found 3 months postoperation. 展开更多
关键词 FOLLICULAR DENDRITIC cell SARCOMA Hepatogastric LIGAMENT Pathology IMMUNOHISTOCHEMISTRY Computed tomography Case report
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Successful treatment of noncirrhotic portal hypertension with eculizumab in paroxysmal nocturnal hemoglobinuria:A case report 预览
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作者 Alexandra Alexopoulou Iliana Mani +5 位作者 Dina G Tiniakos Flora Kontopidou Ioanna Tsironi Marina Noutsou Helen Pantelidaki Spyros P Dourakis 《世界肝病学杂志:英文版(电子版)》 2019年第5期483-488,共6页
BACKGROUND Idiopathic non-cirrhotic portal hypertension(INCPH)is mainly associated with thrombophilia in Western countries.Paroxysmal nocturnal hemoglobinuria(PNH)is a rare hematologic disease that manifests with hemo... BACKGROUND Idiopathic non-cirrhotic portal hypertension(INCPH)is mainly associated with thrombophilia in Western countries.Paroxysmal nocturnal hemoglobinuria(PNH)is a rare hematologic disease that manifests with hemolytic anemia,thrombosis,and peripheral blood cytopenias.Portal and hepatic venous thrombosis were reported in PNH.A rare case of INCPH complicating PNH is described.CASE SUMMARY A 63-year old woman with a 2-year past medical history of PNH without treatment was admitted because of jaundice and refractory ascites requiring large volume paracentesis.Liver histology revealed portal venopathy with portal fibrosis and sclerosis,nodular regenerative hyperplasia,parenchymal ischemic changes,and focal sinusoidal and perivenular fibrosis without bridging fibrosis or cirrhosis,all indicative of INCPH.The flow cytometry confirmed PNH diagnosis and eculizumab treatment was initiated.Her condition was improved gradually,bilirubin was normalized 6 months following initiation of eculizumab,and 1 year later diuretics were stopped.CONCLUSION Eculizumab improved intravascular hemolysis and reversed clinical manifestations of INCPH in a patient with paroxysmal nocturnal hemoglobinuria. 展开更多
关键词 PAROXYSMAL NOCTURNAL HEMOGLOBINURIA IDIOPATHIC non-cirrhotic portal hypertension ECULIZUMAB Case report
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Malignant epidermoid arising from the third ventricle:A case report 预览
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作者 Samadhan Pawar Chaitanya Borde +1 位作者 Atul Patil Rajnish Nagarkar 《世界放射学杂志:英文版(电子版)》 2019年第5期74-80,共7页
BACKGROUND Third epidermoid tumors are a rare finding. The appearance of these tumors often makes them difficult to diagnose, and thus they require multimodality imaging. CASE SUMMARY A 48-year-old male patient report... BACKGROUND Third epidermoid tumors are a rare finding. The appearance of these tumors often makes them difficult to diagnose, and thus they require multimodality imaging. CASE SUMMARY A 48-year-old male patient reported to our hospital with complaints of vomiting and severe headache. The patient also complained of involuntary micturition for the past five days. We used a combination of computed tomography (CT) and magnetic resonance imaging (MRI) imaging modalities to confirm the presence of a malignant epidermoid cyst arising from the third ventricle. A contrastenhanced CT of the head demonstrated minimal perilesional enhancement while an MRI revealed a large, lobulated and septated T2 hyperintense mass arising from the third ventricle. The maximum size of the lesion measured 73 mm × 65 mm × 64 mm in size. CONCLUSION Malignant epidermoid arising from the third ventricle in an adult male was reported using a combination of CT, MRI, and MR spectroscopy. 展开更多
关键词 EPIDERMOID THIRD VENTRICLE Magnetic RESONANCE imaging Case report
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Incomplete capsulotomy and lens fragmentation during femtosecond laser-assisted cataract surgery associated with emulsified anterior chamber silicone oil: a case report
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作者 Wei Chen Yong Wang +1 位作者 Jian Wu Huai-Jin Guan 《国际眼科杂志:英文版》 SCIE CAS 2019年第6期1047-1049,共3页
Dear Editor,I am Dr. Wei Chen, from Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. I write to present one case report of incomplete capsulotomy and lens fragmentation ... Dear Editor,I am Dr. Wei Chen, from Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. I write to present one case report of incomplete capsulotomy and lens fragmentation during femtosecond laser-assisted cataract surgery (FLACS) associated with emulsified anterior chamber silicone oil. 展开更多
关键词 a case report FLACS Figure IOL
Organ-associated pseudosarcomatous myofibroblastic proliferation with ossification in the lower pole of the kidney mimicking renal pelvic carcinoma:A case report 预览
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作者 Tian-Yuan Zhai Bin-Jie Luo +4 位作者 Zhan-Kui Jia Zheng-Guo Zhang Xiang Li Hao Li Jin-Jian Yang 《世界临床病例杂志》 2019年第17期2605-2610,共6页
BACKGROUND Organ-associated pseudosarcomatous myofibroblastic proliferation (PMP) is a very rare disorder.In the urogenital tract,PMP preferentially involves the urinary bladder;kidney involvement is rare.Here,we repo... BACKGROUND Organ-associated pseudosarcomatous myofibroblastic proliferation (PMP) is a very rare disorder.In the urogenital tract,PMP preferentially involves the urinary bladder;kidney involvement is rare.Here,we report a rare case of PMP with ossification in the lower pole of the kidney,which mimics urothelial carcinoma or an osteogenic tumor.CASE SUMMARY A Chinese man was admitted to our hospital due to intermittent hematuria for more than 1 mo.Enhanced renal computed tomography revealed a mass in the left renal pelvis and upper ureter.The preoperative clinical diagnosis was renal pelvic carcinoma,determined by imaging examination and biopsy.After a standard preparation for surgery,the patient underwent retroperitoneoscopic radical nephroureterectomy.The operative findings were an extensive renal tumor (6 cm × 4.5 cm × 4.5 cm) invading the lower pole of the kidney and upper ureter.The final pathological diagnosis was organ-associated PMP with ossification.After 6-mo follow-up,no recurrence or metastasis was found.CONCLUSION This case of PMP was unusual for its mimicking renal pelvic carcinoma in imaging examinations,making biopsy necessary. 展开更多
关键词 Pseudosarcomatous myofibroblastic PROLIFERATION KIDNEY RENAL PELVIC Carcinoma Case report
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Cardiac amyloidosis: A case report and review of literature 预览
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作者 Adeyemi Adedamola Taiwo Lavanya Alapati Assad Movahed 《世界临床病例杂志》 2019年第6期742-752,共11页
BACKGROUND Cardiac amyloidosis, a disease caused by the precipitation of amyloid proteins in the myocardial extracellular matrix has been historically difficult to diagnose due to lack of specific clinical manifestati... BACKGROUND Cardiac amyloidosis, a disease caused by the precipitation of amyloid proteins in the myocardial extracellular matrix has been historically difficult to diagnose due to lack of specific clinical manifestations and necessity of biopsy to demonstrate amyloid deposition. However, advances in cardiovascular imaging techniques have facilitated earlier recognition of this disease. In addition, while once thought of as incurable, treatment strategies are emerging for cardiac amyloidosis, making early diagnosis essential. CASE SUMMARY We outline the case of a 73 years old African American female who was admitted with sudden onset shortness of breath and found to be in cardiogenic shock. Cardiac amyloidosis was suspected due to discordance between electrocardiogram and echocardiogram findings and this was subsequently confirmed with the aid of scintigraphy and an endomyocardial biopsy. CONCLUSION Our objective is to highlight the diagnostic evaluation and clinical implications of cardiac amyloidosis. 展开更多
关键词 CARDIAC AMYLOIDOSIS RESTRICTIVE CARDIOMYOPATHY TRANSTHYRETIN Case report
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Open anterior glenohumeral dislocation with associated supraspinatus avulsion: A case report 预览
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作者 Cosmin Ioan Faur Bogdan Anglitoiu Ana-Maria Ungureanu 《世界临床病例杂志》 2019年第7期849-854,共6页
BACKGROUND Open dislocation of the glenohumeral joint is a very rare complication with only six cases described in the literature. Most cases resulted in severe complications like avascular necrosis of the humeral hea... BACKGROUND Open dislocation of the glenohumeral joint is a very rare complication with only six cases described in the literature. Most cases resulted in severe complications like avascular necrosis of the humeral head or septic arthritis with poor functional results. The “mandatory” treatment of choice is surgery, with accurate debridement and reconstruction of the damaged soft tissues. However, the results in these cases do not approach those seen in classical dislocations. CASE SUMMARY This case report is the first description of an anterior open glenohumeral dislocation without associated fractures, but with complete avulsion of the soft tissue envelope of the proximal humerus. Surgical treatment consisted of copious lavage with saline solution, meticulous debridement of the nonviable soft tissues, reduction of the dislocated humeral head and reconstruction of the soft tissue envelope of the humeral head. The selected surgical approach was an inferior extension of the wound at the level of the delto-pectoral groove, as the best choice to be able to perform an adequate debridement and capsulo-tendinous reinsertion. At 6 mo there were no clinical signs of instability of the glenohumeral joint, the functionality of the joint was restricted to 90o of anterior elevation, internal rotation to L2, with severe limitation of abduction (60o) and external rotation (0o) but without residual pain, with an Oxford shoulder Score of 28. CONCLUSION Thorough reconstruction of the soft tissues surrounding the shoulder joint and an early rehabilitation program are key points to a good functional result. 展开更多
关键词 OPEN shoulder DISLOCATION Case report Functional impairment Surgical treatment AVASCULAR necrosis
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某三甲医院血液科1036例药品不良反应报告分析 预览
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作者 吴菲 沈爱宗 李民 《中国药业》 CAS 2019年第17期91-93,共3页
目的探讨引发药品不良反应(ADR)的原因及影响因素。方法对医院2014年至2016年上报的血液科ADR报告进行统计与分析。结果1036份血液科不良反应报告中,患者男561例(54.15%),女475例(45.85%);41~50岁ADR发生率最高;严重的ADR报告38例(3.67... 目的探讨引发药品不良反应(ADR)的原因及影响因素。方法对医院2014年至2016年上报的血液科ADR报告进行统计与分析。结果1036份血液科不良反应报告中,患者男561例(54.15%),女475例(45.85%);41~50岁ADR发生率最高;严重的ADR报告38例(3.67%),新的ADR报告250例(24.13%);给药途径中静脉滴注引发ADR最多,为834例(80.50%),其次为静脉注射92例(8.88%);抗感染药物所致ADR比例最高,为306例(29.54%),其次为抗肿瘤药物272例(26.25%);以消化系统损害376例(29.22%)最常见。结论血液科要注意抗感染药物的合理使用,静脉给药患者要更加监护,以减少或避免ADR的发生。 展开更多
关键词 药品不良反应 血液科 报告 合理用药 影响因素
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Cause of postprandial vomiting - a giant retroperitoneal ganglioneuroma enclosing large blood vessels:A case report 预览
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作者 Xue Zheng Li Luo Fu-Gang Han 《世界临床病例杂志》 2019年第17期2617-2622,共6页
BACKGROUND Ganglioneuroma (GN) is a rare neurogenic tumor that accounts for about 0.1%- 0.5% of all tumors of the nervous system.It originates from neural crest cells.GN has no specific clinical symptoms or laboratory... BACKGROUND Ganglioneuroma (GN) is a rare neurogenic tumor that accounts for about 0.1%- 0.5% of all tumors of the nervous system.It originates from neural crest cells.GN has no specific clinical symptoms or laboratory findings,which leaves it easily overlooked and misdiagnosed as other tumors.Retroperitoneal GN with very large volume and vascular penetration is extremely rare.CASE SUMMARY We present the imaging and pathological findings of a giant retroperitoneal GN in a child.A 4-year-old boy had suffered from postprandial vomiting for more than 6 mo with no precipitating factors.Abdominal computerized tomographic examination showed a giant cystic mass in the retroperitoneal area.After injection of contrast agent,the mass showed heterogeneous enhancement.Surgery with local excision of the mass was performed to address the embedded abdominal blood vessels,and the histopathological and immunohistochemical diagnosis of the mass was GN.Postprandial vomiting was relieved,and no complications occurred after the operation.CONCLUSION In the diagnosis of giant retroperitoneal hypodense masses in children,GN should be considered if the mass presents delayed enhancement,punctate calcification,and vascular embedding but no invasion.Pathology is the golden standard for the diagnosis of GN,and surgical excision is the optimal treatment for GN. 展开更多
关键词 RETROPERITONEAL GANGLIONEUROMA POSTPRANDIAL VOMITING Case report
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Successful treatment with hysteroscopy for infertility due to isthmocele and hydrometra secondary to cesarean section: A case report 预览
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作者 Luis Pablo López Rivero Miguel Jaimes +1 位作者 Felipe Camargo Esther López-Bayghen 《世界临床病例杂志》 2019年第6期753-758,共6页
BACKGROUND An isthmocele is a scar defect in the uterine wall due to a cesarean section. Its prevalence is unknown, but it has been associated with secondary infertility. Here, we present a case where the patient suff... BACKGROUND An isthmocele is a scar defect in the uterine wall due to a cesarean section. Its prevalence is unknown, but it has been associated with secondary infertility. Here, we present a case where the patient suffered from an isthmocele that was associated with persistent hydrometra, which developed during in vitro fertilization. CASE SUMMARY The patient underwent hysteroscopic surgery, which successfully resolved the isthmocele as well as the hydrometra. Afterward, two high-quality, euploid embryos, determined by morphological assessment and pre-implantation genetic diagnostic testing, were transferred. This resulted in uterine pregnancy, as determined byserum β-human chorionic gonadotropin levels on day 14 (180 mU/mL) and ultrasound-confirmed presence of a gestational sac with a positive embryocardia at week 6. The pregnancy reached 36 wk without any complications, and the product was born in good health. We report a successful isthmocele treatment in a patient with secondary infertility, in which the isthmocele was the cause of persistent hydrometra. CONCLUSION Hydrometra caused by secondary cesarean is an infertility factor, which can be corrected by hysteroscopy plus ablation of the isthmocele. 展开更多
关键词 In VITRO FERTILIZATION Isthmocele Hydrometra Case REPORT
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Aeromonas veronii biovar veronii and sepsis-infrequent complication of biliary drainage placement: A case report 预览
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作者 Manlio Monti Arianna Torri +4 位作者 Elena Amadori Alice Rossi Giulia Bartolini Chiara Casadei Giovanni Luca Frassineti 《世界临床病例杂志》 2019年第6期759-764,共6页
BACKGROUND Aeromonas species are uncommon pathogens in biliary sepsis and cause substantial mortality in patients with impaired hepatobiliary function. Asia has the highest incidence of infection from Aeromonas, where... BACKGROUND Aeromonas species are uncommon pathogens in biliary sepsis and cause substantial mortality in patients with impaired hepatobiliary function. Asia has the highest incidence of infection from Aeromonas, whereas cases in the west are rare. CASE SUMMARY We report the case of a 64-year-old woman with advanced pancreatic cancer and jaundice who manifested fever, abdominal pain, severe thrombocytopenia, anemia and kidney failure following the insertion of a percutaneous transhepatic biliary drainage. Blood culture results revealed the presence of Aeromonas veronii biovar veronii (A. veronii biovar veronii). After antibiotic therapy and transfusions, the life-threatening clinical conditions of the patient improved and she was discharged. CONCLUSION This was a rare case of infection, probably the first to be reported in West countries, caused by A. veronii biovar veronii following biliary drainage. A finding of Aeromonas must alert clinician to the possibility of severe sepsis. 展开更多
关键词 AEROMONAS veronii BIOVAR veronii AEROMONAS Pancreatic cancer CHOLANGITIS Sepsis BILIARY TRACT infection Case report
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Non-Invasive management of invasive cervical resorption associated with periodontal pocket: A case report 预览
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作者 Abdullah Alqedairi 《世界临床病例杂志》 2019年第7期863-871,共9页
BACKGROUND Invasive cervical resorption (ICR), a commonly misdiagnosed condition, is an aggressive form of external tooth resorption that contributes to periodontal tissue inflammation and deepening of the periodontal... BACKGROUND Invasive cervical resorption (ICR), a commonly misdiagnosed condition, is an aggressive form of external tooth resorption that contributes to periodontal tissue inflammation and deepening of the periodontal pockets. Herein we report the case of a patient, exhibiting ICR and elaborate the effects of a non-surgical approach in the amelioration of this condition. CASE SUMMARY A 21-year-old female reporting intermittent pain at the upper left side, multiple restorations, no trauma history, and having received orthodontic treatment was studied. Localized erythematous swelling was noted at the buccal interdental papilla between the left maxillary first molar and second premolar. The diseased pulp and tissue in resorption were removed and the root canal system including the defect were sealed using gutta percha/AH Plus and mineral trioxide aggregate (MTA). At the one-year recall, the tooth showed no symptoms and responded normally to percussion and palpation. The surrounding periodontium exhibited a normal color and the probing depth was normal. Radiographic examination showed a restoration of crestal alveolar bone and good adaption to MTA. CONCLUSION Non-surgical root canal treatment in conjunction with resorption defect orthograde repair with MTA was found to be an effective treatment option in the elimination of ICR. Early diagnoses are recommended in order to employ nonsurgical approaches for management of ICR instead of surgical interventions. 展开更多
关键词 INVASIVE CERVICAL RESORPTION Mineral TRIOXIDE aggregate NON-SURGICAL root canal PERIODONTAL Case report
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Carcinoma ex pleomorphic adenoma of the trachea:A case report 预览
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作者 Heng-Xing Gao Quan Li +3 位作者 Wen-Li Chang Ya-Long Zhang Xiao-Zhi Wang Xue-Xue Zou 《世界临床病例杂志》 2019年第17期2623-2629,共7页
BACKGROUND Carcinoma ex pleomorphic adenoma (CXPA) is defined as a malignant salivary gland tumor arising from a primary or recurrent pleomorphic adenoma.Only three cases of CXPA of the trachea have been reported in t... BACKGROUND Carcinoma ex pleomorphic adenoma (CXPA) is defined as a malignant salivary gland tumor arising from a primary or recurrent pleomorphic adenoma.Only three cases of CXPA of the trachea have been reported in the literature.CASE SUMMARY We report a case of tracheal CXPA in a 55-year-old woman,who presented with a more than 3-mo history of progressive dyspnea.Computed tomography of the neck and thorax revealed an inhomogeneous,broad-based lesion arising from the tracheal wall on the right side.Endoscopy revealed a subglottic neoplasm causing up to 90% luminal stenosis.The tumor was resected using a highfrequency electrosurgical snare combined with argon plasma coagulation.Histopathology and immunohistochemistry revealed that the tumor was a CXPA of the trachea.CONCLUSION We report the fourth case of tracheal CXPA,and present the first instance of resection of CXPA using high-frequency electrosurgical snare and laser ablation.We also discuss the pathogenesis,diagnosis,histopathology,and systemic therapy of this rare disease. 展开更多
关键词 Case report CARCINOMA EX PLEOMORPHIC ADENOMA TRACHEA PLEOMORPHIC ADENOMA
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Robot-assisted gallbladder-preserving hepatectomy for treating S5 hepatoblastoma in a child: A case report and review of the literature 预览
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作者 Di-Xiang Chen Shan-Jie Wang +3 位作者 Ya-Nan Jiang Mu-Chuan Yu Jun-Zhen Fan Xian-Qiang Wang 《世界临床病例杂志》 2019年第7期872-880,共9页
BACKGROUND Hepatoblastoma (HB) is the most common hepatic malignant tumour in children, accounting for approximately 50%-60% of primary hepatic malignant tumours in children, mostly in children under 3 years old. In W... BACKGROUND Hepatoblastoma (HB) is the most common hepatic malignant tumour in children, accounting for approximately 50%-60% of primary hepatic malignant tumours in children, mostly in children under 3 years old. In Western countries, the incidence of hepatoblastoma is approximately 1-2/100000. Da Vinci surgical system is fast becoming a key instrument in microinvasive surgery. The past decade has seen the rapid development of robot-assisted laparoscopy, which expends many fields including the liver surgery. This paper discusses the significance and feasibility of robot-assisted gallbladder-preserving hepatectomy for treating S5 hepatoblastoma in children. The aim of this essay is to compare the safety and effectiveness of robotic surgery with conventional laparoscopic surgery, and explore the meaning of preservation of the gallbladder by sharing this case. CASE SUMMARY A 3-year-old child with a liver mass in the 5th segment was treated using the Da Vinci surgical system, and the gallbladder was retained. The child was admitted to the hospital for 20 d for the discovery of the right hepatic lobe mass. Ultrasonography revealed a low echo mass, 46 mm × 26 mm × 58 mm in size, indicating hepatoblastoma in the right lobe, and enhanced computed tomography showed continuous enhancement of iso-low-density lesions with different sizes and nodules and unclear boundaries, without the dilation of the intrahepatic bile duct, no enlargement of the gallbladder, and uniform thickness of the wall. The diagnosis was “liver mass, hepatoblastoma”. It was decided to perform S5 liver tumour resection. During surgery, the tumour and gallbladder were isolated first, and the gallbladder could be completely separated from the tumour surface without obvious infiltration;therefore, the gallbladder was preserved. The cutting line was marked with an electric hook. The hepatic duodenal ligament was blocked with a urethral catheter using the Pringle method, and the tumour and part of the normal liver tissue were completely resected with a 展开更多
关键词 HEPATECTOMY ROBOTIC surgery PEDIATRICS HEPATOBLASTOMA Case report
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Wilson disease associated with immune thrombocytopenia:A case report and review of the literature 预览
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作者 Tian-Jiao Ma Gui-Lian Sun +1 位作者 Fang Yao Zhi-Liang Yang 《世界临床病例杂志》 2019年第17期2630-2636,共7页
BACKGROUND Wilson disease (WD) is a genetic disorder of hepatic copper excretion,leading to copper accumulation in various tissues.The manifestations are quite variable,and hemolytic anemia is the most common hematolo... BACKGROUND Wilson disease (WD) is a genetic disorder of hepatic copper excretion,leading to copper accumulation in various tissues.The manifestations are quite variable,and hemolytic anemia is the most common hematological presentation.WD associated with thrombocytopenia is very rare.CASE SUMMARY We report the case of an 11-year-old Chinese girl with WD that was associated with immune thrombocytopenia (ITP).Thrombocytopenia was the initial chief complaint for her to visit a hematologist,and ITP was diagnosed based on the results of a bone marrow biopsy and positive antiplatelet autoantibodies.About two weeks before the thrombocytopenia was found,the patient developed drooling.Tremors developed in her right hand about one week after being diagnosed with ITP,after which she was admitted to our hospital.Further evaluations were performed.Ceruloplasmin was decreased,with an increased level of copper in her 24-h urine excretion.Kayser Fleischer's ring (K-F ring) was positive.The ultrasound showed liver cirrhosis,and brain magnetic resonance imaging showed that the lenticular nucleus,caudate nucleus,and brainstem presented a low signal intensity in T1-weighted images and high signal intensity in T2-weighted images.WD was diagnosed and a genetic analysis was performed.A compound heterozygous mutation in ATP7B was detected;c.2333G>T (p.Arg778Leu) in exon 8 and c.3809A>G (p.Asn1270Ser) in exon 18.The former was inherited from her father and the latter from her mother.However,her parents showed normal liver function and negative K-F rings.Such a compound mutation in a case of WD associated with ITP in children has not been published previously.CONCLUSION WD can associate with thrombocytopenia but the mechanism is still unclear.We recommend that antiplatelet autoantibodies should be tested in WD patients with thrombocytopenia in future to verify the association. 展开更多
关键词 WILSON disease IMMUNE THROMBOCYTOPENIA ATP7B Case REPORT
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Small cell lung cancer starting with diabetes mellitus:Two case reports and literature review 预览
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作者 Tong Zhou Yao Wang +4 位作者 Xue Zhao Yang Liu Ying-Xuan Wang Xiao-Kun Gang Gui-Xia Wang 《世界临床病例杂志》 2019年第10期1213-1220,共8页
BACKGROUND Small-cell lung cancer(SCLC)is a type of fatal tumor that is increasing in prevalence.While these are unpleasant facts to consider,it is vitally important to be informed,and it is important to catch the dis... BACKGROUND Small-cell lung cancer(SCLC)is a type of fatal tumor that is increasing in prevalence.While these are unpleasant facts to consider,it is vitally important to be informed,and it is important to catch the disease early.Typically,lung cancer does not show severe clinical symptoms in the early stage.Once lung cancer has progressed,patients might present with classical symptoms of respiratory system dysfunction.Thus,the prognosis of SCLC is closely related to the early diagnosis of the disease.Ectopic adrenocorticotropic hormone(ACTH)syndrome(EAS)is related to cancer occurrence,especially for SCLC with the presence of Cushing's syndrome,which is dependent on markedly elevated ACTH and cortisol levels.CASE SUMMARY In the current report,we describe two middle-age patients who were originally diagnosed with diabetes mellitus with no classical symptoms of lung cancer.The patients were eventually diagnosed with SCLC,which was confirmed by bronchoscopic biopsy and histopathology.SCLC-associated diabetes was related to EAS,which was an endogenous ACTH-dependent form of Cushing’s syndrome with elevated ACTH and cortisol levels.Multiple organ metastases were found in Patient 1,while Patient 2 retained good health at 2 years follow-up.EAS symptoms including thyroid dysfunction,hypercortisolism and glucose intolerance were all resolved after anticancer treatment.CONCLUSION In conclusion,SCLC might start with diabetes mellitus and increased cortisol and hypokalemia or other EAS symptoms.These complex clinical features were the most significant factors to deteriorate a patient’s condition.Early diagnosis and treatment from clinicians were essential for the anti-cancer treatment for patients with SCLC. 展开更多
关键词 Case report Small cell LUNG cancer Diabetes Ectopic adrenocorticotropic HORMONE syndrome Adrenocorticotropic HORMONE Diagnosis
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Significant benefits of osimertinib in treating acquired resistance to first-generation EGFR-TKIs in lung squamous cell cancer:A case report 预览
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作者 Yan Zhang Hui-Min Chen +6 位作者 Yong-Mei Liu Feng Peng Min Yu Wei-Ya Wang Heng Xu Yong-Sheng Wang You Lu 《世界临床病例杂志》 2019年第10期1221-1229,共9页
BACKGROUND Lung squamous cell cancer(LSCC)rarely harbors epidermal growth factor receptor(EGFR)mutations,even much rarer for acquired T790M mutation.Although clinical trials of AURA series illustrated that non-small c... BACKGROUND Lung squamous cell cancer(LSCC)rarely harbors epidermal growth factor receptor(EGFR)mutations,even much rarer for acquired T790M mutation.Although clinical trials of AURA series illustrated that non-small cell lung cancer(NSCLC)with EGFR T790M mutation can benefit from osimertinib,only five LSCC patients were enrolled in total;moreover,the efficacy for LSCC was not shown in the results.Therefore,the response of LSCC to osimertinib is still unclear to date.CASE SUMMARY We report an LSCC case with T790M-related acquired resistance after treatments with first-generation EGFR-tyrosine kinase inhibitors(EGFR-TKIs)and benefited from osimertinib significantly.A 63-year-old Chinese man was diagnosed with stage IV(cT2N2M1b)LSCC harboring an EGFR exon 19-deletion mutation.Following disease progression after gefitinib and multi-line chemotherapy,rebiopsy was conducted.Molecular testing of EGFR by amplification refractory mutation system-polymerase chain reaction detected the exon 19-deletion without T790M mutation.Therefore,the patient was given erlotinib,but progression developed only 3 mo later.Then the frozen re-biopsy tissue was tested by next-generation sequencing(NGS),which detected an EGFR T790M mutation.However,he was very weak with symptoms of dysphagia and cachexia.Fortunately,osimertinib was started,leading to alleviation from the symptoms.Four months later,normal deglutition was restored and partial response was achieved.Finally,the patient achieved an overall survival time period of 29 mo.CONCLUSION Our findings highlight that EGFR T790M mutation may also be an important acquired drug resistance mechanism for LSCC and offer direct evidence of the efficacy of osimertinib in LSCC with T790M mutation.NGS and better preservation conditions may contribute to higher sensitivity of EGFR T790M detection. 展开更多
关键词 LUNG SQUAMOUS cell CANCER LUNG CANCER EPIDERMAL growth factor receptor mutation T790M Osimertinib TYROSINE kinase inhibitor Targeted therapy Case report
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Successful endoscopic extraction of a proximal esophageal foreign body following accurate localization using endoscopic ultrasound:A case report 预览
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作者 Xiao-Ming Wang Shan Yu Xin Chen 《世界临床病例杂志》 2019年第10期1230-1233,共4页
BACKGROUND It is rare to find fish bones completely embedded in the wall of the esophagus with endoscopic findings similar to those of submucosal tumors.Most of the patients had the foreign body removed by thoracotomy... BACKGROUND It is rare to find fish bones completely embedded in the wall of the esophagus with endoscopic findings similar to those of submucosal tumors.Most of the patients had the foreign body removed by thoracotomy or thoracoscopy in the past,which resulted in great trauma.CASE SUMMARY We report a 58-year-old woman who experienced dysphagia for 6 d after eating fish.Cervical computed tomography(CT)and endoscopic ultrasonography(EUS)indicated a fish bone completely embedded in the wall of the esophagus with endoscopic findings similar to those of submucosal tumors.The results of CT reconstruction and EUS suggested that the fish bone was parallel to the longitudinal axis of the esophagus.We performed a longitudinal mucosal incision from the highest point of the uplift by using an Olympus dual knife to find the fish bone.Unfortunately,no fish bone was found,so we extended the incision and endoscopic submucosal dissection(ESD)technique was used to detect and remove the fish bone entirety.CONCLUSION The extraction of fish bone via ESD immediately after the injection of methylene blue into the submucous membrane under EUS guidance to obtain accurate localization of the foreign body may be the best treatment for such patients. 展开更多
关键词 Fish bone ENDOSCOPIC MUCOSAL DISSECTION Upper ESOPHAGEAL wall Case report
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Minimally invasive endoscopic maxillary sinus lifting and immediate implant placement:A case report 预览
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作者 Mahmoud Mudalal Xiao-Lin Sun +5 位作者 Xue Li Jiao Fang Man-Lin Qi Jia Wang Liu-Yi Du Yan-Min Zhou 《世界临床病例杂志》 2019年第10期1234-1241,共8页
BACKGROUND This case report discusses a modified approach for maxillary sinus augmentation,in which platelet-rich fibrin,endoscope,simultaneous implant placement,and sinus floor elevation(PESS)were applied for a maxil... BACKGROUND This case report discusses a modified approach for maxillary sinus augmentation,in which platelet-rich fibrin,endoscope,simultaneous implant placement,and sinus floor elevation(PESS)were applied for a maxillary sinus floor lift in a 40-year-old patient.CASE SUMMARY A 40-year-old woman suffered missing upper right first molar.Implant stability quotient and cone-beam computed tomography(CBCT)were used to evaluate the diagnosis.CBCT showed insufficient posterior maxillary bone with a mean residual alveolar bone height of only 3.5 mm.The patient underwent a minimally invasive sinus floor elevation endoscopically.The sinus membrane was elevated in two stages,and a 12-mm implant was placed immediately.At 3 mo postoperatively,the final impressions were accomplished,and a full-ceramic crown was fit-placed.A 6-mo follow-up demonstrated satisfactory aesthetic and functional results.CONCLUSION This is the first report to use an endoscope for maxillary sinus floor lifting in cases with severe and insufficient bone height.This case report demonstrates the advantages of the PESS technique,which include minimal invasiveness with high precision,being applicable in cases with a residual alveolar bone height<4 mm with a promising result,and a shortened treatment period from 12 to 3 mo. 展开更多
关键词 MAXILLARY SINUS augmentation Platelet-rich FIBRIN ENDOSCOPE Internal SINUS floor elevation Case report
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