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Objective response rate assessment in oncology:Current situation and future expectations 认领
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作者 Nuri Faruk Aykan Tahsin Oatl? 《世界临床肿瘤学杂志(英文版)》 2020年第2期53-73,共21页
The tumor objective response rate(ORR)is an important parameter to demonstrate the efficacy of a treatment in oncology.The ORR is valuable for clinical decision making in routine practice and a significant end-point f... The tumor objective response rate(ORR)is an important parameter to demonstrate the efficacy of a treatment in oncology.The ORR is valuable for clinical decision making in routine practice and a significant end-point for reporting the results of clinical trials.World Health Organization and Response Evaluation Criteria in Solid Tumors(RECIST)are anatomic response criteria developed mainly for cytotoxic chemotherapy.These criteria are based on the visual assessment of tumor size in morphological images provided by computed tomography(CT)or magnetic resonance imaging.Anatomic response criteria may not be optimal for biologic agents,some disease sites,and some regional therapies.Consequently,modifications of RECIST,Choi criteria and Morphologic response criteria were developed based on the concept of the evaluation of viable tumors.Despite its limitations,RECIST v1.1 is validated in prospective studies,is widely accepted by regulatory agencies and has recently shown good performance for targeted cancer agents.Finally,some alternatives of RECIST were developed as immune-specific response criteria for checkpoint inhibitors.Immune RECIST criteria are based essentially on defining true progressive disease after a confirmatory imaging.Some graphical methods may be useful to show longitudinal change in the tumor burden over time.Tumor tissue is a tridimensional heterogenous mass,and tumor shrinkage is not always symmetrical;thus,metabolic response assessments using positron emission tomography(PET)or PET/CT may reflect the viability of cancer cells or functional changes evolving after anticancer treatments.The metabolic response can show the benefit of a treatment earlier than anatomic shrinkage,possibly preventing delays in drug approval.Computer-assisted automated volumetric assessments,quantitative multimodality imaging in radiology,new tracers in nuclear medicine and finally artificial intelligence have great potential in future evaluations. 展开更多
关键词 Objective RESPONSE rate TUMOR SHRINKAGE World Health Organization CRITERIA RESPONSE Evaluation CRITERIA in Solid TUMORS Immune RESPONSE Evaluation CRITERIA in Solid TUMORS CRITERIA Early TUMOR SHRINKAGE Depth of RESPONSE Waterfall PLOT Spider PLOT Swimmer PLOT
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文章速递Structural dynamic responses of a stripped solar sail subjected to solar radiation pressure 认领
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作者 Junhui ZHANG Na WU +1 位作者 An TONG Yinghua LIU 《中国航空学报:英文版》 SCIE EI CAS CSCD 2020年第8期2204-2211,共8页
The stripped solar sail whose membrane is divided into separate narrow membrane strips is believed to have the best structural efficiency.In this paper,the stripped solar sail structure is regarded as an assembly made... The stripped solar sail whose membrane is divided into separate narrow membrane strips is believed to have the best structural efficiency.In this paper,the stripped solar sail structure is regarded as an assembly made by connecting a number of boom-strip components in sequence.Considering the coupling effects between booms and membrane strips,an exact and semianalytical method to calculate structural dynamic responses of the stripped solar sail subjected to solar radiation pressure is established.The case study of a 100 m stripped solar sail shows that the stripped architecture helps to reduce the static deflections and amplitudes of the steady-state dynamic response.Larger prestress of the membrane strips will decrease stiffness of the sail and increase amplitudes of the steady-state dynamic response.Increasing thickness of the boom will benefit to stability of the sail and reduce the resonant amplitudes.This proposed semi-analytical method provides an efficient analysis tool for structure design and attitude control of the stripped solar sail. 展开更多
关键词 Distributed transfer function method Frequency response Solar radiation pressure Solar sail Structural dynamic response
Liquefaction Potential Assessment of Guwahati City Using One Dimensional Ground Response Analysis 认领
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作者 Amar Farooq Siddique Binu Sharma 《地球科学和环境保护期刊(英文)》 2020年第5期176-194,共19页
Guwahati city which lies in the North Eastern region of India, falls in the highest seismic risk zonal level i.e. zone V in India. However, there are very few works on seismic hazard analysis of Guwahati soil consider... Guwahati city which lies in the North Eastern region of India, falls in the highest seismic risk zonal level i.e. zone V in India. However, there are very few works on seismic hazard analysis of Guwahati soil considering the local site effects. The effect of large modifications in seismic waves that occur due to variation in soil properties near the surface of the earth is of great importance in geotechnical earthquake engineering. Seismic soil liquefaction, a soil seismic hazard, is evaluated in Guwahati city in terms of factor of safety against liquefaction along the soil profiles using ground response analysis. One dimensional ground response analysis has been conducted using equivalent linear and non linear method using the Deepsoil software. The input motion of 2011 Sikkim earthquake (Mw = 6.9) having bedrock PGA of 0.152 g at 30 m depth is considered. A comparative study has been made of the equivalent linear and non linear analysis in terms of surface PGA (g), maximum strain (%), maximum stress ratio and liquefaction potential using soil profiles of Guwahati city. It has been observed that stiffer soil layer results in similar PGA from both the analysis however non linear analysis generally gives a lesser surface PGA than by equivalent linear analysis. Non linear analysis generally gives a higher strain range and a lower maximum stress ratio as compared to the equivalent linear method. A slightly higher factor of safety is obtained using non linear analysis than using equivalent linear analysis. A soil database of 200 bore holes was used for the study. Spatial distribution of soil liquefaction potential is presented in the form of GIS based maps of factor of safety values. 展开更多
关键词 GROUND Response Analysis EQUIVALENT LINEAR METHOD Non LINEAR METHOD Soil LIQUEFACTION
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Design of Experiment (DoE): Implementation in Determining Optimum Design Parameters of Portable Workstation 认领
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作者 Nafisa Ali Anika Nadia Tanzeem Himadri Sen Gupta 《工程(英文)(1947-3931)》 2020年第1期25-32,共8页
In the modern era of manufacturing, it is important to optimize every design parameter in product development stage to reduce cost, material usage and to achieve the desired efficacy level. There are various models wh... In the modern era of manufacturing, it is important to optimize every design parameter in product development stage to reduce cost, material usage and to achieve the desired efficacy level. There are various models which serve those purposes, for instance, Design of Experiment (DoE) is used to check the parameters after adopting optimization tactics which results in reduced cost or saving operating time. In this regard, this research aims to construct a DoE model on a portable workstation to optimize its design parameters. The methodology of DOE would be a 2 level 3 factors full factorial DOE which is conducted to determine the optimal value for three design parameters (factors) which are material density, the length of the table and the length of the table stand in terms of the response which is the required time of fold ability function of the portable workstation. Based upon the evaluated interactions between the parameters, the optimized parameters are chosen for responses. Here, the resultant design parameters are at their lowest level, so the goal of time efficiency in fold ability function is achieved. This similar sort of DoE can be implemented in the furniture and other manufacturing industries who wish to optimize their material usage as well as increase efficiency and reduce cycle time. 展开更多
关键词 DESIGN of EXPERIMENT (DoE) PORTABLE WORKSTATION DESIGN Parameters Response Time Efficiency Improvement
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FOXO3a as a sensor of unilateral nerve injury in sensory neurons ipsilateral, contralateral and remote to injury 认领
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作者 Jovan CDHasmatali Jolly De Guzman +4 位作者 Jayne MJohnston Hossein Noyan Bernhard HJuurlink Vikram Misra Valerie MKVerge 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第12期2353-2361,共9页
Emerging evidence supports that the stress response to peripheral nerve injury extends beyond the injured neuron,with alterations in associated transcription factors detected both locally and remote to the lesion.Stre... Emerging evidence supports that the stress response to peripheral nerve injury extends beyond the injured neuron,with alterations in associated transcription factors detected both locally and remote to the lesion.Stress-induced nuclear translocation of the transcription factor forkhead class box O3a(FOXO3a)was initially linked to activation of apoptotic genes in many neuronal subtypes.However,a more complex role of FOXO3a has been suggested in the injury response of sensory neurons,with the injured neuron expressing less FOXO3a.To elucidate this response and test whether non-injured sensory neurons also alter FOXO3a expression,the temporal impact of chronic unilateral L4–6 spinal nerve transection on FOXO3a expression and nuclear localization in adult rat dorsal root ganglion neurons ipsilateral,contralateral or remote to injury relative to na?ve controls was examined.In na?ve neurons,high cytoplasmic and nuclear levels of FOXO3a colocalized with calcitonin gene related peptide,a marker of the nociceptive subpopulation.One hour post-injury,an acute increase in nuclear FOXO3a in small size injured neurons occurred followed by a significant decrease after 1,2 and 4 days,with levels increasing toward pre-injury levels by 1 week post-injury.A more robust biphasic response to the injury was observed in uninjured neurons contralateral to and those remote to injury.Nuclear levels of FOXO3a peaked at 1 day,decreased by 4 days,then increased by 1 week post-injury,a response mirrored in C4 dorsal root ganglion neurons remote to injury.This altered expression contralateral and remote to injury supports that spinal nerve damage has broader systemic impacts,a response we recently reported for another stress transcription factor,Luman/CREB3.The early decreased expression and nuclear localization of FOXO3a in the injured neuron implicate these changes in the cell body response to injury that may be protective.Finally,the broader systemic changes support the existence of stress/injury-induced humeral factor(s)influencing trans 展开更多
关键词 cell body response contralateral response dorsal root ganglion peripheral nerve injury plasticity sciatic nerve sensory neuron stress systemic transcription factor unilateral peripheral nerve injury
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The Dynamical Behavior of a Certain Predator-Prey System with Holling Type II Functional Response 认领
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作者 Shuangte Wang Hengguo Yu +1 位作者 Chuanjun Dai Min Zhao 《应用数学与应用物理(英文)》 2020年第3期527-547,共21页
In this paper we analytically and numerically consider the dynamical behavior of a certain predator-prey system with Holling type II functional response, including local and global stability analysis, existence of lim... In this paper we analytically and numerically consider the dynamical behavior of a certain predator-prey system with Holling type II functional response, including local and global stability analysis, existence of limit cycles, transcritical and Hopf bifurcations. Mathematical theory derivation mainly focuses on the existence and stability of equilibrium point as well as threshold conditions for transcritical and Hopf bifurcation, which can in turn provide a theoretical support for numerical simulation. Numerical analysis indicates that theoretical derivation results are correct and feasible. In addition, it is successful to show that the dynamical behavior of this predator-prey system mainly depends on some critical parameters and mathematical relationships. All these results are expected to be meaningful in the study of the dynamic complexity of predatory ecosystem. 展开更多
关键词 PREDATOR-PREY System HOLLING Type II FUNCTIONAL Response Global Stability BIFURCATION Analysis
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Experimental study on the relationship between traumatic stress and tumor growth,proliferation,and metastasis 认领
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作者 Weigang Cao Baoan Qiu 《肿瘤学与转化医学:英文版》 2020年第2期52-56,共5页
Objective This study aimed to investigate the relationship between traumatic stress and tumor growth,proliferation,and metastasis.Methods A scalding method was used as an injurious factor to induce traumatic stress in... Objective This study aimed to investigate the relationship between traumatic stress and tumor growth,proliferation,and metastasis.Methods A scalding method was used as an injurious factor to induce traumatic stress in Wistar rats.The rats were randomly divided into three groups—the control group,mild-scald group,and severe-scald group,with 14 rats in each group.Wistar rats were used to subculture the Walker-256 cell line for the generation of tumor ascites.Tumor cells from the ascites were cultured and used to establish a rat subcutaneous xenograft model.After 7 days,the mild-burn group and the severe-burn group were subjected burns to 10%and 15%of their backs,respectively.Blood was taken from the tail vein of rats at different times to detect changes in blood cortisol,IL-1β,and TNF-αlevels.Pathological specimens were collected 14 days later,and immunohistochemistry was performed to examine vascular endothelial growth factor(VEGF),proliferating cell nuclear antigen(PCNA),E-cadherin,and vimentin.Results Cortisol,IL-1βand TNF-αlevels were significantly higher in the scalding groups than in the control group.Tumor examination was performed after 14 days.The changes in tumor size showed that the tumor volume in the control group(0.593±0.195 cm3)and the mild-scald group(0.782±0.344 cm3)were not significantly different.However,the tumor volume was significantly larger in the severeburn group(1.806±0.838 cm3)than in the control and the mild-burn groups(P<0.05).Tumor tissue immunohistochemistry showed that the percentage of cells expressing PCNA in the control group,mildscald group,and severe-scald group was 57.1%,71.4%and 85.7%,respectively,and the differences among the groups were statistically significant.The number of VEGF-positive cells in the mild-and severescald groups was significantly higher than those of the control group(P<0.05).The number of E-cadherinpositive cells in the tumor tissues was significantly lower in the severe-scald group than that in the control and mild-scald groups.Vimentin showed th 展开更多
关键词 stress response Wistar rats TUMOR SCALDING
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Seismic Microzonation Study of South Asian Cities and Its Implications to Urban Risk Resiliency under Climate Change Scenario 认领
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作者 O. P. Mishra 《地球科学国际期刊(英文)》 2020年第4期197-237,共41页
In this study, an attempt has been made to review the existing framework of earthquake risk resiliency for the urban agglomerates of South Asian earthquake-prone countries (Afghanistan;Bangladesh;Bhutan, India, and Pa... In this study, an attempt has been made to review the existing framework of earthquake risk resiliency for the urban agglomerates of South Asian earthquake-prone countries (Afghanistan;Bangladesh;Bhutan, India, and Pakistan) with aim of suggesting a plausible model for earthquake risk resiliency for urban agglomerates of the region under the influence of uncontrollable climate change scenario. We demonstrated that the existing infrastructures can be retrofitted to mitigate and reduce the nature and extent of damages to structures to the greater extent whilst site response based comprehensive seismic microzonation is very much required for new settlements and for long-term sustainable urban planning by adopting multi-disciplinary investigations using integrated tools consisted of geophysical, geological, and geotechnical methodologies, which in turn help understand how and why underneath sub-surface layers get amplified to cause destruction of buildings and severe damages to critical infrastructures of South Asian Cities. It is inferred that implementation of fourth level comprehensive seismic Micro, Nano, Pico and Femto zonation study for almost all strategic cities of South Asia is a need of an hour in particular, and of the seismically prone regions of the world, in general, which would be helpful for generating a series of new parameters for development of multi-dimensional risk resilient building design codes for the safer and sustainable infrastructures of urban settlement. The methodology has wide-scale applicability to different kinds of structures and typology of the buildings. 展开更多
关键词 South Asia Seismic MICROZONATION Site Response Climate Change URBAN AGGLOMERATE URBAN RISK Resiliency
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Morphological Characteristics of Cambodia Mekong Delta and Tonle Sap Lake and Its Response to River-Lake Water Exchange Pattern 认领
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作者 Zhaoming Xu Changwen Li +4 位作者 Anqiang Li Zhongqiong You Wei Yao Yongsheng Chen Liyao Huang 《水资源与保护(英文)》 2020年第4期275-302,共28页
Tonle Sap Lake is the largest river-connected lake, buffer area and ecological zone of Mekong River, which plays a huge role in dispelling flood peak and compensating water, and the conservation of biological diversit... Tonle Sap Lake is the largest river-connected lake, buffer area and ecological zone of Mekong River, which plays a huge role in dispelling flood peak and compensating water, and the conservation of biological diversity. The river-lake relationship between Mekong River and Tonle Sap Lake is unique and has always been a major focus in the international community. The land terrain and under-water topography were used to analyze the morphological characteristics of Cambodia Mekong Delta and Tonle Sap Lake. Long series of hydrological data of river-lake controlling stations were used to analyze the water level variation characteristics and water volume exchange pattern between Mekong River and Tonle Sap Lake, and the response relationship to river-lake morphological characteristics were also researched. The results show that: Cambodia Mekong Delta and Tonle Sap Lake Area is low-lying and flat with gentle channel gradient and water surface gradient, making the relationship between water level and area (or volume) smooth. The channel storage capacity of Mekong River and Tonle Sap River is not enough compared to the inflow, so vast flooding plain is extremely prone to be inundated, making the flood relationships between the left and right banks become very complicated. Tonle Sap Lake is a seasonal freshwater lake with water flowing in and flowing out, and the timing and intensity of water exchange with Mekong River are closely related to the water flow resistance at the exit section of Tonle Sap Lake and the cross-sectional area of Tonle Sap River, which can be reflected by the river-lake water level difference and the water level of Tonle Sap River. Affected by the river-lake morphological characteristics, the water exchange intensity between Mekong River and Tonle Sap Lake is great. Tonle Sap Lake not only stores 14.4% of flood volume (39.7 billion m3) from the Mekong River every year, but also supplies 29.7% of dry water (69.4 billion m3) to the Mekong River. Influenced by the adjustment of the floodplain, the water l 展开更多
关键词 Tonle Sap LAKE Mekong RIVER Morphological Characteristic River-Lake RELATIONSHIP Water EXCHANGE PATTERN RESPONSE RELATIONSHIP
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Aeroelastic dynamic response of elastic aircraft with consideration of two-dimensional discrete gust excitation 认领
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作者 Yang YANG Chao YANG Zhigang WU 《中国航空学报:英文版》 SCIE EI CAS CSCD 2020年第4期1228-1241,共14页
Design loads generally require a one-dimensional discrete gust profile without consideration of the spanwise effect,and this profile cannot represent the true gust field exactly.For a high aspect ratio aircraft,two-di... Design loads generally require a one-dimensional discrete gust profile without consideration of the spanwise effect,and this profile cannot represent the true gust field exactly.For a high aspect ratio aircraft,two-dimensional gusts may cause critical load conditions,and approaches for calculating dynamic responses under two-dimensional discrete gust excitation are rarely presented.In this paper,a spanwise non-uniform vertical discrete gust field is established based on a onedimensional‘1-cos’gust profile in reference to a DARPA proposal,while frequency and hybrid approaches to the dynamic response analysis of flexible aircraft under this two-dimensional gust excitation are presented.Solution techniques have been applied to a high aspect ratio aircraft to assess the different response characteristics with a comparison between one-dimensional and two-dimensional discrete gust field conditions.The results show that the two-dimensional discrete gust model produces a higher bending moment than that of the one-dimensional condition.Therefore,the critical load conditions that are derived from the two-dimensional discrete gust for high aspect ratio aircraft should be seriously considered.According to the analysis,an active control scheme to alleviate the bending loads caused by the two-dimensional gust is designed,and alleviation effects in different gust conditions are compared. 展开更多
关键词 AEROSERVOELASTIC Discrete gust Gust response Gust response alleviation Two-dimensional gust
Electromagnetic Emissions Recorded by a Borehole TOA Installment before Four Huge Destructive <i>M</i><sub>S</sub>≥ 8.0 Earthquakes in Asia 认领
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作者 Mei Li Chen Yu +5 位作者 Yan Zhang Huaxing Zhao Xuhui Zhang Wuxian Li Ping Zhang Li Zhang 《地震研究(英文)》 2020年第2期50-68,共19页
In this paper, electromagnetic emissions recorded by a borehole TOA installment with three observing channels of CH1 (0.01 - 0.1 Hz), CH2 (0.1 - 1.0 Hz) and CH3 (1 - 9 kHz) before four large earthquakes with magnitude... In this paper, electromagnetic emissions recorded by a borehole TOA installment with three observing channels of CH1 (0.01 - 0.1 Hz), CH2 (0.1 - 1.0 Hz) and CH3 (1 - 9 kHz) before four large earthquakes with magnitudes more than 8.0 have been depicted. These abnormities present different fluctuating processes from one another. For the Wenchuan MS 8.0 earthquake on 12 May 2008, the nearest one among these four events and only 660 km from the TOA station, electromagnetic information appeared at least 5 months ago in two low frequency bands of CH1 and CH2 and it was subjected to an obvious fluctuating process with several developing stages: initial information, intensive anomaly and large amplitude signals. The typical pulse-like emissions in CH2 happened group by group with large various magnitudes, which can be of 10 mV in the climax period. While during this period, compatible wave-like information with little magnitudes also happened in CH1 channel and a few pulses in CH3. Anomalous emissions occurred about 4 months prior to the 25 April 2015 Nepal MS 8.1 event, 1560 km away from the TOA station. The abnormal information in CH2 also appeared group by group but with small various magnitudes, more than 2 mV during their climax. This process is also effective for the Sumatra MS 8.9 earthquake on 26 December 2004, 2500 km from the borehole TOA, only with a different duration of 2 months and less magnitudes of 0.1 mV in CH1 and 1 mV in CH2 in this case. However, there is no obvious fluctuation and only small constant amplitude signals being ~0.15 mV appeared during 2 weeks before the Japan MS 9.0 earthquake on 11 March 2011. It is the farthest one among these four events and beyond 4000 km from the observing station. So, we can make a conclusion that there is a near relationship between the properties of the abnormities associated with these four earthquakes, such as amplitudes, duration and signal types, and the distances from TOA station: on one hand, the amplitude and duration decreases as the distance increases;o 展开更多
关键词 TOA BOREHOLE Observation Huge Earthquake Electromagnetic Emission Coseismic Response
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Global Asymptotic Stability and Hopf Bifurcation in a Homogeneous Diffusive Predator-Prey System with Holling Type II Functional Response 认领
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作者 Shuangte Wang Hengguo Yu +1 位作者 Chuanjun Dai Min Zhao 《应用数学(英文)》 2020年第5期389-406,共18页
In this paper, we considered a homogeneous reaction-diffusion predator-prey system with Holling type II functional response subject to Neumann boundary conditions. Some new sufficient conditions were analytically esta... In this paper, we considered a homogeneous reaction-diffusion predator-prey system with Holling type II functional response subject to Neumann boundary conditions. Some new sufficient conditions were analytically established to ensure that this system has globally asymptotically stable equilibria and Hopf bifurcation surrounding interior equilibrium. In the analysis of Hopf bifurcation, based on the phenomenon of Turing instability and well-done conditions, the system undergoes a Hopf bifurcation and an example incorporating with numerical simulations to support the existence of Hopf bifurcation is presented. We also derived a useful algorithm for determining direction of Hopf bifurcation and stability of bifurcating periodic solutions correspond to j &#8800;0 and j = 0, respectively. Finally, all these theoretical results are expected to be useful in the future study of dynamical complexity of ecological environment. 展开更多
关键词 HOLLING Type II Functional Response REACTION-DIFFUSION PREDATOR-PREY System Global Stability TURING Instability Hopf Bifurcation
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The Dynamical Behavior of a Predator-Prey System with Holling Type II Functional Response and Allee Effect 认领
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作者 Shuangte Wang Hengguo Yu +1 位作者 Chuanjun Dai Min Zhao 《应用数学(英文)》 2020年第5期407-425,共19页
In this paper, we mainly considered the dynamical behavior of a predator-prey system with Holling type II functional response and Allee-like effect on predator, including stability analysis of equilibria and Hopf bifu... In this paper, we mainly considered the dynamical behavior of a predator-prey system with Holling type II functional response and Allee-like effect on predator, including stability analysis of equilibria and Hopf bifurcation. Firstly, we gave some sufficient conditions to guarantee the existence, the local and global stability of equilibria as well as non-existence of limit cycles. By using the cobweb model, some cases about the existence of interior equilibrium are also illustrated with numerical outcomes. These existence and stability conclusions of interior equilibrium are also suitable in corresponding homogeneous reaction-diffusion system subject to the Neumann boundary conditions. Secondly, we theoretically deduced that our system has saddle-node bifurcation, transcritical bifurcation and Hopf bifurcation under certain conditions. Finally, for the Hopf bifurcation, we choose d as the bifurcation parameter and presented some numerical simulations to verify feasibility and effectiveness of the theoretical derivation corresponding to the existence of yk, respectively. The Hopf bifurcations are supercritical and limit cycles generated by the critical points are stable. 展开更多
关键词 PREDATOR-PREY System HOLLING Type II FUNCTIONAL Response Allee Effect Stability HOPF BIFURCATION
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Optimization Scale Pasteurization of Baobab Juice Using Response Surface Methodology (RSM) 认领
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作者 Ndiaye Ndeye Adiara Bassama Joseph +2 位作者 Dieng Modou N. C. Toure/kane Montet Didier 《食品与营养科学(英文)》 2020年第2期113-122,共10页
The Adansonia digitate L. known as Baobab is the only species present in West Africa and grows wild. All parts of the plant are used by humans. In Senegal, baobab pulp is widely consumed;it is used as raw material in ... The Adansonia digitate L. known as Baobab is the only species present in West Africa and grows wild. All parts of the plant are used by humans. In Senegal, baobab pulp is widely consumed;it is used as raw material in small and medium enterprises (SMEs) for making juices, concentrates, jams, powder. Drinks or juices from baobab are highly appreciated by consumers;however rapid fermentation can happen even after pasteurization that can shorten their shelf-life. A Doehlert experimental design was used to find a good scale of heat treatment ensuring a proper conservation of baobab juice. Results of the experimental design showed that a heat treatment of 80&deg;C for 10 min gives a baobab juice with good sanitary quality that meets the international standards. 展开更多
关键词 Baobab JUICE SCALE of PASTEURIZATION Doehlert EXPERIMENTAL PLAN Response Surface Method
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Myoclonus and Recurrent Cardioinhibitory Vasovagal Syncope after Abdominal Surgery in a Critical Care Setting 认领
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作者 Ana Belén Fernández Elena Martín +1 位作者 Ramsés Marrero David Viera 《心血管病(英文)》 2020年第5期274-277,共4页
Letter to the Editor
关键词 VASOVAGAL REFLEX SYNCOPE Cardioinhibitory Response AUTONOMIC Failure ASYSTOLE
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Comparative Appraisal of Response Surface Methodology and Artificial Neural Network Method for Stabilized Turbulent Confined Jet Diffusion Flames Using Bluff-Body Burners 认领
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作者 Tahani S. Gendy Salwa A. Ghoneim Amal S. Zakhary 《世界工程和技术(英文)》 2020年第1期121-143,共23页
The present study was conducted to present the comparative modeling, predictive and generalization abilities of response surface methodology (RSM) and artificial neural network (ANN) for the thermal structure of stabi... The present study was conducted to present the comparative modeling, predictive and generalization abilities of response surface methodology (RSM) and artificial neural network (ANN) for the thermal structure of stabilized confined jet diffusion flames in the presence of different geometries of bluff-body burners. Two stabilizer disc burners tapered at 30° and 60° and another frustum cone of 60°/30° inclination angle were employed all having the same diameter of 80 (mm) acting as flame holders. The measured radial mean temperature profiles of the developed stabilized flames at different normalized axial distances (x/dj) were considered as the model example of the physical process. The RSM and ANN methods analyze the effect of the two operating parameters namely (r), the radial distance from the center line of the flame, and (x/dj) on the measured temperature of the flames, to find the predicted maximum temperature and the corresponding process variables. A three-layered Feed Forward Neural Network in conjugation with the hyperbolic tangent sigmoid (tansig) as transfer function and the optimized topology of 2:10:1 (input neurons: hidden neurons: output neurons) was developed. Also the ANN method has been employed to illustrate such effects in the three and two dimensions and shows the location of the predicted maximum temperature. The results indicated the superiority of ANN in the prediction capability as the ranges of R2 and F Ratio are 0.868 - 0.947 and 231.7 - 864.1 for RSM method compared to 0.964 - 0.987 and 2878.8 7580.7 for ANN method beside lower values for error analysis terms. 展开更多
关键词 STABILIZED TURBULENT Flames BLUFF-BODY Burners Thermal Structure Modeling Artificial NEURAL NETWORK Response Surface Methodology Multi-Layer PERCEPTRON Feed Forward NEURAL NETWORK
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Evaluation of ^177Lu-Dotatate treatment in patients with metastatic neuroendocrine tumors and prognostic factors 认领
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作者 Estephany Abou Jokh Casas Virginia Pubul Nú?ez +7 位作者 Urbano Anido-Herranz María del Carmen Mallón Araujo Maria del Carmen Pombo Pasín Miguel Garrido Pumar JoséManuel Cabezas Agrícola JoséManuel Cameselle-Teijeiro Ashraf Hilal álvaro Ruibal Morell 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第13期1513-1524,共12页
BACKGROUND^177Lu peptide receptor radionuclide therapy(PRRT)is a recently approved therapy in Spain that has been demonstrated to be a well-tolerated therapy for positive somatostatin receptor advanced gastroenteropan... BACKGROUND^177Lu peptide receptor radionuclide therapy(PRRT)is a recently approved therapy in Spain that has been demonstrated to be a well-tolerated therapy for positive somatostatin receptor advanced gastroenteropancreatic neuroendocrine tumors.AIM To determine the impact of PRRT on quality of life,radiologic and metabolic response,overall survival,prognostic factors and toxicity.METHODS Thirty-six patients treated with^177Lu-PRRT from 2016 to 2019 were included.The most frequent location of the primary tumor was the gastrointestinal tract(52.8%),pancreas(27.8%),and nongastropancreatic neuroendocrine tumor(11.1%).The liver was the most common site of metastasis(91.7%),followed by distant nodes(50.0%),bone(27.8%),peritoneum(25.0%)and lung(11.1%).Toxicity was evaluated after the administration of each dose.Treatment efficacywas evaluated by two parameters:stable disease and disease progression in response evaluation criteria in solid tumors 1.1 criterion and prognostic factors were tested.RESULTS From 36 patients,55.6%were men,with a median age of 61.1±11.8 years.Regarding previous treatments,55.6%of patients underwent surgery of the primary tumor,100%of patients were treated with long-acting somatostatin analogues,66.7%of patients were treated with everolimus,27.8%of patients were treated with tyrosine kinase inhibitor,and 27.8%of patients were treated with interferon.One patient received radioembolization,three patients received chemoembolization,six patients received chemotherapy.Hematological toxicity was registered in 14 patients(G1-G2:55.5%and G3:3.1%).Other events presented were intestinal suboclusion in 4 cases,cholestasis in 2 cases and carcinoid crisis in 1 case.The median follow-up time was 3 years.Currently,24 patients completed treatment.Nineteen are alive with stable disease,two have disease progression,eight have died,and nine are still receiving treatment.The median overall survival was 12.5 mo(95%confidence interval range:9.8–15.2),being inversely proportional to toxicity in previous treatment 展开更多
关键词 Peptide receptor RADIONUCLIDE therapy Gastropancreatic NEUROENDOCRINE TUMORS RADIOLOGICAL RESPONSE Metabolic RESPONSE
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具有12.37%的光电转换效率及18.6%的平均可见光透过率的半透明聚合物太阳能电池 认领
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作者 胡拯豪 王智 +1 位作者 安桥石 张福俊 《科学通报:英文版》 SCIE EI CSCD 2020年第2期131-137,88共8页
本文制备了一系列以PM6为给体、窄带隙材料Y6为受体的聚合物太阳能电池,分别以100 nm铝或1 nm金/(20,15,10 nm)银作为电极来制备不透明及半透明器件.以不透明器件为基础,优化有源层的厚度,当有源层厚度为100 nm时,器件的光电转换效率达... 本文制备了一系列以PM6为给体、窄带隙材料Y6为受体的聚合物太阳能电池,分别以100 nm铝或1 nm金/(20,15,10 nm)银作为电极来制备不透明及半透明器件.以不透明器件为基础,优化有源层的厚度,当有源层厚度为100 nm时,器件的光电转换效率达到了15.83%.100 nm厚的混合薄膜的平均可见光透过率为50.5%,这表明利用该有源层有望制备出高效率半透明聚合物太阳能电池.分别以1 nm金/20 nm银,1 nm金/15 nm银,1 nm金/10nm银复合电极代替铝电极(这种金/银复合电极在可见光范围内透过率较高,在近红外光范围透过率较低),所制备的半透明聚合物太阳能电池的光电转换效率和平均可见光透过率分别达到了14.20%和8.9%,13.32%和12.5%,12.37%和18.6%,这处于目前报道的半透明聚合物太阳能电池性能最高的行列.这一工作表明:开发高可见光透过率、低近红外光透过率电极以及使用窄带隙材料为有源层是制备高效率半透明聚合物太阳能电池的有效方法. 展开更多
关键词 SEMITRANSPARENT polymer solar cells NARROW band gap materials SEMITRANSPARENT electrode Power conversion efficiency Average VISIBLE TRANSMITTANCE PHOTOPIC response of human eye
文章速递Robotics for Disaster Warning and Response in the UAE 认领
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作者 Abdulla Al Hmoudi 《环境科学与工程:B》 2020年第5期215-221,共7页
Over the past decade,robot systems have become more commonplace and increasingly autonomous.In recent years,first responders have started to use novel technologies at the scene of disasters in order to save more lives... Over the past decade,robot systems have become more commonplace and increasingly autonomous.In recent years,first responders have started to use novel technologies at the scene of disasters in order to save more lives.Technologies are also used for early warning,surveillance and to enhance disaster response capabilities.Increasingly,technologies like robots are used for warning people,monitoring compliance,SAR(Search and Rescue),damage assessment,to search disaster sites.In the case of emergency situations,emergency guidance robots are sent inside of buildings or deployed to search for victims,guide evacuees to safety and other unsafe response tasks.This paper explores the application of robotics for disaster warning and response,benefits and factors influencing deployment of robots,in order to justify the effective usage of robotics for disaster management in the UAE(United Arab Emirates).A pilot study is conducted to achieve this aim,with 24 participants selected through random sampling from three emergency organizations in the country.To increase knowledge and usage of robotics for future disaster warning and response in UAE,it is needful to continue to highlight the role of robotics deployment in helping to minimize risks and disaster impacts on first responders and the public. 展开更多
关键词 Robotics early warning disaster response SAR UAE
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文章速递Transactive Demand Response Operation at the Grid Edge using the IEEE 2030.5 Standard 认领
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作者 Javad Fattahi Mikhak Samadi +1 位作者 Melike Erol-Kantarci Henry Schriemer 《工程(英文)》 SCIE EI 2020年第7期801-811,共11页
This paper presents a transactive demand response(TDR)scheme for a network of residential customers with generation assets that emphasizes interoperability within a transactive energy architecture.A complete laborator... This paper presents a transactive demand response(TDR)scheme for a network of residential customers with generation assets that emphasizes interoperability within a transactive energy architecture.A complete laboratory-based implementation provides the first(to our knowledge)realization of a comprehensive TDR use case that is fully compliant with the Institute of Electrical and Electronics Engineers(IEEE)2030.5 standard,which addresses interoperability within a cybersecure smart energy profile(SEP)context.Verification is provided by a full system integration with commercial hardware using Internet Protocol(IP)-based(local area network(LAN)and Wi-Fi)communication protocols and transport layer security(TLS)1.2 cryptographic protocol,and validation is provided by emulation using extensive residential smart meter data.The demand response(DR)scheme is designed to accommodate privacy concerns,allows customers to select their DR compliance level,and provides incentives to maximize their participation.The proposed TDR scheme addresses privacy through the implementation of the SEP 2.0 messaging protocol between a transactive agent(TA)and home energy management system(HEMS)agents.Customer response is handled by a multi-input multi-output(MIMO)fuzzy controller that manages negotiation between the customer agent and the TA.We take a multi-agent system approach to neighborhood coordination,with the TA servicing multiple residences on a common transformer,and use a reward mechanism to maximize customer engagement during the event-based optimization.Based on a set of smart meter data acquired over an extended time period,we engage in multiple TDR scenarios,and demonstrate with a fully-functional IEEE 2030.5-compliant implementation that our scheme can reduce network peak power consumption by 22%under realistic conditions. 展开更多
关键词 Transactive demand response IEEE 2030.5 Smart grid Multi-agent system Neighborhood coordination
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