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Factors associated with unprotected anal intercourse among male students who have sex with men in three Northern regions of China
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作者 De-Chuan Zhang Zun-You Wu Sarah Robbins Scott 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第14期1639-1644,共6页
Background:Unprotected anal intercourse (UAI) has previously been associated with human immunodeficiency virus (HIV) infection.Male students who have sex with men (SMSM) are at increased exposure to experience UAI.The... Background:Unprotected anal intercourse (UAI) has previously been associated with human immunodeficiency virus (HIV) infection.Male students who have sex with men (SMSM) are at increased exposure to experience UAI.The aim of this study was to investigate the status of UAI and related factors among SMSM in three northern regions of China.Methods:From November 2018 to January 2019,SMSM,18 years or older,studying or living in Beijing,Tianjin,or Shijiazhuang,who had anal sex in the past 6 months were recruited by community-based organizations to participate in an unmatched,casecontrol study.Detailed demographic and behavioral information were collected via self-administrated electronic questionnaires and factors related to UAI were assessed using uni-and multivariate logistic regression analyses.Results:Among the 511 SMSM included in the study,210 (41.1%) reported UAI in the past 6 months.SMSM who had sexual partners at least 10 years older than themselves (odds ratio [OR]=2.277,95% confidence interval [CI]:1.380-3.756),used vacant capsules before sexual activity (OR =3.858,95 % CI:1.472-10.106),had a self-perceived moderate-HIV risk (OR =2.128,95 %CI:1.403-3.227),and unprotected,first anal intercourse (OR =2.236,95 % CI:1.506-3.320) had increased odds of UAI.Contusions:Factors associated with increased odds of engaging in UAI in the past 6 months among SMSM included having older sexual partners,using vacant capsules,having a self-perceived moderate risk of HIV,and unprotected,first anal intercourse.Continuing education on risk reduction,including improving condom decision making in age-discordant relationships could help address the sexual risk behaviors among SMSM. 展开更多
关键词 Students MEN WHO HAVE SEX with MEN Unsafe SEX China
Semantic and Phonemic Verbal Fluency Performance in Patients with General Anxiety Disorders and Allostatic Load under Alprazolam Treatment 预览
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作者 Carlos A. Soria Carolina Remedi +1 位作者 Luciana D’Alessio Emilio J. A. Roldán 《精神病学期刊(英文)》 2019年第2期138-152,共15页
Purpose: Anxiety disorders are frequently associated with chronic stress with possible cognitive consequences. The aim of this study was to determine the verbal fluency performance in a cohort of patients with anxiety... Purpose: Anxiety disorders are frequently associated with chronic stress with possible cognitive consequences. The aim of this study was to determine the verbal fluency performance in a cohort of patients with anxiety disorders and allostatic load, treated with alprazolam during 12 weeks. Methods: Patients with GAD (general anxiety disorders, DSM IV), with >6 in Hamilton Anxiety Rating Scale (HAM-A), neuroticism > 18 (NEO-FFI inventory), and normal Mini-Mental State Examination were included. Clinical and Psychiatric examination, Allostatic Load Index and cognitive assessment were analyzed before and after 12 weeks of treatment. The phonemic and semantic verbal fluency tests were determined in all patients. The scoring for each fluency task was determined by counting the number of correct words. The total score from each semantic and phonemic verbal task was analyzed comparing the individual score with normal data controlled by age and sex. Patients with scores > ?2 standard deviation (SD) from normative data were considered impaired. Results: Fifty-four patients completed the semantic verbal fluency test before treatment and fifty patients completed after treatment. According to the z-scores before treatment 7 patients of 54 (12.9%) had verbal fluency impairments. After treatment none patients showed semantic verbal fluency deficits but 3 patients of 50 (6%) showed phonemic impairments. Impaired group was significantly associated with an older age before treatment (p = 0.033) and with a similar tendency but not significant (p = 0.09) after treatment (Student t test). Conclusion: In this study older age factor was associated with verbal fluency impairment in GAD patients. Stratified treatments analyzing age and sex factors, including allostatic load measurements and cognitive assessments may be useful tools to determine the effectiveness and the safety of psychopharmacological treatments. 展开更多
关键词 VERBAL FLUENCY Test CHRONIC Stress Allostatic Load SEX Age
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Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis
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作者 Yun-Fai Chris Lau Yunmin Li Tatsuo Kido 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第3期260-269,共10页
The Y-located testis-specific protein Y-encoded (TSPY) and its X-homologue TSPX originated from the same ancestral gene, but act as a proto-oncogene and a tumor suppressor gene, respectively. TSPY has specialized in m... The Y-located testis-specific protein Y-encoded (TSPY) and its X-homologue TSPX originated from the same ancestral gene, but act as a proto-oncogene and a tumor suppressor gene, respectively. TSPY has specialized in male-specific functions, while TSPX has assumed the functions of the ancestral gene. Both TSPY and TSPX harbor a conserved SET/NAP domain, but are divergent at flanking structures. Specifically, TSPX contains a C-terminal acidic domain, absent in TSPY. They possess contrasting properties, in which TSPY and TSPX, respectively, accelerate and arrest cell proliferation, stimulate and inhibit cyclin B-CDK1 phosphorylation activities, have no effect and promote proteosomal degradation of the viral HBx oncoprotein, and exacerbate and repress androgen receptor (AR) and constitutively active AR variant, such as AR-V7, gene transactivation. The inhibitory domain has been mapped to the carboxyl acidic domain in TSPX, truncation of which results in an abbreviated TSPX exerting positive actions as TSPY. Transposition of the acidic domain to the C-terminus of TSPY results in an inhibitory protein as intact TSPX. Hence, genomic mutations/aberrant splicing events could generate TSPX proteins with truncated acidic domain and oncogenic properties as those for TSPY. Further, TSPY is upregulated by AR and AR-V7 in ligand-dependent and ligand-independent manners, respectively, suggesting the existence of a positive feedback loop between a Y-located proto-oncogene and male sex hormone/receptors, thereby amplifying the respective male oncogenic actions in human cancers and diseases. TSPX counteracts such positive feedback loop. Hence, TSPY and TSPX are homologues on the sex chromosomes that function at the two extremes of the human oncogenic spectrum. 展开更多
关键词 androgen receptor AR-V7 cell cycle regulation cyclin B-CDK1 ONCOGENE SEX chromosomes SEX differences TSPX TSPY tumor suppressor
Breast cancer stem cells:The role of sex steroid receptors 预览
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作者 Pia Giovannelli Marzia Di Donato +5 位作者 Giovanni Galasso Erika Di Zazzo Nicola Medici Antonio Bilancio Antimo Migliaccio Gabriella Castoria 《世界干细胞杂志:英文版(电子版)》 2019年第9期594-603,共10页
Breast cancer(BC)is the most common cancer among women,and current available therapies often have high success rates.Nevertheless,BC might acquire drug resistance and sometimes relapse.Current knowledge about the most... Breast cancer(BC)is the most common cancer among women,and current available therapies often have high success rates.Nevertheless,BC might acquire drug resistance and sometimes relapse.Current knowledge about the most aggressive forms of BC points to the role of specific cells with stem properties located within BC,the so-called“BC stem cells”(BCSCs).The role of BCSCs in cancer formation,growth,invasiveness,therapy resistance and tumor recurrence is becoming increasingly clear.The growth and metastatic properties of BCSCs are regulated by different pathways,which are only partially known.Sex steroid receptors(SSRs),which are involved in BC etiology and progression,promote BCSC proliferation,dedifferentiation and migration.However,in the literature,there is incomplete information about their roles.Particularly,there are contrasting conclusions about the expression and role of the classical BC hormonal biomarkers,such as estrogen receptor alpha(ERα),together with scant,albeit promising information concerning ER beta(ERβ)and androgen receptor(AR)properties that control different transduction pathways in BCSCs.In this review,we will discuss the role that SRs expressed in BCSCs play to BC progression and recurrence and how these findings have opened new therapeutic possibilities. 展开更多
关键词 Breast CANCER STEROIDS SEX STEROID RECEPTORS CANCER stem cells THERAPEUTIC implications
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汾阳市成人血脂水平调查分析 预览
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作者 王元明 郭润民 +1 位作者 郭任维 王全义 《中国医学创新》 CAS 2019年第23期76-79,共4页
目的:调查2017年1-10月汾阳市健康体检成年人中血脂异常的分布特征.方法:对4533名30岁及以上体检者进行血脂测定,分析血脂相关数据,比较不同性别和年龄组间血脂水平及血脂异常检出率的差异.结果:研究人群中48.3%的人至少存在1项血脂异常... 目的:调查2017年1-10月汾阳市健康体检成年人中血脂异常的分布特征.方法:对4533名30岁及以上体检者进行血脂测定,分析血脂相关数据,比较不同性别和年龄组间血脂水平及血脂异常检出率的差异.结果:研究人群中48.3%的人至少存在1项血脂异常,其中TG升高的检出率最高,达29.2%,HDL-C降低、TC升高和LDL-C升高的患病率分别为20.1%、10.5%和8.2%.女性TC、LDL-C、TG水平及异常检出率均高于男性(P<0.05).男性TC、LDL-C峰值水平在≥30岁且<40岁,而女性TC、LDL-C峰值水平在≥60岁且<70岁.结论:汾阳市成人血脂水平及异常检出率较高,其中TG升高检出率最高,青年男性和绝经后女性尤为突出,应加强对这些人群高血脂及相关疾病的重点关注. 展开更多
关键词 年龄 性别 血脂异常 胆固醇 甘油三酯
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首发和慢性精神分裂症患者神经认知功能的性别差异
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作者 李惠 李春波 +3 位作者 王洪艳 徐丽华 张天宏 王继军 《神经疾病与精神卫生》 2019年第4期358-361,共4页
目的探讨首发未服药精神分裂症(FES)和慢性精神分裂症(CSz)患者的神经认知功能的性别差异。方法收集符合ICD-10的FES患者53例和CSz患者104例,同期募集健康对照(HC)52名。3组均采用MATRICS共识认知成套测验(MCCB)中文版评估神经认知功能... 目的探讨首发未服药精神分裂症(FES)和慢性精神分裂症(CSz)患者的神经认知功能的性别差异。方法收集符合ICD-10的FES患者53例和CSz患者104例,同期募集健康对照(HC)52名。3组均采用MATRICS共识认知成套测验(MCCB)中文版评估神经认知功能。结果(1)MCCB测验得分性别差异比较结果显示,组别和性别的交互作用无统计学意义(F=0.80,P=0.67);组别的主效应显著,MCCB6项分测验及神经认知总分差异均有统计学意义;性别的主效应在视觉学习记忆分测验差异有统计学意义(F=5.12,P=0.03)。CSz组视觉学习记忆女性优于男性(t=2.44,P=0.02),FES组和HC组性别差异无统计学意义。(2)与HC组比较,除词语学习和记忆外,FES和CSz组MCCB总分和各分测验评分比较差异均有统计学意义。FES与CSz组比较,FES组在神经认知维度总分优于CSz组(t=2.36,P=0.05)。结论首发和慢性精神分裂症患者的认知功能均受损,且男性慢性患者视觉学习记忆损害较女性更为严重。 展开更多
关键词 精神分裂症 性别 认知功能
Characterization of SOX3 Gene in an Ovoviviparous Teleost,Black Rockfish(Sebastes schlegeli) 预览
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作者 MA Liman WANG Wenji +3 位作者 SHANG Renjie ZHANG Quanqi QI Jie WANG Zhigang 《中国海洋大学学报:英文版》 SCIE CAS CSCD 2019年第2期431-440,共10页
Evolutionary evidence suggests that Sox3,a member of the high-mobility-group(HMG)family of transcription factors,is an ancestral precursor of Sry and is involved in sex determination similar to Sry.However,there is li... Evolutionary evidence suggests that Sox3,a member of the high-mobility-group(HMG)family of transcription factors,is an ancestral precursor of Sry and is involved in sex determination similar to Sry.However,there is limited information regarding the SOX3 gene of the black rockfish(Sebastes schlegeli).In this study,we first isolated SOX3 gene from the gonads of S.schlegeli by homology cloning.The full-length of S.schlegeli SOX3(SsSOX3)cDNA was 1386 bp,comprising a 906-bp open reading frame,which encodes a peptide showing 93.6%and 93.9%homology with the Sox3 proteins of Epinephelus coioides and Oryzias latipe,respectively.Comparison of the cDNA sequence of the SsSOX3 gene with the corresponding genomic DNA fragment revealed that the SsSOX3 gene consists of a single exon.Phylogenetic analysis demonstrated the evolutionary relationship of SsSOX3 with other known SOXB1 genes in fish and tetrapods.The promoter region contains binding sites of several transcriptional factors that might participate in the regulation of SsSOX3 expression.Quantitative real-time PCR analysis indicated that SsSOX3 was expressed in all the investigated larval developmental stages from 1 to 35 days after birth and the level of expression gradually decreased as the development proceeded.SsSOX3 exhibited sexually dimorphic expression in adult gonads,with high expression in the ovary but low expression in the testis.In situ hybridization revealed that SsSOX3 was strongly expressed in oocytes and follicular cells of ovaries but slightly expressed in germ cells of testicular tissues.Therefore,this study suggests that SsSOX3 plays an important role in oogenesis and ovary differentiation in S.schlegeli. 展开更多
关键词 black ROCKFISH PROMOTER analysis SEBASTES schlegeli SEX determination sexual DIFFERENTIATION SOX3
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Flight behavior of the sycamore lace bug, Corythucha ciliata, in relation to temperature, age, and sex 预览
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作者 LU Shao-hui WEI Mei-cai +2 位作者 YUAN Guo-jun CUI Jian-xin GONG Dong-feng 《农业科学学报:英文版》 SCIE CAS CSCD 2019年第10期2330-2337,共8页
The flight capacity of different ages and sexes of the sycamore lace bug, Corythucha ciliata, was studied at different temperatures using a flight mill system. The results of regression analysis showed a significant e... The flight capacity of different ages and sexes of the sycamore lace bug, Corythucha ciliata, was studied at different temperatures using a flight mill system. The results of regression analysis showed a significant effect of temperature on flight distance (P=0.0082). Temperature did not influence flight duration (P=0.212) or flight speed (P=0.175). The mean flight distance (1 024 m) and mean flight duration were the greatest at 25.2°C. The age of C. ciliata had a significant influence on flight distance (P=0.0005), flight duration (P=0.0005) and flight speed (P=0.026). The 12-d-old adult had the greatest flight distance (887 m), duration (3 875 s) and speed (0.22 m s^–1). Flight distances and flight duration of females were significantly longer than that of males. However, the male had significantly greater flight speed than the female. The insect appears to be capable of long distance flights. The understanding of the optimal age and temperature for the flight of this insect through this study provides a foundation for better management of the insect in China. 展开更多
关键词 Corythucha ciliata FLIGHT capacity tethered FLIGHT TEMPERATURE age and SEX
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Does sexual dimorphism vary by population? Laryngeal and ear anatomy in cricket frogs
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作者 Blinda E.MCCLELLAND Michael J.RYAN Walter WILCZYNSKI 《动物学报:英文版》 SCIE CAS CSCD 2019年第3期343-352,共10页
Acoustic communication in many anuran species can show the effects of both natural and sexual selection. This is reflected in the sexually dimorphic an atomy of the lary nx and ear structures, as well as the allometri... Acoustic communication in many anuran species can show the effects of both natural and sexual selection. This is reflected in the sexually dimorphic an atomy of the lary nx and ear structures, as well as the allometric relationship of these morphological traits to head or body size. In this study, we examined laryngeal and ear structures of cricket frogs Acris crepitans not only as sexually dimorphic characteristics, but also as they differ across populations in environmentally different habitats. We used 2-way ANOVA to determine whether the volumetric or linear measurements of these structures differed by sex and population. Females have significantly larger body, head, and ear sizes, but significantly smaller larynges than males. Furthermore, females as well as males show larger body and head sizes, ears, and larynges in a dryer open habitat. An ANCOVA analysis shows that males, but not females, differ in laryngeal size across populations beyond the allometric changes attributable to head size alone indicating that males have a greater degree of laryngeal population variation. In contrast, our covariate analysis found that in both sexes many of the ear differences are non-sigrdficant once head size is accounted for, suggesting that most of the population-level ear variation is due to allometric effects of body size. We conclude that although both sexes show size differences in the larynx related to selection for larger body size in dry, open habitats, selection on males for larger larynx size related to the production of lower frequency calls in those habitats does not result in correlated changes in the female larynx. The results suggest that in anurans, selection for changes in body and head size affects both sexes equally, male calls and the vocal structures responsible for them can further diversify without concordant changes in females. 展开更多
关键词 acoustic communication ALLOMETRY AMPHIBIANS POPULATION variation sex differences
大熊猫双胞胎生长发育影响因素的研究 预览
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作者 王树群 奉永友 +4 位作者 陈波 吴孔菊 方俊 谢意 黄祥明 《四川动物》 北大核心 2019年第4期380-386,401共8页
为了研究影响大熊猫Ailuropoda melanoleuca双胞胎生长发育的因素,以2013—2016年成都大熊猫繁育研究基地出生的22对大熊猫双胞胎幼仔及其母兽为研究对象,分析母兽孕期增重、双胞胎个体性别和双胞胎性别类型与大熊猫双胞胎幼仔初生体质... 为了研究影响大熊猫Ailuropoda melanoleuca双胞胎生长发育的因素,以2013—2016年成都大熊猫繁育研究基地出生的22对大熊猫双胞胎幼仔及其母兽为研究对象,分析母兽孕期增重、双胞胎个体性别和双胞胎性别类型与大熊猫双胞胎幼仔初生体质量之间的关系,以及双胞胎个体性别和大熊猫幼仔初生体质量与1~12月龄大熊猫幼仔体质量之间的关系。结果显示,不同双胞胎性别类型的大熊猫幼仔初生体质量的差异有统计学意义(P=0.015),但母兽孕期增重、双胞胎个体性别与幼仔初生体质量的差异无统计学意义(P=0.257、P=0.170);双胞胎2只个体的初生体质量不同(χ^2=9.043,P=0.041),且双胞胎性别类型与幼仔初生体质量差异程度呈中等强度相关(Cramer s V=0.492,P=0.030),双雌性双胞胎初生体质量差异为20%~40%(调整后标化残差:2.30),双雄性双胞胎初生体质量差异小于20%(调整后标化残差:2.60);双胞胎个体性别和初生体质量对1~12月龄大熊猫幼仔生长发育的影响无统计学意义(P>0.05)。对大熊猫双胞胎幼仔生长发育影响因素的研究,为大熊猫双胞胎的饲养管理提供理论依据。 展开更多
关键词 大熊猫 双胞胎 性别 母兽孕期增重 初生体质量
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某妇幼保健院住院新生儿疾病谱分析
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作者 陈雅娟 金意 江静 《中国病案》 2019年第3期67-70,共4页
目的调查近6年的住院新生儿疾病谱构成,了解某院住院新生儿疾病发生情况,以降低疾病的发生率,提高其治愈率。方法回顾性分析2012年1月1日-2017年12月31日南京市某专科医院住院新生儿疾病相关数据,将住院新生儿的主要诊断按照国际疾病ICD... 目的调查近6年的住院新生儿疾病谱构成,了解某院住院新生儿疾病发生情况,以降低疾病的发生率,提高其治愈率。方法回顾性分析2012年1月1日-2017年12月31日南京市某专科医院住院新生儿疾病相关数据,将住院新生儿的主要诊断按照国际疾病ICD-10分类标准化进行疾病分类,按照新生儿的性别、单胎早产儿或多胎早产儿和孕妇是否高龄产妇进行疾病构成分布的比较。结果住院新生儿疾病前10位疾病分别为新生儿高胆红素血症、新生儿颅内出血、早产儿、新生儿肺炎、新生儿ABO溶血、新生儿败血症、小样儿、新生儿呼吸窘迫综合征、新生儿湿肺、极低体重儿,占住院新生儿数的84. 5%。新生儿疾病在性别、单胎或多胎早产儿以及孕妇是否高龄产妇的分布均存在显著性差异。结论做好孕前的指导、孕期的宣传教育和围生期保健工作并及时与新生儿科医生联系,有针对性的对发生率较高的疾病进行预防、诊断和治疗是降低新生儿发病率的重要措施。 展开更多
关键词 新生儿 疾病谱 性别 早产儿 高龄产妇
系统评价运动性半月板损伤的流行病学特征 预览
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作者 杨远 张凯搏 +1 位作者 付维力 李箭 《中国组织工程研究》 CAS 北大核心 2019年第31期5079-5084,共6页
背景:虽然很多健康效益与体育运动有关,但在过去几年中,随着参与体育运动的人数慢慢增加,被半月板损伤所困扰的人数也在慢慢上升。目的:系统评价运动损伤中半月板损伤的流行病学特征。方法:计算机检索PubMed、EMbase、Wan Fang Data、VI... 背景:虽然很多健康效益与体育运动有关,但在过去几年中,随着参与体育运动的人数慢慢增加,被半月板损伤所困扰的人数也在慢慢上升。目的:系统评价运动损伤中半月板损伤的流行病学特征。方法:计算机检索PubMed、EMbase、Wan Fang Data、VIP和CNKI数据库,搜集有关国内运动损伤中半月板损伤的流行病学研究,检索时限均从建库至2018-09-30。由2位研究者独立筛选文献、提取资料,并评价纳入研究的偏倚风险后,采用Stata 12.0软件进行合并分析。结果与结论:(1)共纳入21篇文献;(2)Meta结果显示,运动损伤中半月板损伤患病率为5%[95%CI(0.04,0.05)],纳入文献中有5篇文献分别介绍了内、外侧半月板损伤患病率,外侧半月板损伤患病率为8%[95%CI(0.05,0.11)],内侧半月板损伤患病率为7%[95%CI(0.04,0.09)];(3)纳入运动损伤男女比例为1.5,男性患者多于女性,运动损伤患者年龄在14-24岁之间;(4)专项训练是运动损伤中最主要的原因;(5)当前证据显示,运动损伤中半月板损伤患病率较高,外侧半月板损伤患病率稍高于内侧,主要由专项训练水平所决定。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。 展开更多
关键词 运动损伤 半月板损伤 流行病学 患病率 专项训练 性别 系统评价
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Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats
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作者 Narges Karbalaei Najmeh Sadeghi +1 位作者 Aliakbar Nekoeian Ahad Malekzadeh 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第7期529-535,共7页
Objective: To investigate the impact of Humulus Lupulus L. hydroalcoholic extract on the body weights, reproductive organs, sperm quality and hormone levels in male rats. Methods: By simple random sampling method, sev... Objective: To investigate the impact of Humulus Lupulus L. hydroalcoholic extract on the body weights, reproductive organs, sperm quality and hormone levels in male rats. Methods: By simple random sampling method, seventy male Sprague-Dawley rats were randomly assigned to 7 groups including control group [distilled water, 1 mL/(kg·d)], Tween 80 group [25% Tween 80 solution, 1 mL/(kg·d)], olive oil group [olive oil, 1 mL/(kg·d)], diethyl stilbestrol(DES) group [DES, 100 μg/(kg·body weight)], H50, H150 and H450 [50, 150 and 400 mg/(kg·d) of Humulus Lupulus L extract, respectively]. The administration was performed via gavage once daily for 7 weeks. Body and reproductive organs weights including testes, seminal vesicles, epididymis and prostate were weighted and epididymal sperm quality were determined by digital balance. Blood samples were collected and serum free testosterone(T), luteinizing hormone(LH), follicle-stimulating hormone(FSH), and estrogen(E2) levels were measured by rat specific enzyme-linked immunosorbent assay. Results: The percentage increase in mean body weights of rats in the DES and H50, H150 and H450 groups decreased significantly compared to olive oil and Tween 80 groups(all P<0.05). The weights of seminal vesicle, epididymis and testes in rats receiving H50 were significantly higher than the control group(P<0.05 or P<0.01). The sperm count in the rats receiving H50 was significantly lower than the control group(P<0.05). The sperm motile characteristics of the rats receiving hydroalcoholic extract and DES were significantly lower than those of the control or rats receiving vehicles(all P<0.05). In H50, H150, H450 and DES groups, T and LH levels were decreased, and E2 was significantly increased compared to the control(P<0.05 or P<0.01). The FSH level did not change in all groups(P>0.05). Conclusion: Humulus Lupulus L. extract significantly increased the seminal vesicle and testes weights and reduced the sperm motility. 展开更多
关键词 SEX ORGAN PHYTOESTROGEN HUMULUS Lupulus L. SPERM quality male rat
豚鼠不同年龄自发性骨关节炎显微变化的观察 预览
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作者 陶剑锋 王莹 +3 位作者 王超 张砚卓 姜旭 吴成爱 《骨科临床与研究杂志》 2019年第3期167-172,共6页
目的探讨雌雄性豚鼠不同年龄自发性骨关节炎发生中关节软骨、软骨下骨显微结构的改变与体质量、性别的相关性。方法选用健康1月龄SPF级Hartley雌雄性豚鼠各18只,将不同性别的豚鼠随机分为3组,每组6只,分为1、3、5月龄组,取后肢膝关节。... 目的探讨雌雄性豚鼠不同年龄自发性骨关节炎发生中关节软骨、软骨下骨显微结构的改变与体质量、性别的相关性。方法选用健康1月龄SPF级Hartley雌雄性豚鼠各18只,将不同性别的豚鼠随机分为3组,每组6只,分为1、3、5月龄组,取后肢膝关节。通过大体形态观察及X线检查评价关节软骨退变情况,采用Micro-CT观察胫骨软骨下骨显微结构的改变情况。结果雄性和雌性Hartley豚鼠的体质量随月龄增加而逐渐增加,3个月后雄性豚鼠体质量明显高于雌性豚鼠体质量。大体观察:5月龄雌雄性豚鼠胫骨平台、股骨髁、股骨髌面等关节面粗糙,光泽暗淡。X线检查:与1月龄相比,3月龄和5月龄雌雄性豚鼠膝关节间隙变窄。Micro-CT显示,3月龄和5月龄雌雄性豚鼠结构模型指数和各向异性的程度明显低于1月龄,而骨小梁厚度高于1月龄,内侧较外侧明显。结论随着年龄增加至5月龄的豚鼠自发性骨关节炎的发生可能与性别、体质量无关,对于软骨和软骨下骨两者的因果关系暂时难以确定。 展开更多
关键词 骨关节炎 MICRO-CT 体质量 性别 Hartley豚鼠
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基于社区人群的性别与颈动脉粥样硬化斑块内出血关系的研究 预览
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作者 王宇 张润华 +9 位作者 姜勇 于淼欣 洪音 王畇 乔会昱 韩永军 李东野 赵锡海 王拥军 刘改芬 《中国卒中杂志》 2019年第1期43-48,共6页
目的探讨性别与通过HR-MRI诊断颅外颈动脉粥样硬化斑块内出血之间的关系。方法在清华大学社区人群中进行横断面调查,通过现场调查问卷获得人口统计学、既往史、行为生活方式、实验室检查结果等信息,根据HR-MRI对颅外颈动脉粥样硬化斑块... 目的探讨性别与通过HR-MRI诊断颅外颈动脉粥样硬化斑块内出血之间的关系。方法在清华大学社区人群中进行横断面调查,通过现场调查问卷获得人口统计学、既往史、行为生活方式、实验室检查结果等信息,根据HR-MRI对颅外颈动脉粥样硬化斑块内出血进行判读,分为斑块内出血组和无斑块内出血组。采用多因素Logistic回归分析探讨性别与斑块内出血之间的关系。结果本研究共纳入246例有颈动脉粥样硬化斑块的研究对象,男性105例(42.7%),平均年龄(64.8±11.5)岁,其中12例(4.88%)有斑块内出血。与无斑块内出血组相比,斑块内出血组男性较多(83.3%vs40.6%,P=0.004),高血压病史(91.7%vs43.2%,P=0.001)和糖尿病病史(50.0%vs12.4%,P<0.001)的比例较高;空腹血糖[(6.30±1.63)mmol/Lvs(5.00±0.99)mmol/L,P<0.001]的水平较高。多因素Logistic回归分析发现,男性是颅外颈动脉粥样硬化斑块内出血的独立危险因素(OR7.68,95%CI1.10~53.81,P=0.040)。结论男性可能是颅外颈动脉粥样硬化斑块内出血的危险因素。 展开更多
关键词 性别 颈动脉 动脉粥样硬化 斑块内出血 危险因素
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某院2008—2017年泌尿系结石病例分析 预览
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作者 李生辉 柴雪 +5 位作者 程庆水 卓栋 宋帅帅 王建帮 程浪 黄后宝 《右江民族医学院学报》 2019年第2期187-189,共3页
目的调查皖南医学院第一附属医院2008—2017年因泌尿系结石住院患者的病例情况,为我院规范化治疗制定合理的治疗方案,为优化医疗资源提供理论基础。方法根据国际疾病分类(ICD-10)标准,收集我院2008—2017年泌尿系结石病住院患者的病例... 目的调查皖南医学院第一附属医院2008—2017年因泌尿系结石住院患者的病例情况,为我院规范化治疗制定合理的治疗方案,为优化医疗资源提供理论基础。方法根据国际疾病分类(ICD-10)标准,收集我院2008—2017年泌尿系结石病住院患者的病例信息。用Excel2016版软件整理病人的临床资料,并采用SPSS17.0软件对数据进行统计分析。结果我院近10年泌尿系结石病住院病例中,主要发病年龄在31~60岁之间,41~50岁之间的发病率最高;泌尿系结石住院患者各个年龄段中均以肾结石发病率最高,输尿管结石次之,差异具有统计学意义(P<0.001);在泌尿系结石病住院患者中男性高于女性,差异无统计学意义(P>0.05),治疗方式以经皮肾镜手术(PCNL)以及输尿管镜碎石术(URL)为主,差异具有统计学意义(P<0.001)。结论我院近10年泌尿系结石病患者主要分布在中老年年龄阶段,且男多于女,其中以肾结石最为常见,治疗方式以内镜取石治疗为主。 展开更多
关键词 泌尿系结石 年龄 结石类型 性别 内镜取石
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昆虫性别决定研究的文献计量分析
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作者 陈天阳 殷玉梦 +2 位作者 邓文辉 邱可睿 朱芬 《华中昆虫研究》 2019年第1期199-206,共8页
为了解昆虫性别决定研究发展态势,运用中国知网、Web of Science数据库对该领域文献进行数据检索,采集和分析。结果表明,国内相关文献总体呈现增长趋势,其中2015年出现一次大增长,主力研究单位为大学。现有文献中,国内以家蚕为材料的研... 为了解昆虫性别决定研究发展态势,运用中国知网、Web of Science数据库对该领域文献进行数据检索,采集和分析。结果表明,国内相关文献总体呈现增长趋势,其中2015年出现一次大增长,主力研究单位为大学。现有文献中,国内以家蚕为材料的研究较多,国际上则是研究果蝇较多,其次是蜜蜂,围绕性别决定机制,性别比例,性别差异等领域的研究比较多。本研究结果为今后昆虫性别决定研究的深入提供了参考。 展开更多
关键词 昆虫 性别 文献题录信息 词频共现
CRISPR/Cas9-mediated PBP1 and PBP3 mutagenesis induced significant reduction in electrophysiological response to sex pheromones in male Chilo suppressalis
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作者 Xiao-Tong Dong Hui Liao +4 位作者 Guan-Heng Zhu Sajjad Ali Khuhro Zhan-Feng Ye Qi Yan Shuang-Lin Dong 《昆虫科学:英文版》 SCIE CAS CSCD 2019年第3期388-399,共12页
Pheromone-binding proteins (PBPs) are thought to bind and transport sex pheromones onto the olfactory receptors on the dendrite membrane of olfactory neurons, and thus play a vital role in sex pheromone perception. Ho... Pheromone-binding proteins (PBPs) are thought to bind and transport sex pheromones onto the olfactory receptors on the dendrite membrane of olfactory neurons, and thus play a vital role in sex pheromone perception. However, the function of PBPs has rarely been demonstrated in vivo.In this study, two PBPs (PBP1 and PBP3) of Chilo suppressalis, one of the most notorious pyralid pests, were in vivo functionally characterized using insects with the PBP gene knocked out by the CRISPR/Cas9 system. First, through direct injection of PBP-single guide RNA (sgRNA)/Cas9 messenger RNA into newly laid eggs, a high rate of target-gene editing (checked with polled eggs) was induced at 24 h after injection, 21.3% for PBPl-sgRNA injected eggs and 19.5% for PBP3-sgRNA injected eggs. Second, by an in-crossing strategy, insects with mutant PBP1 or PBP3 (both with a premature stop codon) were screened and homozygous mutants were obtained in the G3 generation. Third, the mutant insects were measured for electroantennogram (EAG) response to female sex pheromones. As a result, both PBP mutant males displayed significant reduction in EAG response, and this reduction in PBP1 mutants was higher than that in PBP3 mutants, indicating a more important role of PBP1. Finally, the relative importance of two PBPs and the possible off target effect induced by sgRNA-injection are discussed. Taken together, our study provides a deeper insight into the function of and interaction between different PBP genes in sex pheromone perception of C. suppressalis, as well as a valuable reference in methodology for gene functional study in other genes and other moth species. 展开更多
关键词 CRISPR/Cas9 system ELECTROANTENNOGRAM PHEROMONE binding protein sex PHEROMONE STRIPED stem BORER
Nature and Sex:The Latitude and Longitude of Lady Chatterley’s Lover 预览
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作者 陈灏君 《校园英语》 2019年第18期232-234,共3页
Lady Chatterley’s Lover is D.H.Lawr ence’s last novel.It is also one of the mos t controversial works in the world.A number of r eaders and critics only focus on its bold descriptions of sex,but they neglect the aut... Lady Chatterley’s Lover is D.H.Lawr ence’s last novel.It is also one of the mos t controversial works in the world.A number of r eaders and critics only focus on its bold descriptions of sex,but they neglect the author’s serious motivation and deep thoughts about this topic.In addition,the remarkable descriptions of the environment in the novel,which fully show Lawrence’s views of the nature,is the other clue.Therefore,nature and sex are the very latitude and longitude to properly locate the novel,Lady Chatterley’s Lover. 展开更多
关键词 SEX NATURE INDUSTRIALIZATION
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特应性皮炎不同性别、年龄和发病部位聚集效应的临床研究 预览
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作者 梅雪岭 王莉 +1 位作者 张蕊娜 李邻峰 《首都医科大学学报》 CAS 北大核心 2019年第3期458-465,共8页
目的探讨特应性皮炎(atopic dermatitis,AD)的发病情况以及不同性别、发病年龄和部位的聚集效应。方法收集2014年1月至2015年12月在中国13个城市31所三级医院皮肤科就诊的湿疹患者,回顾性分析5 953例湿疹患者的资料,其中AD患者964例。... 目的探讨特应性皮炎(atopic dermatitis,AD)的发病情况以及不同性别、发病年龄和部位的聚集效应。方法收集2014年1月至2015年12月在中国13个城市31所三级医院皮肤科就诊的湿疹患者,回顾性分析5 953例湿疹患者的资料,其中AD患者964例。通过对性别、年龄和部位的AD发病情况进行统计处理,分析和总结AD发病的聚集效应。结果5 953例湿疹患者中,AD共964例,占16.19%。男性与女性患者间AD比例差异无统计学意义(P>0.05);男性与女性患者间年龄因素未见明显影响(P>0.05)。婴儿期(<3岁)和儿童期(3岁≤年龄<12岁)比例均高于其他年龄组(P<0.05),差异有统计学意义。婴幼儿(<3岁组)71例患者中70例为头面眼睑,而老年(≥61岁组)以四肢伸侧为主。低年龄(<24岁)患者发病部位为头面眼睑的占比高于其他年龄组;24≤年龄<41岁患者足-四肢伸侧、躯干-手-四肢伸侧、项颈-躯干的占比高于其他年龄组;24岁以上患者四肢伸侧占比高于其他年龄组。差异均有统计学意义(P<0.001)。964例患者中,发病部位为四肢伸侧最多(50.10%),其次为头面眼睑(41.08%);前10位的发病部位共有583例患者,占60.48%;发病部位个数平均为(2.07±1.12)个,1个和2个发病部位分别占35.06%和37.66%。1个发病部位患者以头面眼睑和四肢伸侧为主(共占71.01%),双部位发病患者以足-四肢伸侧、头面眼睑-项颈、躯干-四肢伸侧为主。女性发病部位为足-四肢伸侧和项颈-躯干的比例高于男性(P<0.001),男性躯干-四肢伸侧和肘窝膝窝-项颈的比例高于女性(P<0.001)。低年龄组(<24岁)患者发病部位为头面眼睑的占比高于其他年龄组(P<0.001),24岁≤年龄<41岁患者足-四肢伸侧、躯干-手-四肢伸侧、项颈-躯干的占比高于其他年龄组(P<0.001),24岁以上年龄组四肢伸侧占比高于其他年龄组(P<0.001)。结论性别对于不同年龄患者AD发病情况并无显著影响;年龄具有明显“聚集效 展开更多
关键词 特应性皮炎 性别 年龄 部位 聚集效应
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