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A mathematical model of synaptotagmin 7 revealing functional importance of short-term synaptic plasticity 预览
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作者 Yao He Don Kulasiri Jingyi Liang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第4期621-631,共11页
Synaptotagmin 7(Syt7),a presynaptic calcium sensor,has a significant role in the facilitation in shortterm synaptic plasticity:Syt7 knock out mice show a significant reduction in the facilitation.The functional import... Synaptotagmin 7(Syt7),a presynaptic calcium sensor,has a significant role in the facilitation in shortterm synaptic plasticity:Syt7 knock out mice show a significant reduction in the facilitation.The functional importance of short-term synaptic plasticity such as facilitation is not well understood.In this study,we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice.We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials.These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic response and related synaptic properties.In agreement with previous modeling studies,we show that release sites are governed by non-uniform release probabilities of neurotransmitters.The structure of non-uniform release of neurotransmitters makes shortterm synaptic plasticity to act as a high-pass filter.We also propose that Syt7 may be a modulator for the long-term changes of postsynaptic response that helps to train the target frequency of the filter.We have developed a mathematical model of short-term plasticity which explains the experimental data. 展开更多
关键词 SYNAPSE SHORT-TERM plasticity SHORT-TERM FACILITATION and depression MATHEMATICAL model low-frequency STIMULATION high-frequency STIMULATION
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Effect of electrically stimulating acupoint, Zusanli (ST 36), on patient's recovery after laparoscopic colorectal cancer resection: a randomized controlled trial
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作者 Huang Wei Yu Tingyu +2 位作者 Long Wenfei Xiao Jianbin Zhao Gaofeng 《中医杂志:英文版》 SCIE CAS CSCD 2019年第3期433-439,共7页
OBJECTIVE:To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on enhanced recovery after surgery (ERAS) in laparoscopic colorectal cancer resection and its clinical significance.METHODS:... OBJECTIVE:To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on enhanced recovery after surgery (ERAS) in laparoscopic colorectal cancer resection and its clinical significance.METHODS:Sixty-four patients undergoing laparoscopic colorectal resection were randomly divided into two groups,the control group (group A) and the TEAS group (group B).Patients in the TEAS group received electroacupuncture stimulation of bilateral Zusanli (ST 36) at 30 min before anesthesia to the end of surgery.The patients in the control group were not given the stimulation.Perioperative anesthesia management of the two groups were performed according to the ERAS guidelines,and postoperative patient-controlled intravenous analgesia (PCIA) was used.The amount of remifentanil used in the two groups was observed and recorded,and the visual analogue scale (VAS) of the 4,12,24 and 48 h after surgery in the two groups was recorded.Moreover,postoperative anal exhaust time,postoperative feeding time,postoperative first ambulation time and postoperative hospital stay length were compared between the two groups.RESULTS:Compared with group A,the VAS score of group B decreased significantly at 48 h after operation (P < 0.05).The postoperative anal exhaust time in group B was significantly shorter than that of group A (P < 0.05).There was no significant difference between the two groups with regards to remifentanil consumption,postoperative feeding time,postoperative first ambulation time and postoperative hospital stay (all P > 0.05).CONCLUSION:TEAS can promote the recovery of postoperative gastrointestinal function and reduce the pain intensity 48 h after surgery,thus satisfying the need of early postoperative analgesia. 展开更多
关键词 Colorectal neoplasms Laparoscopes TRANSCUTANEOUS electric NERVE stimulation RECOVERY of function RANDOMIZED controlled trial
针刺复合全麻应用于不停跳冠状动脉搭桥手术临床规范 预览
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作者 徐美英 王东信 +1 位作者 卢家凯 王祥瑞 《中国疼痛医学杂志》 CAS CSCD 北大核心 2019年第6期461-464,共4页
该课题组依托国家重点研究发展计划(973计划)制定了针药复合麻醉心肺手术方案和临床评价指标,阐明了针药复合麻醉在心肺手术围术期的镇痛效应和机体保护效应的机制。本文主要介绍的是针刺麻醉心肌保护作用、穴位刺激治疗方案、术前访视... 该课题组依托国家重点研究发展计划(973计划)制定了针药复合麻醉心肺手术方案和临床评价指标,阐明了针药复合麻醉在心肺手术围术期的镇痛效应和机体保护效应的机制。本文主要介绍的是针刺麻醉心肌保护作用、穴位刺激治疗方案、术前访视以及围术期麻醉管理。 展开更多
关键词 电针(electroacupuncture EA) 经皮穴位电刺激(transcutanclus electrical ACUPOINT stimulation TEAS) 不停跳冠状动脉搭桥手术(off-pump CABG OPCABG) 围术期管理
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Paired associative stimulation improves synaptic plasticity and functional outcomes after cerebral ischemia 预览
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作者 Yan Hu Tie-Cheng Guo +2 位作者 Xiang-Yu Zhang Jun Tian Yin-Shan Lu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1968-1976,共9页
Paired associative stimulation is a relatively new non-invasive brain stimulation technique that combines transcranial magnetic stimulation and peripheral nerve stimulation. The effects of paired associative stimulati... Paired associative stimulation is a relatively new non-invasive brain stimulation technique that combines transcranial magnetic stimulation and peripheral nerve stimulation. The effects of paired associative stimulation on the excitability of the cerebral cortex can vary according to the time interval between the transcranial magnetic stimulation and peripheral nerve stimulation. We established a model of cerebral ischemia in rats via transient middle cerebral artery occlusion. We administered paired associative stimulation with a frequency of 0.05 Hz 90 times over 4 weeks. We then evaluated spatial learning and memory using the Morris water maze. Changes in the cerebral ultra-structure and synaptic plasticity were assessed via transmission electron microscopy and a 64-channel multi-electrode array. We measured mRNA and protein expression levels of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor 1 in the hippocampus using a real-time polymerase chain reaction and western blot assay. Paired associative stimulation treatment significantly improved learning and memory in rats subjected to cerebral ischemia. The ultra-structures of synapses in the CA1 area of the hippocampus in rats subjected to cerebral ischemia were restored by paired associative stimulation. Long-term potentiation at synapses in the CA3 and CA1 regions of the hippocampus was enhanced as well. The protein and mRNA expression of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor 1 increased after paired associative stimulation treatment. These data indicate that paired associative stimulation can protect cog-nition after cerebral ischemia. The observed effect may be mediated by increases in the mRNA and protein expression of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor 1, and by enhanced synaptic plasticity in the CA1 area of the hippocampus. The animal experiments were approved by the Animal Ethics Committee of Tongji Medical College, Huazhong University of Science & Technology, China(appr 展开更多
关键词 cerebral ischemia paired ASSOCIATIVE stimulation cognitive function long-term POTENTIATION SYNAPTIC plasticity Morris water maze SYNAPTIC structure N-methyl-D-aspartic acid receptor BRAIN-DERIVED NEUROTROPHIC factor MULTI-ELECTRODE array neural regeneration
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浅谈如何创造性地运用高中语文教材 预览
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作者 毛团结 《科教文汇》 2019年第16期126-127,130共3页
创造性地设计教学方法,激发和维护学生学习语文的兴趣;创造性地选择教学手段,生动、深刻地理解教材;创造性地解读教材,激发学生思维的火花;创造性地鉴赏教材,汲取写作的营养。
关键词 创造性 激发 维护 深刻理解 激活思维
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政府采购激励了企业技术创新吗?——无所作为还是毋庸置疑 预览
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作者 王小平 《宜春学院学报》 2019年第4期39-48,共10页
利用2006-2016年中国上市公司数据,实证检验政府采购对技术创新的政策效果,并分析政府采购激励企业技术创新的内在机理。研究发现:政府采购均激励了技术创新;政府采购对民营企业、高新技术企业的技术创新的激励作用更显著;进一步检验结... 利用2006-2016年中国上市公司数据,实证检验政府采购对技术创新的政策效果,并分析政府采购激励企业技术创新的内在机理。研究发现:政府采购均激励了技术创新;政府采购对民营企业、高新技术企业的技术创新的激励作用更显著;进一步检验结果表明,政府采购对企业技术创新的激励作用通过弥补市场失灵和降低信息不对称实现。研究结论为优化支持自主创新的政府采购政策提供了有益的参考。 展开更多
关键词 政府采购 技术创新 激励
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Current status and potential application of navigated transcranial magnetic stimulation in neurosurgery: a literature review
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作者 Xiaojing Fang Meige Liu +2 位作者 Changyu Lu Yuanli Zhao Xianzeng Liu 《中华神经外科杂志(英文)》 CSCD 2019年第2期108-114,共7页
Transcranial magnetic stimulation (TMS) is a noninvasive neurophysiologic technique that can stimulate the human brain.Positioning of the coil was often performed based merely on external landmarks on the head,meaning... Transcranial magnetic stimulation (TMS) is a noninvasive neurophysiologic technique that can stimulate the human brain.Positioning of the coil was often performed based merely on external landmarks on the head,meaning that the anatomical target in the cortex remains inaccurate.Navigated transcranial magnetic stimulation (nTMS) combines a frameless stereotactic navigational system and TMS coil and can provide a highly accurate delivery of TMS pulses with the guidance of imaging.Therefore,many novel utilities for TMS could be explored due to the ability of precise localization.Many studies have been published,which indicate nTMS enables presurgical functional mapping.This review aimed to provide a comprehensive literature review on nTMS,especially the principles and clinical applications of nTMS.All articles in PubMed with keywords of 'motor mapping,' 'presurgical mapping,' 'navigated transcranial magnetic stimulation,' and 'language mapping' published from 2000 to 2018 were included in the study.Frequently cited publications before 2000 were also included.The most valuable published original and review articles related to our objective were selected.Motor mapping of nTMS is validated to be a trustful tool to recognize functional areas belonging to both normal and lesioned primary motor cortex.It can offer reliable mapping of speech and motor regions at cortex prior to operation and has comparable accuracy as direct electrical cortical stimulation.nTMS is a powerful tool for mapping of motor and linguistic function prior to operation,has high application value in neurosurgery and the treatment of neurological and psychiatric diseases,and has gained increasing acceptance in neurosurgical centers across the world. 展开更多
关键词 TRANSCRANIAL magnetic STIMULATION Motor MAPPING SPEECH MAPPING NEUROSURGERY
Low-dose radiation and Alzheimer's disease:Neuronal effects and a potential modality for therapy?
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作者 Feng Li Liu Qiang +1 位作者 Wang Bing Cai Lu 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2019年第8期581-589,共9页
Exposure to low-dose radiation(LDR,mostly less than 100 mGy)may reduce the vulnerability of exposed tissues to subsequent high-dose radiation(HDR)-induced damage,a phenomenon known as adaptive responses,which occurs v... Exposure to low-dose radiation(LDR,mostly less than 100 mGy)may reduce the vulnerability of exposed tissues to subsequent high-dose radiation(HDR)-induced damage,a phenomenon known as adaptive responses,which occurs via mechanisms including anti-inflammation and anti-oxidation.Alzheimer′s disease(AD)is a type of dementia that causes problems with memory,thinking,and behavior.Using the available literature,this review will examine whether there is any effect of LDR on AD.The available evidence shows that although LDR can alter the expression of some genes related to AD such as Apbb1,Lrp1,and Il1α,these alterations do not cause AD-like syndromes in animals,suggesting that LDR may also simultaneously upregulate several protective mechanisms that prevent the eventual development of AD.Furthermore,LDR seems capable of improving the symptoms of AD,as evidenced by the experience of an 81-year-old female AD patient.This patient was diagnosed with AD more than 10 years ago and gradually progressed to advanced AD in 2015,despite routine treatment.The patient then received about 12 computed tomography scans(about 40 mGy each)up until Nov.2017,which significantly improved her quality of life and reduced several AD symptoms.The improvement in this patient′s medical condition led to a few recent clinical trials investigating the effects of LDR on AD.To date,there is no efficient therapy available for AD,thus whether exposure to LDR at 100 mGy can provide a preventive or therapeutic effect for AD is an important issue.If LDR is a potential treatment for AD,as suggested by this reported case,this non-invasive approach would also bear the merit that it would be unlikely to cause a significant radiation health risk,as the LDR could be delivered locally to the head without any impact on other organs. 展开更多
关键词 LOW-DOSE radiation Alzheimer's disease Adaptive response HORMESIS NEURONAL STIMULATION
Study on variation trend of repetitive nerve stimulation waveform in amyotrophic lateral sclerosis
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作者 Li-Lan Fu He-Xiang Yin +1 位作者 Ming-Sheng Liu Li-Ying Cui 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第5期542-550,共9页
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower neurons with no effective cure. Electrophysiological studies have found decremental responses d... Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower neurons with no effective cure. Electrophysiological studies have found decremental responses during low-frequency repetitive nerve stimulation (RNS) except for diffused neurogenic activities. However, the difference between ALS and generalized myasthenia gravis (GMG) in terms of waveform features is unclear. In the current study, we explored the variation trend of the amplitudes curve between ALS and GMG with low-frequency, positive RNS, and the possible mechanism is discussed preliminarily. Methods: A total of 85 ALS patients and 41 GMG patients were recruited. All patients were from Peking Union Medical College Hospital (PUMCH) between July 1,2012 and February 28,2015. RNS study included ulnar nerve, accessory nerve and facial nerve at 3 Hz and 5 Hz stimulation. The percentage reduction in the amplitude of the fourth or fifth wave from the first wave was calculated and compared with the normal values of our hospital. A 15% decrease in amplitude is defined as a decrease in amplitude. Results: The decremental response at low-frequency RNS showed the abnormal rate of RNS decline was 54.1%(46/85) in the ALS group, and the results of different nerves were 54.1 %(46/85) of the accessory nerve, 8.2%(7/85) of the ulnar nerve and 0%(0/85) of the facial nerve stimulation, respectively. In the GMG group, the abnormal rate of RNS decline was 100%(41/41) at low-frequency RNS of accessory nerves. However, there was a significant difference between the 2 groups in the amplitude after the sixth wave. Conclusions: Both groups of patients are able to show a decreasing amplitude of low-frequency stimulation RNS, but the recovery trend after the sixth wave has significant variation. It implies the different pathogenesis of NMJ dysfunction of these 2 diseases. 展开更多
关键词 Amyotrophic lateral SCLEROSIS Generalized MYASTHENIA GRAVIS NEUROMUSCULAR junction REPETITIVE nerve stimulation
Evidence and explanation for the involvement of the nucleus accumbens in pain processing 预览
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作者 Haley N.Harris Yuan B.Peng 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期597-605,共9页
The nucleus accumbens(NAc)is a subcortical brain structure known primarily for its roles in pleasure,reward,and addiction.Despite less focus on the NAc in pain research,it also plays a large role in the mediation of p... The nucleus accumbens(NAc)is a subcortical brain structure known primarily for its roles in pleasure,reward,and addiction.Despite less focus on the NAc in pain research,it also plays a large role in the mediation of pain and is effective as a source of analgesia.Evidence for this involvement lies in the NAc’s cortical connections,functions,pharmacology,and therapeutic targeting.The NAc projects to and receives information from notable pain structures,such as the prefrontal cortex,anterior cingulate cortex,periaqueductal gray,habenula,thalamus,etc.Additionally,the NAc and other pain-modulating structures share functions involving opioid regulation and motivational and emotional processing,which each work beyond simply the rewarding experience of pain offset.Pharmacologically speaking,the NAc responds heavily to painful stimuli,due to its high density ofμopioid receptors and the activation of several different neurotransmitter systems in the NAc,such as opioids,dopamine,calcitonin gene-related peptide,γ-aminobutyric acid,glutamate,and substance P,each of which have been shown to elicit analgesic effects.In both preclinical and clinical models,deep brain stimulation of the NAc has elicited successful analgesia.The multi-functional NAc is important in motivational behavior,and the motivation for avoiding pain is just as important to survival as the motivation for seeking pleasure.It is possible,then,that the NAc must be involved in both pleasure and pain in order to help determine the motivational salience of positive and negative events. 展开更多
关键词 ANALGESIA CIRCUITRY deep brain stimulation NOCICEPTION nucleus accumbens PAIN pain relief pain signaling REWARD STRIATUM
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Bridging larger gaps in peripheral nerves using neural prosthetics and physical therapeutic agents 预览
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作者 Muhammad Sana Ullah Sahar Matthew Barton Geoffrey Douglas Tansley 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第7期1109-1115,共7页
Peripheral nerve injuries are relatively common and can be caused by a variety of traumatic events such as motor vehicle accidents.They can lead to long-term disability,pain,and financial burden,and contribute to poor... Peripheral nerve injuries are relatively common and can be caused by a variety of traumatic events such as motor vehicle accidents.They can lead to long-term disability,pain,and financial burden,and contribute to poor quality of life.In this review,we systematically analyze the contemporary literature on peripheral nerve gap management using nerve prostheses in conjunction with physical therapeutic agents.The use of nerve prostheses to assist nerve regeneration across large gaps(>30 mm)has revolutionized neural surgery.The materials used for nerve prostheses have been greatly refined,making them suitable for repairing large nerve gaps.However,research on peripheral nerve gap management using nerve prostheses reports inconsistent functional outcomes,especially when prostheses are integrated with physical therapeutic agents,and thus warrants careful investigation.This review explores the effectiveness of nerve prostheses for bridging large nerve gaps and then addresses their use in combination with physical therapeutic agents. 展开更多
关键词 NERVE repair NERVE conduits NERVE PROSTHESIS PHYSICAL therapeutic agents electric stimulation NERVE gap AXONAL growth NERVE regeneration
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Practice and understanding of sidetracking horizontal drilling in old wells in Sulige Gas Field, NW China 预览
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作者 ZHANG Jinwu WANG Guoyong +1 位作者 HE Kai YE Chenglin 《石油勘探与开发:英文版》 2019年第2期384-392,共9页
To seek effective ways of lowering development cost and tapping inter-well remaining reserves, sidetracking horizontal wells from old wells in Su10 and Su53 Block were conducted. The engineering and geological problem... To seek effective ways of lowering development cost and tapping inter-well remaining reserves, sidetracking horizontal wells from old wells in Su10 and Su53 Block were conducted. The engineering and geological problems such as leakage, collapse and sticking in slim-hole sidetracking, and difficult evaluation of remaining gas were gradually overcome, and a set of drilling and completion technology, well deployment optimization technology and geo-steering technology suitable for sidetracking horizontal wells in tight sandstone gas reservoirs have been worked out. By making full use of the old well, sidetracking horizontal wells can greatly reduce development costs, enhance the producing degree of inter-well remaining reserves, and get production 3-5 times of that of adjacent vertical wells.Its production effect is influenced by encountered sandstone length, the position of the horizontal segment in the reservoir, produced effective reservoir thickness, gas saturation, controlled reserves and fracturing effect, etc. Up to now, in Block Su10 and Su53, 12 sidetracking horizontal wells have been drilled, which have an average drilling cycle of 49 days, average horizontal section length of 689 m,average effective drilling ratio of 61.5%, average well-head pressure of 16.2 MPa, and daily output of 4.7×10~4 m~3 at the initial stage after production. By the end of 2017, the average yield increment was more than 1 000×10~4 m~3 with good effect. With the increase of low yield old wells, wells in the enrichment regions tend to be saturated and the rest gas-bearing areas are lower in grade, therefore, sidetracking horizontal well can be used for optimization of well pattern, well deployment mode and exploitation of remaining oil areas. 展开更多
关键词 SULIGE Gas Field sidetracking horizontal WELL TIGHT SANDSTONE old WELL STIMULATION RESERVES producing
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Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies
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作者 Qiong-Bin Zhu Ai-Min Bao Dick Swaab 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第2期253-266,共14页
Alzheimer’s disease(AD) is characterized by decreased neuronal activity and atrophy, while hyperactivity of neurons seems to make them resistant to aging and neurodegeneration, a phenomenon which we have paraphrased ... Alzheimer’s disease(AD) is characterized by decreased neuronal activity and atrophy, while hyperactivity of neurons seems to make them resistant to aging and neurodegeneration, a phenomenon which we have paraphrased as ‘use it or lose it’. Our hypothesis proposes that(1) during their functioning, neurons are damaged;(2)accumulation of damage that is not repaired is the basis of aging;(3) the vulnerability to AD is determined by the genetic background and the balance between the amount of damage and the efficiency of repair, and(4) by stimulating the brain, repair mechanisms are stimulated and cognitive reserve is increased, resulting in a decreased rate of aging and risk for AD. Environmental stimulating factors such as bilingualism/multilingualism, education, occupation, musical experience, physical exercise, and leisure activities have been reported to reduce the risk of dementia and decrease the rate of cognitive decline, although methodological problems are present. 展开更多
关键词 DEMENTIA Genes Environmental stimulation BRAIN ACTIVATION Cognitive RESERVE Use IT or lose IT
油母页岩干馏油气冷凝回收工艺系统模拟与优化 预览
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作者 尹晓含 曹祖宾 +1 位作者 曹传洋 吕娜 《石油化工高等学校学报》 CAS 2019年第3期20-27,共8页
通过对油母页岩干馏油气冷凝回收工艺的深入研究,并运用Aspen plus模拟软件对油页岩冷凝回收系统进行模拟与优化。结果表明,经过Aspen软件模拟,本工艺页岩油收率80.6%。采用两组方案优化,优化方案一,在不需要饱和瓦斯热载体的前提下,回... 通过对油母页岩干馏油气冷凝回收工艺的深入研究,并运用Aspen plus模拟软件对油页岩冷凝回收系统进行模拟与优化。结果表明,经过Aspen软件模拟,本工艺页岩油收率80.6%。采用两组方案优化,优化方案一,在不需要饱和瓦斯热载体的前提下,回收系统去掉吸收塔,节约设备费。优化方案二,通过改变风机位置,对比全负压和半负压状态下的油收率,半负压状态下页岩油收率增加1%,收益增加近300万元。 展开更多
关键词 页岩油 ASPENPLUS 模拟 压力
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基于RFM的商场会员画像描绘模型 预览
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作者 游晋峰 《太原师范学院学报:自然科学版》 2019年第3期15-20,共6页
文章针对2018年全国大学生数学建模竞赛C题“大型百货商场会员画像描绘”问题,首先对数据进行了分析和清洗,然后给出了相关问题的求解办法,建立了基于RFM的商场会员购买力评价模型、基于RFM的客户促销参与模型、基于Apriori算法的连带... 文章针对2018年全国大学生数学建模竞赛C题“大型百货商场会员画像描绘”问题,首先对数据进行了分析和清洗,然后给出了相关问题的求解办法,建立了基于RFM的商场会员购买力评价模型、基于RFM的客户促销参与模型、基于Apriori算法的连带销售方案.最后,提出了进一步研究的问题. 展开更多
关键词 RFM 关联规则 会员生命周期 激活率 促销活动
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C-AICD复合型智能控水装置试验研究 预览
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作者 潘豪 张磊 +3 位作者 曹砚锋 黄辉 林德纯 许昊东 《石油矿场机械》 2019年第5期48-53,共6页
为抑制底水油藏开采过程中水平生产井含水率过快上升,开展了复合型智能控水装置(C-AICD)的控水机理研究,并进行了C-AICD、AICD、ICD控水效果的室内对比试验和分析。研究结果表明,C-AICD能同时发挥AICD和ICD的优势,实现生产早期均匀流入... 为抑制底水油藏开采过程中水平生产井含水率过快上升,开展了复合型智能控水装置(C-AICD)的控水机理研究,并进行了C-AICD、AICD、ICD控水效果的室内对比试验和分析。研究结果表明,C-AICD能同时发挥AICD和ICD的优势,实现生产早期均匀流入剖面,中后期自动控制产水量。通过在1口井中的控水方案设计和效果模拟发现,C-AICD控水在生产周期内的综合含水率相比于普通筛管下降约13%,为油田经济有效的控水提供了新的技术手段。 展开更多
关键词 复合型智能控水技术 试验 模拟
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Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury
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作者 Qian Huang Wanru Duan +6 位作者 Eellan Sivanesan Shuguang Liu Fei Yang Zhiyong Chen Neil C.Ford Xueming Chen Yun Guan 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第3期527-539,共13页
In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury(SCI). Curren... In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury(SCI). Currently,however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation(SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations,classification, potential underlying etiology, and currentchallenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed. 展开更多
关键词 Pain TRAUMA SPINAL CORD injury SPINAL CORD stimulation NEUROMODULATION ANALGESIA
Stimulation impact of electric currents on heterotrophic denitrifying microbial viability and denitrification performance in high concentration nitrate-contaminated wastewater
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作者 Shuang Tong Hengyuan Liu +5 位作者 Chuanping Feng Nan Chen Yan Zhao Baocai Xu Jiamin Zhao Ming Zhu 《环境科学学报:英文版》 SCIE EI CAS CSCD 2019年第3期363-371,共9页
Electric current stimulation has been shown to have a positive influence on heterotrophic denitrifying microbial viability and has the potential to improve wastewater denitrification performance. This study investigat... Electric current stimulation has been shown to have a positive influence on heterotrophic denitrifying microbial viability and has the potential to improve wastewater denitrification performance. This study investigated the effects of varying current densities on microbial activity and NO3- removal efficiency under heterotrophic conditions.NO3-removal rate was highest at an applied current density of 400 mA/m2. However, the optimum removal efficiency of total inorganic nitrogen(TIN;99%) was achieved when the current density was fixed at 200 m A/m2. Accumulation of NH4+-N and NO2--N byproducts were also minimized at this current density. The activity of heterotrophic denitrifying microorganisms was much higher at both 200 and 400 mA/m2. Moreover, the average adenosine-5′-triphosphate(ATP)content(an indicator of cell metabolism) at a current density of 1600 mA/m2 was lower than that under no current, indicating heterotrophic denitrifying microbial activity can be inhibited at high current densities. Hence, direct electrical stimulation on the activity of heterotrophic denitrifying microorganisms in the developed system should be lower than 1600 mA/m2. This study improves the understanding of electric current influence on heterotrophic denitrifying microorganisms and promotes the intelligent application of direct electrical stimulation on wastewater treatment processes. 展开更多
关键词 Direct electrical STIMULATION NITRATE removal DENITRIFICATION HETEROTROPHIC MICROBIAL activity Current density WASTEWATER treatment
Effects of routine rehabilitation therapy combined with low frequency electrical stimulation on monoamine neurotransmitters, NSE, ET-1 and cerebral hemodynamics in children with cerebral palsy
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作者 Sai Xun Pei-Pei Wang +5 位作者 Nuan Yang Mei Hou Jun Chen Dian-Rong Sun Jian-Hui Zhao Li-Ping Lyu 《海南医科大学学报(英文版)》 2019年第5期61-64,共4页
Objective:To investigate the effects of routine rehabilitation therapy combined with low frequency head stimulation on monoamine neurotransmitters, neuron-specific enolase (NSE), endothelin-1 (ET-1) and cerebral hemod... Objective:To investigate the effects of routine rehabilitation therapy combined with low frequency head stimulation on monoamine neurotransmitters, neuron-specific enolase (NSE), endothelin-1 (ET-1) and cerebral hemodynamics in children with cerebral palsy.Methods:From January 2017 to June 2018, 110 children with cerebral palsy were randomly divided into observation group (55 cases) and control group (55 cases). The control group received routine rehabilitation treatment, while the observation group received low-frequency head stimulation on the basis of routine rehabilitation treatment. The changes of dopamine (DA), norepinephrine (NE), serotonin (5-HT), NSE, ET-1 levels and mean blood flow velocity of anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA) were compared in two groups.Results:Before treatment, there was no significant difference in DA, NE and 5-HT levels in two groups. After treatment, DA, NE and 5-HT levels in the observation group were (192.23±22.71) ng/mL, (98.02±11.71) ng/L, (210.07±25.03) ng/L, and in the control group. the DA, NE, 5-HT levels were (147.06±17.02) ng/mL, (83.07±11.15) ng/L, and (171.88±20.45) ng/L, respectively. The DA, NE and 5-HT levels in two groups were higher than those before treatment, and DA, NE and 5-HT levels in the observation group were higher than those in the control group. Before treatment, there was no significant difference in NSE and ET-1 levels between the two groups. After treatment, the NSE and ET-1 levels in the observation group were (7.97±2.07) μg/L and (41.01±10.07) pg/mL, and the NSE and ET-1 levels in the control group were (10.38±3.02) μg/L, (58.46±15.02) pg/mL, respectively. the NSE and ET-1 in two groups were lower than those before treatment, and the NSE and ET-1 of the observation group were lower than the control group. Before treatment, there was no significant difference in mean blood flow velocity between ACA, MCA and PCA. After treatment, the mean blood flow velocities of ACA, MCA, and PCA 展开更多
关键词 Low frequency electrical stimulation MONOAMINE NEUROTRANSMITTER NEURON specific ENOLASE ENDOTHELIN-1 Cerebral HEMODYNAMICS
Effect of exit location on flow of mice under emergency condition
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作者 张腾 黄申石 +2 位作者 张学林 陆守香 黎昌海 《中国物理B:英文版》 SCIE EI CAS CSCD 2019年第1期290-299,共10页
The evacuation of crowds in a building has always emerged as a vital issue in many accidents. The geometrical structure of a room, especially the exit design has a great influence on crowd evacuation under emergency c... The evacuation of crowds in a building has always emerged as a vital issue in many accidents. The geometrical structure of a room, especially the exit design has a great influence on crowd evacuation under emergency conditions. In this paper, the effect of exit location of a room on crowd evacuation in an emergency is investigated with mice. Two different exits are set in a rectangular chamber. One is located in the middle of a wall(middle-exit) and the other is at the corner of the chamber(corner-exit). Arching and clogging are observed in the flow of mice. The result based on the escape trajectories of mice shows a dynamic balance in the arch near the exit wherever the exit is located. We demonstrate that the occupant position in the arch has an effect on the escape sequence of mice. At a low stimulation level, the narrow middle-exit is more effective in increasing the flow rate of mice than the narrow corner-exit. However, the opposite result appears when the exit becomes wider. At a high stimulation level, the effect of exit location on flow of mice tends to be weakened. The results suggest that the specific level of stimulation needs to be taken into account when optimizing the evacuation efficiency of a crowd through the geometrical structure of a room. 展开更多
关键词 EXIT LOCATION EVACUATION MICE STIMULATION level
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