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Contribution of ghrelin to functional gastrointestinal disorders’pathogenesis
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作者 Tilemachos Koutouratsas Theodora Kalli +1 位作者 Georgios Karamanolis Maria Gazouli 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第5期539-551,共13页
Functional gastrointestinal disorders(FGID)are heterogeneous disorders with a variety of clinical manifestations,primarily defined by signs and symptoms rather than a definite underlying cause.Their pathophysiology re... Functional gastrointestinal disorders(FGID)are heterogeneous disorders with a variety of clinical manifestations,primarily defined by signs and symptoms rather than a definite underlying cause.Their pathophysiology remains obscure and,although it is expected to differ according to the specific FGID,disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis.The hormone ghrelin is an important component of this axis,exerting a wide repertoire of physiological actions,including regulation of gastrointestinal motility and protection of mucosal tissue.Ghrelin’s gene shows genetic polymorphism,while its protein product undergoes complex regulation and metabolism in the human body.Numerous studies have studied ghrelin’s relation to the emergence of FGIDs,its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment.Despite the mixed results currently available in scientific literature,the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis.The aim of this paper is to review current literature studying these associations,in an effort to uncover certain patterns of alterations in both genetics and expression,which could delineate its true contribution to FGID emergence,either as a causative agent or as a pathogenetic intermediate. 展开更多
关键词 FUNCTIONAL GASTROINTESTINAL disorders FUNCTIONAL colonic diseases Irritable bowel SYNDROME Cyclic VOMITING SYNDROME Infantile COLIC GASTROINTESTINAL disease GHRELIN Genetics Epigenetic processes
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短期大剂量氢化可的松诱发小鼠药源性证候的评价研究
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作者 李亚 潘志强 +1 位作者 钱宏梁 方肇勤 《上海中医药大学学报》 CAS 2019年第2期55-60,65共7页
目的:研究大剂量氢化可的松短期给药诱发小鼠药源性证候的特征及对肾上腺皮质功能的影响。方法:32只雄性ICR小鼠随机分为对照组与氢化可的松不同剂量干预组(12.5 mg·kg^-1·d^-1组、25 mg·kg^-1·d^-1组、50 mg·... 目的:研究大剂量氢化可的松短期给药诱发小鼠药源性证候的特征及对肾上腺皮质功能的影响。方法:32只雄性ICR小鼠随机分为对照组与氢化可的松不同剂量干预组(12.5 mg·kg^-1·d^-1组、25 mg·kg^-1·d^-1组、50 mg·kg^-1·d^-1组),每组8只。氢化可的松不同剂量组小鼠分别灌胃给予相应浓度的氢化可的松溶液,对照组小鼠灌胃给予相同体积灭菌水,连续5 d。分别于给药第1、3、5天称量每只小鼠体质量。末次给药后,采用课题组前期建立的小鼠辨证论治实验方法学检测小鼠表征信息(躯体不同部位红外温度、腋温、抓力);取各只小鼠胸腺、脾脏称重,计算脏器指数;分离肾上腺组织,实时荧光定量PCR技术检测类固醇激素合成酶(Star、Cyp11a1、Cyp21a1、Cyp11b1)基因表达,Western blot检测StAR、SRBI与LDLR蛋白表达。结果:①给药1、3、5 d后,氢化可的松25 mg·kg^-1·d^-1和50 mg·kg^-1·d^-1组小鼠的体质量均较对照组显著降低(P<0.05,P<0.01)。②给药5 d后,氢化可的松12.5 mg·kg^-1·d^-1和25 mg·kg^-1·d^-1组小鼠的头部最高温度均较对照组显著降低(P<0.05),但氢化可的松各剂量组小鼠的躯干平均温度、尾部最低温度、腋温、抓力无明显变化。③与对照组相比,氢化可的松各剂量组小鼠的脾脏指数均明显下降(P<0.01),且呈剂量依赖性;50 mg·kg^-1·d^-1组小鼠的胸腺指数较对照组显著降低(P<0.01)。④与对照组相比,氢化可的松25 mg·kg^-1·d^-1和50 mg·kg^-1·d^-1组肾上腺组织中Star、Cyp11a1、Cyp11b1和Cyp21a1的mRNA表达均显著减少(P<0.05,P<0.01),StAR、LDLR和SRBI蛋白表达均显著降低(P<0.05,P<0.01)。结论:大剂量氢化可的松(25 mg·kg^-1·d^-1和50 mg·kg^-1·d^-1)短期给药5 d可显著抑制小鼠肾上腺皮质功能,其证候表现以药源性阴虚证为主。 展开更多
关键词 氢化可的松 肾上腺皮质 证候 阴虚证 小鼠
A review of Behcet’s disease from the perspectives of both Western and Chinese Medicine
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作者 Zhang Jing Tang Yuping +5 位作者 Liu Pei Zhou Guisheng Kang An Yue Shijun Chen Yanyan Duan Jinao 《中医杂志:英文版》 SCIE CAS CSCD 2019年第1期139-148,共10页
Behcet’s disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet’s disease can affect every tissue and organ in the body,and is characte... Behcet’s disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet’s disease can affect every tissue and organ in the body,and is characterized by recurrent oral and genital ulcers, ocular inflammation, skin lesions, and other manifestations. The incidence of Behcet’s disease has a distinct regional specificity, and is most prevalent along the Silk Road, a route that stretched between the Mediterranean, Middle East and Far East.This article reviews the recent literature to evaluate the prevalence, clinical manifestations, pathogenesis and mechanism, and current treatments of Behcet’s disease. Furthermore, the etiology of Behcet’s disease will be evaluated from the aspect of Traditional Chinese Medicine(TCM) syndrome differentiation. As Behcet’s disease is complex and intractable, its treatment warrants further research.Traditionally, Behcet’s disease is treated with Western Medicine(WM) via medications that act locally and systemically;this WM treatment protocol usually has a good effect, but relapse can occur after reducing the dosage. Thus, it may be ideal to treat Behcet’s disease via a combination of WM and TCM.Recent studies have indicated that such a combination of Chinese and Western treatments has a better effect than either treatment alone. The aim of the present review is to describe the clinical features of Behcet’s disease, and to outline its possible pathogenesis in terms of both TCM and WM. Based on these findings, the present review proposes a Behcet’s disease treatment protocol composed of a combination of Chinese and WM that can effectively improve the occurrence of relapse caused by the reduction of the dosage of Western medication. 展开更多
关键词 Behcet SYNDROME SYNDROME differentiation treatment VIRULENCE RECURRENCE THERAPEUTICS Review
Spectrum of gastrointestinal involvement in Stevens-Johnson syndrome
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作者 Ashish Kumar Jha Arya Suchismita +1 位作者 Rajeev Kumar Jha Vikas Kumar Raj 《世界胃肠内镜杂志:英文版(电子版)》 2019年第2期115-123,共9页
Stevens-Johnson syndrome(SJS)or toxic epidermal necrolysis(TEN)is a severe adverse drug reaction associated with involvement of skin and mucosal membranes,and carries significant risk of mortality and morbidity.Mucus ... Stevens-Johnson syndrome(SJS)or toxic epidermal necrolysis(TEN)is a severe adverse drug reaction associated with involvement of skin and mucosal membranes,and carries significant risk of mortality and morbidity.Mucus membrane lesions usually involve the oral cavity,lips,bulbar conjunctiva and the anogenitalia.The oral/anal mucosa and liver are commonly involved in SJS or TEN.However,intestinal involvement is distinctly rare.We herein review the current literature regarding the gastrointestinal involvement in SJS or TEN.This review focuses mainly on the small bowel and colonic involvement in patients with SJS or TEN. 展开更多
关键词 STEVENS-JOHNSON SYNDROME TOXIC EPIDERMAL necrolysis Lyell’s SYNDROME Gastrointestinal involvement COLON ILEUM
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Exploratory metabolomics of metabolic syndrome:A status report
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作者 Daniella Lent-Schochet Matthew McLaughlin +1 位作者 Neeraj Ramakrishnan Ishwarlal Jialal 《世界糖尿病杂志:英文版(电子版)》 2019年第1期23-36,共14页
Metabolic syndrome(MetS)is as a cluster of cardio-metabolic factors that greatly increase the risk of chronic diseases such as type II diabetes mellitus and atherosclerotic cardiovascular disease.In the United States,... Metabolic syndrome(MetS)is as a cluster of cardio-metabolic factors that greatly increase the risk of chronic diseases such as type II diabetes mellitus and atherosclerotic cardiovascular disease.In the United States,obesity,physical inactivity,aging,and genetics(to a minor extent)have arisen as risk factors for developing MetS.Although 35%of American adults suffer from MetS,its pathogenesis largely remains unknown.Worse,there is a lack of screening and optimum therapy for this disease.Researchers have consequently turned towards metabolomics to identify biomarkers to better understand MetS.The purpose of this review is to characterize various metabolites and their potential connections to MetS.Numerous studies have also characterized MetS as a disease of increased inflammation,and therefore this review also explores how metabolites play a role in various inflammatory pathways.Our review explores a broad range of metabolites including biogenic amines,branched chain amino acids,aromatic amines,phosphatidylcholines,as well as a variety of other molecules.We will explore their biochemical pathways and their potential role in serving as biomarkers. 展开更多
关键词 METABOLIC SYNDROME SYNDROME X Metabolomics Amino ACIDS CARNITINE Inflammation Biomarkers Diabetes
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小儿手足口病中医证候演变规律的研究
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作者 王有鹏 刘璐佳 +3 位作者 曲婉莹 杨阳 景伟超 刘志伟 《辽宁中医杂志》 CAS 2019年第3期521-524,共4页
目的:分析黑龙江地区小儿手足口病各证型演变规律,提出治疗方案。方法:通过收集患儿临床资料,观察入院当天(基线点)、治疗后第3、5、7、10天的临床表现,确定各观察点中医分型,统计不同观察点各证型演变规律。应用证候演变概率法对患儿... 目的:分析黑龙江地区小儿手足口病各证型演变规律,提出治疗方案。方法:通过收集患儿临床资料,观察入院当天(基线点)、治疗后第3、5、7、10天的临床表现,确定各观察点中医分型,统计不同观察点各证型演变规律。应用证候演变概率法对患儿各证候在不同观察点的证候演变规律进行系统分析,并提出相应治疗方案。结果:从基线点当天的发病数量来看,邪犯肺卫证和肺胃热炽证的发病人数居多,从基线点到第3天,以证候的持续存在概率较为突出,其中,湿热交阻证持续存在概率为89. 17%,心脾积热证持续存在概率为84. 41%。第3~5天,邪犯肺卫证及肺胃热炽证发病人数仍较多,且以邪犯肺卫证的持续存在概率较为明显。第5~7天,各证候的持续存在概率大幅度下降的同时,转愈及向肺胃阴伤证的概率增大。第7~10天,剩余患儿仍存在向肺胃阴伤证及其他证型转变的情况。结论:手足口病患儿在各观察点存在不同的演变规律,证实了本病符合温病转归的同时,作者提出了相应的治疗方案。 展开更多
关键词 手足口病 证候 演变规律 治疗
影响证候转化的因素及与疾病预后的关系 预览
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作者 周小青 郑彩杏 《湖南中医药大学学报》 CAS 2019年第1期1-5,共5页
精准医疗,要求诊断的精细观察。除了已经被重视的精准辨证诊病外,证候转化的细致观察应当引起重视。在疾病过程中,证候可有好转或恶化两种转归情况。证候转化,是疾病向愈或恶化的转折处,也是检验辨治正确与否的标准之一。临床中,影响证... 精准医疗,要求诊断的精细观察。除了已经被重视的精准辨证诊病外,证候转化的细致观察应当引起重视。在疾病过程中,证候可有好转或恶化两种转归情况。证候转化,是疾病向愈或恶化的转折处,也是检验辨治正确与否的标准之一。临床中,影响证候转化的因素举不胜举,而证候转化方向提示疾病预后。笔者从疾病的病位、病性、患者的体质等角度阐述影响证候转化的因素,探讨证候转化与疾病预后的相关问题,期望有利于精准诊疗。 展开更多
关键词 证候 证候转化 病位 病性 体质 精准医疗
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当代名中医治疗溃疡性结肠炎经验集萃 预览
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作者 钟晨 王佳佳 +2 位作者 迟莉 巴寅颖 王智瑜 《中国医药导报》 CAS 2019年第4期137-140,共4页
溃疡性结肠炎(UC)是一种慢性难治性肠道炎症疾病,其病因尚未明确,临床治疗复杂,严重影响患者生存质量。当代名中医治疗溃疡性结肠炎积累了丰富的临床经验,认为UC发病以脾虚湿蕴为基本病机,涉及气滞、瘀血、痰浊、寒湿、毒疫、伏毒、血... 溃疡性结肠炎(UC)是一种慢性难治性肠道炎症疾病,其病因尚未明确,临床治疗复杂,严重影响患者生存质量。当代名中医治疗溃疡性结肠炎积累了丰富的临床经验,认为UC发病以脾虚湿蕴为基本病机,涉及气滞、瘀血、痰浊、寒湿、毒疫、伏毒、血热等。证候类型主要有肝郁脾虚证、脾气亏虚证、脾虚湿蕴证、气滞血瘀证、脾肾阳虚证、大肠湿热证、热毒炽盛证等。临床治疗注重将临床分期与辨证论治相结合,消补兼施,内外结合,取得了显著的临床疗效。 展开更多
关键词 溃疡性结肠炎 病因病机 证候 辨证 灌肠
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Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values
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作者 Pierluigi Marzuillo Stefano Guarino +5 位作者 Tiziana Esposito Anna Di Sessa Sara Immacolata Orsini Daniela Capalbo Emanuele Miraglia del Giudice Angela La Manna 《世界临床病例杂志》 2019年第9期1021-1027,共7页
BACKGROUND In paediatric patients with complicated nephrotic syndrome (NS), rituximab (RTX) administration can induce persistent IgG hypogammaglobulinemia among subjects showing low basal immunoglobulin G (IgG) levels... BACKGROUND In paediatric patients with complicated nephrotic syndrome (NS), rituximab (RTX) administration can induce persistent IgG hypogammaglobulinemia among subjects showing low basal immunoglobulin G (IgG) levels. AIM To evaluate the effect of RTX on IgG levels and infections in patients with complicated NS and normal basal IgG levels. METHODS We consecutively enrolled all patients with complicated NS and normal basal IgG levels undergoing the first RTX infusion from January 2008 to January 2016. Basal IgG levels were dosed after 6 wk of absent proteinuria and with a maximal interval of 3 mo before RTX infusion. The primary outcome was the onset of IgG hypogammaglobulinemia during the follow-up according to the IgG normal values for age [mean ± standard deviation (SD)]. RESULTS We enrolled 20 patients with mean age at NS diagnosis of 4.2 ± 3.3 years. The mean age at the first RTX infusion was 10.9 ± 3.5 years. Eleven out of twenty patients (55%) developed IgG hypogammaglobulinemia. None of these patients showed severe or recurrent infections. Only one patient suffered from recurrent acute otitis media and underwent substitutive IgG infusion. Three patients undergoing only the two “starting doses” experienced normalization of IgG levels. Using Kaplan-Meier analysis, the cumulative proportion of patients free of IgG hypogammaglobulinemia was 57.8% after the first RTX dose, 51.5% after the third dose, 44.1% after the fourth dose, and 35.5% after the fifth dose.CONCLUSION RTX can induce IgG hypogammaglobulinemia in patients with pre-RTX IgG normal values. None of the treated patients showed severe infections. 展开更多
关键词 Nephrotic SYNDROME RITUXIMAB IGG hypogammaglobulinemia IMMUNOGLOBULIN
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基于临床辨证的类风湿关节炎常见中医证候Logistic回归分析
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作者 王伟杰 唐晓颇 +2 位作者 王新昌 范永升 姜泉 《中华中医药杂志》 CAS CSCD 北大核心 2019年第2期807-810,共4页
目的:采用Logistic回归分析方法探讨类风湿关节炎(RA)症状、舌脉与常见中医证候之间的关系,为指导临床辨证提供科学依据。方法:采用前瞻、多中心的横断面观察性研究方法,于北京、杭州两地5家医疗机构共采集302例RA患者,应用SPSS 20.0软... 目的:采用Logistic回归分析方法探讨类风湿关节炎(RA)症状、舌脉与常见中医证候之间的关系,为指导临床辨证提供科学依据。方法:采用前瞻、多中心的横断面观察性研究方法,于北京、杭州两地5家医疗机构共采集302例RA患者,应用SPSS 20.0软件对所得数据进行Logistic回归分析。结果:通过Logistic回归分析,得到了RA 6个常见证候中与证候诊断相关的症状表现。风湿痹阻证:关节疼痛游走不定和怕风怕凉;寒湿痹阻证:舌体胖大、舌质淡暗、舌质淡白;湿热瘀阻证:关节触热、舌苔薄黄、舌苔黄腻、脉率数、脉势滑;痰瘀痹阻证:关节刺痛、关节周围或皮下结节、舌质青紫、脉位沉、脉形弦;气血两虚证:神疲乏力;肝肾不足证:腰膝酸软无力、肢体沉重、舌苔少苔、脉形细。结论:本研究借助Logistic回归分析方法,归纳出RA主要证候与症状、舌脉之间的相关关系,为临床辨证提供了客观依据。 展开更多
关键词 类风湿关节炎 LOGISTIC回归分析 证候 症状 临床流行病学
Effects of medicinal diets on patients with non-small cell lung cancer undergoing chemotherapy 预览
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作者 Liang Lei Li-Sen Wang 《TMR食疗与健康管理》 2019年第2期44-49,共6页
Chemotherapy is the main treatment for non-small cell lung cancer(NSCLC),but it often leads to serious side effects.Modern studies indicated that medicinal diets can reduce the side effects of chemotherapy.However,bli... Chemotherapy is the main treatment for non-small cell lung cancer(NSCLC),but it often leads to serious side effects.Modern studies indicated that medicinal diets can reduce the side effects of chemotherapy.However,blindly taking medicinal diet always fails to achieve curative effect and even aggravates the patient's condition.In order to provide dietary guidance for NSCLC patients undergoing chemotherapy,based on the basic theory of traditional Chinese medicine,the article elaborates the application of medicinal diets in those NSCLC patients who have been treated by chemotherapy. 展开更多
关键词 MEDICINAL DIETS NON-SMALL cell LUNG cancer CHEMOTHERAPY Syndrome DIFFERENTIATION and treatment Mechanisms
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De-escalation of anti-platelet therapy in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a narrative review
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作者 Ya-Ling Han 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第2期197-210,共14页
Objective:Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of treatment in patients with acute coronary syndromes (ACS) and in those undergoing percutaneous coronary inte... Objective:Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of treatment in patients with acute coronary syndromes (ACS) and in those undergoing percutaneous coronary intervention (PCI).In current clinical situation, availability of different oral P2Y12 inhibitors (clopidogrel, prasugrel, and ticagrelor) has enabled physicians to switch among therapies owing to specific clinical scenarios.Although optimum time, loading dose and interval of transition between P2Y12 inhibitors is still controversial and needs further evidence, switching between oral inhibitors frequently occurs in clinical practice for several reasons.Data sources:This review was based on data in articles published in PubMed up to June 2018, with the following keywords "antiplatelet therapy" , "ACS" , "PCI" , "ticagrelor" and "clopidogrel" .Study selection:Original articles and critical reviews on de-escalation strategy in ACS patients after PCI were selected.References of the retrieved articles were also screened to search for potentially relevant papers.Results:Safety concerns associated with switching between antiplatelet agents, has prompted the use of clopidogrel for patients with ACS especially after PCI as a de-escalation strategy.Practical considerations for de-escalating therapies in patients with ACS such as reducing dose of P2Y12 inhibitors or shortening duration of DAPT (followed by aspirin or P2Y12 receptor inhibitor monotherapy) as potential options are yet to be standardized and validated.Conclusions:Current review will provide an overview of the pharmacology of common P2Y12 inhibitors, definitions of deescalation and different de-escalating strategies and its outcomes, along with possible direction to be explored in de-escalation. 展开更多
关键词 ACUTE CORONARY SYNDROME ANTIPLATELET therapy CLOPIDOGREL De-escalation Ticagrelor
Insulin Resistance in Polycystic Ovary Syndrome Improved by Chinese Medicine Dingkun Pill(定坤丹):A Randomized Controlled Clinical Trial
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作者 DENG Yan XUE Wei +7 位作者 WANG Yan-fang LIU Xiao-hui ZHU Shi-yang MA Xiao ZUO Hong-ling JIANG Jian-fa ZHENG Ting-ping SUN Ai-jun 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第4期246-251,共6页
Objective: To assess the ef?cacy and safety of the Chinese medicine Dingkun Pill(定坤丹,DKP) on insulin resistance in women with polycystic ovary syndrome(PCOS).Methods: A total of 117 women with PCOS were randomly as... Objective: To assess the ef?cacy and safety of the Chinese medicine Dingkun Pill(定坤丹,DKP) on insulin resistance in women with polycystic ovary syndrome(PCOS).Methods: A total of 117 women with PCOS were randomly assigned to Group A(38 women),Group B(40 women),or Group C(39 women) in a randomization sequence with SAS software and a 1:1:1 allocation ratio using random block sizes of 6,and were given 7 g of oral DKP daily(Group A),1 tablet of Diane-35 orally daily(Group B),or 7 g of oral DKP daily plus 1 tablet of Diane-35 orally daily(Group C).Patients took all drugs cyclically for 21 consecutive days,followed by 7 drug-free days.The treatment course for the 3 groups was continued for 3 consecutive months.Oral glucose tolerance tests(OGTT)were performed before treatment and again after 2 and 3 months of therapy,respectively,and homeostasis model assessment for insulin resistance(HOMA-IR) and quantitative insulin sensitivity check index(QUICKI) were calculated.Results: Of 117 women with PCOS,110 completed the entire course of therapy: 35 in Group A,36 in Group B,and 39 in Group C.After treatment,all three groups showed signi?cant decreases in fasting glucose: at1 h glucose decreased signi?cantly in Group A(by 0.5±1.4 mmol/L,P=0.028) and Group C(by 0.5±1.2 mmol/L,P=0.045);while showing a tendency to increase in Group B(by 0.4±1.9 mmol/L,P=0.238).HOMA-IR decreased signi?cantly in Group C [by 0.5(–2.2 to 0.5) m IU mmol/L2,P=0.034].QUICKI was signi?cantly increased in Groups A and C(by 0.009±0.02,P=0.033 and by 0.009±0.027,P=0.049,respectively),while no change was observed in Group B.Repeated-measure ANOVA showed that the absolute changes in all parameters(except for glucose at1 h),including glucose and insulin levels at all time-points during OGTT and in HbA1 c,HOMA-IR,and QUICKI,were not signi?cantly different among the 3 groups after treatment(P>0.05).Conclusion: DKP or DKP combined with Diane-35 produce a slight improvement in insulin sensitivity compared with Diane-35 alone in PCOS patients(Trial Regis 展开更多
关键词 DIANE-35 Dingkun PILL Chinese medicine POLYCYSTIC OVARY syndrome oral glucose tolerance tests insulin resistance
心悸证素研究
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作者 王慧敏 杨涛 骆文斌 《中医药学报》 CAS 2019年第1期14-16,共3页
藏象辨证理论体系的核心理论-证素辨证,揭示了辨证的基本原理和普遍规律。采用回顾性临床病例调查方法,收集112例心悸病例,在规范临床信息的基础上提取病位和病性特征,归纳其常见症状与体征。利用spss统计软件进行聚类分析,研究其证素... 藏象辨证理论体系的核心理论-证素辨证,揭示了辨证的基本原理和普遍规律。采用回顾性临床病例调查方法,收集112例心悸病例,在规范临床信息的基础上提取病位和病性特征,归纳其常见症状与体征。利用spss统计软件进行聚类分析,研究其证素分布和组合规律,使中医研究心悸病证更加深入和规范,以期对临床辨证论治提供参考。 展开更多
关键词 心悸 证素 流行病学
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200例酒精性肝病患者中医证候分布调查分析 预览
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作者 傅克模 谢圣影 +4 位作者 莫耘松 孟爱红 高建华 程时峰 戴东良 《中西医结合肝病杂志》 CAS 2019年第2期133-136,共4页
目的:探索酒精性肝病的中医证候分布特点,为酒精性肝病预防及治疗提供依据。方法:运用数据挖掘技术,以因子分析优化方案和回归分析方法,对200例酒精性肝病患者的证候分布进行统计分析。结果:通过本研究获得14种常见的酒精性肝病中医证... 目的:探索酒精性肝病的中医证候分布特点,为酒精性肝病预防及治疗提供依据。方法:运用数据挖掘技术,以因子分析优化方案和回归分析方法,对200例酒精性肝病患者的证候分布进行统计分析。结果:通过本研究获得14种常见的酒精性肝病中医证候类型,分别为肝胃不和证(6.5%)、湿热内蕴证(10.0%)、肝胃积热证(7.5%)、脾虚湿困证(6.5%)、肝胃气滞证(3.5%)、肝胃气滞阴虚证(9.5%)、脾虚气滞证(8.0%)、肝胆湿热证(9.0%)、痰湿瘀滞证(6.0%)、湿困脾胃证(5.0%)、脾虚痰湿证(10.0%)、气虚气滞证(4.5%)、肝胃阴虚证(5.0%)、气滞痰凝证(9.0%)等。回归分析显示轻症酒精性肝病与气虚气滞证显著相关(P=0.007 <0.01);酒精性肝炎与湿热内蕴证(P=0.000<0.01)、肝胃气滞证(P=0.016<0.05)、痰湿瘀滞证(P=0.018<0.05)、脾虚气滞证(P=0.026 <0.05)显著相关;酒精性肝硬化与肝胆湿热证显著相关(P=0.01);酒精性脂肪肝优势相关证型不明显(P>0.05)。结论:以因子分析方法等数据挖掘技术所获得的证候分布,能够客观阐释中医证候分布特点,比较适用于中医证候的研究。 展开更多
关键词 酒精性肝病 证候 因子分析 回归分析
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Liver involvement in the drug reaction, eosinophilia, and systemic symptoms syndrome
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作者 Sylvia A Martinez-Cabriales Neil H Shear Emmanuel I Gonzalez-Moreno 《世界临床病例杂志》 2019年第6期705-716,共12页
First described in 1996, the drug reaction, eosinophilia, and systemic symptoms syndrome (DReSS) is considered, along with Stevens-Johnson syndrome and toxic epidermal necrolysis, a severe cutaneous drug reaction. It ... First described in 1996, the drug reaction, eosinophilia, and systemic symptoms syndrome (DReSS) is considered, along with Stevens-Johnson syndrome and toxic epidermal necrolysis, a severe cutaneous drug reaction. It is characterized by the presence of a maculopapular erythematous skin eruption, fever, lymphadenopathy, influenza-like symptoms, eosinophilia, and visceral involvement such as hepatitis, pneumonitis, myocarditis, pericarditis, nephritis, and colitis. The prognosis of patients with DReSS is related to the severity of visceral involvement. The mortality ranges from approximately 5% to 10%, and death is mainly due to liver failure, which is also the organ most commonly involved in this syndrome. Although it was previously hypothesized in 1994, DReSS syndrome can lead to reactivation of one or more human herpesvirus family members. Now being included as diagnostic criteria in a proposed diagnostic score system, this reactivation can be detected up to 2-3 wk after DReSS syndrome onset. Other causes of mortality in DReSS syndrome include myocardial or pulmonary lesions and hemophagocytosis. We reviewed the literature of previously reported case-series of DReSS and liver involvement, highlighting the pattern of liver damage, the treatment used, and the outcome. 展开更多
关键词 DRUG reaction eosinophilia and SYSTEMIC SYMPTOMS SYNDROME SEVERE
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桑菊清解汤对大鼠单肺通气肺损伤的影响 预览
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作者 刘小平 朱小兵 吴论 《北方药学》 2019年第1期149-150,共2页
目的:评价桑菊清解汤对大鼠单肺通气肺损伤的影响。方法:健康成年雄性SD大鼠48只,体重300~350g,随机分为4组(n=12):对照组(C组)、双肺通气组(S组)、单肺通气组(D组)和桑菊清解汤组(SJ组)。采用大潮气量通气建立肺损伤模型,D组和SJ组气... 目的:评价桑菊清解汤对大鼠单肺通气肺损伤的影响。方法:健康成年雄性SD大鼠48只,体重300~350g,随机分为4组(n=12):对照组(C组)、双肺通气组(S组)、单肺通气组(D组)和桑菊清解汤组(SJ组)。采用大潮气量通气建立肺损伤模型,D组和SJ组气管插管行右肺通气1h,潮气量5mL/kg,频率80次/min,I∶E 1∶2;C组行气管插管自主呼吸。采用桑菊清解汤300g灌胃,1次/d,于第10次灌胃后2h时开始制备模型;C组、S组及D组给予等容量生理盐水。于机械通气前(T0)、机械通气结束时(T1)、机械通气后30min(T2)时采集动脉血样,检测动脉血气,测定呼吸指数(RI)和氧合指数(OI)后处死大鼠,取肺组织,ELISA法检测肺组织TNF-a、IL-6和IL-10的含量,肺组织湿/干重比(W/D)和HO-1表达,观察肺组织病理学改变。结果:与C组比较,D组和SJ组肺组织TNF-a、IL-6、IL-10含量及W/D比升高,HO-1表达上调(P<0.05),S组各指标差异无统计学意义;与S组比较,D组和SJ组肺组织HO-1表达上调,TNF-a、IL-6、IL-10含量及W/D比升高,RI升高,OI降低(P<0.05)。与D组比较,SJ组肺组织、IL-10含量升高,TNF-a、IL-6含量及W/D比降低,HO-1表达上调,RI降低、OI升高(P<0.05)。结论:桑菊清解汤可通过上调肺组织HO-1的表达进而减轻大鼠单肺通气所致肺损伤。 展开更多
关键词 桑菊清解汤 呼吸 人工 血红素加氧酶-1
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Ceftriaxone-induced immune hemolytic anemia in a case with large vestibular aqueduct syndrome after cochlear implant
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作者 Yu Wang Tao Pan +6 位作者 Fu-Rong Ma Ji-Jun Wang Ke Zhang Wei-Wei Pan Jing-Hui Zhang Zhan-Miao Yi Ying-Qiu Ying 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第1期100-102,共3页
To the Editor:Drug-induced immune hemolytic anemia (DIIHA)is a rare but severe condition.Ceftriaxone,a third-generation cephalosporin with a wide antibacterial spectrum and effective antibacterial action,is one of the... To the Editor:Drug-induced immune hemolytic anemia (DIIHA)is a rare but severe condition.Ceftriaxone,a third-generation cephalosporin with a wide antibacterial spectrum and effective antibacterial action,is one of the most common drugs causing DIIHA.^[1]Ceftriaxoneinduced immune hemolytic anemia (CIIHA)is a potentially fatal complication.^[2]Most of the patients were children.The reported fatality rate of CIIHA was as high as 40%. 展开更多
关键词 Ceftriaxone-induced immune HEMOLYTIC anemia large VESTIBULAR AQUEDUCT syndrome cochlear implant
Traditional Chinese medicine nursing protocols for acute attack of hepatolithiasis 预览
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作者 Editorial Board of Nursing of Integrated Traditional Chinese and Western Medicine 《中西医结合护理(中英文)》 2019年第2期229-234,共6页
Hepatolithiasis is characterized by the presence of stones within the intrahepatic bile ducts proximal to the right and left hepatic ducts. It is universally recognized that the occurrence of hepatolithiasis is closel... Hepatolithiasis is characterized by the presence of stones within the intrahepatic bile ducts proximal to the right and left hepatic ducts. It is universally recognized that the occurrence of hepatolithiasis is closely related to cholangitis, cholestasis, abnormal bile metabolism, anatomical abnormality of bile ducts, malnutrition and low socio-economic status. Surgery is the primary treatment method for hepatolithiasis in clinic, but some patients may still suffer from recurrence or complications after surgery. Traditional Chinese medicine(TCM) has its own unique advantages in preventing and treating recurrence of calculi. This article mainly explored the key points of common syndromes, TCM nursing methods and health guidance of acute attack of hepatolithiasis in order to further develop the advantages of TCM, improve its efficacy and standardized its nursing behavior. 展开更多
关键词 HEPATOLITHIASIS acute ATTACK JAUNDICE CONSTIPATION traditional Chinese medicine NURSING syndrome DIFFERENTIATION
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Bilateral adrenocortical adenomas causing adrenocorticotropic hormone-independent Cushing’s syndrome: A case report and review of the literature
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作者 Yu-Lin Gu Wei-Jun Gu +11 位作者 Jing-Tao Dou Zhao-Hui Lv Jie Li Sai-Chun Zhang Guo-Qing Yang Qing-Hua Guo Jian-Ming Ba Li Zang Nan Jin Jin Du Yu Pei Yi-Ming Mu 《世界临床病例杂志》 2019年第8期961-971,共11页
BACKGROUND Adrenocorticotropic hormone (ACTH)-independent Cushing’s syndrome (CS) is mostly due to unilateral tumors, with bilateral tumors rarely reported. Its common causes include primary pigmented nodular adrenoc... BACKGROUND Adrenocorticotropic hormone (ACTH)-independent Cushing’s syndrome (CS) is mostly due to unilateral tumors, with bilateral tumors rarely reported. Its common causes include primary pigmented nodular adrenocortical disease, ACTH-independent macronodular adrenal hyperplasia, and bilateral adrenocortical adenomas (BAAs) or carcinomas. BAAs causing ACTH?independent CS are rare;up to now, fewer than 40 BAA cases have been reported. The accurate diagnosis and evaluation of BAAs are critical for determining optimal treatment options. Adrenal vein sampling (AVS) is a good way to diagnose ACTH-independent CS. CASE SUMMARY A 31-year-old woman had a typical appearance of CS. The oral glucose tolerance test showed impaired glucose tolerance and obviously increased insulin and C?peptide levels. Her baseline serum cortisol and urine free cortisol were elevated and did not show either a circadian rhythm or suppression with dexamethasone administration. The peripheral 1-deamino-8-D-arginine-vasopressin (DDVAP) stimulation test showed a delay of the peak level, which was 1.05 times as high as the baseline level. Bilateral AVS results suggested the possibility of BAAs. Abdominal computed tomography showed bilateral adrenal adenomas with atrophic adrenal glands (right: 3.1 cm × 2.0 cm × 1.9 cm;left: 2.2 cm × 1.9 cm × 2.1 cm). Magnetic resonance imaging of the pituitary gland demonstrated normal findings. A left adenomectomy by retroperitoneoscopy was performed first,followed by resection of the right-side adrenal mass 3 mo later. Biopsy results of both adenomas showed cortical tumors. Evaluations of ACTH and cortisol showed a significant decrease after left adenomectomy but could still not be suppressed, and the circadian rhythm was absent. Following bilateral adenomectomy, this patient has been administered with prednisone until now, all of her symptoms were alleviated, and she had normal blood pressure without edema in either of her lower extremities. CONCLUSION BAAs causing ACTH-independent CS are rare. AVS is of 展开更多
关键词 BILATERAL adrenocortical ADENOMAS Adrenocorticotropic hormone-independent Cushing's syndrome ADRENAL VENOUS sampling Case report
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