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Prevalence of amblyopia in congenital blepharoptosis: a systematic review and Meta-analysis
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作者 Jia-Ying Zhang Xiao-Wei Zhu +2 位作者 Xia Ding Ming Lin Jin Li 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1187-1193,共7页
AIM: To con duct a systematic review and Meta-analysis of the published literature to evaluate the pooled prevalence rate of amblyopia in patients with congenital ptosis.METHODS: We searched the PubMed, Embase, the Co... AIM: To con duct a systematic review and Meta-analysis of the published literature to evaluate the pooled prevalence rate of amblyopia in patients with congenital ptosis.METHODS: We searched the PubMed, Embase, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Wanfang Data, and Chongqing VIP databases for studies reporting the prevalence of amblyopia in patients with congenital ptosis. The reference lists of relevant studies were scanned. Heterogeneity of effect sizes across studies was tested. We calculated prevalence ratios to compare prevale nee estimates for different causes of amblyopia in patients with congenital ptosis, as well as for different geographical regions, year of publication and sample size in subgroup analyses. A systematic review and Meta-analysis were performed.RESULTS: We identified 29 eligible surveys with a total population of 2436. Prevalence rates of amblyopia ranged from 13.8% to 69%. We noted substantial heterogeneity in prevalence estimates for amblyopia in congenital ptosis (Cochran's χ2 significant at P<0.0001;I^2=90%). The pooled prevalence using random-effects models of 29 studies was 32.8%(95%CI: 27.3%-38.4%) in the overall population. Compared to the overall pooled prevalence, amblyopia prevalence was higher in studies in which only subjects with blepharophimosis syndrome were included. CONCLUSION: We con firm that nearly on e-third of congenital ptosis patients are suffering from or at risk for amblyopia. Patients with blepharophimosis syndrome are more likely to develop amblyopia. The identification and management of amblyopia should be integral to the treatment of congenital ptosis. 展开更多
关键词 AMBLYOPIA CONGENITAL PTOSIS BLEPHAROPHIMOSIS systematic review
Investigational growth factors utilized in animal models of spinal fusion: Systematic review 预览
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作者 Ethan Cottrill A Karim Ahmed +10 位作者 Noah Lessing Zachary Pennington Wataru Ishida Alexander Perdomo-Pantoja Sheng-fu Lo Elizabeth Howell Christina Holmes C Rory Goodwin Nicholas Theodore Daniel M Sciubba Timothy F Witham 《世界骨科杂志(英文版)》 2019年第4期176-191,共16页
BACKGROUND Over 400000 Americans annually undergo spinal fusion surgeries, yet up to 40% of these procedures result in pseudoarthrosis even with iliac crest autograft, the current “gold standard” treatment. Tissue e... BACKGROUND Over 400000 Americans annually undergo spinal fusion surgeries, yet up to 40% of these procedures result in pseudoarthrosis even with iliac crest autograft, the current “gold standard” treatment. Tissue engineering has the potential to solve this problem via the creation of bone grafts involving bone-promoting growth factors (e.g., bone morphogenetic protein 2). A broad assessment of experimental growth factors is important to inform future work and clinical potential in this area. To date, however, no study has systematically reviewed the investigational growth factors utilized in preclinical animal models of spinal fusion. AIM To review all published studies assessing investigational growth factors for spinal fusion in animal models and identify promising agents for translation. METHODS We conducted a systematic review of the literature using PubMed, Embase, Cochrane Library, and Web of Science databases with searches run on May 29th, 2018. The search query was designed to include all non-human, preclinical animal models of spinal fusion reported in the literature without a timespan limit. Extracted data for each model included surgical approach, level of fusion, animal species and breed, animal age and sex, and any other relevant characteristics. The dosages/sizes of all implant materials, spinal fusion rates, and follow-up time points were recorded. The data were analyzed and the results reported in tables and text. PRISMA guidelines were followed for this systematic review. RESULTS Twenty-six articles were included in this study, comprising 14 experimental growth factors: AB204 (n = 1);angiopoietin 1 (n = 1);calcitonin (n = 3);erythropoietin (n = 1);basic fibroblast growth factor (n = 1);growth differentiation factor 5 (n = 4), combined insulin-like growth factor 1 + transforming growth factor beta (n = 4);insulin (n = 1);NELL-1 (n = 5);noggin (n = 1);P-15 (n = 1);peptide B2A (n = 2);and secreted phosphoprotein 24 (n = 1). The fusion rates of the current gold standard treatment (autologous ili 展开更多
关键词 SPINAL FUSION GROWTH FACTOR Pseudoarthrosis Systematic REVIEW
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基于灰色综合评价的毕业要求达成度评价与解析
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作者 瞿英 范默苒 +1 位作者 邵冬 吴长莉 《数学的实践与认识》 北大核心 2019年第11期254-260,共7页
毕业要求达成度是基于学习产出教育模式(Outcomes-based Education,OBE)的核心概念,对其评价的合理性直接影响到OBE教育模式的实施效果.以工程教育认证标准对毕业要求的12条能力中的研究能力综合评价为例,以信息管理与信息系统专业的人... 毕业要求达成度是基于学习产出教育模式(Outcomes-based Education,OBE)的核心概念,对其评价的合理性直接影响到OBE教育模式的实施效果.以工程教育认证标准对毕业要求的12条能力中的研究能力综合评价为例,以信息管理与信息系统专业的人才培养目标及学生的毕业要求为依托,建立研究能力指标点与支撑课程关系,形成毕业能力达成度评价指标,运用古林法确定各指标点课程的重要性,避免了主观赋权的弱点;运用灰色综合评价法,对毕业生个体毕业研究能力达成度进行评价,并建立毕业班级整体毕业研究能力达成度的两种评价方法,通过对比研究,给出评价方法使用建议,为OBE实施过程中科学有效评价毕业要求达成度提供方法上指导. 展开更多
关键词 成果导向 毕业要求达成度 灰色综合评价法 系统评价
法律行为的非有效及相关概念的体系化难点——以澳门现行法之规则为起点 预览
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作者 唐晓晴 王星 《求是学刊》 CSSCI 北大核心 2019年第1期119-130,共12页
'非有效'一词用来表示法律行为不发生预定效力的状态,然而它并不是一个被广泛认同的术语。实际上,关于效力的术语在罗马法当中就没有什么章法,《德国民法典》也并没有完成效力否定的体系化工作。相关术语在学理解释和法律移植... '非有效'一词用来表示法律行为不发生预定效力的状态,然而它并不是一个被广泛认同的术语。实际上,关于效力的术语在罗马法当中就没有什么章法,《德国民法典》也并没有完成效力否定的体系化工作。相关术语在学理解释和法律移植过程中,又随着时间而不断演化,生出了更多疑窦。可见,效力否定术语难以体系化的现象,只能在术语的使用中逐渐积累共识,再加以解决。因为这种混乱的形成,本就是历史的结果,是文化的结果,而不是始发的预先安排。 展开更多
关键词 法律行为非有效 无效 可撤销 体系化
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Association of proton pump inhibitors with risk of hepatic encephalopathy in advanced liver disease: A meta-analysis 预览
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作者 Xin-Xing Tantai Long-Bao Yang +4 位作者 Zhong-Cao Wei Cai-Lan Xiao Li-Rong Chen Jin-Hai Wang Na Liu 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第21期2683-2698,共16页
BACKGROUND Several studies have explored the association between the use of proton pump inhibitors (PPIs) and the risk of developing hepatic encephalopathy (HE) in patients with advanced liver disease. However, the ev... BACKGROUND Several studies have explored the association between the use of proton pump inhibitors (PPIs) and the risk of developing hepatic encephalopathy (HE) in patients with advanced liver disease. However, the evidence-based conclusions are controversial. We hypothesized that using PPIs may increase the risk of HE in patients with advanced liver disease. If confirmed, clinicians must strictly adhere to the indications for PPI treatment in this population. AIM To evaluate the pooled risk of HE in patients with advanced liver disease who use PPIs. METHODS Three electronic databases (PubMed, EMBASE, and the Cochrane Library) were searched from the date of database inception through January 8, 2019 to identify comparative studies evaluating the association between PPI use and the risk of HE. Data from the included studies were extracted. The random-effects model was used for pooling risk estimates and the corresponding 95% confidence intervals (CIs). Subgroup and sensitivity analyses were also performed. RESULTS In total, 4342 patients from five case-control studies and 188053 patients from four cohort studies were included in this analysis. In patients with advanced liver disease, PPI use was associated with an elevated risk of developing HE, with significant heterogeneity. The pooled odds ratio for case-control studies was 2.58 (95%CI: 1.68-3.94, I2 = 72%). The pooled RR for cohort studies was 1.67 (95%CI: 1.30-2.14, I2 = 67%). The results of the subgroup analyses suggested that the heterogeneity may be the result of differences in the study designs and the definitions of PPI use. The sensitivity and subgroup analyses did not alter our findings. CONCLUSION In patients with advanced liver disease, PPI use is associated with an elevated risk of HE. Future large prospective studies are needed to confirm this association. 展开更多
关键词 PROTON PUMP INHIBITORS CIRRHOSIS Hepatic ENCEPHALOPATHY Systematic review META-ANALYSIS
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Reporting and methodological quality of systematic reviews or meta-analyses in nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis 预览
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作者 Si-Yuan Yang Li-Min Guo +1 位作者 Yuan Jia Fan-Jie Meng 《TMR食疗与健康管理》 2019年第2期35-43,共9页
Objective:To evaluate the methodological and reporting quality of systematic reviews and meta-analyses(SRs/MAs)in the nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis(SAP).Methods:The SRs/MA... Objective:To evaluate the methodological and reporting quality of systematic reviews and meta-analyses(SRs/MAs)in the nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis(SAP).Methods:The SRs/MAs of nasogastric and nasojejunal enteral nutrition for SAP published in the journal before July.1st 2018 were identified by searching the databases of OVID,Cochrane Library,Wiley,PubMed,CNKI,Wanfang Data and VIP.The methodological and reporting quality of included studies was respectively assessed by AMSTAR 2 scale and PRISMA statement.Results:A total of 6 articles included at last.(1)Several issues of methodological quality in 6 studies were reviewed,such as:no prior design,comprehensive searching strategy,assessment of publication bias,the reason for incorporating the type of research design,or the statement of conflict of interest.(2)The average PRISMA score is 18.83±1.97(17-22).Results on the quality of reporting evaluation showed that 5 SRs/MAs were rated as moderate and 1 as high.What’s more,we assessed the quality of indicators of the result by GRADE,but the grade was low.Conclusion:The quality of the involved studies published at home and abroad is uneven,so it is necessary to seek for further improvement of methodology and standardization of reporting to provide high-quality support for evidenced-based decision. 展开更多
关键词 ENTERAL NUTRITION SEVERE acute pancreatiti Systematic review META-ANALYSIS AMSTAR 2 PRISMA
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新时代国际贸易理论与政策课程体系建设问题研究--以北方民族大学国际经济与贸易专业为例 预览
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作者 夏合群 《对外经贸》 2019年第7期144-145,共2页
课程体系建设是专业体系建设和专业课程(群)体系建设的基础。首先分析当前国际贸易理论与政策课程体系存在的问题,接着分析建设系统化的国际贸易理论与政策课程群的意义,提出课程体系建设过程中要与师资队伍、教材建设、实践教学有机结... 课程体系建设是专业体系建设和专业课程(群)体系建设的基础。首先分析当前国际贸易理论与政策课程体系存在的问题,接着分析建设系统化的国际贸易理论与政策课程群的意义,提出课程体系建设过程中要与师资队伍、教材建设、实践教学有机结合,整合课程资源,改革授课方式,形成多层次的专业课程群的构想。对于深化高校课程体系改革,利用"互联网+"等技术建立在线教学平台,促进高校课程体系建设和质量工程的发展有一定的促进作用。 展开更多
关键词 国际贸易理论与政策 课程体系 系统化 互联网+
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Speech databases for mental disorders: A systematic review 预览
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作者 Yiling Li Yi Lin +1 位作者 Hongwei Ding Chunbo Li 《综合精神医学(英文)》 CSCD 2019年第3期119-129,共11页
Background The employment of clinical databases in the study of mental disorders is essential to the diagnosis and treatment of patients with mental illness. While text corpora obtain merely limited information of con... Background The employment of clinical databases in the study of mental disorders is essential to the diagnosis and treatment of patients with mental illness. While text corpora obtain merely limited information of content, speech corpora capture tones, emotions, rhythms and many other signals beyond content. Hence, the design and development of speech corpora for patients with mental disorders is increasingly important. Aim This review aims to extract the existing speech corpora for mental disorders from online databases and peer-reviewed journals in order to demonstrate both achievements and challenges in this area. Methods The review first covers publications or resources worldwide, and then leads to the reports from China, followed by a comparison between Chinese and nonChinese regions. Results Most of the speech databases were recorded in Europe or the United States by audio or video. Some were even supplemented by brain images and Event- Related Potential (ERP) statistics. The corpora were mostly developed for patients with neurocognitive disorders like stutter and aphasia, and mental illness like dementia, while other types of mental illness such as bipolar disorder, anxiety, d即ression and autism were scarce in number in database development. Strengths and limitations The results demonstrated that database development of neurocognitive disorders in China is much scarcer than that in some European countries, but the existing databases pave an instructive road for psychiatric problems. Also, the methods and applications of databases from the leading countries are inspiring for Chinese scholars, who are searchi ng methods for developing a comprehensive resource for clinical studies. 展开更多
关键词 SPEECH DATABASES MENTAL DISORDERS A systematic REVIEW
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Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis 预览
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作者 Fernanda P Logiudice Wanderlei M Bernardo +9 位作者 Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura 《世界胃肠内镜杂志:英文版(电子版)》 2019年第4期281-291,共11页
BACKGROUND For palliation of malignant biliary obstruction (MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography (ERCP) with the placement of metallic stents. Endoscopic... BACKGROUND For palliation of malignant biliary obstruction (MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography (ERCP) with the placement of metallic stents. Endoscopic ultrasound (EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure. Recently, however, there have been robust randomized clinical trials (RCTs) comparing EUS-guided drainage and ERCP as primary approaches to MBO. AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO. METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation criteria. RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients (112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96% and 91.81%, respectively, with a risk difference (RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97;I2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of ?0.01%(95%CI:-0.12, 0.10;P = 0.90;I2 = 0%). The mean difference (MD) for the duration of the procedure was -0.12%(95%CI:-8.20, 7.97;P = 0.98;I2 = 84%). In the EUS and ERCP groups, there were 14 and 25 adverse events, respectively, with an RD of -0.06%(95%CI:-0.23, 0.12;P = 0.54;I2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18;P = 0.19;I2 = 44%). The stent dysfunction rate was significantly lower in the EUS group (MD =-0. 展开更多
关键词 Common bile duct neoplasms ENDOSCOPIC retrograde cholangiopancreatography ENDOSONOGRAPHY Ultrasonography Interventional/methods ENDOSCOPIC ultrasound Systematic review META-ANALYSIS
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Cautery-assisted palatal stiffening operation for obstructive sleep apnea: A systematic review and meta-analysis
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作者 Charles M.Llewellyn Michael W.Noller Macario Camacho 《世界耳鼻咽喉头颈外科杂志(英文)》 2019年第1期49-56,共8页
Objective:To systematically review outcomes for cautery-assisted palatal stiffening operation (CAPSO) as a treatment for adult obstructive sleep apnea (OSA).Methods:Five databases (including PubMed/MEDLINE) were searc... Objective:To systematically review outcomes for cautery-assisted palatal stiffening operation (CAPSO) as a treatment for adult obstructive sleep apnea (OSA).Methods:Five databases (including PubMed/MEDLINE) were searched through July 12,2017.Results:Eight studies (307 patients) met criteria.Overall,CAPSO alone (80 patients) improved AHI from a mean ± standard deviation (M±SD) of (16.8±11.9) to (9.9±10.9) events/h (41.1% decrease).Mixed CAPSO with/without tonsillectomy (92 patients) improved AHI from a M] SD of (24.8 ± 12.6) to (10.6 ± 9.5) events/h (61.7% decrease).CAPSO with expansion pharyngoplasty (EP),(78 patients) improved AHI from a M ± SD of (26.3 ± 17.7) to (12.6 ± 5.8) events/h (52.1% decrease).CAPSO alone (90 patients) improved lowest oxygen saturation (LSAT) by 5.4 points.Mixed CAPSO with/without tonsillectomy (77 patients) improved LSAT by 10.6 points,and CAPSO with EP (78 patients) improved LSAT by 5.2 points.Sleepiness improved (182 patients) from an Epworth Sleepiness Scale score of 11.8 to 5.1,P < 0.001.Snoring reduced (120 patients) from 7.9 to 2.5 on visual analog scales (0-10 scale),P < 0.001.Conclusions:Apnea-hypopnea index has improved by 41.0% for CAPSO alone,61.7% for CAPSO with tonsillectomy and 52.1% for CAPSO with expansion pharyngoplasty.Additionally,lowest oxygen saturation,sleepiness and snoring have also improved after CAPSO. 展开更多
关键词 Surgery SLEEP APNEA SYNDROMES Systematic review META-ANALYSIS
罪刑法定原则与刑法基本原则体系的结构性 预览
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作者 马荣春 《时代法学》 2019年第2期24-30,共7页
罪刑法定原则、罪责性相适应原则和适用刑法人人平等原则,在相互蕴含之中构成了刑法基本原则体系。罪刑法定原则是刑法基本原则的“龙头”和“奠基”,其保障权利的核心价值和由形式侧面与实质层面所合成的内在构造延伸着刑法基本原则的... 罪刑法定原则、罪责性相适应原则和适用刑法人人平等原则,在相互蕴含之中构成了刑法基本原则体系。罪刑法定原则是刑法基本原则的“龙头”和“奠基”,其保障权利的核心价值和由形式侧面与实质层面所合成的内在构造延伸着刑法基本原则的“经脉”;罪责刑相适应原则是刑法基本原则体系的“中枢”,其在刑法基本原则体系中起着“承上启下”的作用;适用刑法人人平等原则,是罪刑法定原则和罪责性相适应原则的当然延伸,其构成了刑法基本原则中的一种“补强”。刑法基本原则体系是一个有机的“结构体系”,从而是一个完整的“功能体系”,同时是一个有机和完整的“认知体系”与“价值体系”。刑法基本原则体系观念是刑法法治和权利保障的最大保障。 展开更多
关键词 刑法基本原则 罪刑法定原则 罪责性相适应原则 适用刑法人人平等原则 体系性
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系统化康复护理促进脑卒中患者有效康复
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作者 段懿 罗凤 刘玲 《基因组学与应用生物学》 CAS CSCD 北大核心 2019年第4期1791-1796,共6页
为了探讨系统化康复护理对脑卒中患者有效的康复效果,本研究选取132例脑卒中患者,采用随机数字表法将患者随机分为观察组(n=68)和对照组(n=64),观察组给予系统化康复护理,对照组给予常规护理,采用简易智能状态检查量表(MMSE)和洛文斯顿... 为了探讨系统化康复护理对脑卒中患者有效的康复效果,本研究选取132例脑卒中患者,采用随机数字表法将患者随机分为观察组(n=68)和对照组(n=64),观察组给予系统化康复护理,对照组给予常规护理,采用简易智能状态检查量表(MMSE)和洛文斯顿作业疗法认知评定量表(LOTCA)评估患者认知功能,采用Barthel指数(BI)评估患者日常生活能力,采用抑郁自评量表(SDS)评估患者抑郁情况。MMSE评估结果表明,观察组干预后定向力、注意力和计算力、语言能力以及MMSE总分分别为(9.24±1.31)分、(4.54±0.97)分、(7.86±1.22)分和(25.57±2.03)分,明显高于对照组(p<0.05);LOTCA结果表明,观察组干预后定向力、知觉、视运动、思维能力以及LOTCA总分分别为(5.30±1.24)分、(13.24±1.90)分、(17.41±2.55)分、(18.16±1.80)分和(55.64±4.56)分,明显高于对照组(p<0.05);观察组干预后BI评分为(76.82±10.46)分,明显高于对照组(p<0.05);观察组干预后SDS评分为(42.15±6.41)分,明显低于对照组(p<0.05)。初步的研究表明,系统化康复护理对脑卒中患者康复有较好的促进作用,明显改善了患者认知功能、日常生活能力以及抑郁状态,值得临床上推广使用。 展开更多
关键词 系统化 康复护理 脑卒中 认知功能 日常生活能力 抑郁
Pancreatogastrostomy vs pancreatojejunostomy after pancreaticoduodenectomy:An updated meta-analysis of RCTs and our experience 预览
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作者 Yun Jin Yang-Yang Feng +4 位作者 Xiao-Gang Qi Geng Hao Yuan-Quan Yu Jiang-Tao Li Shu-You Peng 《世界胃肠外科杂志:英文版(电子版)》 2019年第7期322-332,共11页
BACKGROUND Pancreatoduodenectomy(PD)is one of the most important operations in hepatobiliary and pancreatic surgery.AIM To evaluate the advantages and disadvantages of pancreaticojejunostomy(PJ)and pancreaticogastrost... BACKGROUND Pancreatoduodenectomy(PD)is one of the most important operations in hepatobiliary and pancreatic surgery.AIM To evaluate the advantages and disadvantages of pancreaticojejunostomy(PJ)and pancreaticogastrostomy(PG).METHODS This meta-analysis was performed using Review Manager 5.3.All clinical randomized controlled trials,in which patients underwent PD with pancreaticodigestive tract reconstruction via PJ or PG,were included.RESULTS The search of PubMed,Wanfang Data,EMBASE,and the Cochrane Library provided 125 citations.After further analysis,11 trials were included from nine counties.In all,909 patients underwent PG and 856 underwent PJ.Meta-analysis showed that pancreatic fistula(PF)was a significantly lower morbidity in the PG group than in the PJ group(odds ratio[OR]=0.67,95%confidence interval[CI]:0.53-0.86,P=0.002);however,grades B and C PF was not significantly different between the two groups(OR=0.61,95%CI:0.34-1.09,P=0.09).Postoperative hemorrhage showed a significantly lower morbidity in the PJ group than in the PG group(OR=1.47,95%CI:1.05-2.06,P=0.03).Delayed gastric emptying was not significantly different between the two groups(OR=1.09,95%CI:0.83-1.41,P=0.54).CONCLUSION There is no difference in the incidence of grades B and C PF between the two groups.However,postoperative bleeding is significantly higher in PG than in PJ.Binding PJ or binding PG is a safe and secure technique according to our decades of experience. 展开更多
关键词 PANCREATICOJEJUNOSTOMY PANCREATICOGASTROSTOMY Systematic review Metaanalysis
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Treatment options for rumination syndrome: A systematic review 预览
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作者 Andrew Ming-Liang Ong Shu-Wen Tay Yu-Tien Wang 《世界荟萃分析杂志》 2019年第6期297-308,共12页
BACKGROUND Rumination syndrome (RS) is characterized by recurrent effortless postprandial regurgitation of recently ingested food from the stomach to the oral cavity and has been associated with quality of life impair... BACKGROUND Rumination syndrome (RS) is characterized by recurrent effortless postprandial regurgitation of recently ingested food from the stomach to the oral cavity and has been associated with quality of life impairment and malnutrition. There is a general lack of consensus on the most appropriate treatment options for RS. AIM To summarize the literature on treatment options for RS. METHODS We conducted a systematic review according to PRISMA guidelines. We searched Medline (1946 to February 2019), EMBASE (1947 to February 2019), PsycINFO (1806 to February 2019) and Cochrane central register of controlled trials for articles discussing treatment options for adult patients (> 18 years) with RS. All relevant articles were accessed in full text. We extracted data on study designs, patient profiles, duration of symptoms, follow up periods, date, diagnostic criteria, interventions and outcomes. Risk of bias assessment was carried out independently by 3 reviewers via Cochrane Risk of Bias tool and Newcastle Ottawa Scale for randomized controlled trials and Cohort studies respectively. RESULTS Twelve articles were identified. A total of 254 patients were included in the analysis, with a mean age of 36.1 (range 18-89). 185 patients (72.8%) were females. 5 studies looked into behavioral therapies, primarily diaphragmatic breathing (DB) 2 studies looked at baclofen, 1 fundoplication and 1 supportive lifestyle changes. 3 studies looked at a combination of therapies involving pharmacological, behavioral and psychotherapies. CONCLUSION Although evidence for treatment options is still limited, the strongest evidence point towards the use of DB and Baclofen, and both should be considered depending on their availabilities. 展开更多
关键词 RUMINATION RUMINATION SYNDROME DIAPHRAGMATIC BREATHING TREATMENT Systematic REVIEW
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Benefits and Safety of Tripterygium Glycosides and Total Glucosides of Paeony for Rheumatoid Arthritis: An Overview of Systematic Reviews
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作者 LUO Jing SONG Wei-jiang +3 位作者 XU Yuan CHEN Guang-yao HU Qi TAO Qing-wen 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第9期696-703,共8页
Objective: To summarize the evidence from systematic reviews(SRs) on the benefits and safety of Tripterygium glycosides(TG) and total glucosides of paeony(TGP), commonly used to treat rheumatoid arthritis(RA) in China... Objective: To summarize the evidence from systematic reviews(SRs) on the benefits and safety of Tripterygium glycosides(TG) and total glucosides of paeony(TGP), commonly used to treat rheumatoid arthritis(RA) in China, for patients with RA. Methods: SRs of randomized controlled trials(RCTs) on TG or TGP in treating RA were included, by searching 8 databases from their inception until December 2017. Two authors extracted data independently. We assessed the quality of SRs using AMSTAR and graded the quality of evidence according to the GRADE approach. Results: Eleven SRs containing an average of 7.6 RCTs, involving a total of 7,012 participants were included in this overview. On the basis of included SRs, TG and TGP could improve the following indexes for RA patients: American College of Rheumatology(ACR) 20 response rate, ACR50 response rate and ACR70 response rate, swollen joint count, tender joint count, erythrocyte sedimentation rate and C-reactive protein. Moreover, TGP could reduce incidence of hepatotoxicity. The most common adverse effects of TG were gastrointestinal discomfort and gonad toxicity, while for TGP was mild to moderate diarrhea. The overall quality of evidence for these findings ranged from "low" to "moderate". Conclusions: TG and TGP might be 2 potentially effective complementary and alternative drugs for patients with RA. Nevertheless, due to gonad toxicity, TG should only be considered in elderly patients or patients without reproductive needs. More evidence from high quality RCTs and SRs is warranted to support the use of TG and TGP for RA patients. 展开更多
关键词 RHEUMATOID ARTHRITIS TRIPTERYGIUM GLYCOSIDES total GLUCOSIDES of paeony OVERVIEW systematic review
The relationship between human papillomavirus and penile cancer over the past decade:a systematic review and meta-analysis
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作者 Yong-Bo Yu Yong-Hua Wang +4 位作者 Xue-Cheng Yang Yang Zhao Mei-Lan Wang Ye Liang Hai-Tao Niu 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第4期375-380,共6页
Human papillomavirus (HPV) infection appears to play an important role in the development of penile cancer (PeCa), but their relationship remains unclear. Therefore, we performed a systematic review and meta-analysis ... Human papillomavirus (HPV) infection appears to play an important role in the development of penile cancer (PeCa), but their relationship remains unclear. Therefore, we performed a systematic review and meta-analysis to elucidate their relationship. We systematically searched Embase, PubMed, Cochrane Library, and Web of Science for case-control studies and cross-sectional studies using polymerase chain reaction (PCR) tech no logy on formali n?fixed paraffi n-embedded (FFPE) or pa raff i n-embedded (PE) PeCa tissues to detect HPV (published between January 1, 2007, and December 29, 2017;no language restrictions). Twenty-two studies were identified, and 1664 cases were available for analysis. The combined HPV infectious risk of PeCa is 51.0%(95% confidence interval [Cl]: 43.0%-60.0%). The three most common subtypes of HPV were HPV16 (28.5%), HPV18 (2.3%), and HPV6 (2.3%). The virus was relevantly associated with basaloid (85.5%, 95% Cl: 77.2%-93.8%) and warty (50.0%, 95% Cl: 35.2%-64.8%) carcinomas. The invasiveness of PeCa was not associated with HPV (X^2 = 0.181, df = 1, P< 0.671). HPV infection in PeCa tended to be moderately differentiated (54.4%, 95% Cl: 47.7%-61.1%). This study found that almost half of PeCa patients are associated with HPV. The most comm only associated geno type is HPV16, but several other geno types were also detected. In addition to types 6 and 11, other single low-risk HPV infections have been found to contribute to PeCa to a lesser degree. HPVpositive tumors tend to exhibit warty and/or basaloid features, corresponding to a moderate histological grade. The role of HPV in PeCa should be revisited to provide evidenee for the development of PeCa in the presenee of HPV infection. 展开更多
关键词 human PAPILLOMAVIRUS PENILE cancer systematic REVIEW and META-ANALYSIS
MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis 预览
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作者 Nan-Xing Yi Long-Yun Zhou +8 位作者 Xiao-Yun Wang Yong-Jia Song Hai-Hui Han Tian-Song Zhang Yong-Jun Wang Qi Shi Hao Xu Qian-Qian Liang Ting Zhang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1919-1931,共13页
OBJECTIVE: To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury.DATA SOURCES: Key terms were "stroke","brain diseases","brain injur... OBJECTIVE: To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury.DATA SOURCES: Key terms were "stroke","brain diseases","brain injuries","brain hemorrhage, traumatic","acute brain injury","dizocilpine maleate","dizocilpine","MK-801","MK801","rat","rats","rattus" and "murine". PubMed, Cochrane library, EMBASE, the China National Knowledge Infrastructure, WanFang database, the VIP Journal Integration Platform(VJIP) and SinoMed databases were searched from their inception dates to March 2018.DATA SELECTION: Studies were selected if they reported the effects of MK-801 in experimental acute brain injury. Two investigators independently conducted literature screening, data extraction, and methodological quality assessments.OUTCOME MEASURES: The primary outcomes included lesion volume and brain edema. The secondary outcomes included behavioral assessments with the Bederson neurological grading system and the water maze test 24 hours after brain injury.RESULTS: A total of 52 studies with 2530 samples were included in the systematic review. Seventeen of these studies had a high methodological quality. Overall, the lesion volume(34 studies, n = 966, MD =-58.31, 95% CI:-66.55 to-50.07;P < 0.00001) and degree of cerebral edema(5 studies, n = 75, MD =-1.21, 95% CI:-1.50 to-0.91;P < 0.00001) were significantly decreased in the MK-801 group compared with the control group. MK-801 improved spatial cognition assessed with the water maze test(2 studies, n = 60, MD =-10.88, 95% CI:-20.75 to-1.00;P = 0.03) and neurological function 24 hours after brain injury(11 studies, n = 335, MD =-1.04, 95% CI:-1.47 to-0.60;P < 0.00001). Subgroup analysis suggested an association of reduction in lesion volume with various injury models(34 studies, n = 966, MD =-58.31, 95% CI:-66.55 to-50.07;P = 0.004). Further network analysis showed that 0–1 mg/kg MK-801 may be the optimal dose for treatment in the middle cerebral artery occlusion animal model.CONCLUSION: MK-801 effectively reduces b 展开更多
关键词 nerve REGENERATION acute BRAIN injury NEUROLOGICAL function spatial cognition water MAZE test LESION volume BRAIN edema rat systematic review META-ANALYSIS neural REGENERATION
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Efficacy and safety of ginkgo injections in the treatment of angina pectoris caused by coronary heart disease in China: a network Meta-analysis and systematic review
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作者 Tan Di Wu Jiarui +3 位作者 Jing Zhiwei Duan Xiaojiao Cui Yingying Liu Shi 《中医杂志:英文版》 SCIE CAS CSCD 2019年第3期285-296,共12页
OBJECTIVE:To assess the clinical efficacy and safety of ginkgo injections(GIs)combined with conventional treatment(CT)against angina pectoris(AP)due to coronary heart disease(CH D).METHODS:Randomized controlled trials... OBJECTIVE:To assess the clinical efficacy and safety of ginkgo injections(GIs)combined with conventional treatment(CT)against angina pectoris(AP)due to coronary heart disease(CH D).METHODS:Randomized controlled trials(RCTs)that used GIs to treat AP were searched in SinoMed,PubMed,China National Knowledge Infrastructure Database,Chinese Scientific Journals Database,Wanfang Database,Embase and Cochrane Library until March 2017.The Cochrane "risk of bias" method was used to evaluate the methodological quality of RCTs.Data were analyzed using Stata v13.1 and WinBUGS v1.4.3.RESULTS:A total of 73 RCTs involving 7621 patients were included.A Bayesian network Meta-analysis of RCTs was undertaken,and the advantages of four types of Gl-supplemented CT in AP treatment were determined.CONCLUSION:Gl-assisted CT was more effective against AP than CT alone.However,based on the limitations of the study,additional high-quality RCTs are required to confirm our findings. 展开更多
关键词 GINKGO INJECTIONS ANGINA PECTORIS Network META-ANALYSIS Systematic review
Blood-Letting Therapy for Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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作者 XIONG Xing-jiang WANG Peng-qian LI Sheng-jie 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第2期139-146,共8页
Objective:To evaluate the efficacy and safety of blood-letting therapy(BLT)in treatment of hypertension.Methods:A comprehensive electronic and manual bibliographic searches were performed in Cochrane Central Register ... Objective:To evaluate the efficacy and safety of blood-letting therapy(BLT)in treatment of hypertension.Methods:A comprehensive electronic and manual bibliographic searches were performed in Cochrane Central Register of Controlled Trials,Excerpt Medica Database(EMBASE),PubMed,China National Knowledge Infrastructure,Chinese Scientific Journal Database,Chinese Biomedical Literature Database,and Wanfang Database to identify randomized controlled trials(RCTs)in which hypertensive patients were treated with BLT or BLT plus antihypertensive drugs(BPAD)against placebo,no treatment or antihypertensive drugs.The Cochrane Risk Assessment Tool was used to assess the methodological quality of trials.The Review Manager 5.3 software was used for meta-analysis.Results:A total of 7 RCTs with 637 hypertensive patients from 1989 to 2017 were identified.Compared with antihypertensive drugs,blood pressure was significantly reduced by BLT(RR=1.21,95%CI:1.01 to 1.44,P=0.03;heterogeneity:P=0.06,I^2=60%)and BPAD(RR=1.25,95%CI,1.02 to 1.53,P=0.03;heterogeneity:P=0.01,I^2=71%).Moreover,a significant improvement in Chinese medicine syndrome by BLT(RR=1.32;95%CI:1.14 to 1.53,P=0.0002;heterogeneity:P=0.53,I^2=0%)and BPAD(RR=1.47;95%CI:1.06 to 2.04,P=0.02;heterogeneity:P=0.13,I^2=56%)was identified.The reported adverse effects were well tolerated.Conclusions:Although some positive findings were identified,no definite conclusions regarding the efficacy and safety of BLT as complementary and alternative approach for treatment of hypertension could be drew due to the generally poor methodological design,significant heterogeneity,and insufficient clinical data.Further rigorously designed trials are warranted to confirm the results. 展开更多
关键词 blood-letting THERAPY PHLEBOTOMY BLOOD pressure Chinese MEDICINE COMPLEMENTARY and alternative MEDICINE systematic review META-ANALYSIS randomized controlled trials
黄廖本《现代汉语》(增订五版)语法问题指析 预览
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作者 徐连祥 《辽宁师范大学学报:社会科学版》 2019年第2期123-128,共6页
黄伯荣、廖序东主编《现代汉语》增订五版,确实比前几版更加完善了。然而,在近些年的语法教学实践中仍发现一些问题,主要体现在以下几个方面:动词单独作谓语的问题,中性宾语的分类问题,谓词性宾语的相关问题,'时地补语'与'... 黄伯荣、廖序东主编《现代汉语》增订五版,确实比前几版更加完善了。然而,在近些年的语法教学实践中仍发现一些问题,主要体现在以下几个方面:动词单独作谓语的问题,中性宾语的分类问题,谓词性宾语的相关问题,'时地补语'与'时地宾语'的归属问题,存现句判定标准问题以及其他零散问题。把这些问题写出来,供教材的编纂者、从教者和学习者参考,希望这套教材能够更加科学,更加系统,更加稳定,更加完善,更好地利泽于广大的使用者。 展开更多
关键词 语法问题 句法成分 三个平面理论 系统 科学
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