期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment
1
作者 Yongjuan Li Jian Hu +6 位作者 Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong Ji Jinlin He Lichen Yin 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第5期999-1008,共10页
Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemi... Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug release.Herein,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle stability.In tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle cores.As such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic therapy.This study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy. 展开更多
关键词 core-cross-linked micelles ON-DEMAND drug release photodynamic THERAPY reactive oxygen species (ROS) RESPONSIVENESS SYNERGISTIC an ti-cancer THERAPY
上一页 1 下一页 到第
使用帮助 返回顶部 意见反馈