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Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1
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作者 Nai-jun Miao Hong-yan Xie +13 位作者 Dan Xu Jian-yong Yin Yan-zhe Wang Bao Wang Fan Yin Zhuan-li Zhou Qian Cheng Pan-pan Chen Li Zhou Hong Xue Wei Zhang Xiao-xia Wang Jun Liu Li-min Lu 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第6期790-800,共11页
Caspase-11 is a key upstream modulator for activation of inflammatory response under pathological conditions. In this study, we investigated the roles of caspase-11 in the maturation of interleukin-1β (IL-1β) and de... Caspase-11 is a key upstream modulator for activation of inflammatory response under pathological conditions. In this study, we investigated the roles of caspase-11 in the maturation of interleukin-1β (IL-1β) and development of renal interstitial fibrosis in vivo and in vitro. Mice were subjected to unilateral ureteral obstruction (UUO). The mice were treated with either caspase-11 inhibitor wedelolactone (Wed, 30 mg/kg/day, ig) for 7 days or caspase-11 siRNA (10 nmol/20 g body weight per day, iv) for 14 days. The mice were euthanized on day 14, their renal tissue and blood sample were collected. We found that the obstructed kidney had significantly higher caspase-11 levels and obvious tubular injury and interstitial fibrosis. Treatment with Wed or caspase-11 siRNA significantly mitigated renal fibrosis in UUO mice, evidenced by the improved histological changes. Furthermore, caspase-11 inhibition significantly blunted caspase-1 activation, IL-ip maturation, transforming growth factor-p (TGF-P), fibronectin, and collagen I expressions in the obstructed kidney. Renal tubular epithelial NRK-52E cells were treated in vitro with angiotensin (Ang, 1 pmol/L), which stimulated caspase-11 activation and IL-ip maturation. Treatment with IL-1β (20ng/ml) significantly increased the expression of TGF-β, fibronectin, and collagen I in the cells. Ang ll-induced expression of TGF-β, fibronectin, and collagen I were suppressed by caspase-11 siRNA or Wed. Finally, we revealed using co-immunoprecipitation that caspase-11 was able to interact with caspase-1 in NRK-52E cells. These results suggest that caspase-11 is involved in UUO-induced renal fibrosis. Elevation of caspase-11 in the obstructed kidney promotes renal fibrosis by stimulating caspase-1 activation and IL-1β maturation. 展开更多
关键词 caspase-11 INTERLEUKIN-1Β angiotensin UNILATERAL ureteral OBSTRUCTION renal fibrosis
Effects of RIRS and Mini-PCNL on liver and kidney function,endocrine changes and trauma in patients with upper ureteral calculi
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作者 Jin-Cheng Yin Jian-Hua Chen +1 位作者 Yan-Qing Gu Hong-Xin Liu 《海南医科大学学报(英文版)》 2019年第3期44-47,共4页
Objective: To investigate the effects of retrograde intrarenal surgery (RIRS) and Mini-percutaneous nephroscope lithoipsy (Mini-PCNL) on liver and kidney function, endocrine changes and trauma in patients with upper u... Objective: To investigate the effects of retrograde intrarenal surgery (RIRS) and Mini-percutaneous nephroscope lithoipsy (Mini-PCNL) on liver and kidney function, endocrine changes and trauma in patients with upper ureteral calculi. Methods: 100 patients with upper ureteral calculi admitted to our hospital from March 2016 to February 2018 were selected. They were randomly divided into observation group (RIRS group) and control group (Mini-PCNL group), with 50 cases in each group. The observation group was given RIRS, while the control group was given Mini-PCNL. At the same time, the expression levels of the liver function [including alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma transpeptidase (gamma-GT)], renal function [including urea nitrogen (BUN) and serum creatinine (Scr) levels], endocrine changes [including corticotropin (ACTH), cortisol (Cor), norepinephrine (NE)] and trauma related indexes [Including soluble vascular cell adhesion molecule-1 (sVCAM-1) and erythrocyte sedimentation rate (ESR)] were analyzed and compared between the two groups. Results: There was no significant difference in ALT, AST, γ-GT, BUN and Scr before and after operation between the two groups. The difference was not statistically significant (P>0.05). After operation, the levels of ACTH (27.37±3.29) pg/mL, Cor (150.09±18.47) ng/mL, NE (165.48±26.74) ug/L and sVCAM-1, (596.55±56.24) ng/mL in RIRS group were significantly lower than those in Mini-PCNL group ((38.42±4.33) pg/mL, (222.37±28.70) ng/mL, (287.26±25.29) ug/L and (820.62±72) mL)The differences were statistically significant (P<0.05). While the ESR level in RIRS group (8.29±0.63) mm/h was significantly higher than that in Mini-PCNL group (7.16±0.68) mm/h, and the differences were statistically significant (P<0.05). Conclusions: There is no significant difference in the liver and renal function between RIRS and Mini-PCNL in the treatment of upper ureteral calculi. RIRS can better improve the endocrine status of patients and reduce the 展开更多
关键词 Upper ureteral CALCULI Liver FUNCTION RENAL FUNCTION ENDOCRINE TRAUMA
Effect of Quyu Chencuo Formula(去菀陈莝方)on Renal Fibrosis in Obstructive Nephropathy Rats
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作者 ZHU Rui DU Xing-guo +2 位作者 YANG Sheng-lan WU Yan-ran LIU Jian-guo 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第3期190-196,共7页
Objective: To observe the effect of Quyu Chencuo Formula(去菀陈莝方, QCF) on renal fibrosis in rats with obstructive nephropathy. Methods: Twenty-four rats were randomly divided into three groups, 4 for sham operation... Objective: To observe the effect of Quyu Chencuo Formula(去菀陈莝方, QCF) on renal fibrosis in rats with obstructive nephropathy. Methods: Twenty-four rats were randomly divided into three groups, 4 for sham operation as the control group, 10 for unilateral ureteral obstruction(UUO) model group, and the rest 10 for QCF treating UUO model group. All rats were sacrificed under 3% pentobarbital(50 mg/kg) anesthesia on the 14 th day after surgery, then the right kidney samples of rats were harvested for hematoxylin eosin(HE) staining and Masson staining to observe the renal pathological changes. Immunohistochemistry and Western blotting were used to examine the expression of transforming growth factor β1(TGF-β1), and real-time polymerase chain reaction(RT-PCR) was employed to examine the expressions of TGF-β1, α-smooth muscle actin(α-SMA) and E-cadherin mRNA. Results: HE and Masson staining showed that the renal interstitial of the rats in the control group had no significant fibrotic lesion;in the model group, there were obvious interstitial fibrosis;for the QCF group, there were epithelial cell necrosis, infiltration of lymphocytes and mononuclear cells, aggravated interstitial fibrosis in varied degrees, but the pathological changes were less in the QCF group than in the model group. The immunohistochemistry and Western blotting results showed that the TGF-β1 expression was increased significantly in the model group, while decreased significantly in the QCF group(P<0.05);RT-PCR showed that the mRNA expression of α-SMA and TGF-β1 increased significantly in the model group, while both were significantly decreased in the QCF group compared with the model group(P<0.05). The mRNA expression of E-cadherin was decreased significantly in the model group, and it was significantly increased in the QCF group as compared with the model group(P<0.05). Conclusion: QCF may improve renal fibrosis by regulating the expressions of TGF-β1, α-SMA and E-cadherin, and prevent the progress of kidney fibrosis. 展开更多
关键词 UNILATERAL ureteral LIGATION Quyu Chencuo FORMULA E-cadherin transforming growth factor β 1 α-smooth muscle ACTIN kidney FIBROSIS Chinese medicine
输尿管结石疼痛程度与碎石取石术后双J管并发症的相关性研究 预览
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作者 杨澎 于田强 +5 位作者 朱宇 陈定超 何佳 许皆钿 乔宏宇 李建兰 《吉林医学》 CAS 2018年第9期1726-1728,共3页
目的:探讨输尿管结石患者术前疼痛的剧烈程度与碎石取石术后留置双J管并发症的关系。方法:根据输尿管结石患者术前疼痛的剧烈程度不同,将所有患者分成两组,即微痛组和剧痛组。两组患者均采用输尿管镜下钬激光碎石取石,术后均留置F6双J... 目的:探讨输尿管结石患者术前疼痛的剧烈程度与碎石取石术后留置双J管并发症的关系。方法:根据输尿管结石患者术前疼痛的剧烈程度不同,将所有患者分成两组,即微痛组和剧痛组。两组患者均采用输尿管镜下钬激光碎石取石,术后均留置F6双J管4周,比较两组患者双J管导致的并发症发生情况。结果:前两周,两组患者尿路刺激征、肉眼血尿、尿路感染、腰痛或侧腹痛的发生率相近,差异无统计学意义(P〉0.05)。后两周,剧痛组患者出现腰痛或侧腹痛的概率较微痛组增高,差异具有统计学意义(P〈0.05,OR=0.39),其余并发症的发生率比较,差异仍无统计学意义(P〉0.05)。结论:术前疼痛剧烈的输尿管结石患者痛域较低,对异物刺激较敏感,留置双J管后腰痛或侧腹痛的出现的概率较高。 展开更多
关键词 输尿管 结石 双J管 疼痛
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PAX2 regulates NRP-1 expression in renal tubular epithelial cellsto promote epithelial-to-mesenchymal transition and renal fibrosis 预览
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作者 Ling Hou Yue Du +2 位作者 Chengguang Zhao Xiuli Wang Yubin Wu 《儿科疾病杂志》 2018年第1期32-40,共9页
To observe the expression of neuropilin-1 (NRP-1) induced by paired-box gene 2 (PAX2) during the process of epithelial-to-mesenchymal transition (EMT) and renal fibrosis in unilateral ureteral obstruction (UUO) model ... To observe the expression of neuropilin-1 (NRP-1) induced by paired-box gene 2 (PAX2) during the process of epithelial-to-mesenchymal transition (EMT) and renal fibrosis in unilateral ureteral obstruction (UUO) model in rats, and explore the mechanism of EMT induced by PAX2. Methods: The recombinant lentivirus expression vector for PAX2 was constructed and transfected into rat normal renal tubular epithelial cell line (NRK52E). The experimental cells were divided into three groups: transfection group, empty vector group, and normal group. E-cadherin and oup, empty vector group, and normal and real-time PCR. Expression of NRP-1 was detected by western blot, real-time PCR, and immunofluorescence. Sixty male Wistar rats were randomly divided into two groups: the sham-operation group (n = 30) underwent left ureteral dissection, the UUO group (n = 30) underwent left ureteral ligation. Post-operation on days 3, 7, 14, 21 and 28, 6 rats from each of the groups were sacrificed and the obstructed kidneys were dissected out. The histopathological changes were observed by hematoxylin-eosin and Masson staining. E-cadherin and dhSMA were detected by western blot and immunohistochemistry. Expression of NRP-1 and PAX2 were determined by western blot, immunohistochemistry, and real-time PCR. Results: Expression of NRP-1 mRNA and protein and d by western blot, immunoh < 0.05) while E-cadherin protein expression decreased (P < 0.05) in the transfection group as compared to the empty vector group in vitro. In the UUO group, fibrosis was obvious, and there was decreased expression of E-cadherin protein (P < 0.05) and increased expression of 5) and increased expression in (Pious, and < 0.05) in comparison to the sham group. Conclusion: NRP-1 maybe mediate PAX2-induced EMT in renal tubular epithelial cells and renal fibrosis. 展开更多
关键词 renal INTERSTITIAL fibrosis ureteral OBSTRUCTION epithelial-to-mesenchymal transition paired-box gene 2 NEUROPILIN-1
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两种体位体外冲击波碎石术治疗输尿管上段结石的疗效比较 预览
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作者 宋立超 张忠君 +3 位作者 张翰林 马奔 王金珍 金昌洙 《滨州医学院学报》 2018年第2期124-126,共3页
目的通过比较同侧俯卧位、患侧倾斜仰卧位在体外冲击波碎石术(ESWL)治疗输尿管上段长径≥1.0cm结石的疗效、安全性,探寻体外冲击波碎石治疗输尿管上段结石的有效体位。方法收集30例输尿管上段结石患者,随机分为同侧俯卧位组、患侧倾... 目的通过比较同侧俯卧位、患侧倾斜仰卧位在体外冲击波碎石术(ESWL)治疗输尿管上段长径≥1.0cm结石的疗效、安全性,探寻体外冲击波碎石治疗输尿管上段结石的有效体位。方法收集30例输尿管上段结石患者,随机分为同侧俯卧位组、患侧倾斜仰卧位组两组,随访2周,统计这些患者碎石后24h内疼痛VAS评分、2d内的排石率,1、2周后结石排净率,碎石后并发症发生率,分析比较两种体位体外冲击波碎石治疗输尿管上段结石的有效性、安全性。结果两组患者的性别、年龄、体重、结石左右侧、碎石冲击次数、结石长径差异无统计学意义。碎石后2组24h内疼痛VAS评分、术后2天内排石率差异无统计学差异。但2组患者碎石后1周、2周结石排净率差异有统计学意义,2组患者碎石后血尿等并发症发生率差异有统计学意义。结论 ESWL治疗长径≥1.0cm输尿管上段结石,患侧倾斜仰卧位术后并发症发生率少于同侧俯卧位,远期结石排净率高于同侧俯卧位,是一种有效、安全的治疗体位。 展开更多
关键词 冲击波碎石 体位 输尿管 结石
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Ovarian Vein Thrombosis卵巢静脉血栓 预览
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作者 关键 《影像诊断与介入放射学》 2017年第4期348-350,共3页
Key Facts Synonyms:Gonadal vein thrombosis.Definition:Rare complication usually associated with ascending postpartum ovarian vein thrombophlebitis.Incidence:1%-2%following cesarean section complicated by endometrit... Key Facts Synonyms:Gonadal vein thrombosis.Definition:Rare complication usually associated with ascending postpartum ovarian vein thrombophlebitis.Incidence:1%-2%following cesarean section complicated by endometritis;less than 0.2% following vaginal delivery. 展开更多
关键词 POSTPARTUM 静脉血栓 VAGINAL ascending CESAREAN THROMBUS 卵巢扭转 ureteral tubular PREFIX
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Persistent fever during treatment of a pregnant woman with acute pyelonephritis
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作者 Hasan Tahsin Gozdas Mehmet Dinek 《急性病杂志(英文版)》 2017年第1期41-42,共2页
Acute pyelonephritis is a serious infection in pregnancy. It is presented with fever, shaking chills and flank pain. Intravenous hydration and antimicrobial therapy are sufficient in the treatment unless pyelonephriti... Acute pyelonephritis is a serious infection in pregnancy. It is presented with fever, shaking chills and flank pain. Intravenous hydration and antimicrobial therapy are sufficient in the treatment unless pyelonephritis is complicated. In case of fever persisting for more than 48 h despite appropriate antimicrobial treatment, a possible complication such as urinary tract obstruction, abscess or phlegmon should be considered. Here, we present an 18-year-old pregnant woman with acute pyelonephritis whose persistent fever returned to normal after double-J ureteral stent was placed even if she had no finding of such a complication. 展开更多
关键词 PERSISTENT FEVER ACUTE PYELONEPHRITIS PREGNANCY Double-J ureteral STENT
Comparison of the trauma between combined retrograde intrarenal surgery and mini-percutaneous nephrolithotomy for upper ureteral calculi
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作者 Liang-Suo Zhang Chun-Yu Huang 《海南医科大学学报(英文版)》 2017年第19期80-83,共4页
Objective: To compare the trauma between combined retrograde intrarenal surgery and mini-percutaneous nephrolithotomy for upper ureteral calculi. Methods: Patients with upper ureteral calculi who received lithotripsy ... Objective: To compare the trauma between combined retrograde intrarenal surgery and mini-percutaneous nephrolithotomy for upper ureteral calculi. Methods: Patients with upper ureteral calculi who received lithotripsy in Pengzhou Hospital of Traditional Chinese Medicine between February 2015 and March 2017 were selected and randomly divided into two groups;RIRS group received combined retrograde intrarenal surgery and the Mini-PCNL group received mini-percutaneous nephrolithotomy. 3 d after surgery;the contents of liver and kidney function indexes and stress hormones in serum as well as the expression of CD4+T cell transcription factors in peripheral blood were measured. Results: Serum ALT;AST;γ-GT;BUN and Cr contents of RIRS group 3 d after surgery were not significantly different from those of Mini-PCNL group;and HO-1;ET-1;ACTH;Cor and YKL-40 contents in serum as well as RORγt and T-bet mRNA expression in peripheral blood were significantly lower than those of Mini-PCNL group while Gata-3 and Foxp3 mRNA expression in peripheral blood were higher than those of Mini-PCNL group. Conclusion: Combined retrograde intrarenal surgery for upper ureteral calculi activates less stress response and inflammatory response than mini-percutaneous nephrolithotomy. 展开更多
关键词 Upper ureteral CALCULI COMBINED RETROGRADE intrarenal surgery Mini-percutaneous NEPHROLITHOTOMY Stress RESPONSE Inflammatory RESPONSE
自拟排石汤联合坦索罗辛辅助治疗对输尿管下段结石患者结石排净率及肾绞痛的影响 预览 被引量:4
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作者 陈雪莲 陈旭伟 陈嗣平 《中国生化药物杂志》 CAS 2017年第2期59-61,共3页
目的探讨自拟排石汤联合坦索罗辛辅助排石对输尿管下段结石患者结石排净率及肾绞痛的影响。方法选取2014年1月~2016年2月义乌市中心医院泌尿外科就诊的90例输尿管下段结石患者,按照随机、平等的分配原则分为A组(自拟排石汤联合坦索罗... 目的探讨自拟排石汤联合坦索罗辛辅助排石对输尿管下段结石患者结石排净率及肾绞痛的影响。方法选取2014年1月~2016年2月义乌市中心医院泌尿外科就诊的90例输尿管下段结石患者,按照随机、平等的分配原则分为A组(自拟排石汤联合坦索罗辛组)、B组(单纯坦索罗辛组)、C组(单纯中药汤剂组),每组各30例。观察并比较3组患者膀胱刺激征(尿频尿急)、输尿管绞痛、结石排出时间、结石排净率及不良反应发生率。结果 A组结石排出时间及结石排净率明显优于B、C组,差异具有统计学意义(P〈0.05);B、C 2组结石排出时间及结石排净率比较差异无统计学意义。C组尿频尿急和输尿管绞痛发生率均高于A、B组,差异具有统计学意义(P〈0.05);A、B组频尿急和输尿管绞痛发生率比较差异无统计学意义。3组在治疗过程中出现的不良反应情况:A组出现1例轻度腹泻和1例轻度眩晕,B组出现1例轻度头痛和1例轻度眩晕,C组未出现任何的不良反应情况。3组不良反应率比较差异无统计学意义。结论自拟排石汤联合坦索罗辛辅助排石治疗对于输尿管下段结石患者有着良好的效果,既能充分发挥西药的止痛解痉作用,也能更好地发挥中医排石通淋、镇痛消炎、清利湿热的作用,能提高结石排净率,缓解患者的肾绞痛。 展开更多
关键词 排石方法 药物保守治疗 输尿管 结石 肾绞痛
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Repair of a common bile duct defect with a decellularized ureteral graft 预览
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作者 Yao Cheng Xian-Ze Xiong +5 位作者 Rong-Xing Zhou Yi-Lei Deng Yan-Wen Jin Jiong Lu Fu-Yu Li Nan-Sheng Cheng 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第48期10575-10583,共9页
AIM To evaluate the feasibility of repairing a common bile duct defect with a decellularized ureteral graft in a porcine model.METHODS Eighteen pigs were randomly divided into three groups. An approximately 1 cm segme... AIM To evaluate the feasibility of repairing a common bile duct defect with a decellularized ureteral graft in a porcine model.METHODS Eighteen pigs were randomly divided into three groups. An approximately 1 cm segment of the common bile duct was excised from all the pigs. The defect was repaired using a 2 cm long decellularized ureteral graft over a T-tube(T-tube group, n = 6) or a silicone stent(stent group, n = 6). Six pigs underwent bile duct reconstruction with a graft alone(stentless group). The surviving animals were euthanized at 3 mo. Specimens of the common bile ducts were obtained for histological analysis.RESULTS The animals in the T-tube and stent groups survived until sacrifice. The blood test results were normal in both groups. The histology results showed a biliary epithelial layer covering the neo-bile duct. In contrast, all the animals in the stentless group died due to biliary peritonitis and cholangitis within two months post-surgery. Neither biliary epithelial cells nor accessory glands were observed at the graft sites in the stentless group.CONCLUSION Repair of a common bile duct defect with a decellularized ureteral graft appears to be feasible. A T-tube or intraluminal stent was necessary to reduce postoperative complications. 展开更多
关键词 DECELLULARIZATION STENT BILE DUCT injury BILIARY reconstruction Ureteral GRAFT
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超声造影在输尿管结核诊断中的价值 被引量:1
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作者 徐建平 杨高怡 +3 位作者 何宁 张文智 张莹 张林 《中国超声医学杂志》 CSCD 北大核心 2016年第4期358-360,共3页
目的探讨超声造影在输尿管结核中的应用价值。方法对22例经手术病理证实的输尿管结核患者超声造影图像进行回顾性分析。结果输尿管结核常规超声主要表现为输尿管内径增宽、黏膜增厚,管腔内可见不均匀絮状高回声、弥漫性高回声、结节状... 目的探讨超声造影在输尿管结核中的应用价值。方法对22例经手术病理证实的输尿管结核患者超声造影图像进行回顾性分析。结果输尿管结核常规超声主要表现为输尿管内径增宽、黏膜增厚,管腔内可见不均匀絮状高回声、弥漫性高回声、结节状低回声。根据超声造影表现将22例输尿管结核分为以下两型:不均匀增强型18例(81.8%);无增强型4例(18.2%)。结论超声造影能反映输尿管结核的血流灌注情况,为诊断提供帮助。 展开更多
关键词 输尿管 结核 超声造影
输尿管内支架管常见并发症发生原因分析与护理对策 预览 被引量:4
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作者 陆荣枢 蔡慧 潘小蔓 《护理实践与研究》 2016年第10期77-78,共2页
目的:总结肾输尿管结石术后植入输尿管内支架管常见发症发生原因,以采取相应护理措施,提高患者手术质量。方法:选择2012年1月~2015年12月在我院接受治疗的162例肾输尿管结石术后植入双J管患者,患者出院时进行问卷调查,对并发症的发生... 目的:总结肾输尿管结石术后植入输尿管内支架管常见发症发生原因,以采取相应护理措施,提高患者手术质量。方法:选择2012年1月~2015年12月在我院接受治疗的162例肾输尿管结石术后植入双J管患者,患者出院时进行问卷调查,对并发症的发生进行归类分析。结果:88.89%的患者出现疼痛,62.35%患者出现血尿,41.97%患者出现膀胱刺激征,31.48%患者出现双J管反流,8.02%患者出现双J管位移,4.94%患者出现引流不畅,4.93%患者出现结石情况,1.23%患者出现尿路感染。结论:通过对输尿管内支架管患者并发症发生原因进行分析,采取有针对性的护理对策,并加强健康宣教,为预防并发症的发生提供依据。 展开更多
关键词 输尿管 双J管 并发症 原因 护理
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输尿管多发结石的超声检查分析 预览
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作者 罗伍山 彭红辉 +2 位作者 彭佳丽 李井秀 周智虹 《现代医用影像学》 2016年第3期518-520,共3页
目的:探讨单侧输尿管多发结石的分型,分析各型的声像特征,进一步提高超声诊断水平。材料与方法:对68例经临床证实单侧输尿管多发结石患者(1型堆积型结石、Ⅱ型多段型结石、Ⅲ型游走型结石)的声像图表现进行分型,结合各型检查方法进... 目的:探讨单侧输尿管多发结石的分型,分析各型的声像特征,进一步提高超声诊断水平。材料与方法:对68例经临床证实单侧输尿管多发结石患者(1型堆积型结石、Ⅱ型多段型结石、Ⅲ型游走型结石)的声像图表现进行分型,结合各型检查方法进行分析。结果:68例患者声像图表现l型45例,Ⅱ型l7例,Ⅲ型6例,其中上段结石27例,中段结石l5例,下段结石41例。结论:重视对单侧输尿管多发结石的认识,完善相应的探查方法,有利于提高输尿管多发结石的检出率和诊断准确率。 展开更多
关键词 输尿管 多发结石 超声检查
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Kidney tissue targeted metabolic profiling of renal interstitial fibrosis rats induced by unilateral ureteral obstruction using NMR 预览
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《中国药理学通报》 CAS CSCD 北大核心 2015年第B11期99-100,共2页
Aim Renal interstitial fibrosis (RIF) is a common final pathological process in the progression of kid- hey disease. To investigate the pathogenesis of RIF and offer invaluable instructions for diagnosis and therapy... Aim Renal interstitial fibrosis (RIF) is a common final pathological process in the progression of kid- hey disease. To investigate the pathogenesis of RIF and offer invaluable instructions for diagnosis and therapy treat- 1 ment of RIF. Method: H NMR based-metabolomics study on targeted kidney tissue of RIF rats induced by uni- lateral ureteral obstruction was conducted combined with multivariate data analysis to characterize the alteration of endogenous metabolites and elucidate the molecular mechanism of RIF. Results The combination of a variety of statistical methods was used to screen out 14 potential significantly changed metabolites, including increased levels of lactate, methionine, aspartate, allantoin, uracil, 3-HB and decreased levels of TMAO, leucine, valine, lysine, adenosine, adenine, tyrosine and phenylalanine in the left kidney of UUO rats, compared with SO rats. To gain ad- ditional insight about the relationship between metabolites, they were mapped to KEGG IDs and built compound network by Metscape reflecting the complex pathology and providing evidence for the involvement of such processes as altered amino acid metabolism, adenine metabolism, energy metabolism, osmolyte change and induced oxidative stress. In addition, we have explored the morphology and size, calculated the degree of fibrosis based on altered differential metabolites, and speculated the probable causes of moderate RIF of contralateral kidneys to help to un- derstand the disease, which was also supported by serum biochemistry and kidney histopathology results. In addi- tion, the correlation analysis of the pathological parameters ( clinical chemistry, histological and immunohistochem- istry results) with the significantly changed differential metabolites responsible for the cluster (different groups) was also performed. Conclusion Our work shows that target tissue metabolomics analysis can be used as a power-ful tool to gain a better understanding of the mechanism of the disease and provide a novel insight in th 展开更多
关键词 metabolomics renal INTERSTITIAL FIBROSIS UNILATERAL ureteral oObstruction NMR correlation ANALYSIS pathway ANALYSIS PATHOGENESIS
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输尿管导管在妇科临床的应用观察 预览 被引量:1
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作者 田江 张娟 《中国卫生标准管理》 2015年第1期21-22,共2页
目的:探讨输尿管导管在妇科手术中的应用的可行性及临床应用价值。方法术前放置输尿管导管,对50例巨大子宫肌瘤子宫切除手术适应证者行术前放置输尿管导管指示下手术,术后立即拔除输尿管导管,取同期未放置而切除子宫50例作对比分析... 目的:探讨输尿管导管在妇科手术中的应用的可行性及临床应用价值。方法术前放置输尿管导管,对50例巨大子宫肌瘤子宫切除手术适应证者行术前放置输尿管导管指示下手术,术后立即拔除输尿管导管,取同期未放置而切除子宫50例作对比分析。结果放置输尿管导管组手术时间短、手术安全系数增加,而术后24小时肉眼血尿放置组多于未放置组;术后患者满意度放置组明显高于未放置组。结论子宫切除术术前放置输尿管导管是一种安全、手术效果好、副反应少的手术方式。 展开更多
关键词 输尿管 导管 妇科手术
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输尿管上段单发大结石的术式选择:后腹腔镜或经皮肾镜 预览 被引量:1
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作者 黄细汉 湛海伦 +3 位作者 黄桂连 刘永昌 潘翔 赵敏生 《中华腔镜泌尿外科杂志(电子版)》 2015年第6期23-26,共4页
目的探讨后腹腔镜输尿管上段切开取石术(RLTP)和微通道经皮肾镜碎石取石术(MPCNL)治疗输尿管上段单发大结石的临床效果,为临床决策提供具体的临床证据。方法 2013年1月至2015年1月高要市人民医院根据入选标准和排除标准入选57例输... 目的探讨后腹腔镜输尿管上段切开取石术(RLTP)和微通道经皮肾镜碎石取石术(MPCNL)治疗输尿管上段单发大结石的临床效果,为临床决策提供具体的临床证据。方法 2013年1月至2015年1月高要市人民医院根据入选标准和排除标准入选57例输尿管上段单发大结石患者,结石直径大于1.5 cm,随机分为MPCNL组(29例)和RLTP组(28例),比较两组的手术时间、术中出血量、术中中转开放情况、结石清除率、术后胃肠道恢复时间、术后住院时间及尿瘘等并发症情况。结果两组手术均获成功,MPCNL组的手术时间及术后双J管的留置时间均短于RLTP组,但出血量MPCNL组大于RLTP组,两组在结石取净率、中转开放手术、尿瘘、术后胃肠道恢复时间、尿管留置时间及术后住院时间上差异并无统计学意义。结论 MPCNL和RLTP处理输尿管上段单发大结石均安全可靠。采用何种手术方式,除了患者的具体情况,还应考虑术者对术式的偏好。 展开更多
关键词 输尿管 上段 结石 肾造口术 经皮 腹腔镜
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Kidney and Urinary Tract
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《中国医学文摘:内科学分册(英文版)》 2015年第2期111-114,共4页
【正】2015225 Systolic blood pressure and progression of renal dysfunction in the elderly patients with moderate to severe chronic kidney disease:a cohort study from a tertiary hospital.ZHAO Hui(赵慧),et al.Renal Div,... 【正】2015225 Systolic blood pressure and progression of renal dysfunction in the elderly patients with moderate to severe chronic kidney disease:a cohort study from a tertiary hospital.ZHAO Hui(赵慧),et al.Renal Div,Dept Med,Peking Univ 1st Hosp,Instit Nephrol,Peking Univ,Beijing 100034.Chin J Intern Med 2015;54(3):181-187. 展开更多
关键词 PEKING KIDNEY MODERATE progression TERTIARY glomerular COHORT SEPTIC ureteral elderly
Percutaneous nephrolithotomy vs laparoscopic ureterolithotomy for large upper ureteral stone:A review article 预览
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作者 Pejman Shadpour Seyed Saeed Modaresi +1 位作者 Robab Maghsoudi Roozbeh Roohinezhad 《世界临床泌尿杂志》 2014年第3期336-339,共4页
To investigate the best treatment option for large upper ureteral stone,percutaneous nephrolithotomy or laparoscopic ureterolithotomy.We searched three key word of upper ureteral stone,laparoscopic ureterolithotomy,pe... To investigate the best treatment option for large upper ureteral stone,percutaneous nephrolithotomy or laparoscopic ureterolithotomy.We searched three key word of upper ureteral stone,laparoscopic ureterolithotomy,percutaneous nephrolithotomy in PubMed,Scopus and Ebsco.We found approximately twenty suitable articles about this subject since January 1980 until January 2014.All articles studies and reviewed meticulously and brief review of these articles was written and some Ideas of experts was added.In many studies,it is suggested that success rate and complications of laparoscopic ureterolithotomy and percutaneous nephrolithotomy are the same,but percutaneous nephrolithotomy has less hospital stay time,duration of surgery and it is more cost effective.Overall it seems that percutaneous nephrolithotomy for treatment of upper ureteral stones is preferable rather than laparoscopic ureterolitothomy. 展开更多
关键词 UPPER ureteral STONES Percutaneous NEPHROLITHOTOMY Laparoscopic URETEROLITHOTOMY LAPAROSCOPY Ureteral CALCULI
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Norcantharidin inhibits renal interstitial fibrosis through down-regulating protein phosphatase 2Ac
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作者 尤燕华 《中国医学文摘:内科学分册(英文版)》 2014年第2期114-115,共2页
Objective To observe the relationship between protein phosphatase-2Ac(PP2Ac)and renal interstitial fibrosis,and to investigate the effects and the underlying mechanism of norcantharidin(NCTD)on renal fibrosis in unil... Objective To observe the relationship between protein phosphatase-2Ac(PP2Ac)and renal interstitial fibrosis,and to investigate the effects and the underlying mechanism of norcantharidin(NCTD)on renal fibrosis in unilateral ureteral obstruction(UUO)rats.Methods Sixteen male Sprague-Dawley rats were randomly divided into four groups:Sham operation group,UUO day 3 展开更多
关键词 INTERSTITIAL ureteral REGULATING UNILATERAL obstruction FIBRONECTIN underlying collagen SALINE cadherin
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