期刊文献+

《生物科学与医学(英文)》

作品数595被引量0H指数0
《生物科学与医学(英文)》
  • 主办单位美国科研出版社
  • 国际标准连续出版物号2327-5081
  • 出版周期月刊
共找到595篇文章
< 1 2 30 >
每页显示 20 50 100
The Current and Future Role of Drugs and Probiotics in the Management of Inflammatory Bowel Disease 认领
1
作者 Maricelma da Silva Soares de Souza Sandra Maria Barbalho +1 位作者 Ricardo de Alvares Goulart Antonely de Cássio Alves de Carvalho 《生物科学与医学(英文)》 2015年第8期76-85,共10页
Inflammatory Bowel Disease (IBD) and other auto-inflammatory disorders are conditions caused by chronic and persistent intestinal inflammation, which is mainly represented by Ulcerative Colitis (UC) or Crohn’s Diseas... Inflammatory Bowel Disease (IBD) and other auto-inflammatory disorders are conditions caused by chronic and persistent intestinal inflammation, which is mainly represented by Ulcerative Colitis (UC) or Crohn’s Disease (CD), both of which typically arise as chronic inflammation of the gastrointestinal mucosa. Doctor’s main focus for treating IBD is the decrease on inflammation processes when the disease is active and promotes the maintenance of inflammation at normal levels. However, to deal with these two parameters is not easy, because the drugs usually used are related to several side effects and they are not totally effective to reduce inflammation and to keep the remission. Authors agree that the therapy approach should include drugs, dietary intervention and use of alternative substances as probiotics. The standard treatment approach for patients with CD and UC is traditionally done with the use of anti-inflammatory agents, like corticosteroids, mesalamine, immunomodulators such as azathioprine and methotrexate, and biologic agents such as infliximab and others. Probiotics are known as viable micro-organisms (or live microorganisms or live microbial dietary supplements) that may promote beneficial physiologic or therapeutic properties when used correctly. The interest in the role of these substances in improving human health is the reason of several researches. They may be used to help the immune system, to control gastro-intestinal infections and to prevent several diseases. Prebiotics, symbiotics, and probiotics may be helpful as adjuvants in the treatment of IBD. Probiotics are normally well-tolerated and are associated with few side effects which are undoubtedly important in the treatment of any disease. 展开更多
关键词 INFLAMMATORY BOWEL Diseases IMMUNOMODULATORS Biological AGENTS PROBIOTICS
在线阅读 免费下载
A Method for Normal Direction Judge Applied in Electrocardiographic Problem 认领
2
作者 Chengcheng Tang Jian Wu Riqing Chen 《生物科学与医学(英文)》 2018年第1期1-8,共8页
Boundary Element Method (BEM) is widely used in electrocardiographic (ECG) problem. Formulations of these problems based on mathematical and numerical approximations of the known source in heart and the volume conduct... Boundary Element Method (BEM) is widely used in electrocardiographic (ECG) problem. Formulations of these problems based on mathematical and numerical approximations of the known source in heart and the volume conductor that can transfer voltages on the surface of the body. To analyze the electric potentials on body surface or epicardial surface, a set of discrete equations derived from a boundary integral equations need to be solved. Solving these equations means to get the potential distribution eventually. In the process of solving, transfer matrix of discrete equations has received considerable attention, how to get an appropriate transfer matrix is an important issue. This paper found that the direction of normal vector could affect the results when calculating the transfer matrix and presents a method analogous to Mesh Current Method to deal with this direction problem. Several simulations have been carried out to verify the accurate results with the correct direction of normal vector using new method within a torso model given simultaneous epicardial and body surface potential recordings. 展开更多
关键词 ECG PROBLEM BEM Transfer Matrix NORMAL VECTOR Direction
在线阅读 免费下载
Clinical Characteristics of Vaginal Discharge Associated Streptococcus pyogenes at General Japanese Hospital 认领
3
作者 Masaaki Minami Ryoko Sakakibara +3 位作者 Mika Watanabe Hideo Morita Naoto Kanemaki Michio Ohta 《生物科学与医学(英文)》 2018年第1期9-16,共8页
Streptococcus pyogenes (S. pyogenes) is popular pathogen caused various infectious disease. This study was conducted to find out the recent clinical characteristics of S. pyogenes isolates from vaginal discharge at Ja... Streptococcus pyogenes (S. pyogenes) is popular pathogen caused various infectious disease. This study was conducted to find out the recent clinical characteristics of S. pyogenes isolates from vaginal discharge at Japanese hospital. S. pyogenes was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by microdilution assay according to CLSI recommendation. Total 61 S. pyogenes were isolated from vaginal discharge. The major age incidence among 0 - 10 years age group was 14 (23%), among 21 - 30 years age group, 7 (11.5%), among 31 - 40 years age group, 13 (21.3%), among 51 - 60 years age group, 8 (13.1%), and among 61 - 70 years age group, 11 (18%). The numbers of ciprofloxacin and clarithromycin no-susceptible S. pyogenes from 0 - 10, 31 - 40, and 61-70 years age group were higher than those from other groups. The numbers of clindamycin and minocycline no susceptible S. pyogenes from 0 - 10, and 21 - 40 years age group were higher than those from other group. Furthermore, our study revealed that clarithromycin was completely ineffective in 21 - 30 years age group (p S. pyogenes because the trend of infectious disease epidemiology is always changing drastically. 展开更多
关键词 STREPTOCOCCUS PYOGENES SUSCEPTIBILITY ANTIMICROBIAL Resistance VAGINAL Discharge CLARITHROMYCIN
在线阅读 免费下载
How to Pool Medical Services in Preventive Medicine Unit at 01/01/18 of Orléans Metropole/Orléans City Hall Structure: A Multi Disciplinary Network 认领
4
作者 Rapha?l Serreau 《生物科学与医学(英文)》 2018年第1期17-21,共5页
To reform the unit of preventive medicine in Orleans metropole, the Director of the Administration decided to co-sign an agreement to optimize the organization of a common preventive medicine service: we made a delibe... To reform the unit of preventive medicine in Orleans metropole, the Director of the Administration decided to co-sign an agreement to optimize the organization of a common preventive medicine service: we made a deliberation model to permit for others towns which wanted to join us. The cost evaluated to reach the service was the cost for medical examination, regardless of the professional which included staff costs and operating costs (social benefits, costs of supplies and materials, training costs). A statement of the tasks performed for the beneficiary community was kept daily by the SMP. A strong will of the Metropolis and municipalities is to develop a synergy around health and safety at work. A joint Metropolis of Orleans, an organization chart since 1/2/2016 integrates the preventive medicine service within a Quality of Life at Work service: a multi-disciplinary service composed of prevention specialists, social workers, responsible for social action and SMP, a Department of Preventive Medicine was developed and itself multidisciplinary in accordance with the law of July 20, 2011: including doctors, nurses, psychologists, sophrologist, and a dietician. A new and active network of health is now operant with specialist correspondents. An audit is programmed in April 2018 to assess the efficacy of this network. 展开更多
关键词 OCCUPATIONAL MEDICINE PREVENTIVE MEDICINE Cost Efficiency Analysis MULTIDISCIPLINARY NETWORK
在线阅读 免费下载
Anti-Obesity, Anti-Atherosclerotic and Anti-Oxidant Effects of Pu-Erh Tea on a High Fat Diet-Induced Obese Rat Model 认领
5
作者 Changyun Xiong Yuanju Peng +2 位作者 Benying Liu Wenrui Cui Xuncheng Liu 《生物科学与医学(英文)》 2019年第2期120-130,共11页
Pu-erh tea, a traditional Chinese beverage, has been believed to have many benefits to human health and without side effects. In this study, we systematically analyzed the main active components of Pu-erh tea and inve... Pu-erh tea, a traditional Chinese beverage, has been believed to have many benefits to human health and without side effects. In this study, we systematically analyzed the main active components of Pu-erh tea and investigated its anti-obesity, anti-atherosclerotic and anti-oxidant effects using an obese rat model. Obesity was induced by feeding a high-fat diet and subsequently the experimental obese mice were fed with high-fat diet supplemented with low (2.5%), medium (5%) or high (7.5%) doses of Pu-erh tea powder for 6 weeks respectively. As result, the body weight gain of the rats was decreased by medium and high doses of Pu-erh tea treatments. Furthermore, the levels of serum total cholesterol (TC), triglyceride (TG) and atherosclerosis index (AI) were significantly lowered by Pu-erh tea compared to the control group. Conversely, high density lipoproteincholesterol (HDL-C) level of the rats was significantly elevated by Pu-erh tea treatments. In addition, Pu-erh tea treatments increased the activities of anti-oxidative enzymes such as superoxide dismutase (SOD) and glutathione peroxides (GSH-Px), whereas reduced the level of lipid peroxidation product malondialdehyde (MDA) in obese rats. Collectively, our find-ings revealed that Pu-erh tea exerts comprehensive benefits in anti-obesity, anti-atherosclerotic and anti-oxidant effects, therefore can be used as a promising functional food in obesity management. 展开更多
关键词 Pu-Erh Tea ANTI-OBESITY Anti-Atherosclerotic ANTI-OXIDANT OBESE Rat Model
在线阅读 免费下载
Long-Term Nikotine Administration Impairs Blood Parameters and Femoral Bone Tissue Structure in an Osteoporosis Model of Rats 认领
6
作者 Murat Baloglu Ebru Gö +1 位作者 kalp Ö zkorkmaz 《生物科学与医学(英文)》 2019年第11期1-9,共9页
Osteoporosis is a systemic bone disease that results in the loss of bone mass and impared bone structure. Animal models for osteoporosis are generated by ovariectomy. Adult female Sprague-Dawley rats were divided into... Osteoporosis is a systemic bone disease that results in the loss of bone mass and impared bone structure. Animal models for osteoporosis are generated by ovariectomy. Adult female Sprague-Dawley rats were divided into control, bilateral ovariectomy and bilateral ovariectomy and subcutaneous nicotine administered (received nicotine sulphate, 2 mg/kg) groups, daily for 28 days. At the end of the period, rats were sacrified under anesthesia blood samples were taken and femoral tissues were dissected. Estrogen, calcium and alkaline phosphatase levels were measured. Tissue samples were prepared for histopathogical examination. Sections were stained with Hematoxylin and Eosin and examined under light microcope. Biochemical parameters were decreased depending on the overiectomy, also decrement was notable with nicotine intake. In the ovariectomy group;increased inflammatory cells with degenerative changes around the femoral compact bone and dilatation of osteon structures in bone trabeculae and apoptotic changes in osteocyte cells in bone lacuna were apparent. In the ovariectomy with nicotine administration group, excessive dilatation of the havers lamellae in the compact bone region, increased osteoclastic activity, picnosis and apoptotic nucleus of the osteoclastic cells located in the lacuna, and increased collagen fibers in the matrix were observed. We suggest that ovariectomy and nicotine administration together effect estrogen and calcium metabolism negatively, stimulate alterations in the structural properties of bone matrix, also affect osteocyte development and bone lamellar structure that may accelerate osteoporosis development. 展开更多
关键词 OSTEOPOROSIS OVARIECTOMY FEMORAL Bone ESTROGEN HISTOPATHOLOGY
在线阅读 免费下载
Prevalence and Drug-Resistance Patterns of Enterotoxigenic <i>Escherichia coli</i>and <i>Shigella</i>Species among Children with Diarrhea in Merida City, Mexico 认领
7
作者 Claribel Huchin Mario A. Brice?o +3 位作者 Tahali Mendoza Ana P. Martínez Mario A. Ramírez Julio C. Torres 《生物科学与医学(英文)》 2018年第1期22-33,共12页
Enterotoxigenic Escherichia coli (ETEC) and Shigella are two of the leading causes of diarrhea among children in developing countries. The prevalence of ETEC and Shigella species resistant to antimicrobial agents is i... Enterotoxigenic Escherichia coli (ETEC) and Shigella are two of the leading causes of diarrhea among children in developing countries. The prevalence of ETEC and Shigella species resistant to antimicrobial agents is increasing. The aim of this study was to determine prevalence and antimicrobial resistance patterns of ETEC and Shigella species among under-five children with diarrhea in an urban region of southeastern Mexico. A cross-sectional study was conducted among under-five children with acute diarrhea from January 2013 to January 2014 at Merida city. Isolation, identification and antimicrobial susceptibility test of ETEC and Shigella species were performed using standard bacteriological protocols. Of 200 stool samples collected, 18 (9.0%) ETEC and 12 (6.0%) Shigella strains were isolated. Among 12 Shigella species Shigellaflexneri founded as 8 (66.7%), followed by Shigellaboydii 4 (33.3%). One hundred percent of ETEC and Shigella isolates showed resistance to ampicillin, carbenicillin and cephalothin. Also, high frequency of resistance for both ETEC and Shigella isolates was observed to nitrofurantoin (100%, 83.3%), respectively. However, when we analyzed the resistance patterns of Shigella by species, S. boydii showed more resistance (8 of 12 antimicrobials tested) in comparison to S. flexneri isolates. Multidrug resistance (MDR) (≥3 drugs) was observed among all ETEC and Shigella isolates, being the aminoglycosides the more effective drugs against these pathogens. In conclusion, these findings indicate that ETEC and Shigella spp. are important etiological agents of diarrhea among under-five children and a high rate of drug resistance, including MDR, to the commonly used drugs was observed in our region. 展开更多
关键词 ETEC SHIGELLA DIARRHEA Antibiotic Resistance
在线阅读 免费下载
Mutagenic Potential of Medicinal Polyherbal Preparations 认领
8
作者 Mohd Fuat Abd Razak 《生物科学与医学(英文)》 2019年第11期10-19,共10页
Extracts of twelve medicinal polyherbal preparations in powder form sold at retail shops were tested for mutagenicity using Ames in vitro test. Five of the polyherbal preparations were found to be mutagenic (p ≤ 0.05... Extracts of twelve medicinal polyherbal preparations in powder form sold at retail shops were tested for mutagenicity using Ames in vitro test. Five of the polyherbal preparations were found to be mutagenic (p ≤ 0.05) at 250 μg/ml. Two mutagenic preparations comprised of traditionally used medicinal plants with no mutagenicity property being reported. However, one polyherbal preparation which contained one mutagenic plant was found not mutagenic. Under the conditions of this study, it can be concluded that some polyherbal preparations were potentially mutagenic and mutagenicity of polyherbal preparation cannot always be deduced from the mutagenicity status of each individual plant components of the polyherbal preparations. 展开更多
关键词 AMES Test Mutagenic MUTAGENICITY POLYHERBAL SALMONELLA typhimuri-um TA100
在线阅读 免费下载
Main Microbial Genres and Its Profile of Resistance and Sensitivity to Antimicrobials Used in the Treatment of Oncological Patients with Febril Neutropenia 认领
9
作者 Hélvecio Cardoso Póvoa Richard Raphael Borges Tavares Vieira +7 位作者 Elias Sobreira Sathler Isabela Nardoni Bernardes Rafael Batista Ferreira Mário Henrique Couto Lima Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Lamara Laguardia Valente Rocha Daniel Almeida da Costa 《生物科学与医学(英文)》 2018年第1期34-50,共17页
Objective: To determine the main microbial genotypes and their antimicrobial resistance and susceptibility profile commonly used in the treatment of oncologic patients with febrile neutropenia, carried out through the... Objective: To determine the main microbial genotypes and their antimicrobial resistance and susceptibility profile commonly used in the treatment of oncologic patients with febrile neutropenia, carried out through the review of the clinical histories of the patients’ medical records at the Hospital do Cancer de Muriaé-Fundacao Cristiano Varella. Methods: Quantitative research, determined the susceptibility profile of microorganisms in patients with febrile neutropenia from April 2007 to April 2008 by reviewing clinical histories of patients’ medical records at the referred hospital. Results: Of the total of 8 patients evaluated with Gram-negative microorganisms, 50% of the patients were female and 50% were male. Of the 18 patients evaluated with Gram-positive microorganisms 66% were female and 34% male. Gram-positive bacteria are prevalent and cause around 60% of documented bacteremias, although Gram-negative bacteria are more common in febrile neutropenic patientes. Conclusion: Exaggerated use of antimicrobials in hospitalized patients leads to the suppression of drug-sensitive microorganisms from the intestinal flora and promotes the persistence and growth of resistant bacteria. The antibiotic should be used in a curative manner with other therapeutic measures with the determined bacterial infection. 展开更多
关键词 FEBRILE NEUTROPENIA ANTIMICROBIAL RESISTANCE Oncologic PATIENTS
在线阅读 免费下载
Ocular Fundus Abnormalities in Pre-Dialytic Chronic Kidney Disease Patients 认领
10
作者 Mohammad Kamrul Ahsan Muhammad Rafiqul Alam +7 位作者 Asia Khanam A. H. Hamid Ahmed Md. Omar Faroque K. B. M. Hadiuzzaman A. K. M. Shahidur Rahman Rafi Nazrul Islam Manik Chandra Mondal Md. Azizur Rahman 《生物科学与医学(英文)》 2019年第11期20-35,共16页
Background: Chronic kidney disease (CKD) affects 10% - 16% of the adult population. Although ocular findings related to renal insufficiency include cataract, conjunctival calcification, lid edema, conjunctival pallor ... Background: Chronic kidney disease (CKD) affects 10% - 16% of the adult population. Although ocular findings related to renal insufficiency include cataract, conjunctival calcification, lid edema, conjunctival pallor and xanthalesma, by far the most important is retinopathy. Objective: To evaluate the ocular fundus abnormalities in pre-dialytic chronic kidney disease patients of the adult population. Methodology: This cross-sectional observational study was conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from April 2012 to March 2014. A total of 100 hospital admitted CKD patients were purposively selected for this study. Age, gender, blood pressure, Body Mass Index (BMI), 24 hours Urinary Total Protein (UTP), haemoglobin level, serum creatinine, serum cholesterol, serum triglyceride and color fundus photography findings of both eyes were recorded for each patient. Inter-group comparisons were made between patients with retinopathy and those without retinopathy. Results: Out of 100 adult non-dialytic CKD patients, 43 (43%) had ocular fundus abnormalities, among them 27 (62.8%) were male and 16 (37.2%) were female. The risk of development of retinopathy was significantly higher among older patients (p = 0.006), those with low haemoglobin level (p = 0.0001) and high blood pressure. Retinopathy was significantly (p = 0.0001) increased with reduction of e-GFR. There was no relationship between BMI and high serum triglyceride level with retinal abnormality. Among 43 (43%) patients with retinal abnormality, 30 (69.76%) patients showed only hypertensive retinopathy and 5 (11.6%) patients showed only diabetic retinopathy. Mixed hypertensive and diabetic retinopathy was found in 8 (18.6%) patients. Maculopathy was seen in 11 (25.58%) patients, of whom 3 (6.98%) had hypertensive retinopathy and 8 (18.87%) had diabetic retinopathy. Optic atrophy was seen in 2 (4.6%) patients and drusen like retinal deposits were seen in 2 (4.6%) patients. Conclusion: Ocular fu 展开更多
关键词 Chronic KIDNEY Disease (CKD) OCULAR FUNDUS RETINOPATHY
在线阅读 免费下载
Biocompatibility and Antibacterial Effects of 6-Deoxy-6-Aminoethyleneamino Cellulose 认领
11
作者 Susanne Finger Michael Zieger +4 位作者 Cornelia Wiegand Tim Liebert Thomas Heinze Peter Elsner Uta-Christina Hipler 《生物科学与医学(英文)》 2018年第1期51-62,共12页
Recently, there is a need of alternatives to antibiotics due to increasing antibiotic-resistant microorganism. Promising classes of bioactive polymers are 6-deoxy-6-amino cellulose derivatives. The purpose of the stud... Recently, there is a need of alternatives to antibiotics due to increasing antibiotic-resistant microorganism. Promising classes of bioactive polymers are 6-deoxy-6-amino cellulose derivatives. The purpose of the study was the assessment of the biocompatibility of 6-deoxy-6-aminoethyleneamino cellulose (AEAC) with different degree of substitution (DS). HaCaT keratinocyte cell viability was analyzed by measuring the cellular ATP content. The antibacterial activity against Staphylococcus aureus and Klebsiella pneumoniae was examined by microplate laser nephelometry. Thus, the ratio of half-maximal lethal concentration (LC50) and half-maximal inhibitory concentration (IC50) was calculated and described as biocompatibility index. The study revealed that biocompatibility of AEAC depends on the DS. AEAC of low DS (0.3) showed the best biocompatibility. 展开更多
关键词 6-Deoxy-6-Aminoethyleneamino Celluloses ANTIBACTERIAL BACTERIA BIOCOMPATIBILITY BIOMACROMOLECULE KERATINOCYTE
在线阅读 免费下载
Effects of 17<i>β</i>-Estradiol on Dopamine D2 Receptors in Thiamine-Deficient Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight 认领
12
作者 Seydou Silué Abdoulaye Bâ 《生物科学与医学(英文)》 2019年第11期36-55,共20页
Our previous studies showed that 17β-estradiol (E2) modulated dopamine D2 receptor in regulating body weight set-point. The aim of this study was to understand whether thiamine deficiency influenced the E2 modulation... Our previous studies showed that 17β-estradiol (E2) modulated dopamine D2 receptor in regulating body weight set-point. The aim of this study was to understand whether thiamine deficiency influenced the E2 modulation on dopamine D2 receptors, using bromocriptine mesylate (BR) and sulpiride (SUL) as selective central dopamine-D2 receptors agonist and antagonist respectively. We studied the E2-dopamine D2 receptors interferences in a 10-day thiamine-deficient female rats for which consumptions of water, sugar, alcohol and food were daily-recorded and their consequences on body weights assessed. Our results showed that the volume of water daily ingested doubled in thiamine-deficient female rats (OXT), while sugar and alcohol consumptions collapsed with decreased weight and food consumption. On the one hand, thiamine potentiated D2/BR activity (bromocriptine-activated D2 receptors) to induce sugar intake and inhibited the same D2/BR receptors to induce water intake. On the other hand, thiamine promoted D2/SUL receptors (sulpiride-inhibited D2 receptors) for enhanced alcohol intake, increased food consumption and weight gain. Taking together, thiamine modulated the actions of 17β-estradiol on both D2/BR and D2/SUL receptors activities. 展开更多
关键词 THIAMINE Deficiency 17β-Estradiol D2 Receptors SUCROSE ALCOHOL INTAKES Body Weight
在线阅读 免费下载
Glycemic Index and Glycemic Load of Juice from Edible Wild Fruits (<i>Adansonia digitata</i>, <i>Tamarindus indica</i>and <i>Parkia biglobosa</i>) Consumed in C&ocirc;te d’Ivoire 认领
13
作者 Antoine Kouamé Kouassi Nestor Kouakou Kouassi +3 位作者 Maxwell Avit Grah Beugré Denis Yao N’Dri Georges N’Guessan Amani Dago Gnakri 《生物科学与医学(英文)》 2018年第1期63-74,共12页
The diabetes mellitus is a public health problem in C?te d’Ivoire. The Glycemic index (GI) and the Glycemic load (GL) determination of commonly consumed foods such as juice fruits is an alternative to prevent metabol... The diabetes mellitus is a public health problem in C?te d’Ivoire. The Glycemic index (GI) and the Glycemic load (GL) determination of commonly consumed foods such as juice fruits is an alternative to prevent metabolic diseases. This study carried out three wild fruits locally named Baobab (Adansonia digitata), Tomi (Tamarindus indica) and Néré (Parkia biglobosa) collected at maturity stage. The juices from the pulp of fruits have been elaborated, pasteurized, submitted to microbiological and physicochemical analysis before GIs/GLs determination. Ten healthy subjects with body mass index and age average respectively 21.57 ± 1.06 and 28 ± 2 years old tested the three juices and glucose (50 g) as reference food. Blood samples have been collected at 0, 15, 30, 45, 60, 90 and 120 min after foods consumption. The GIs/GLs has been determined according to ISO/FDI 26642:2010 protocol. Data showed that pasteurized juices has a weak microbiologic load (1.0102 - 2.4102 of Mesophylls Aerobic Germs) and not contain pathogen germs. The GI and GL of Néré juice are high with respective values of 89.54 ± 1.63 and 29.22 ± 4.09 whereas those of Baobab and Tomi juice are moderate with respective GI/GL values of 66.48 ± 2.12/13.24 ± 1.99 and 60.41 ± 2.63/12.87 ± 1.67. The juice of Néré should be consumed occasionally when those of Baobab and Tomi should be consumed with moderation. It would be suitable to know more about the GI and GL of all the juice fruits produced locally so as to prevent efficiently diabetes mellitus in the country. 展开更多
关键词 EDIBLE Wild Fruits Pasteurized JUICES Glycemic Index Glycemic Load C?te D’Ivoire
在线阅读 免费下载
Evaluation of Oxidative Stress and Antioxidant Level of Stroke Patients in Osun State, South-Western Nigeria 认领
14
作者 I. Akinlua M. F. Asaolu +1 位作者 O. C. Ojo G. O. Oyebanji 《生物科学与医学(英文)》 2019年第5期189-194,共6页
Stroke is a leading cause of morbidity and mortality worldwide. Oxidative stress which is as a result of increased activity of free radicals and decreased antioxidant mechanism plays a major role in the pathogenesis o... Stroke is a leading cause of morbidity and mortality worldwide. Oxidative stress which is as a result of increased activity of free radicals and decreased antioxidant mechanism plays a major role in the pathogenesis of stroke. This study determined the plasma level of malondialdehyde (MDA), a marker of lipid peroxidation and oxidative stress and enzymatic Antioxidants namely, superoxide dismutase (SOD), Glutathione peroxidase (GPx), and Catalase (CAT) in sixty stroke patients of both sexes attending Wesley Guide Hospital, Obafemi Awolowo University Teaching Hospital, Ilesa, Osun State. An equal number of healthy subjects were used as control. The result of this study revealed a significantly (p < 0.05) high plasma level of MDA in stroke patients when compared with the control subjects. Plasma level of SOD in stroke patients was significantly higher (p < 0.05) than the control subjects while plasma GPx and CAT level were found to be significantly lower (p < 0.05) in stroke patients than the control subjects. The result of the study indicated high level of lipid peroxidation and oxidative stress in stroke patients and high degree of free radicals presence as indicated by the high level of SOD. 展开更多
关键词 Stroke MALONDIALDEHYDE CATALASE Superoxide DISMUTASE GLUTATHIONE PEROXIDASE Lipid PEROXIDATION
在线阅读 免费下载
Frequency of Neurological Disorders and Related EEG Finding in a Tertiary Care Hospital of Karachi 认领
15
作者 Danish Mohammad Syeda Saba Zaidi +6 位作者 Bina Fawad Muhammad Fazal Hussain Qureshi Zain Jawed Abubaker Muhammad Zubair Shaikh Muzna Shah Mahira Lakhani Sara Sadiq 《生物科学与医学(英文)》 2019年第11期56-64,共9页
Background: Electroencephalogram (EEG) is defined as a method of detecting brain waves signifying the electrical conductivity of the brain. Globally, EEG is used to further classify neuropsychiatric disorders. Objecti... Background: Electroencephalogram (EEG) is defined as a method of detecting brain waves signifying the electrical conductivity of the brain. Globally, EEG is used to further classify neuropsychiatric disorders. Objective: To evaluate the prevalence of abnormal EEGs and related neurological disorders and it’s correlation with age and gender. Methodology: A descriptive cross sectional study was conducted in Neurology department, Ziauddin hospital, Karachi, Pakistan from June 2018 to May 2019. A total of 440 individuals based on inclusion criteria were selected through Non-probability consecutive sampling. Informed consent was obtained from study participants. A self-designed structured questionnaire and EEG record were used for data collection. Data were entered and analyzed using SPSS v 20. Mean and standard deviation was calculated for numerical variable and frequency and percentages were calculated for categorical variable. Independent t-test and chi square was used to check association of abnormal EEG with age and gender. P value of ≤0.05 was considered statistically significant. Results: The mean age of study participants was 52.98 ± 22.68 years. There were 54.5% (n = 240) males. Approximately 45.2% (n = 199) participants had predisposing condition which can lead to abnormal EEG. EEG records of 39.8% (n = 175) of the patients was normal while 60.2% (n = 265) had abnormal records. Diffuse neuronal dysfunction consistent with encephalopathy was found in 45.2%. Mild neuronal dysfunction consistent with encephalopathy accounted for 33.5% of cases. Significant difference was found in Abnormal EEG among different age group (p = 0.01). Chi square shows an association between abnormal EEG and male gender (p = 0.025). Conclusion: EEG plays a vital role in the diagnosis of neuropsychiatric conditions in developing countries. EEGs can further help to determine the relationship of different neuropsychiatric conditions and can help in early diagnosis and better prognosis. 展开更多
关键词 NEUROLOGICAL DISORDERS EEG ASSOCIATION
在线阅读 免费下载
Epstein Bar Virus—The Cause of Hodgkin’s Lymphoma 认领
16
作者 Ilija Baruk?i? 《生物科学与医学(英文)》 2018年第1期75-100,共26页
Objective: Epstein-Barr virus (EBV), a herpes virus which persists in memory B cells in the peripheral blood for the lifetime of a person, is accused to be associated with several malignancies. Hodgkin’s lymphoma (HL... Objective: Epstein-Barr virus (EBV), a herpes virus which persists in memory B cells in the peripheral blood for the lifetime of a person, is accused to be associated with several malignancies. Hodgkin’s lymphoma (HL) has long been suspected to have an Epstein-Barr virus infection as a causal agent. Some recent studies identified an EBV latent infection to a high degree in Hodgkin’s lymphoma. However, despite intensive study, the role of Epstein-Barr virus infection in Hodgkin lymphoma remains enigmatic. Methods: To explore the cause-effect relationship between EBV and HL and so to understand the role of EBV in HL etiology more clearly, a systematic review and re-analysis of studies published is performed. The method of the conditio per quam relationship was used to proof the hypothesis if Epstein-Barr virus infection (DNA) in human lymph nodes is present then Hodgkin lymphoma is present too. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause effect relationship between an Epstein-Barr virus infection (EBV DNA) and Hodgkin lymphoma. Significance was indicated by a p-value of less than 0.05. Result: The data analyzed support the Null-hypotheses that if Epstein-Barr virus infection (EBV DNA) is present in human lymph nodes then Hodgkin lymphoma is present too. In the same respect, the studies analyzed provide highly significant evidence that Epstein-Barr virus the cause of Hodgkin lymphoma. Conclusion: The findings of this study suggest that Epstein-Barr virus is the cause of Hodgkin’s lymphoma besides of the complexity of Hodgkin’s disease. 展开更多
关键词 EPSTEIN-BARR VIRUS Hodgkin’s LYMPHOMA CAUSAL Relationship
在线阅读 免费下载
Histopathological Evaluation of Prevalent <i>H. pylori</i>Induced Gastro Intestinal Diseases According to Updated Sydney Classification 认领
17
作者 Samreen Soomro Tazeen Mustansir Talat Mirza 《生物科学与医学(英文)》 2019年第5期195-201,共7页
Objective: To determine the prevalence of H. pylori induced gastritis and its association with development of chronic inflammation and carcinoma with reference to updated Sydney classification, to ensure the proper di... Objective: To determine the prevalence of H. pylori induced gastritis and its association with development of chronic inflammation and carcinoma with reference to updated Sydney classification, to ensure the proper diagnosis and timely treatment. Methods: This was a cross sectional study conducted at the Department of Pathology, Dow Diagnostic Reference and Research Laboratory for the year 2018. Analysis of about 726 gastric biopsy specimens was performed to identify the epidemiological status of the disease. On the other hand, 100 of the specimens were analysed according to Sydney classification to ensure the accurate diagnosis of the gastritis and related disorders. Out of 726 biopsy samples positive samples for carcinoma were investigated in detail histological features. Giemsa stain was used to visualize the h pylori bacteria and the sections of biopsies were subjected to haematoxylin and eosin staining for histological analysis. Results: Out of 727 cases, H. pylori was found in 492 (67.8%) patients. About 1.79% (13) cases were identified as adenocarcinoma, 0.27% (2) squamous cell carcinoma and 0.13% (1) as B cell non Hodgkin lymphoma. Results of Sydney classification. The degree of chronic inflammatory activity was 57% mild;38% moderate and 3% severe out of a total of 67% cases in an active phase of Hp gastritis. Hp-associated gastritis was the most common form of chronic gastritis, without intestinal metaplasia and with mild activity. The association of h pylori with mild inflammation and Neutrophilic infiltrates of the lamina propria, pits, or surface epithelium was statistically significant (p value Conclusion: The frequency of H. pylori infection is common in our population but the infection is mild to moderate and its Sydney classification reveals that early diagnosis may prevent the later complication. 展开更多
关键词 Helicobacter PYLORI SYDNEY CLASSIFICATION Histology Gastritis
在线阅读 免费下载
Comparative Analysis on the Haematological Parameters and Antioxidant Levels of Parboiled and Un-Parboiled Dichlorvos (DDVP)-Treated Beans 认领
18
作者 Nwuke Chinedu Nwauzobilom Darlington 《生物科学与医学(英文)》 2019年第11期65-75,共11页
This study comparatively evaluates the haematological and antioxidant effects of differently prepared (parboiled and un-parboiled) beans treated with sniper (i.e. a dichlorvos insecticide) and fed to wistar albino rat... This study comparatively evaluates the haematological and antioxidant effects of differently prepared (parboiled and un-parboiled) beans treated with sniper (i.e. a dichlorvos insecticide) and fed to wistar albino rats. Thirty (30) male wistar albino rats of known body weight were assigned into six (6) groups of 5 each. The groups received: 70 g and 30 g of un-parboiled beans (groups 1 & 2), 70 g and 30 g (groups 3 & 4) of parboiled beans compounded in the pellets as feed stock, beans only and standard feed for a period of 30 days. The rats were euthanized, and blood samples were collected after the termination of the study. Dichlorvos significantly decreased (P < 0.05) the concentration of the antioxidant enzymes (GSH, GPx, SOD, CAT) in the groups fed with un-parboiled beans unlike the groups fed with parboiled beans which were non-significantly decreased. There was significant increase in the malondialdehyde concentration of the groups fed with un-parboiled beans. Dose dependent variations were seen in the packed cell volume (PCV), white blood cell (WBC), haemoglobin (Hb) and platelet. But a reduced concentration of red blood cell count (RBC) for the un-parboiled groups and an increase in the parboiled group were seen, although both were not significant (P < 0.05). 展开更多
关键词 DICHLORVOS Vigna unguiculata REACTIVE Oxygen Species ANTIOXIDANT ENZYMES
在线阅读 免费下载
Expression of Skin Barrier Protein Filaggrin in Skin Diseases without Atopic Dermatitis 认领
19
作者 Yang Zhang Chen Tu +1 位作者 Shuang Wang Shengxiang Xiao 《生物科学与医学(英文)》 2018年第1期101-112,共12页
The epidermis represents an essential barrier versus a broad range of exogenous stimuli. To form a functional epidermis, keratinocytes express filaggrin which plays a vital role in atopic dermatitis. However the relat... The epidermis represents an essential barrier versus a broad range of exogenous stimuli. To form a functional epidermis, keratinocytes express filaggrin which plays a vital role in atopic dermatitis. However the relationship between filaggrin and other skin diseases remains unknown. In our study we chose 5 different common skin diseases and analyzed the expression of filaggrin in the skin using immunohistochemistry. Imiquimod (IMQ)-induced mouse model was used for detecting the filaggrin level and barrier function. The results indicated that the expression of filaggrin is reduced in psoriasis compared to the other skin diseases. Furthermore in vivo study showed that the skin barrier is defected with a decreased expression of filaggrin in IMQ-induced psoriasis mouse model, which is accompanied with an increased level of IL-17/IL-23. In conclusion, the defective skin barrier is involved in the development of psoriasis in human and mice with a reduced expression of filaggrin which may be regulated by the increased level of IL-17/IL-23 in the skin. 展开更多
关键词 SKIN BARRIER PSORIASIS FILAGGRIN ATOPIC Dermatits
在线阅读 免费下载
Comparative Nursing Study of Patients Undergoing Coronary Intervention Therapy in Different Ways 认领
20
作者 Qilian He Yuquan Luan +1 位作者 Yanfen Fu Jun Tang 《生物科学与医学(英文)》 2019年第5期203-212,共10页
Purpose: To compare the surgical indicators, perioperative complications and postoperative psychological status of patients with coronary interventional therapy (CIT) by radical artery and femoral artery puncture appr... Purpose: To compare the surgical indicators, perioperative complications and postoperative psychological status of patients with coronary interventional therapy (CIT) by radical artery and femoral artery puncture approaches. Methods: 120 patients with CIT were divided into femoral artery group (FAG) and radial artery group (RAG) according to the operation ways. The interventional operation was performed by the same surgeon team and methods. Data of surgical indicators and perioperative complications were recorded and collected. The psychological questionare survey was made within 48 hours the after surgery by the hospital anxiety and depression scale (HAD), and the results were scored by the psychiatrist. Results: The age, sex, ethnicity, education level, disease type, and combined diseases of the two groups had homogeneity without statistical difference. There was no obvious difference in X-ray exposure time, contrast agent usage and operation time in two ways (P > 0.05). The success rate of one-time catheterization was higher in FAG than in RAG (P Conclusion: CIT via radial artery can reduce the incidence of postoperative complications, postoperative physical discomfort and psychological problems such as anxiety and depression of patients. 展开更多
关键词 NURSING CORONARY INTERVENTIONAL Therapy (CIT) CORONARY Arterial ANGIOGRAPHY (CAG) Percutaneous CORONARY Intervention (PCI) Radical ARTERY FEMORAL ARTERY The Hospital Anxiety and Depression Scale (HAD)
在线阅读 免费下载
上一页 1 2 30 下一页 到第
使用帮助 返回顶部 意见反馈