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乳酸红霉素对油酸致大鼠急性肺损伤后肺纤维化的防护作用 认领 被引量:2

Prophylaxis effect of erythromycin on rat with fibrosis of lung
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摘要 目的 了解红霉素对肺纤维化的防护作用。方法 采用大鼠油酸尾静脉注射制作急性肺损伤后肺纤维化模型 ,观察红霉素对损伤肺组织中中性粒细胞聚集及氧自由基的干预作用。结果 血清检测 :油酸注射后第 12天和第 2 4天的MDA明显升高 ,而SOD明显降低 ,MDA和SOD呈负相关 (r =- 0 .91) ;红霉素干预后GSH明显降低 ;注射油酸组GSH -Px水平最高 ,红霉素干预后GSH -PX水平最低。组织匀浆检测 :MDA变化同血清 ;SOD、GSH组间无差异 ;油酸注射后第 12天和第 2 4天的GSH -Px水平明显低于红霉素干预组。镜下观察 :注射油酸组中性粒细胞浸润和纤维化程度明显重于红霉素干预组。结论 红霉素可通过抑制中性粒细胞而减少氧自由基的产生 ,减轻纤维化程度 ,对油酸所致急性肺损伤后的肺纤维化有一定防护作用 Objective: To understand the prophylaxis effect of erythromycin on fibrosis of lung .Methods: Model of fibrosis of lung with injection by oil-acid to rat, observed the effect of erythromycin to neutrophil and oxygen-free radical. Result: Serum test: MDA increased obviously after injection oil-acid 12 and 24days, but SOD decreased obviously, MDA and SOD showed negative correlation(-0.91). GSH decreased after use of Erythromycin; GSH-PX was lowest in using oil-acid and highest in using Erythromycin. Tissue liquid test: The change of MDA was similar to serum; SOD and GSH had no difference among groups. 12 and 24 days after of injection oil-acid, GSH-PX was lower obviously lower than group of Erythromycin. Micrography: Congestion and neutrophil infiltration in the group of oil-acid injection was severer than those in group using erythromycin.Conclusion: Erythromycin can reduce the production of oxygen-free radical by repressing neutrophil, subdue inflammation and exudation of alveolus, mitigate chronic prompting of injury factor and prevent fibrosis of lung . Erythromycin has prophylaxis effect on fibrosis of lung with oil-acid.
出处 《中国现代医学杂志》 CAS CSCD 2004年第13期30-33,共4页 China Journal of Modern Medicine
关键词 红霉素 肺纤维化 防护 erythromycin rat with fibrosis of lung prophylaxis
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参考文献7

  • 1LI JH, SONG MC (review). Research advance in treatment of pulmonary interstitial fibrosis[ J]. Sub - volume of respiratory system of foreign medicine, 1998, 18 (1): 18-20. Chinese 被引量:1
  • 2LI GL, HE B, ZHAO GR, et al. Observation of therapeutic effect of hormone on acute pulmonary injury caused by oleic acid and Bacillus coli, 1995, 27 (1): 40-42. 被引量:1
  • 3OU YY, ZHAO MW, LIAO SL. Pulmonary morphological observation of experimental oleic acid type of RDS[ J]. Guizhou Medicine and Pharmacy, 1998, 24 (4): 245-247. Chinese 被引量:1
  • 4JUN T, Junko N, Etsuko T, et al .Effetc of roxithromycin and thremycin on interleukin 8 - induced neutophil recruitment and let cell secretion in guinea pig tracheas [ J ]. Antimicrobchemther,1996, 40:1726-1730. 被引量:1
  • 5Azuma A, Furuta T, Enomoto T, et al. Preventive effect of erythromycin on experimental bleomycin - induced acute lung injury in rats [J]. Thorax, 1998, 53 (3): 186-189. 被引量:1
  • 6Yosuke A, Peter N. Erythromycin inhibits transcriptional activation of NF - KB, but not NFAT, through Calcineurin - independent signaling in T Cells [J]. Antimicrob Agents Chemother, 1999, 43(11): 2678 -2684. 被引量:1
  • 7Translated by ZHAO Y. Gao Keming Chronic interstitial pneumonia, pulmonary interstitial fibrosis and their diagnosis and treatment [J]. Introduction of Japanese Medicine, 1998, 19 (7): 327. 被引量:1

同被引文献20

  • 1陶仲为.红霉素治疗慢性哮喘持续状态[J].山东医药,1993,33(9):32-32. 被引量:16
  • 2李燕燕.第一届中日弥漫性泛细支气管炎学术研讨会概况[J].中华结核和呼吸杂志,1996,19(4):253-254. 被引量:10
  • 3冲良生.红霉素治疗支扩的效果[J].国外医学呼吸分册,1994,14(2):107-107. 被引量:2
  • 4蔡柏蔷.抗菌药物在肺部感染时的应用进展.呼吸内科学[M].北京:中国协和医科大学出版社,2000.132. 被引量:68
  • 5[1]BERNARD GR, ARTIGAS A, BRIGHAM KL, et al. Report of the American-European Consensus Conference on ARDS[J]. Intensive Care Med, 1994, 20: 225-232. 被引量:1
  • 6[3]YANG YL, XU XP, LI KZ, et al. Prevention of postoperative peritoneal adhesions by ulinastatin in mice [J]. China Journal of Modem Medicine, 2003, 13(10): 55-57. 被引量:1
  • 7[4]SCHUSTER DP. ARDS: Clinical lessons from the oleic acid model of acute lung injury[J]. Crit Care Med, 1994, 149: 245-260. 被引量:1
  • 8[5]OVERBACK MC, PRANIKOFF T, YADAO CM et al. Efficacy of perfluorocarbon partial liquid ventilation in a large animal model of acute respiratory failure[J]. Crit-Care-Med, 1996, 24(7):1208. 被引量:1
  • 9[11]CHEN TT, WANG G, ZHANG H. Effects of ulinastatin on plasma levels of TXA2/PGI2 and cytokines in traumatic hemorrhagic shock in rabbits [J]. China Journal of Modem Medicine,2003, 13(19): 1-8. 被引量:1
  • 10大野彰二,须贺达夫.Bronchiolitis obliterans orgarnizing pneumonia[J]. 日胸会志,1994,53(8):674. 被引量:1

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