Objective To study the influence of Bacillus coagulans （TQ33） upon the immune function model mice. Methods Injecting the suspension of chicken red blood cell into the mice abdominal cavlty.then the influence of TQ33 upon the phagocytic function of the macrophages in the mice abdominal cavity was observed;the SRBC was prepared.the degree of the blood corpuscle coagulation was observed,then determination of the serum hemolysin was did ;the mice NK cell activity were detectedd by the Interaction between the target cell （YAC-1） and spleen cell （the response cell）;the observation of the influence of TQaa upon the cellular immunity was made by the lym- phocyte transforming assay;then the influence upon the organ/body weight ratio was measured by calculating the thymus/body and spleen/body ratio. Results Compared with the control,TQ33 could significantly improve phagocytic function of the macrophages in the mice abdominal cavity;it could also improve the humoral immune function in the mice;It could increase NK cell activity;it could enhance the lymphocyte transforming,inducing by the ConA; and it had no effect upon the organ/body weight ratio. Conclusion The Bacillus coagulans could increase the im munomodulating effect,indicating it would have a good using perspect.
Chinese Journal of Microecology