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乌司他丁在急危重症临床应用的进展 认领 被引量:125

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摘要 乌司他丁(ulinastatin,UTI)是从人尿液中提取精制而成的糖蛋白,分子质量为67000ku,能抑制胰蛋白酶、α-糜蛋白酶、透明质酸酶、弹性蛋白酶、组织蛋白酶G等多种水解酶的活性。UTI分子中还具有与细胞膜受体识别和结合的位点。加上第10位丝氨酸上带负电荷的硫酸软骨素糖链,使其表现出稳定细胞膜和溶酶体膜的生理功能。UTI静脉给药半衰期约为40min,不与血浆蛋白结合,给药后在肾脏与肝脏迅速积累,
出处 《中国危重病急救医学》 CAS CSCD 北大核心 2006年第2期 117-120,共4页 Chinese Critical Care Medicine
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参考文献42

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