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百草枯致急性肺损伤大鼠模型的建立 认领 被引量:12

Establishment of Rat Model with Acute Lung Injury Induced by Paraquat
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摘要 目的建立一种百草枯诱导的急性肺损伤(ALI)大鼠模型。方法将20只SD大鼠随机分为正常对照组10只、实验组10只。实验组一次性口服灌胃百草枯(PQ)80mg/kg,于给药后1天处死大鼠,观察光镜下肺组织病理改变、肺动脉血氧分压(PaO2)、支气管肺泡灌洗液(BALF)蛋白含量等。结果给予百草枯1天后肺形态学出现显著异常,PaO2及BALF蛋白含量出现显著改变。结论一次性灌胃百草枯80mg/kg成功建立急性肺损伤动物模型。 Objective To establish a kind of models of acute lung injury (ALI) induced by paraquat. Methods 20 Sprague-Dawley rats were divided into 2 groups,including test (n= 10) group and normal (n= 10) group. Paraquat (80 mg/kg) was administered to the animals in test group only once by oral and the animals were killed on day 1 after administration. The indexes of test included: pathological alteration,arterial, partial pressure of oxygen(PaO2) and the pro- tein in Bronchoalveolar lavage fluid(BALF). Results PaO2 changed significantly at ld after paraquat infusion. Significant anomaly was observed in bronehoalveolar lavage liquid analysis and lung pathomorphology. Conclusion An acute lung injury model of rats can be successfully established only once by oral of 80 mg/kg paraquat.
作者 磨静佳 赵晓琴 邝晓聪 MO Jing-jia, ZHAO Xiao-qin, KUANG Xiao-cong (1. Department of Emergency, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, China;2. Department of Pathophysiology, Guangxi Medical University, Nanning, Guangxi, 530021, China)
出处 《蛇志》 2009年第2期 101-102,共2页 Journal of Snake
关键词 急性肺损伤 百草枯 模型 动物 Acute lung injury Paraquat Models Animal
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