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右美托咪定对心脏瓣膜置换术患者围术期应激水平及镇静评分的影响 认领

Effects of dexmedetomidine on perioperative stress level and sedation score in patients undergoing cardiac valve replacement
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摘要 目的探讨右美托咪定对心脏瓣膜置换术患者围术期应激水平及镇静评分的影响。方法回顾性分析2019-05—2020-04间在南阳医学高等专科学校第一附属医院行心脏瓣膜置换术的78例患者的临床资料,根据麻醉方法分为全身麻醉组(对照组)和右美托咪定联合全身麻醉组(观察组),各39例。比较2组患者的基线资料。术前、术后第1天的血清皮质醇(Cor)、去甲肾上腺素(NE)、肾上腺素(E)水平。术后2 h、6 h、12 h的Ramsay镇静评分。结果术后第1天,2组患者的血清Cor、NE、E水平均上升,但观察组低于对照组,差异有统计学意义(P<0.05)。观察组术后2 h、6 h、12 h的Ramsay镇静评分均低于对照组,差异有统计学意义(P<0.05)。结论右美托咪定联合全身麻醉,可调节心脏瓣膜置换术患者围术期的应激水平,且镇静效果较好。 Objective To investigate the effect of dexmedetomidine on perioperative stress level and sedation score in patients undergoing cardiac valve replacement.Methods Retrospective analysis of clinical data of 78 patients undergoing cardiac valve replacement in the first affiliated hospital of Nanyang Medical College from 2019-05 to 2020-04,According to the anesthetic method,the general anesthesia group(control group)and dexmedetomidine combined with general anesthesia group(observation group),39 cases each.Baseline data of 2 groups were compared.serum cortisol(Cor),norepinephrine(NE),and epinephrine(E)levels before and on day 1 after operation.Ramsay sedation score 2 h、6 h、12 h postoperative.Results The serum Cor、NE、E level of the two groups increased on the first day after operation,but the observation group was lower than that of the control group(P<0.05).The Ramsay sedation scores of 2 h、6 h、12 h after operation in the observation group were lower than those of control group(P<0.05).Conclusion dexmedetomidine combined with general anesthesia can regulate the stress level in patients with cardiac valve replacement during perioperative period,and the sedation effect is better.Conclusion Dexmedetomidine can adjust the perioperative stress level of patients with cardiac valve replacement,and has a good sedative effect and high application value.
作者 丁刘欣 Ding Liuxin(Department of External Surgery,Department of Anesthesia and Perioperative Medicine,the First Affiliated Hospital of Nanyang Medical College,Nanyang Henan,473000,China)
出处 《河南外科学杂志》 2021年第2期5-7,共3页 Henan Journal of Surgery
关键词 心脏瓣膜置换术 右美托咪定 围术期应激水平 镇静评分 Cardiac valve replacement Dexmedetomidine Perioperative stress level Sedation score
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