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Small balloon strategy associated with low pacemaker implantation rate after self-expanding transcatheter valve implantation 认领
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作者 Yuan Zhang Wen-zhi Pan +8 位作者 Li-hua Guan Xiao-chun Zhang Sha-sha Chen Li-fan Yang Lei Zhang Ming-fei Li Dan-dan Chen Da-xin Zhou Jun-bo Ge 《世界急诊医学杂志(英文)》 SCIE CAS CSCD 2021年第1期48-53,共6页
BACKGROUND: This study aims to investigate whether small balloon aortic valvuloplasty(BAV) reduces the need for permanent pacemaker implantation (PPMI) after transcatheter aortic valveimplantation (TAVI).METHODS: This... BACKGROUND: This study aims to investigate whether small balloon aortic valvuloplasty(BAV) reduces the need for permanent pacemaker implantation (PPMI) after transcatheter aortic valveimplantation (TAVI).METHODS: This was a retrospective analysis using data from our local TAVI database. SmallBAV was defined as a small balloon size (=18 mm) pre-dilatation. Normal BAV was defined as aballoon size >18 mm. The primary endpoint was the incidence of new PPMI.RESULTS: Of 99 consecutive TAVI patients, five patients were excluded due to pre-existingpermanent pacemaker. Patients in the small BAV group (n=57) had a signifi cantly lower PPMI ratecompared with the normal BAV group (n=37) (3.5% vs. 18.9%, P=0.026). Moderate or severe aorticvalve regurgitation post-procedure was similar between the small BAV and normal BAV groups (5.3%vs. 8.1%, P=0.480);likewise, the mean aortic gradient post-procedure did not differ significantly(11.5±5.2 mmHg vs. 12.2±7.3 mmHg, 1 mmHg=0.133 kPa, P=0.580) between the groups. Devicesuccess rates were also similar (94.7% vs. 91.8%, P=0.680). In multivariable analysis, small BAV(P=0.027), the ratio of prosthesis diameter to annulus diameter (P=0.048), and mean aortic gradientby echo in the basement (P=0.021) were independent predictors of PPMI.CONCLUSIONS: The small BAV strategy is associated with a low rate of permanentpacemaker implantation after transcatheter self-expanding valve implantation in this single-centerobservational study. 展开更多
关键词 Transcatheter aortic valve implantation Balloon aortic valvuloplasty Balloon size Permanent pacemaker implantation
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Does Stem Cell Implantation Have an Effect on Severity of Retinitis Pigmentosa: Evaluation with a Classification System? 认领
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作者 Ayşe Öner Neslihan Sinim Kahraman 《眼科学期刊(英文)》 2021年第1期36-48,共13页
<strong>Background:</strong> Cell replacement therapies have been evaluated in recent years as an alternative for various retinal pathologies to evaluate the therapeutic efficacy of cell therapy, it is imp... <strong>Background:</strong> Cell replacement therapies have been evaluated in recent years as an alternative for various retinal pathologies to evaluate the therapeutic efficacy of cell therapy, it is important to measure the severity of the disease. The aim of this study was to evaluate the effect of umbilical cord derived Mesenchymal Stem Cell (UC-MSC) implantation on severity of Retinitis Pigmentosa (RP). <strong>Methods:</strong> This single-center, clinical study included data of 138 eyes of 92 patients who had a confirmed diagnosis of RP and received stem cell implantation to the suprachoroidal area with a surgical procedure. Patients were evaluated before and 1 year after the surgery regarding to the outcome measures of Best Corrected Visual Acuity (BCVA), Optical Coherence Tomography (OCT) and Visual Field (VF) tests. BCVA, VF width and ellipsoid zone (EZ) width on OCT were recorded for each patient and a scoring criterion was established for each variable varying from 0 to 5 depending on its distribution. The cumulative score (from 0 to 15) was used to classify disease severity from grade 0 to 5. <strong>Results:</strong> All of the patients completed 12-month follow-up period. The median age of the patients was 40.8 years, 46% were female, 77% had been diagnosed within 10 years and 41% had a family history. 79% of the patients with family history had autosomal recessive inheritance pattern. There were statistically significant improvements in the mean BCVA and VF scores during the study (p < 0.05). The mean score and the mean grade of the disease also improved after the treatment (p < 0.05). There was a negative correlation between BCVA improvement and scoring and grading of the disease. <strong>Conclusions:</strong> This study demonstrated beneficial effect of suprachoroidally applied UC-MSCs on BCVA, VF and the severity score and grade of the disease during 12-month follow-up period. Cell mediated therapy based on the secretion of Growth Factors (GFs) seems to be an effective and safe option for the 展开更多
关键词 Cell Mediated Therapy Retinitis Pigmentosa Suprachoroidal Implantation Umbilical Cord Derived Mesenchymal Stem Cell Visual Function Classification
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A direct observation of aqueous humour flow in vivo after implantable collamer lens with a central hole implantation 认领
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作者 Mei-Yan Li Feng Zhao +3 位作者 Pei-Jun Yao Ying-Jun Chen Ruo-Yan Wei Xing-Tao Zhou 《国际眼科杂志:英文版》 SCIE CAS 2021年第1期160-162,共3页
Dear Editor,We present the reported case of the aqueous humour flow observed in vivo after implantable collamer lens(ICL)with a central hole implantation surgery.ICL,a phakic intraocular lens which is located in the p... Dear Editor,We present the reported case of the aqueous humour flow observed in vivo after implantable collamer lens(ICL)with a central hole implantation surgery.ICL,a phakic intraocular lens which is located in the posterior chamber,is an effective treatment to correct moderate-tohigh myopia[1-2]. 展开更多
关键词 IMPLANTATION VIVO FLOW
Endothelial keratoplasty combined with scleral fixation intraocular lens 认领
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作者 Mariantonia Ferrara Danilo Iannetta +2 位作者 Luca Pagano Kunal A Gadhvi Vito Romano 《国际眼科杂志:英文版》 SCIE CAS 2021年第1期163-166,共4页
Dear Editor,We describe,for the first time,the surgical management of two aphakic patients with corneal decompensation treated with concomitant ultrathin-Descemet stripping automated endothelial keratoplasty(UT-DSAEK)... Dear Editor,We describe,for the first time,the surgical management of two aphakic patients with corneal decompensation treated with concomitant ultrathin-Descemet stripping automated endothelial keratoplasty(UT-DSAEK)and implantation of two different scleral-fixated(SF)intraocular lenses(IOLs),namely sutureless SF(SSF)Carlevale IOL(Soleko,Italy;Figure 1)or Morcher Type 90 L IOL(Morcher Gmb H,Germany;Figure 2). 展开更多
关键词 FIGURE STRIPPING IMPLANTATION
转录组测序技术与口腔疾病、牙种植及组织再生 认领
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作者 龙茜 管晓燕 +2 位作者 王倩 胡欢 刘建国 《中国组织工程研究》 CAS 北大核心 2021年第11期1791-1798,共8页
背景:自从转录组测序技术的应用使得黑色素瘤和乳腺癌的研究取得显著成果以来,转录组测序技术成为科学研究中最具应用前景的研究手段,在口腔医学领域的应用亦十分广泛。目的:通过检索、筛选和阅读文献,综述转录组测序技术的发展和在口... 背景:自从转录组测序技术的应用使得黑色素瘤和乳腺癌的研究取得显著成果以来,转录组测序技术成为科学研究中最具应用前景的研究手段,在口腔医学领域的应用亦十分广泛。目的:通过检索、筛选和阅读文献,综述转录组测序技术的发展和在口腔医学领域各学科中的应用。方法:计算机检索CNKI、CBM以及PubMed数据库,英文关键词为“Transcriptome,sequencing technology,RNA-seq,microarray,oral cancers,OSCC,periodontal,caries,pulp disease,tooth development,DPSCs,PDLSCs,orthodontics,implant”,中文关键词为“转录组,测序技术,RNA-seq,微阵列,口腔癌,口腔鳞状细胞癌,牙周病,龋病,牙髓病,牙齿发育,牙髓干细胞,牙周膜干细胞,正畸,种植”,重点查阅2015年至2020年间的相关文献。根据纳入标准和排除标准,共纳入72篇文献对转录组测序技术的发展及其在口腔医学领域应用进行综述。结果与结论:在转录组测序技术发展历程中,RNA-seq技术是目前在科学研究中优势最大的,因为其具有准确度高、通量大、价格低等优点。在口腔医学领域,该技术用于口腔鳞癌、牙周炎、牙体牙髓病、牙再生和正畸种植的研究,并取得一定成果。但目前针对同一种类疾病的研究没有体现出各研究之间的联系,且内容局限。从各研究之间的联系和扩展研究内容范围着手,相信口腔医学能有更多新发现。 展开更多
关键词 牙周病 龋病 牙齿发育 转录组 口腔癌 牙髓干细胞 牙周膜干细胞 种植
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Influence of normal to high stroke volume on congestive heart failure development after transcatheter aortic valve implantation:case series 认领
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作者 Tomoko Tomioka Tomohiro Ito +1 位作者 Ryokichi Takahasi Shuhei Tanaka 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2021年第1期83-88,共6页
Aortic stenosis(AS)is the most common valvular disease in the older adults'population,and its prevalence will likely continue to increase with the aging society.[1]Surgical aortic valve replacement(SAVR)for elderl... Aortic stenosis(AS)is the most common valvular disease in the older adults'population,and its prevalence will likely continue to increase with the aging society.[1]Surgical aortic valve replacement(SAVR)for elderly patients is known as a high-risk procedure.[2-4]Transcatheter aortic valve implantation(TAVI)is a reasonable alternative to SAVR for older and inoperable patients with AS,and TAVI significantly improves outcomes in elderly patients with severe AS and serious comorbidities,[5,6]TAVI achieves a 20%relative reduction in mortality compared with SAVR. 展开更多
关键词 AORTIC MORTALITY IMPLANTATION
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Radioactive 125I seed implantation for pancreatic cancer with unexpected liver metastasis:A preliminary experience with 26 patients 认领
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作者 Cheng-Gang Li Zhi-Peng Zhou +2 位作者 Yu-Ze Jia Xiang-Long Tan Yu-Yao Song 《世界临床病例杂志》 SCIE 2021年第4期792-800,共9页
BACKGROUND Preoperative diagnosis rate of pancreatic cancer has increased year by year.The prognosis of pancreatic cancer patients with unexpected liver metastasis found by intraoperative exploration is very poor,and ... BACKGROUND Preoperative diagnosis rate of pancreatic cancer has increased year by year.The prognosis of pancreatic cancer patients with unexpected liver metastasis found by intraoperative exploration is very poor,and there is no effective and unified treatment strategy.AIM To evaluate the therapeutic effect of radioactive 125I seed implantation for pancreatic cancer patients with unexpected liver metastasis.METHODS The demographics and perioperative outcomes of patients who underwent 125I seed implantation to treat pancreatic cancer with unexpected liver metastasis between January 1,2017 and June 1,2019 were retrospectively analyzed.During the operation,125I seeds were implanted into the pancreatic tumor under the guidance of intraoperative ultrasound,with a spacing of 1.5 cm and a row spacing of 1.5 cm.For patients with obstructive jaundice and digestive tract obstruction,choledochojejunostomy and gastroenterostomy were performed simultaneously.After operation,the patients were divided into a non-chemotherapy group and a chemotherapy group that received gemcitabine combined with albumin-bound paclitaxel treatment.RESULTS Preoperative imaging evaluation of all patients in this study showed that the tumor was resectable without liver metastasis.There were 26 patients in this study,including 18 males and 8 females,aged 60.5±9.7 years.The most common tumor site was the pancreatic head(17,65.4%),followed by the pancreatic neck and body(6,23.2%)and pancreatic tail(3,11.4%).Fourteen patients(53.8%)underwent palliative surgery and postoperative pain relief occurred in 22 patients(84.6%).The estimated blood loss in operation was 148.3±282.1 mL and one patient received blood transfusion.The postoperative hospital stay was 7.6±2.8 d.One patient had biliary fistula,one had pancreatic fistula,and all recovered after conservative treatment.After operation,7 patients received chemotherapy and 19 did not.The 1-year survival rate was significantly higher in patients who received chemotherapy than in those who did not(68.6%vs 展开更多
关键词 Pancreatic cancer Liver metastases Radioactive 125I seeds RADIOTHERAPY Permanent implantation Therapeutic effect
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Oxygen vacancies enable the visible light photoactivity of chromium-implanted TiO2 nanowires 认领
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作者 Xianyin Song Wenqing Li +8 位作者 Xiaojing Liu Yishang Wu Dong He Zunjian Ke Li Cheng Changzhong Jiang Gongming Wang Xiangheng Xiao Yat Li 《能源化学:英文版》 SCIE EI CAS CSCD 2021年第4期154-161,共8页
Although computational studies have demonstrated that metal ion doping can effectively narrow the bandgap of TiO2,the visible-light photoactivity of metal-doped TiO2 photoanodes is still far from satisfactory.He... Although computational studies have demonstrated that metal ion doping can effectively narrow the bandgap of TiO2,the visible-light photoactivity of metal-doped TiO2 photoanodes is still far from satisfactory.Herein,we report an effective strategy to activate the visible-light photoactivity of chromiumimplanted TiO2 via the incorporation of oxygen vacancies.The chromium-doped TiO2 activated by oxygen vacancies(Cr-TiO2-vac)exhibited an incident photon-to-electron conversion efficiency(IPCE)of~6.8%at450 nm,which is one of the best values reported for metal-doped TiO2.Moreover,Cr-TiO2-vac showed no obvious photocurrent decay after 100 h under visible-light illumination. 展开更多
关键词 TiO2nanowires Photoelectrochemical water splitting Chromium implantation Visible-light photoactivity
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Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice 认领
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作者 Wenhao Chen Qian Zhang +2 位作者 Haibin Wang Dongmei Tan Yi Tan 《基因与疾病》 SCIE 2021年第1期79-86,共8页
Embryo implantation and decidualization are crucial for successful pregnancy,which include multiple genes and signaling pathways,while the precise mechanism regarding embryo implantation and decidualization has yet to... Embryo implantation and decidualization are crucial for successful pregnancy,which include multiple genes and signaling pathways,while the precise mechanism regarding embryo implantation and decidualization has yet to be explored.The GABA which activates GABAAor GABABreceptors has been found playing an important role in early pregnancy.Here we seek to investigate whether GABABreceptors participate in embryo implantation in mice.This study first characterized the spatiotemporal expression pattern of GABABreceptors in the uterus during the peri-implantation period and found that GABAB1expression was drastically upregulated in stromal cells on days 4e6,a period of embryo implantation and early stages of decidualization.Embryo delayed implantation and oil-induced decidualization models were further used to confirm that the GABAB1was associated with embryo implantation and decidualization.We also found estrogen or progesterone had no directly effect on expression of GABAB1in ovariectomized model.Because we were unable to detect significant GABAB2which couples with GABAB1to form whole GABABreceptors,and the agonist and antagonist of whole GABABreceptors had weak effect on the proliferation and differentiation of stromal cells as well,we excluded the possibility whole GABABreceptors function,and concluded it should be non-classical signals of GABAB1involving in embryo implantation and decidualization.Future studies should focus on investigating the roles and mechanisms of GABAB1during embryo implantation and decidualization. 展开更多
关键词 DECIDUALIZATION Embryo implantation Endometrial stromal cells GABAB1 Ovarian hormones PROLIFERATION
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54例晕厥患者植入心电事件监测器的观察护理 认领
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作者 虞彬 芦颜美 《新疆医科大学学报》 CAS 2021年第2期248-251,共4页
目的探讨晕厥患者植入心电事件监测器(ICM)诊断前后临床护理技术方法,为ICM的临床推广应用提供护理经验。方法2015年9月-2017年7月在新疆医科大学第一附属医院收治的110例患者,根据纳入和排除标准,最终入选54例。依据ICM技术特点,针对... 目的探讨晕厥患者植入心电事件监测器(ICM)诊断前后临床护理技术方法,为ICM的临床推广应用提供护理经验。方法2015年9月-2017年7月在新疆医科大学第一附属医院收治的110例患者,根据纳入和排除标准,最终入选54例。依据ICM技术特点,针对性开展晕厥患者的心理、临床和延续性护理及随访指导,并统计分析。结果本组共入选54例植入ICM晕厥患者,围手术期给予心理护理、临床护理。ICM植入前后就诊次数及检查次数差异有统计学意义(P均<0.01)。出院后延续性护理平均随访天数为(305.87±102.07)d。随访期间共检出心脏停搏8例(14.81%)、缓慢性心律失常6例(11.11%)、快速心房颤动3例(5.55%)、阵发性室上性心动过速2例(3.70%)。事件激活与自动记录两种监测方式比较心律失常事件检出率结果无差异,但ICM植入超过1年较ICM植入不到1年的心律失常检出率高(P<0.01)。结论针对晕厥患者ICM开展的心理护理、临床护理、延续性护理及随访指导等护理经验对临床治疗康复具有较大意义。 展开更多
关键词 植入式心电事件监测器 植入术 护理 晕厥
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Aqueous wood-ash extract of Parkia biglobosa causes reproductive toxicity in female mice 认领
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作者 Timothy Auta 《TMR生命研究》 2021年第1期29-35,共7页
Background: The traditional culture of eating wood-ash extracts in some countries has led to many health problems.The study assessed the anti-fertility effects of the aqueous wood-ash extract of Parkia biglobosa on fe... Background: The traditional culture of eating wood-ash extracts in some countries has led to many health problems.The study assessed the anti-fertility effects of the aqueous wood-ash extract of Parkia biglobosa on female Swissalbino mice. Methods: Healthy female albino mice were procured and randomly grouped into four groups (5/group)where control, 5, 50 and 100 mg/kg doses of the extract were orally administered for 20 days and microscopy ofvaginal smear carried out daily to determine anti-ovulatory activity. Oestrus cycle, including metestrus, diestrus andoestrus phases and histopathology of the uterus were examined daily and at the termination of the experiment.Results: At the end of the study, the highest number of circles (4.80 ± 0.20) was recorded in the control group,administered distilled water, while the lowest number of circles (3.00 ± 0.32) was in the 100 mg/kg dose group.Oestrus (5.80 ± 0.37) also is highest in the control group and lowest (1.20 ± 0.37) in the 100 mg/kg dose group. Thegroup administered 100 mg/kg dose of the aqueous wood-ash extract of Parkia biglobosa had the highest diestrusindex of 45, while the lowest of 17 was obtained in the control group. Histopathology of the uterus tissues shows afew degenerate epithelial cells in 50 mg/kg group and moderate dilatation of lumen and glandular epithelial cells in100 mg/kg group. Conclusion: The study revealed dose-dependent anti-fertility effects of the aqueous wood-ashextract of Parkia biglobosa on female albino mice, which implies its potential reproductive toxicity in humans. 展开更多
关键词 Wood-ash Reproductive toxicity Oestrus cycle IMPLANTATION Abortifacient
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术前应用康柏西普以不同手术方法治疗新生血管性青光眼 认领
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作者 吴含春 《中华眼外伤职业眼病杂志》 2021年第2期155-160,共6页
目的比较术前应用康柏西普两种手术方法治疗糖尿病继发新生血管性青光眼(NVG)的效果。方法前瞻性随机临床对照研究。以荷泽市中医医院眼科2018年2月至2019年8月诊治的糖尿病所致NVG 61例(62眼)为研究对象。患者按随机数字表法分为两组,... 目的比较术前应用康柏西普两种手术方法治疗糖尿病继发新生血管性青光眼(NVG)的效果。方法前瞻性随机临床对照研究。以荷泽市中医医院眼科2018年2月至2019年8月诊治的糖尿病所致NVG 61例(62眼)为研究对象。患者按随机数字表法分为两组,两组患者手术前均进行康柏西普玻璃体内注射。试验组,31例(32眼),采取玻璃体切除联合青光眼引流阀植入及视网膜激光光凝术;对照组,30例(30眼),采取玻璃体切除联合小梁切除及视网膜激光光凝术;随访6个月,观察两组术后眼压、视力及并发症等。结果试验组眼压低于对照组(F=42.599.P<0.001),随访结束时,两组视力、并发症的发生率及疗效的比较差异均无统计学意义(P>0.05)。结论康柏西普玻璃体内注射后采用玻璃体切除联合青光眼引流阀值入术治疗糖尿病继发的NVG,降低眼用幅度更大且平稳。 展开更多
关键词 康柏西普 青光眼 新生血管性 植入术 引流阀 小梁切除术 玻璃体切除术
内镜下前房角分离联合超声乳化术治疗青光眼伴白内障的效果观察 认领
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作者 汤伟 张玉杰 张亦农 《中华眼外伤职业眼病杂志》 2021年第1期11-16,共6页
目的观察内镜下前房角分离联合超声乳化人工晶状体植入术治疗原发性闭角型青光眼伴发白内障的临床效果。方法采用前瞻性病例研究。对无锡市第二人民医院眼科2018年11月至2019年4月原发性闭角型青光眼伴发白内障33例(33只眼),采用内镜下... 目的观察内镜下前房角分离联合超声乳化人工晶状体植入术治疗原发性闭角型青光眼伴发白内障的临床效果。方法采用前瞻性病例研究。对无锡市第二人民医院眼科2018年11月至2019年4月原发性闭角型青光眼伴发白内障33例(33只眼),采用内镜下前房角分离联合超声乳化人工晶状体植入术。术后随访6~10个月。观察术后视力、眼压、抗青光眼药物种类、前房角开放范围及并发症的发生率。结果末次随访时眼压(15.01±4.37)mmHg(1 mmHg=0.133 kPa),较术前(28.58±11.14)mmHg明显下降(t=8.353,P<0.001)。术后最佳矫正视力(logMAR)0.64±0.32较术前的1.02±0.36提高(t=1.382,P=0.074);术前使用抗青光眼药物数量(3.48±0.94)种降至(0.24±0.66)种,差异具有统计学意义(t=6.372,P=0.008);术后前房角开放范围达270°者28只眼(84.85%),相比术前差异具有统计学意义(χ^2=91.495,P<0.001)。随访期间未见明显并发症。结论内镜下前房角分离联合超声乳化人工晶状体植入术治疗闭角型青光眼伴白内障安全有效。 展开更多
关键词 青光眼 闭角型 白内障 超声乳化术 前房角分离术 直视下 内镜 植入术 晶状体 人工
Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts 认领
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作者 Lanyu Wang Qiming Luo +3 位作者 Xianming Zhang Jiajun Qiu Shi Qian Xuanyong Liu 《生物活性材料》 SCIE 2021年第1期64-74,共11页
Soft tissue sealing around implants acts as a barrier between the alveolar bone and oral environment,protecting implants from the invasion of bacteria or external stimuli.In this work,magnesium(Mg)and zinc(Zn)are intr... Soft tissue sealing around implants acts as a barrier between the alveolar bone and oral environment,protecting implants from the invasion of bacteria or external stimuli.In this work,magnesium(Mg)and zinc(Zn)are introduced into titanium by plasma immersed ion implantation technology,and their effects on the behaviors of human gingival fibroblasts(HGFs)as well as the underlying mechanisms are investigated.Surface characterization confirms Mg and Zn exist on the surface in metallic and oxidized states.Contact angle test suggests that surface wettability of titanium changes after ion implantation and thus influences protein adsorption of surfaces.In vitro studies disclose that HGFs on Mg ion-implanted samples exhibit better adhesion and migration while cells on Zn ion-implanted samples have higher proliferation rate and amounts.The results of immunofluorescence staining and real-time reverse-transcriptase polymerase chain reaction(RT-PCR)suggest that Mg mainly regulates the motility and adhesion of HGFs through activating the MAPK signal pathway whereas Zn influences HGFs proliferation by triggering the TGF-βsignal pathway.The synergistic effect of Mg and Zn ions ensure that HGFs cultured on co-implanted samples possessed both high proliferation rate and motility,which are critical to soft tissue sealing of implants. 展开更多
关键词 Human gingival fibroblasts Soft tissue sealing MAGNESIUM Zinc Plasma immersion ion implantation
玻切术后继发性青光眼Ahmed阀玻璃体腔植入与前房植入效果比较 认领
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作者 赵英迪 解正高 朱俊 《中华眼外伤职业眼病杂志》 2021年第1期34-38,共5页
目的比较Ahmed青光眼阀玻璃体腔植入和前房植入治疗玻璃体切除术后继发性青光眼的效果。方法回顾性分析江苏省苏北人民医院眼科2015年1月至2019年10月玻璃体切除术后继发性青光眼23例(23眼)的临床资料。所有患者分别采用两种方法行Ahme... 目的比较Ahmed青光眼阀玻璃体腔植入和前房植入治疗玻璃体切除术后继发性青光眼的效果。方法回顾性分析江苏省苏北人民医院眼科2015年1月至2019年10月玻璃体切除术后继发性青光眼23例(23眼)的临床资料。所有患者分别采用两种方法行Ahmed青光眼阀植入术。前房组12例(12眼),经角膜缘植入前房;玻璃体腔组11例(11眼),经睫状体平坦部植入玻璃体腔。术后随访4~32个月,比较两组疗效。结果玻璃体腔组手术耗时为(31.88±5.30)分钟,少于前房组的(45.63±8.63)分钟(t=3.838,P=0.002)。前房组成功率为75.00%(9/12),低于玻璃体腔组81.81%(9/11)。两组术后眼压均较术前降低(均P<0.05),但两组之间术后各时间点差异均无统计学意义(均P>0.05)。两组均未出现严重并发症。结论玻璃体腔植入与前房植入Ahmed青光眼阀均可安全有效地控制玻切术后继发性青光眼,而玻璃体腔植入手术操作较为简便省时。 展开更多
关键词 玻璃体切除术 青光眼 继发性 植入 青光眼阀 Ahmed 前房 玻璃体腔
全唾液法分析糖尿病及牙周炎伴牙列缺损患者行种植义齿修复的临床效果 认领
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作者 周琦琪 韩祥祯 +1 位作者 张文静 崔杰 《中国美容医学》 CAS 2021年第1期104-108,共5页
目的:探究糖尿病及牙周炎伴牙列缺损患者种植治疗的预后疗效,以此作为该类患者种植治疗术前评估,为提高种植成功率提供参考依据。方法:分别于种植前和种植后4周、12周与24周收集2型糖尿病患者组、牙周炎患者组以及对照组患者唾液,记录... 目的:探究糖尿病及牙周炎伴牙列缺损患者种植治疗的预后疗效,以此作为该类患者种植治疗术前评估,为提高种植成功率提供参考依据。方法:分别于种植前和种植后4周、12周与24周收集2型糖尿病患者组、牙周炎患者组以及对照组患者唾液,记录探诊深度、测量种植体稳定性,实验ELISA法检测唾液中的IL-1β与TNF-α,荧光定量PCR测量TF、Pg、Td、Fn的相对SQ值变化。结果:2型糖尿病患者组、牙周炎患者组的ISQ值与对照组比较无统计学差异(P<0.05),组内显示对比ISQ值在12周时明显高于术中,提示稳定性呈增加趋势,具有统计学意义(P<0.05);两实验组的唾液中IL-1β和TNF-α的含量高于对照组,并有统计学意义(P<0.05),且两组随时间推移,唾液中IL-1β和TNF-α的含量均降低,具有统计学意义(P<0.05);Tf、Pg、Fn的相对SQ值四次检查结果逐渐减少,差异有统计学意义(P<0.05),Td相对SQ值四次检查结果无显著性差异(P>0.05)。结论:菌斑控制良好的牙周炎患者与血糖控制良好的糖尿病患者,均可取得与正常患者一致的种植初期稳定性,且炎性因子和细菌水平持续降低,提示两者均可以取得较好的种植预后效果。 展开更多
关键词 全唾液 糖尿病 慢性牙周炎 种植术 种植体稳定性
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高龄患者植入心脏起搏器的临床效果研究 认领
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作者 阿拉腾其木格 王志勇 +1 位作者 俞波 李建飞 《中国实用医药》 2021年第8期42-45,共4页
目的探究高龄患者植入心脏起搏器的临床效果。方法60例高龄患者,根据植入类型不同分为观察组与对照组,各30例。对照组植入单腔心脏起搏器,观察组植入双腔心脏起搏器。对比两组生活质量评分、心功能指标[左室射血分数(LVEF)、左室收缩末... 目的探究高龄患者植入心脏起搏器的临床效果。方法60例高龄患者,根据植入类型不同分为观察组与对照组,各30例。对照组植入单腔心脏起搏器,观察组植入双腔心脏起搏器。对比两组生活质量评分、心功能指标[左室射血分数(LVEF)、左室收缩末期容积(LVESV)、左室舒张末期容积(LVEDV)]及治疗效果。结果观察组生理功能、社会功能、情感职能、心理健康评分均高于对照组,差异具有统计学意义(P<0.05)。观察组植入心脏起搏器3个月后LVEF、LVESV、LVEDV分别为(58.31±1.12)%、(45.65±1.03)ml、(96.25±1.03)ml,均优于对照组的(52.64±1.03)%、(39.14±1.54)ml、(94.13±1.03)ml,差异具有统计学意义(P<0.05)。观察组治疗总有效率为96.67%,高于对照组的66.67%,差异具有统计学意义(P<0.05)。结论高龄患者植入双腔心脏起搏器效果显著,能有效提升患者生活质量水平,改善心功能指标,值得研究和推广。 展开更多
关键词 心脏起搏器 高龄 植入 单腔 双腔 临床效果
Radiologic anatomy of the round window relevant to cochlear implantation and inner ear drug delivery 认领
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作者 Nguy Peter L. Saidha Sheela +2 位作者 Jay Ann Kim H.Jeffrey Hoa Michael 《世界耳鼻咽喉头颈外科杂志(英文)》 2021年第1期9-16,共8页
Objective:To determine anatomic relationships and variation of the round window membrane to bony surgical landmarks on computed tomography.Study design:Retrospective imaging review.Methods:100 temporal bone images wer... Objective:To determine anatomic relationships and variation of the round window membrane to bony surgical landmarks on computed tomography.Study design:Retrospective imaging review.Methods:100 temporal bone images were evaluated.Direct measurements were obtained for membrane position.Vector distances and angulation from umbo and bony annulus were calculated from image viewer software coordinates.Results:The angle of round window membrane at junction with cochlear basal turn was(42.1±8.6)°.The membrane’s position relative to plane of the facial nerve through facial recess was(14.7±5.2)°posterior from a reference line drawn through facial recess to carotid canal.Regarding transtympanic drug delivery,the round window membrane was directed 4.1 mm superiorly from the inferior annulus and 5.4 mm anteriorly from the posterior annulus.The round window membrane on average was angled superiorly from the inferior annulus(77.1±27.9)°and slightly anteriorly from the posterior annulus(19.1±11.1°).The mean distance of round window membrane from umbo was 4 mm and posteriorly rotated 30°clockwise from a perpendicular drawn from umbo to inferior annulus towards posterior annulus.Together,these measurements approximate the round window membrane in the tympanic membrane’s posteroinferior quadrant.Conclusions:These radiologic measurements demonstrate normal variations seen in round window anatomy relative to facial recess approach and bony tympanic annulus,providing a baseline to assess round window insertion for cochlear implantation and outlines anatomic factors affecting transtympanic drug delivery. 展开更多
关键词 Round window Cochlear implantation Transtympanic drug delivery Computed tomography
Effects of Micro-Milling and Laser Engraving on Processing Quality and Implantation Mechanics of PEG-Dexamethasone Coated Neural Probe 认领
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作者 周旭晖 张文光 谢颉 《上海交通大学学报:英文版》 EI 2021年第1期1-9,共9页
Compared with stiff silicon-based probes,flexible neural probes can alleviate biological inflammation and tissue rejection.A polyethylene glycol(PEG)coating can facilitate the insertion of flexible probes,and the fabr... Compared with stiff silicon-based probes,flexible neural probes can alleviate biological inflammation and tissue rejection.A polyethylene glycol(PEG)coating can facilitate the insertion of flexible probes,and the fabrication methods have a significant impact on the dimensional accuracy and structural strength of the coating.In this study,a novel melting injection moulding method is used to process a PEG-dexamethasone(PEG-DEX)coating with high structural strength for a type of mesh-shaped photosensitive polyimide(PSPI)based neural probe.Combined with the digital image correlation(DIC)method,an in vitro test system with high accuracy is developed to evaluate the effects of the elastic modulus of the PEG component and two fabrication methods,i.e.,computer-numerical-control(CNC)micro-milling and laser engraving,on the processing quality and implantation mechanics of a PEG-DEX coated probe.The results show that compared with laser engraving,CNC micro-milling can ensure high dimensional accuracy and sharpness for the composite coating,thus leading to small damage from implantation,whereas the elastic modulus of the composite coating has a limited effect on the implantation mechanics of the PEG-DEX coated probe. 展开更多
关键词 flexible neural probe composite coating digital image correlation(DIC) polyethylene glycol(PEG) dexamethasone(DEX) insertion force implantation injury
Preimplantation genetic testing for a new abnormal cleavage behavior 认领
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作者 Ming-Zhao Li Hai-Yan Bai +1 位作者 Xia Xue Juan-Zi Shi 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2021年第2期227-228,共2页
Dear Editor,Time-lapse systems(TLSs)have increasingly been introduced to fertility laboratories to improve the identification of embryo quality.TLSs detect some forms of abnormal division,such as direct and reverse cl... Dear Editor,Time-lapse systems(TLSs)have increasingly been introduced to fertility laboratories to improve the identification of embryo quality.TLSs detect some forms of abnormal division,such as direct and reverse cleavage divisions.Direct cleavage occurs when one blastomere divides directly into three or more daughter blastomeres.It strongly correlates with impaired preimplantation development,ploidy,and implantation capacity. 展开更多
关键词 DAUGHTER IMPLANTATION SUCH
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