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<i>In Vivo</i>Evaluation of Anti-Mycobacterial Activity of a Phytomedicine “MATHESIA” on <i>Mycobacterium ulcerans</i>: Influence of Alkalinity on the Activity of Antibiotics Used in the Treatment of Buruli Ulcer 认领
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作者 L. H. Nkasa K. J. Kadinekene +8 位作者 O. Kiabanzawoko B. Tchey S. Kimbonza M. O. Lunguya S. S. Karhemere Bin M. C. Mulenga T. J. J. Muyembe S. J. Kayembe K. M. Taba 《医学微生物学(英文)》 2021年第1期47-57,共11页
<span style="font-family:""><span style="font-family:Verdana;">T</span><span><span style="font-family:Verdana;">he present study reports the </span&g... <span style="font-family:""><span style="font-family:Verdana;">T</span><span><span style="font-family:Verdana;">he present study reports the </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> anti-Mycobacterial Activity of a Phytomedicine </span></span></span><span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">MATHESIA</span><span style="font-family:Verdana;">”</span><span style="font-family:""><span style="font-family:Verdana;"> on </span><i><span style="font-family:Verdana;">Mycobacterium ulcerans</span></i><span style="font-family:Verdana;">. It also explores the influence of ethanolamine (alkali agent) on the </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> activity of some antibiotics (Isoniazid, Rifampicin, Ethambutol) used in the treatment of Buruli ulcers in DR Congo. Experiments were conducted on adult white Wistar rats of both sex</span></span><span style="font-family:Verdana;">es</span><span style="font-family:Verdana;"> with the weights comprising between 110</span><span style="font-family:Verdana;"> - </span><span style="font-family:Verdana;">165</span><span style="font-family:""> </span><span style="font-family:Verdana;">g.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The result obtained have show</span><span style="font-family:Verdana;">n</span><span style="font-family:""><span style="font-family:Verdana;"> that the phytomedicine MATHESIA (pH 10) has a good </span><i><span style="font-family:Verdana;">in vivo </span></i><span style="font-family:Verdana;">activity on </span><i><span style="font-family:Verdana;">M. ulcerans</span></i><span style="font-family:Verdana;"> and the duration for wounds healing and total cicatrization was 6 days;whereas this duration was 10, 12, 14, and 16 days respectively</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">for Rifampicin (IV, pH 10), Kibadi</span><span style="font-fa 展开更多
关键词 Buruli Ulcer Mycobacterium ulcerans Mathesia ETHANOLAMINE RIFAMPICIN ETHAMBUTOL Isoniazid Kibadi Solution
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Comprehensive Left Ventricular Mechanics Analysis by Speckle Tracking Echocardiography in COVID-19 认领
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作者 Francisco J. González-Ruiz Emmanuel A. Lazcano-Díaz +15 位作者 Zuilma Y. Vásquez-Ortiz Fernanda Bernal-Ceballos Rodrigo Gopar-Nieto Consuelo Orihuela-Sandoval José P. Hernández-Reyes Edgar García-Cruz Eduardo Bucio-Reta Ángel Ramos-Enríquez Luis A. Cota-Apodaca Luis Efren-Santos Blanca Estela Broca-García Daniel Manzur-Sandoval Efrén Melano-Carranza Fernandez de la Reguera Guillermo Gustavo Rojas-Velasco Francisco Baranda-Tovar 《心血管病(英文)》 2021年第2期113-125,共13页
<div style="text-align:justify;"> <strong>Background:</strong> <span "="">Cardiac involvement and the consequences of inflammation induced by SARS-CoV2 infection could ... <div style="text-align:justify;"> <strong>Background:</strong> <span "="">Cardiac involvement and the consequences of inflammation induced by SARS-CoV2 infection could have catastrophic long-term consequences. Left ventricular mechanics could identify a specific pattern of myocardial fiber damage in patients infected with COVID-19. To our knowledge there are no publications referring to the global description of ventricular mechanics in patients with COVID-19. <b>Objective: </b>To describe left ventricular mechanics in hospitalized patients with COVID-19. <b>Methods:</b> In this cross-sectional study, we included 40 hospitalized patients with confirmed diagnostic of COVID-19, from April 11, 2020, to September 6, 2020. Demographic and laboratory data, clinical and echocardiographic characteristics were collected, as well as events during hospitalization. Left ventricular deformation was analyzed and reported. <b>Results: </b>Subclinical dysfunction was observed in 82.5% (left ventricular longitudinal strain [LVGLS] </span><span "="">-17.05% and global circumferential strain [GCS] -18.6%) of the patients, likewise, the mean twist and apical rotation were preserved, and even increased as part of the compensating mechanism to maintain the ejection fraction. <b>Conclusion:</b> In patients hospitalized with COVID-19, despite having a normal left ventricular ejection fraction, subclinical myocardial damage was found, manifested by a decrease in Global Longitudinal Strain (GLS) and Global Circumferential Strain (GCS). This behavior is similar to that of cardiomyopathies in the early stage of the disease, and given the pathophysiological mechanisms involved in the disease, its long-term consequences should be monitored and evaluated</span>. </div> 展开更多
关键词 COVID-19 Speckle Tracking Echocardiography MYOCARDITIS Cardiomyopa-thy Cardiac Mechanics Strain Myocardial Damage Deformation Imaging Myocardial Strain
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Acidification of the Skin and Maintenance of the Physiological Skin pH Value by Buffered Skin Care Products Formulated around pH 4 认领
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作者 Anke Schulte to Brinke Antje Mehlich +1 位作者 Claudia Doberenz Ciska Janssens-Böcker 《化妆品、皮肤病及应用期刊(英文)》 2021年第1期44-57,共14页
Each biological system possesses a widely unrecognized buffer system to maintain acid-base balance to a specific pH. The skin pH is crucial for physiological skin function. In aged or diseased skin, pH increase is obs... Each biological system possesses a widely unrecognized buffer system to maintain acid-base balance to a specific pH. The skin pH is crucial for physiological skin function. In aged or diseased skin, pH increase is observed and may negatively affect skin health. Skin care products with a pH that is slightly more acidic than the average normal skin pH and have an adequate buffering capacity, are considered beneficial for the skin. However, the buffer capacity of these products also plays an important role. In the present study, a possible normalization or acidification of skin surface pH and influence on skin hydration and skin barrier function was assessed via application of buffered skin care products that are formulated with pH ≤ 4.5. 48 subjects aged above 50 were treated with three different skin care products (Vitamin C Spheres, Collagen Spray, and Collagen Mask) and skin surface pH, skin hydration and barrier integrity were assessed before treatment start and after 4 weeks. The results show that after 4-week treatment with Vitamin C, the skin pH is acidified. Treatment with Collagen Spray and Collagen Mask showed maintenance of a physiological skin pH. Subgroup analysis of subjects that had a higher than average skin pH at study start demonstrated that all three tested skin care products were able to acidify the skin surface. In addition, skin hydration was also increased for two of the three tested products, whereas skin barrier is not significantly changed. This demonstrates that buffered skin care products formulated to a pH ≤ 4.5 are able to acidify and maintain physiological skin pH and may contribute to a physiological skin function. 展开更多
关键词 Skin pH Buffer Capacity Skin Care Skin Aging ACIDIFICATION
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Extraction of selected rare earth elements from anthracite acid mine drainage using supercritical CO2 via coagulation and complexation 认领
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作者 Guanrong Song Xingchao Wang +10 位作者 Carlos Romero Huazhi Chen Zheng Yao Alfred Kaziunas Rolf Schlake Madhu Anand Tom Lowe Greg Driscoll Boyd Kreglow Harold Schobert Jonas Baltrusaitis 《稀土学报:英文版》 SCIE EI CAS CSCD 2021年第1期83-89,I0004,共8页
Rare earth elements(REEs)are valuable raw materials which are in great demand in modern high technology industries.Developing methods to produce/recover REEs from waste is significant to the national security of any d... Rare earth elements(REEs)are valuable raw materials which are in great demand in modern high technology industries.Developing methods to produce/recover REEs from waste is significant to the national security of any developed country.This study was focused on investigating the use of supercritical CO2(sCO2)to extract REEs from anthracite acid mine drainage(AMD).Four different mine drainage water source locations at Blaschak Coal Corp.in Pennsylvania,USA were selected for sample collection.An extraction process was developed and demonstrated for two of those water sources containing the highest concentration of REEs.A method involving metal ion coagulation,their dissolution from the sludge into a concentrated aqueous HNO3 solution,complexation with organic ligands and sCO2 extraction was developed to recover REEs from AMD.Specifically,sodium aluminate(NaAlO2)was used as the coagulant to concentrate REEs from the AMD into a solid precipitate.Consequently,over 99%of the REEs in AMD is concentrated in the remaining sludge.During the coagulation process,the effects of pH and NaAlO2 concentration on REE precipitation were investigated.Fuming nitric acid(HNO3)was used to digest the pre-concentrated sludge and tributyl phosphate(TBP)was used to form REE/TBP/HNO3,a non-polar complex with selected REEs,specifically,cerium(Ce),lanthanum(La)and neodymium(Nd).HNO3 concentration and organic/aqueous phase ratio were considered as the variables to improve complexation efficiency.Dynamic extraction experiments using sCO2 and REE/TBP/HNO3 solutions were then conducted at optimal conditions of 60℃and 20 MPa.The overall REE extraction efficiencies are found to increase with the atomic number of the REE.As a result,the average overall REE extraction efficiencies of 41.8%,40.1%and 58.2%for Ce,La and Nd,respectively,are obtained.The potential improvements in the overall extraction efficiency are also discussed. 展开更多
关键词 Supercritical CO2 extraction Rare earth elements Acid mine drainage
A Study of Laser Effectiveness in Injured Tissues Regeneration 认领
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作者 Marcus Vinicius de Mello Pinto Aline Ronis Sampaio +12 位作者 Miriam Viviane Baron Carolina Macedo Alves Moreira Carolina Gonçalves Pinheiro Michele Paula dos Santos Andres Felipe Mantilla Santamaria Cristine Brandenburg Nathália Ken Pereira Iketani Mara Alessandra Porto dos Reis Oliveira Alexandre Sancho Felice Picariello Esteban Fortuny Juliano Tibola Nilton Petrone Vilardi Junior 《生物科学与医学(英文)》 2021年第3期55-63,共9页
This study aimed to understand the use of low level laser in the regeneration of injured tissues. Also to design our own opinion on the subject, as chemists. Laser is nothing more than a light with very special charac... This study aimed to understand the use of low level laser in the regeneration of injured tissues. Also to design our own opinion on the subject, as chemists. Laser is nothing more than a light with very special characteristics that grant it therapeutic properties. We can observe the existence of three different types of laser, being one of them the therapeutic laser, which is used in substitution for medications or along with them. Another type of laser is the surgical one and, in addition to these, there is a diagnostic type. A great advantage is that, instead of taking the medicine, the patient’s own body can be activated by the laser to produce certain substances that can often replace the drugs. This is a literature review emphasizing the use of low level laser. Thus, the reflections from this study can contribute to the amplification of the production of knowledge that aims at the resignification of the use of laser in therapy. Greater attention was given to two types of laser radiation: He-Ne and As-Ga, both presenting a high therapeutic potential in superficial and deep injures. However, the He-Ne laser excels in superficial lesions, whereas the As-Ga laser does so in deep injures, such as articular, muscular, etc. 展开更多
关键词 Laser INJURY REGENERATION
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Hepato-Preventive Effects of Hydroethanolic Leaves Extract of <i>Persea</i>Americana, Mill (Lauraceae) “Avocado” against Antouka Super<sup>®</sup>Induced Damage in Male Japanese Quail (<i>Coturnix coturnix</i>Japonica) 认领
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作者 Ngoumtsop Victor Herman Tchoffo Herve +2 位作者 Guiekep Nounamo Arthénice Jemima Mutwedu Valence Ngoula Ferdinand 《兽医学(英文)》 2021年第1期41-56,共16页
The present study was undertaken to evaluate the protective effects of Hydroethanolic leaves extract of <em>Persea americana</em> (HEPA) against Antouka Super<sup><span style="font-family:Ver... The present study was undertaken to evaluate the protective effects of Hydroethanolic leaves extract of <em>Persea americana</em> (HEPA) against Antouka Super<sup><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&reg;</sup></span>(AS) induced hepatotoxicity in male Japanese quail. In total, 40 immature male Japanese quails aged 28 days were used and divided equally into 5 groups. The groups were designed as the control group (received only a 10 ml/kg of distilled water) and the AS group (75 mg/kg b.w). Other three groups received AS (75 mg of AS/kg b.w) plus HEPA (50, 100, and 200 mg/kg b.w/day respectively) by the oral route. After 60 days of the experiment, the crushed liver was performed to obtain homogenate. The protective effects of HEPA on the biochemical parameters, oxidative stress biomarkers and histology changes in the liver were evaluated. The results indicated that AS treatment caused significant alterations in the clinical signs and behavior. It induces the increase in the content of Urea, Creatinine, Protein, AST and ALT in liver tissues and serum. The activities of enzymatic oxidative stress markers such as Superoxide Dismutase (SOD);Catalase (CAT) and Total Peroxidase (POD) also showed significant perturbations in AS-treated quails. Histopathological examination of the liver of AS-treated quails revealed liver lesions characterized by moderate to severe degenerative changes showing a number of hepatocytes undergo fatty changes, focal aggregation of the lymphocytes, multiple necrotic changes and inflammatory infiltrate. The administration of HEPA however, markedly ameliorated the toxicity of AS by protecting the levels of aforesaid biomarkers to near normal levels. These results suggested that HEPA due to its phytochemical constituents with antioxidant properties possesses significant effects against AS-induced toxicity. However, these effects were more pronounced at a dose of 200 mg/kg bw. 展开更多
关键词 Antouka Super® (AS) Hepatoprotective Toxicity Hydroethanolic Leaves Extract Persea americana Japanese Quail
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Pregnancy Rate after Embryo Transfer on Day 5 and Day 6 in IVF. A Systematic Review and Meta-Analysis 认领
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作者 Hassan S. Abduljabbar H. Hashim +2 位作者 M. Gehad Heba E. Hashish A. Algaradi 《生殖科学(英文)》 2021年第1期97-105,共9页
<strong>Study Question:</strong> The question: is there any difference in pregnancy rate between embryo transfer day 5 and day 6 in IVF? What Is Known Already? Blastocyst transfer is increasingly popular i... <strong>Study Question:</strong> The question: is there any difference in pregnancy rate between embryo transfer day 5 and day 6 in IVF? What Is Known Already? Blastocyst transfer is increasingly popular in assisted reproductive technology (ART) centers today. Very few articles concentrate on comparing Day 5 and Day 6 embryo transfer with conflict results. <strong>Objective, Study Design:</strong> Systematic review and meta-analysis of published controlled studies. Searches conducted from 2001-2020 on PubMed. Medline, EMBASE, and ISI Web of Science Electronic database is used to collect data, using the following search terms: blastocyst, Day 5, Day 6, embryo transfer (E.T.) and pregnancy rate. <strong>Materials, Setting, Methods:</strong> A total of 6 full-text articles preselected from 211 references, based on title and abstract. Two independent reviewers performed data selection and extraction according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement (PRISMA). This systematic review was conducted according to (PICO) standard. Random-effect meta-analysis performed on all data (overall analysis). <strong>Results and the Role of Chance:</strong> Data from 6 relevant articles were extracted and integrated into the meta-analysis that reported clinical pregnancy rate (CPR) as an outcome in 5640 cycles, 2274 cycle had embryo transfer at day 6 and the control was 3366 cycle had embryo transfer day 5 showed a significantly higher clinical pregnancy rate following Day 5 embryo transfer compared with Day 6 embryo transfer with odd ratio and 95% confidence limit 0.73 (0.66 - 0.82)<em> p</em> value < 0.000. Sensitivity analysis led to similar results and conclusions.<strong> Limitations, Reasons for Caution: </strong>The validity of meta-analysis results depends mainly on the quality and the number of published studies available. Indeed, this meta-analysis included no randomized controlled trial (RCT). <strong>Wider Implications of the Findings: </strong>In regards to the results of this 展开更多
关键词 Day 5 Day 6 IVF BLASTOCYST Clinical Pregnancy Rate
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Vitamin D Status and the Determinants of Preeclampsia in Pregnant Women in Goma (Democratic Republic of the Congo) 认领
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作者 Kabuyanga Kabuseba Richard Balungwe Sifa Marcelline +3 位作者 Elongi Moyene Jean-Pierre Lundimu Tugirimana Pierrot Kalenga Muenze Kayamba Prosper Kakoma Sakatolo Zambeze Jean-Baptiste 《妇产科期刊(英文)》 2020年第6期820-835,共16页
<span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Background</span></b></span><span style="font-family:Verdana;"><span ... <span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Background</span></b></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">: Preeclampsia (PE) is a common condition, causing maternal and perinatal morbidity and mortality worldwide. In the absence of fully satisfactory treatment, screening remains one of the pillars of management. Low vitamin D status has been identified as a risk factor for PE. But, data on vitamin D status and risk factors for PE in the Democratic Republic of </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">t</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">he </span><span style="font-family:Verdana;">Congo (DRC) is scanty. The aim of this study is to determine the level of Vitamin D and risk factors in preeclamptic patients in our environment.</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Methods</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">: To fill this gap, we conducted a multicenter incident case control study on 190 pregnant women, 95 cases and 95 controls, receiving care from seven hospitals </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">in Goma, in the eastern DRC, from April 1 to December </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">31</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">, 2019. Socioeconomic, diet habits, clinical data, urinalysis and serum 25-hydroxy</span></span></span><span><span><span style="font-family:" 展开更多
关键词 Democratic Republic of the Congo Vitamin D Deficiency Preeclampsia Determinants
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Assessment of Membrane Erythrocyte Cholesterol Level in Sickle Cell Disease 认领
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作者 J. A. N. Mwelo Z. Diakiese +5 位作者 L. Diyi O. Nzingula N. Misengabu G. Inkalaba M. Luvandu K. K. Kodondi 《生物科学与医学(英文)》 2020年第11期16-22,共7页
<strong>Objective:</strong> The aim of this study was to assess the level of erythrocyte membrane cholesterol in sickle cell patients, which is one of the essential parameters of membrane fluidity that con... <strong>Objective:</strong> The aim of this study was to assess the level of erythrocyte membrane cholesterol in sickle cell patients, which is one of the essential parameters of membrane fluidity that contributes to understanding the hemolytic state of the erythrocyte. <strong>Methods: </strong>We worked with blood specimens from 20 controls and 50 sickle cell patients. The blood count and the isoelectric focusing (IEF) were performed on the samples in order to select them. The titration of the erythrocyte membrane cholesterol was made after washing and lysing the erythrocytes with the hemolyzing solution (EDTA, 2 Mercapto-Ethanol, NADP, NaOH). The cholesterol level was assessed by the enzymatic colorimetric method. The results were analyzed by Student’s test. <strong>Results: </strong>We worked with 16 control subjects with a hemoglobin status and a normal hemogram. The evaluation of the erythrocyte membrane cholesterol level of the samples allows us to define the reference interval (<em>α</em> = 0.05) at 17.55 ± 3.83 mg of cholesterol/g of hemoglobin. The erythrocyte membrane cholesterol levels of sickle cell patients found in this study were 11.58 ± 2.98 mg cholesterol/g of hemoglobin. In this study, 38 sickle cell patients (76%) were found with a low erythrocyte membrane cholesterol level compared to the reference interval. Statistical analysis showed that there was a significant difference (<em>α </em>= 5%) between the erythrocyte membrane cholesterol level of normal subjects and sickle cell patients. <strong>Conclusion: </strong>Most of the sickle cells patients had a decreased erythrocyte membrane cholesterol level. This reduces the membrane fluidity making the erythrocyte membrane rigid and more fragile. This may be one of the factors responsible for the lyses of erythrocytes. 展开更多
关键词 CHOLESTEROL Membrane Fluidity Sickle Cell Anemia Erythrocytes
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Cytoreductive surgery with hyperthermic thoracoabdominal chemotherapy in stage Ⅳ ovarian cancer - a technical description 认领
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作者 Mukur Dipi Ray Raghuram Kuppusamy +1 位作者 Navin Kumar Rakesh Garg 《癌症转移与治疗:英文版》 2020年第4期1-9,共9页
Systemic chemotherapy for peritoneal disease in ovarian carcinoma is associated with a recurrence rate of more than 75%, and most of the cases are confined to the peritoneal cavity. The propensity of locoregional trea... Systemic chemotherapy for peritoneal disease in ovarian carcinoma is associated with a recurrence rate of more than 75%, and most of the cases are confined to the peritoneal cavity. The propensity of locoregional treatment failure has paved the way for the discovery of cytoreductive surgery with intra-cavitary chemotherapy. Cytoreductive surgery (CRS) is the present-day treatment modality for a variety of peritoneal carcinomatosis including ovarian cancer, and multi-visceral resection is critical for completion of CRS. In cases of diaphragmatic infiltration by tumor deposits, partial resection leads to a diaphragmatic rent, which can be used for the perfusion of chemotherapeutic drugs into the pleural cavity. Disease transmission from the peritoneal to pleural cavity is a poor prognostic factor however. Hence, intrathoracic hyperthermic chemotherapy may be a reasonable treatment option for ovarian carcinoma with malignant pleural effusion or pleural deposits. Hyperthermic intraperitoneal chemotherapy (HIPEC) is added to the treatment plan in cases of complete CRS but this is a technically demanding procedure. Therefore, performing hyperthermic intrathoracic chemotherapy on top of CRS and HIPEC may be even more complicated for such advanced cancers. The technique of combining HIPEC and hyperthermic intrathoracic chemotherapy is also commonly known as hyperthermic thoracoabdominal chemotherapy (HITAC). The perioperative morbidity and mortality may be remarkably high in such scenarios. We describe our CRS technique with HITAC, which was performed in three FIGO stage IVA ovarian carcinoma patients with metastatic pleural effusion after complete CRS. The patients were retrospectively identified from a prospectively maintained database. All had partial diaphragmatic resection followed by HITAC as part of CRS treatment. Surgical techniques ;are outlined along with accompanying intra-operative images. Patient demographics, clinical and follow-up details were also described briefly. No comparative analysis with control pa 展开更多
关键词 Hyperthermic intraperitoneal chemotherapy hyperthermic intrathoracic chemotherapy ovarian carcinoma cytoreduction surgery peritoneal carcinoma index
Code blue applications as an indicator of clinical quality 认领
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作者 Mehmet Süleyman Sabaz Nagihan Sabaz +1 位作者 G?khan Sert?akac?lar Sinan A?ar 《急性病杂志:英文版》 2020年第1期14-19,共6页
Objective:To investigate the code blue application at a training and research hospital in Turkey.Methods:The code blue declaration forms and the hospital database with 238 complete records between January 2016 and Jul... Objective:To investigate the code blue application at a training and research hospital in Turkey.Methods:The code blue declaration forms and the hospital database with 238 complete records between January 2016 and July 2017 were collected.The form involved individual characteristics,the reason for issuing the code blue call,the unit and block where the code was given,time and location related properties such as working time and arrival duration,properties regarding the intervention process such as its type,duration or result.The 24-hour and 30-day long survival data of the patients to whom cardiopulmonary resuscitation was implemented were obtained from the hospital database,or from their relatives.The influencing factors of arrival duration were analyzed.Results:The median duration of arrival was 2.14(2.00-3.02)min.Code blue applications were performed more frequently in Departments of General Surgery,Internal Medicine,Orthopaedics,and Cardiology Clinics.Half of the code blue calls were due to cardiac arrest;the other half was due to shortness of breath or respiratory distress,syncope,and respiratory arrest.Three-out-of four code blue calls were treated with orotracheal intubation and cardiopulmonary resuscitation,or only orotracheal intubation or only medical treatment;one-fourth of the calls were not intervened.Altogether,72.36%of the code blue calls patients were intervened;69.35%of them were made both orotracheal intubation and cardiopulmonary resuscitation,and 20.5%of them were made only orotracheal intubation and 10.55%of them made only medical treatment.It was found that giving the code blue day or night had no effect on the time to reach the area where the code was given.Similarly,it was found that giving the code blue within daytime or night shift had no effect on the time to reach the area where the code was given.(P>0.05).The survival rates were 39.1%within the first 24 h and 18.1%within the first 30 d.Conclusions:Applications of code blue should be analyzed at regular intervals as clinical quality in 展开更多
关键词 CODE BLUE CARDIOPULMONARY RESUSCITATION Heart ARREST Respiratory ARREST PAGING system
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Social Networks and Their Role in Current Medicine: An Indispensable Tool for Doctors 认领
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作者 Israel Espino-Gaucin Carlos Eduardo Rodríguez Rodríguez +3 位作者 Javier Ruiz Ávila Javier Soto Catalina Ortiz Monasterio Ruge Rogelio Martinez Wagner 《生物科学与医学(英文)》 2020年第8期15-25,共11页
Social networks have had a substantial impact on the current methods of professional development and practice within the health services industry. They have proven to have a wide range of suitable applications that fa... Social networks have had a substantial impact on the current methods of professional development and practice within the health services industry. They have proven to have a wide range of suitable applications that facilitate communication, training, and medical practice. Currently, there are many web systems that allow people to have a public or semi-public profile, allowing the creation of shared connections with a list of users within the same system, which may vary in nature and terminology depending on the site in which it is used, shaping the concept of the social network. The purpose of this review is to highlight the usefulness of social media networks in academic medicine and its impact on health services. 展开更多
关键词 Social Networks Academic Medicine Health Services
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Neonatal Outcome of Induced Prematurity for Severe Preeclampsia in Four Great Kinshasa Maternities 认领
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作者 Olive Yalala Ambambula Andy Muela Mbangama +2 位作者 Therese Biselele Rashid Rahma Tozin Dieudonné Mushengezi Sengeyi 《妇产科期刊(英文)》 2020年第11期1637-1643,共7页
Severe preeclampsia (SPE) is associated with fetal complications including intrauterine growth retardation (IUGR), prematurity and in utero fetal death. Its treatment remains child birth that often is planned before t... Severe preeclampsia (SPE) is associated with fetal complications including intrauterine growth retardation (IUGR), prematurity and in utero fetal death. Its treatment remains child birth that often is planned before term. However, this attitude can lead to fetal complications related to prematurity. Several studies on preeclampsia have already been studied in the DRC and several aspects have already been realized, but to date, the neonatal outcome has not yet been addressed. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This is cross-sectional study performed in four public hospitals in Kinshasa (Democratic Republic of Congo). We included 400 cases of induced prematurity (IP) for SPE;the analysis compared pregnant women who gave birth before 34 weeks of amenorrhea (WA) and those after 34 WA. The comparison of the proportions was made by the Chi</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">square test and the calculation of Means by the Student’s test. The significance level was set at P < 0.05. </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> To determine the frequency of induced prematurity for severe preeclampsia (SPE), to identify the indications and to evaluate neonatal outcome. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The IP frequency for SPE was 46.2%. The retro placental hematoma was the most indication in pregnancies before 34 WA 24.9%, while high blood pressure 54.5% in the after 34 WA group. </span><i><span style="font-family:Verdana;">In</span></i> <i><span style="font-family:Verdana;">utero</span></i><span style="font-family:Verdana;"> death was more common in pregnant women who gave birth before 34 weeks 25.4%;chronic fetal distress was elevated in the after 34 展开更多
关键词 PREECLAMPSIA Induced Prematurity Neonatal Outcome
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Acute ascites as a clinical manifestation of dengue: A case report 认领
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作者 Beuy Joob Viroj Wiwanitkit 《急性病杂志:英文版》 2020年第6期270-271,共2页
Rationale:Dengue is an important tropical disease that can cause acute hemorrhagic fever.Other atypical clinical presentations of dengue also can occur,and acute ascites is one of them.Patients'concern:A 47-year-o... Rationale:Dengue is an important tropical disease that can cause acute hemorrhagic fever.Other atypical clinical presentations of dengue also can occur,and acute ascites is one of them.Patients'concern:A 47-year-old male patient was referred to the physician with acute abdominal extension for 2 days.He revealed a history of fatigue and right upper abdominal pain in the past 4 days.Diagnosis:Dengue-induced acute ascites.Intervention:Standard fluid replacement therapy.Outcome:The clinical finding of the patient returned to normal within 5 days.Lesson:Since dengue has been expanding its endemic area at present,an atypical clinical presentation is possible and should not be ignored in the process of diagnosis.In addition,the clinical presentation of acute distention of abdomen with abnormal petechiae is a good diagnostic implication for dengue-induced ascites. 展开更多
关键词 DENGUE ASCITES ACUTE MANIFESTATION
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Use of the Scar Acceleration Method/Método de Aceleração Cicatricial—MAC®—in the Treatment of Capsular Contracture: Case Report 认领
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作者 Carolina Macedo Alves Moreira Carolina Gonçalves Pinheiro +10 位作者 Aline Ronis Sampaio Michele Paula dos Santos Andres Felipe Mantilla Santamaria Miriam Viviane Baron Cristine Brandenburg Nathália Ken Pereira Iketani Mara Alessandra Porto dos Reis Oliveira Alexandre Sancho Esteban Fortuny Felice Picariello Marcus Vinicius de Mello Pinto 《康复医学(英文)》 2020年第4期131-142,共12页
<span style="font-family:Verdana;">Capsular contracture is a frequent complication in the postoperative period of breast implantation. It usually accompanies the appearance of a firm breast that can pr... <span style="font-family:Verdana;">Capsular contracture is a frequent complication in the postoperative period of breast implantation. It usually accompanies the appearance of a firm breast that can progress to pain, distortion, and asymmetry of the breasts, requiring surgical revision. The present study is a case report. A 58-year-old woman with a medical diagnosis of capsular contracture of the right breast evidenced by ultrasound. She was referred to the physiotherapy clinic in October 2019 with an initial complaint of pain on palpation, swelling, and stiffness in her right breast. The patient was evaluated and the MAC</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><sup><span style="font-family:Verdana;"><span style="font-family:Verdana;">ò</span></span></sup></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> method was used to treat capsular contracture. For this, 12 sessions of photodynamic therapy were carried out. The treatment included the use of LED by doping: red (300</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s), violet (60</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s) and blue (120</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s), with the use of 1% methylene blue in target areas, three times a week. The patient had the beginning of symptoms’ remission in the fourth visit and total remission in the 12th visit. It was concluded that the use of photodynamic therapy using the MAC</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><sup><span style 展开更多
关键词 Breast Implants Fibroses Methylene Blue Semiconductor Diode Laser Photodynamic Therapy
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Alternative Control of Alternaria Brown Spot in Tangerine 认领
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作者 Antonio Manoel Da Silva Filho Élida Barbosa Corrêa +1 位作者 Alisson Queiroz Moura Juan Manuel Anda Rocabado 《农业科学(英文)》 2020年第12期1217-1231,共15页
Alternaria brown spot is considered the main disease of tangerines in the State of Paraiba. The objective of work was to evaluate vegetal tinctures from bitter melon (<em>Momordica charantia</em>) and guav... Alternaria brown spot is considered the main disease of tangerines in the State of Paraiba. The objective of work was to evaluate vegetal tinctures from bitter melon (<em>Momordica charantia</em>) and guava (<em>Psidium guajava</em>) leaves, as an alternative control for Alternaria brown spot in tangerine. The effects of vegetal tinctures were tested in leaves and fruits (detached) of tangerine “Dancy” inoculated with tangerine pathotype of <em>Alternaria alternata</em>. The effect of tinctures on mycelium growth and spore germination of the pathogen was tested. Tinctures at 20% concentration promoted reduction of disease severity. A reduction of 80% in the diameter of leaf lesions was observed for bitter melon tinctures and 75.3% for guava tinctures. In fruits, the reduction was 48.4% (bitter melon tinctures) and 43.3% (guava tinctures). Guava tinctures, starting at a concentration of 5%, inhibited 100% of mycelium growth of tangerine pathotype of <em>A. alternata</em>, while the use of bitter melon tinctures inhibited 100% of mycelium growth starting at a concentration of 10%. The greater sensitivity to tinctures observed when these were added to the culture medium when compared to inoculation in leaves and fruits may be explained due to the higher exposition of the pathogen to the active principle when the vegetal tinctures were added to the culture medium, than when tinctures were sprayed over the vegetal surface in fruits and leaves. The number of germinated spores decreases 76.7% and 82% when using tinctures from guava and bitter melon (20%). Tinctures from bitter melon and guava are potential tools for alternative management of the Alternaria brown spot in tangerine “Dancy”. 展开更多
关键词 Alternaria alternata f. sp. citri Momordica charantia Psidium guajava Vegetal Extracts Vegetal Tinctures
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Survey on proper and safe use of biological safety cabinets (BSCs) in research, bio-medical and animal laboratories in Karachi, Pakistan a cross sectional study 认领
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作者 Shamsul Arfin Qasmi Sarmad Pirzada +1 位作者 Afsheen Ghani Saima Mohsin 《生物安全和生物安保杂志》 2020年第2期77-80,共4页
Introduction:Past incidences have been recorded relating to mishandling of hazardous material either due to insufficient knowledge or inappropriate equipment resulting in the indirect transfer of infectious agents.It ... Introduction:Past incidences have been recorded relating to mishandling of hazardous material either due to insufficient knowledge or inappropriate equipment resulting in the indirect transfer of infectious agents.It is necessary to identify gaps that inhibit proper protection of healthcare professionals from being inadvertently exposed to biological risks.Methods:A cross sectional study was conducted at multiple laboratories across Karachi,Pakistan from January to August 2018.Descriptive questionnaire was used to record data about types and usage of Biological Safety Cabinets(BSCs),along with policies and practices adapted for its certification.Results:A total of 30 laboratories were visited which included Clinical/Biomedical,University hospital,R&D and animal laboratories.Among these 60%always used BSCs,30%periodically used BSCs while 10%did not have any BSCs.Among these facilities 63.6%had BSC class II-A2,39.9%had BSC class II-B2,4.5%had BSC class III and only 0.9%had BSC class I cabinet.No protocols for field certification of BSCs were available.Conclusion:Establishment of biosafety training sessions,implementation and development of protocol for field certification for proper and safe use of BSCs on a local basis accompanied by continuous monitoring is required,for creating a safe environment for all laboratory staff. 展开更多
关键词 BIOSAFETY Public health Biohazard containment Equipment and supplies
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Discovery of unique African Helicobacter pylori CagAmultimerization motif in the Dominican Republic 认领
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作者 Takaaki Ono Modesto Cruz +8 位作者 Hiroyuki Nagashima Phawinee Subsomwong Junko Akada Takashi Matsumoto Tomohisa Uchida Rumiko Suzuki Celso Hosking Jose A Jimenez Abreu Yoshio Yamaoka 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第45期7118-7130,共13页
BACKGROUND Helicobacter pylori(H.pylori)colonizes the human stomach and is a major cause of peptic ulcer disease and gastric cancer.However,although the prevalence of H.pylori is high in Africa,the incidence of gastri... BACKGROUND Helicobacter pylori(H.pylori)colonizes the human stomach and is a major cause of peptic ulcer disease and gastric cancer.However,although the prevalence of H.pylori is high in Africa,the incidence of gastric cancer is low,and this phenomenon is called to be African enigma.The CagA protein produced by H.pylori is the most studied virulence factor.The carcinogenic potential of CagA is associated with the Glu-Pro-Ile-Tyr-Ala(EPIYA)patterns and CagAmultimerization(CM)motifs.AIM To better understand the EPIYA patterns and CM motifs of the cagA gene.METHODS Gastric mucosal biopsy specimens were obtained from 258 patients with dyspepsia living in the Dominican Republic,from which 120 H.pylori strains were cultured.After the bacterial DNA extraction,the EPIYA pattern and CM motif genotypes were determined using a polymerase chain reaction-based sequencing.The population structure of the Dominican Republic strains was analyzed using multilocus sequence typing(MLST).Peptic ulcer disease and gastric cancer were identified via endoscopy,and gastric cancer was confirmed by histopathology.Histological scores of the gastric mucosa were evaluated using the updated Sydney system.RESULTS All CagA-positive strains carried the Western-type CagA according to the identified EPIYA patterns.Twenty-seven kinds of CM motifs were observed.Although the typical Western CM motif(FPLKRHDKVDDLSKVG)was observed most frequently,the typical East Asian CM motif(FPLRRSAAVNDLSKVG)was not observed.However,“FPLRRSAKVEDLSKVG”,similar to the typical East Asian CM motif,was found in 21 strains.Since this type was significantly more frequent in strains classified as hpAfrica1 using MLST analysis(P=0.034),we termed it Africa1-CM(Af1-CM).A few hpEurope strains carried the Af1-CM motif,but they had a significantly higher ancestral Africa1 component than that of those without the Af1-CM motif(P=0.030).In 30 cagA-positive strains,the"GKDKGPE"motif was observed immediately upstream of the EPIYA motif in the EPIYA-A segment,and there was a signific 展开更多
关键词 Helicobacter pylori CAGA CagA 3'region CagA-multimerization motif Glu-Pro-Ile-Tyr-Ala motif Dominican Republic
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Regeneration patterns of key pine species in a mixed-pine forest indicate a positive effect of variable retention harvesting and an increase in recruitment with time 认领
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作者 Priscilla A.Nyamai P.Charles Goebel +1 位作者 R.Gregory Corace III David M.Hix 《森林生态系统:英文版》 SCIE CSCD 2020年第4期659-671,共13页
Background:Many fire-dependent forests have experienced significant declines in species,structural,and functional diversity.These changes are attributed in part to traditional management approaches that were dominated... Background:Many fire-dependent forests have experienced significant declines in species,structural,and functional diversity.These changes are attributed in part to traditional management approaches that were dominated by even-aged regeneration methods such as clearcutting.Variable retention harvesting(VRH)is an ecologically based forestry practice that involves retention of some mature overstory trees and other biological structures in the postharvest stand to emulate the effects of natural disturbance events.In this study,we examined the effect of a VRH treatment on recruitment of historically dominant pine species and understory vegetation twoand six years after its implementation in a naturally regenerated mixed pine forest in the Upper Peninsula of Michigan,USA.Results:We found greater regeneration of red pine(Pinus resinosa L.)and eastern white pine(Pinus strobus L.)in VRH stands compared to the unharvested controls.Although red pine recruitment was very low during the first 2 years,both species increased significantly from year two to year six.Recruitment responses for the two species did not differ significantly between the aggregated and dispersed retention treatments.We also found high recruitment of deciduous tree species,consisting primarily of sprouts,and red pine exhibited a negative correlation with these sprouts.Treatment,time,and the interaction of treatment and time were significant factors in red pine recruitment.Time had a strong effect on the understory vegetation,with significant decreases in shrubs and ferns over time.Conclusions:The results suggest that VRH enhanced recruitment of red pine and eastern white pine and that this recruitment increased with time.We identify competition from sprouts and unfavorable seedbed conditions as the main factors that limited recruitment of red pine during the first 2 years.To reduce competing vegetation and improve seedbed conditions,we suggest following the VRH with a prescribed fire,mechanically removing sprouts,and implementing herbicide treatments.At 展开更多
关键词 Variable retention harvesting Aggregated retention Dispersed retention Mixed-pine forest Pinus resinosa Pinus strobus
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Pulmonary Function by Spirometry in Children with Perinatal HIV Infection 认领
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作者 Nancy J. Gálvez Julio W. Juárez 《艾滋病(英文)》 2020年第4期215-222,共8页
<strong>Background:</strong> In an age of antiretroviral therapy, the life expectancy of children perinatally infected with Human Immunodeficiency Virus (HIV) has significantly increased. At the same time,... <strong>Background:</strong> In an age of antiretroviral therapy, the life expectancy of children perinatally infected with Human Immunodeficiency Virus (HIV) has significantly increased. At the same time, however, pulmonary pathologies secondary to opportunistic infections have decreased thanks to increased diagnostics and access to antiretroviral therapy (ART). Despite this, in these children an immune dysregulation is maintained due to chronic infection. There is evidence that these patients have increased probability of presenting with abnormalities in pulmonary function, mainly with chronic obstructive clinical pictures (25% - 40% of perinatally infected adolescents display some anomaly in the spirometry), which predisposes them to increased risk of chronic pulmonary disease. Since lung development occurs mainly during infancy, patients perinatally infected with HIV may suffer consequences. This can be secondary to opportunistic infections, chronic inflammation due to the virus, and immunologic effects of ART, mainly in non-industrialized countries, where late diagnosis is frequent. <strong>Methodology:</strong> An analytical, observational, cross-sectional study was conducted at Roosevelt Hospital Pediatric infectious disease clinic, from January to December 2019. A sample of 76 patients was obtained, out of a population of 362 patients. A total of 62 subjects, who met the criterion of reproducibility in the spirometry, were analyzed. Results were analyzed with percentages and the association of variables using the chi-squared test (<em>χ</em><sup>2</sup>). <strong>Results:</strong> A decrease in pulmonary function was found in 34% of patients, mild obstructive pattern (16%) predominating. Significant association between basal viral load greater than 100,000 cp/ml and a decrease in Forced expiratory flow 25 - 75 (FEF 25-75) (<em>p</em> 0.046) and in relationship between forced expiratory volume and forced vital capacity (FEV1/ FVC <em>p</em> = 0.024) was observed, as well as a non-statistically significant 展开更多
关键词 Pulmonary Function Perinatal HIV Infection SPIROMETRY
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